General Information of the Compound
Compound ID
CP0011180
Compound Name
DEXTROMETHORPHAN
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Synonyms
(+)-3-Methoxy-17-methylmorphinan
(-)-3-Methoxy-N-methylmorphinan
(9alpha,13alpha,14alpha)-17-methyl-3-(methyloxy)morphinan
3-Methoxy-17-methyl-9alpha,13alpha,14alpha-morphinan
3-Methoxy-17-methylmorphinan
3-Methoxy-N-methylmorphinon
9alpha,13alpha,14alpha-Morphinan, 3-methoxy-17-methyl-(8CI)
Albutussin
BA 2666
Balminil DM
Balminil DM Children
Benylin Adult Formula Cough Suppressant
Benylin DM 12 Hour
Benylin DM for Children
Benylin DM for Children 12 Hour
Benylin Pediatric Cough Suppressant
Calmylin #1
Canfodion
Cis-1,3,4,9,10,10a-Hexahydro-6-methoxy-11-methyl-2H-10,4alpha-iminoethanophenanthren
Cosylan
Cough-X
Creo-Terpin
D-Methorphan
Delsym Cough Formula
Delta-Methorphan
Demorphan hydrobromide
Demorphine
Destrometerfano
Destrometerfano [DCIT]
Dextromethorfan
Dextromethorfan [Czech]
Dextromethorphan
Dextromethorphan (USP)
Dextromethorphan Bromhydrate
Dextromethorphan [USP:INN:BAN]
Dextromethorphane
Dextromethorphane [INN-French]
Dextromethorphanum
Dextromethorphanum [INN-Latin]
Dextrometorfano
Dextrometorfano [INN-Spanish]
Dextrometorphan
Dextromorphan
Dexyromethorphan
Diabe-Tuss DM Syrup
Dormetan
Hihustan MHold DM
Koffex DM
L-Methorphan
Levomethorphan
Levomethorphan [BAN:DCF:INN]
Levomethorphan [INN:BAN:DCF]
Levomethorphane
Levomethorphane [INN-French]
Levomethorphanum
Levomethorphanum [INN-Latin]
Levometorfano
Levometorfano [INN-Spanish]
Methorphan
Morphinan, 3-methoxy-17-methyl-, (9-alpha,13-alpha,14-alpha)-(9CI)
Neurodex (TN)
Novahistex DM
Novahistine DM
Pertussin CS Children's Strength
Pertussin DM Extra Strength
RACEMETHORPHAN
Robitussin Maximum Strength Cough Suppressant
Robitussin Pediatric
Robitussin Pediatric Cough Suppressant
Romilar (TN)
Sucrets 4 Hour Cough Suppressant
Triaminic DM Long Lasting for Children
Trocal
Vicks 44 Cough Relief
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Structure
Formula
C18H25NO
Molecular Weight
271.404
Canonical SMILES
COc1ccc2C[C@H]3[C@H]4CCCC[C@@]4(CCN3C)c2c1
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InChI
InChI=1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m1/s1
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InChIKey
MKXZASYAUGDDCJ-NJAFHUGGSA-N
CAS
125-71-3
18046-32-7
32062-10-5
Physicochemical Property
logP
3.3834
Rotatable Bonds
1
Heavy Atom Count
20
Polar Areas
12.47
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
2
Complexity
20

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 5360696
SID: 15197408
ChEMBL ID
CHEMBL52440
DrugBank ID
DB00514
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03795, Solute carrier family 22 member 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 10450 nM
   TI
   LI
   LO
   TS
2
IC50 = 15000 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( Dextromethorphan )
Drug Name Dextromethorphan
Indication
Cough
Approved
Target(s)
Opioid receptor sigma 1 (OPRS1)
Agonist