General Information of the Compound
Compound ID
CP0012959
Compound Name
2-(6-ethylpyridin-2-yl)-4,5,5-trimethyl-3-pyridin-4-yl-4,6-dihydropyrrolo[1,2-b]pyrazole
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Structure
Formula
C21H24N4
Molecular Weight
332.451
Canonical SMILES
CCc1cccc(n1)-c1nn2CC(C)(C)C(C)c2c1-c1ccncc1
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InChI
InChI=1S/C21H24N4/c1-5-16-7-6-8-17(23-16)19-18(15-9-11-22-12-10-15)20-14(2)21(3,4)13-25(20)24-19/h6-12,14H,5,13H2,1-4H3
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InChIKey
ILAAKUYADOQGQJ-UHFFFAOYSA-N
Physicochemical Property
logP
4.7128
Rotatable Bonds
3
Heavy Atom Count
25
Polar Areas
43.6
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Complexity
25

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 145979031
ChEMBL ID
CHEMBL4281030
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01221, TGF-beta receptor type-1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000013 Sf9 Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 183 nM
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   LI
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Protein ID: PT03338, Tyrosine-protein kinase ABL1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000013 Sf9 Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 43000 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000083 MCF-7 Homo sapiens (Human)  1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS