General Information of the Compound
Compound ID
CP0001023
Compound Name
(6-Methoxy-1H-2-indolyl)(1H-2-indolyl)methanone
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Synonyms
(1H-indol-2-yl)(6-methoxy-1H-indol-2-yl)methanone
1H-indol-2-yl-(6-methoxy-1H-indol-2-yl)methanone
2-(1H-indol-2-ylcarbonyl)-6-methoxy-1H-indole
6-Methoxy-[2,2'-carbonylbis(1H-indole)]
AC1NS9C2
BDBM6574
Bis(1H-2-indolyl)methanone 12
CHEMBL7602
SCHEMBL6864570
ZINC13472534
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Structure
Formula
C18H14N2O2
Molecular Weight
290.322
Canonical SMILES
COc1ccc2cc([nH]c2c1)C(=O)c1cc2ccccc2[nH]1
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InChI
InChI=1S/C18H14N2O2/c1-22-13-7-6-12-9-17(20-15(12)10-13)18(21)16-8-11-4-2-3-5-14(11)19-16/h2-10,19-20H,1H3
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InChIKey
RSMLCEQJLGXMPQ-UHFFFAOYSA-N
Physicochemical Property
logP
3.8888
Rotatable Bonds
3
Heavy Atom Count
22
Polar Areas
57.88
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
2
Complexity
22

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 5330528
SID: 16024317
ChEMBL ID
CHEMBL7602
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01204, Receptor-type tyrosine-protein kinase FLT3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000075 EoL-1 Homo sapiens (Human)  1
1
IC50 = 890 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( (1H-indol-2-yl)(6-methoxy-1H-indol-2-yl)methanone )
Drug Name (1H-indol-2-yl)(6-methoxy-1H-indol-2-yl)methanone
Target(s)
Platelet-derived growth factor receptor alpha (PDGFRA)
Inhibitor
Platelet-derived growth factor receptor beta (PDGFRB)
Inhibitor
Fms-like tyrosine kinase 3 (FLT-3)
Inhibitor