General Information of the Compound
Compound ID
CP0010647
Compound Name
(5-Hydroxy-1H-2-indolyl)(1H-2-indolyl)-methanone
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Synonyms
(5-Hydroxy-1H-2-indolyl)(1H-2-indolyl)-methanone
(5-hydroxy-1H-indol-2-yl)(1H-indol-2-yl)methanone
(5-hydroxy-1H-indol-2-yl)-(1H-indol-2-yl)methanone
2-(1H-indol-2-ylcarbonyl)-1H-indol-5-ol
249762-62-7
5-Hydroxy-[2,2'-carbonylbis(1H-indole)]
AC1NS9CN
BDBM6581
BRD-K27665173-001-01-3
Bis(1H-2-indolyl)methanone 39
CHEBI:92486
CHEMBL7735
CTK0J4476
D-64406
DTXSID20416205
HSCI1_000198
IN1158
Methanone, (5-hydroxy-1H-indol-2-yl)-1H-indol-2-yl-
NCGC00185731-01
PDGF Receptor Tyrosine Kinase Inhibitor I
SCHEMBL4456469
ZINC24261
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Structure
Formula
C17H12N2O2
Molecular Weight
276.295
Canonical SMILES
Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1
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InChI
InChI=1S/C17H12N2O2/c20-12-5-6-14-11(7-12)9-16(19-14)17(21)15-8-10-3-1-2-4-13(10)18-15/h1-9,18-20H
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InChIKey
AALNCHNFTKRFEL-UHFFFAOYSA-N
Physicochemical Property
logP
3.5858
Rotatable Bonds
2
Heavy Atom Count
21
Polar Areas
68.88
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
2
Complexity
21

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 5330535
SID: 14824297
ChEMBL ID
CHEMBL7735
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01204, Receptor-type tyrosine-protein kinase FLT3
 Protein Info 
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000075 EoL-1
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 570 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( (5-hydroxy-1H-indol-2-yl)(1H-indol-2-yl)methanone )
Drug Name (5-hydroxy-1H-indol-2-yl)(1H-indol-2-yl)methanone
Target(s)
Platelet-derived growth factor receptor beta (PDGFRB)
 Target Info 
Inhibitor
Fms-like tyrosine kinase 3 (FLT-3)
 Target Info 
Inhibitor
Platelet-derived growth factor receptor alpha (PDGFRA)
 Target Info 
Inhibitor