General Information of the Compound
Compound ID
CP0016203
Compound Name
Bis-(5-hydroxy-1H-indol-2-yl)-methanone
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Synonyms
896138-40-2
AKOS028113701
BDBM50187351
Bis(5-hydroxy-1H-indol-2-yl)methanone
Bis-(5-hydroxy-1H-indol-2-yl)-methanone
Bis-(5-hydroxy-1H-indol-2-yl)methanone
CCG-206752
CHEMBL377193
CTK8F1061
DTXSID40469293
Flt-3 Inhibitor II
Flt-3 inhibitor II
GTPL5971
HMS3229E09
IN1480
RT-012728
SCHEMBL2230377
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Structure
Formula
C17H12N2O3
Molecular Weight
292.294
Canonical SMILES
Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2cc(O)ccc2[nH]1
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InChI
InChI=1S/C17H12N2O3/c20-11-1-3-13-9(5-11)7-15(18-13)17(22)16-8-10-6-12(21)2-4-14(10)19-16/h1-8,18-21H
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InChIKey
NIMIWWQLOGNYHD-UHFFFAOYSA-N
Physicochemical Property
logP
3.2914
Rotatable Bonds
2
Heavy Atom Count
22
Polar Areas
89.11
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
3
Complexity
22

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11601743
SID: 16704450
ChEMBL ID
CHEMBL377193
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00888, Mast/stem cell growth factor receptor Kit
 Protein Info 
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000121 FDC-P1
 Cell Line Info 
Mus musculus (Mouse)  1
1
IC50 = 500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein ID: PT01204, Receptor-type tyrosine-protein kinase FLT3
 Protein Info 
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000075 EoL-1
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 40 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 33 nM
Clinical Information about the Compound
Drug 1 ( Bis-(5-hydroxy-1H-indol-2-yl)-methanone )
Drug Name Bis-(5-hydroxy-1H-indol-2-yl)-methanone
Target(s)
Fms-like tyrosine kinase 3 (FLT-3)
 Target Info 
Inhibitor
Platelet-derived growth factor receptor beta (PDGFRB)
 Target Info 
Inhibitor
Platelet-derived growth factor receptor alpha (PDGFRA)
 Target Info 
Inhibitor
Tyrosine-protein kinase Kit (KIT)
 Target Info 
Inhibitor
Tyrosine-protein kinase ABL1 (ABL)
 Target Info 
Inhibitor