General Information of the Cell Line
Cell Line ID
CL000624
Cell Line Name
B6
Category
Finite cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_L814
Tissue Information
Trophoblast
Disease None
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01379, ERK activator kinase 2
Compound ID Compound Name Compound Formula
CP0447664
2,2-dimethyl-N-[2-[[(2S)-1'-methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl]amino]-2-oxoethyl]-N-[(1R)-1-phenylethyl]propanamide
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C27H32N4O4
 1
1
Ki = 670 nM
   TI
   LI
   LO
   TS
CP0327608
(S)-N-benzyl-N-(2-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidine-4,2'-indene]-5'-ylamino)-2-oxoethyl)pivalamide
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C26H30N4O4
 1
1
Ki = 710 nM
   TI
   LI
   LO
   TS
CP0428910
(+/-)-N-(3-fluorobenzyl)-N-(2-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidine-4,2'-indene]-5'-ylamino)-2-oxoethyl)pivalamide
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C26H29FN4O4
 1
1
Ki = 1400 nM
   TI
   LI
   LO
   TS
CP0447680
(+/-)-N-(3-chlorobenzyl)-N-(2-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidine-4,2'-indene]-5'-ylamino)-2-oxoethyl)pivalamide
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C26H29ClN4O4
 1
1
Ki = 1400 nM
   TI
   LI
   LO
   TS
CP0485748
N-[(1R)-1-(3,5-difluorophenyl)ethyl]-2,2-dimethyl-N-[2-[[(2S)-1'-methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl]amino]-2-oxoethyl]propanamide
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C27H30F2N4O4
 1
1
Ki = 1400 nM
   TI
   LI
   LO
   TS
CP0428911
(S)-N-(3-chloro-5-fluorobenzyl)-N-(2-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidine-4,2'-indene]-5'-ylamino)-2-oxoethyl)pivalamide
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C26H28ClFN4O4
 1
1
Ki = 1800 nM
   TI
   LI
   LO
   TS
CP0469942
(+/-)-N-(2-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidine-4,2'-indene]-5'-ylamino)-2-oxoethyl)-N-(3-methylbenzyl)pivalamide
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C27H32N4O4
 1
1
Ki = 1800 nM
   TI
   LI
   LO
   TS
CP0415042
(S)-N-(3,5-dichlorobenzyl)-N-(2-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidine-4,2'-indene]-5'-ylamino)-2-oxoethyl)pivalamide
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C26H28Cl2N4O4
 1
1
Ki = 2100 nM
   TI
   LI
   LO
   TS
CP0401577
(S)-N-(3,5-difluorobenzyl)-N-(2-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidine-4,2'-indene]-5'-ylamino)-2-oxoethyl)pivalamide
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C26H28F2N4O4
 1
1
Ki = 2400 nM
   TI
   LI
   LO
   TS
CP0397184
(+/-)-N-(4-fluorobenzyl)-N-(2-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidine-4,2'-indene]-5'-ylamino)-2-oxoethyl)pivalamide
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C26H29FN4O4
 1
1
Ki = 3700 nM
   TI
   LI
   LO
   TS
CP0388412
(+/-)-N-(2-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidine-4,2'-indene]-5'-ylamino)-2-oxoethyl)-N-(4-(trifluoromethyl)benzyl)pivalamide
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C27H29F3N4O4
 1
1
Ki = 6200 nM
   TI
   LI
   LO
   TS
CP0415041
(+/-)-N-(3-methoxybenzyl)-N-(2-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidine-4,2'-indene]-5'-ylamino)-2-oxoethyl)pivalamide
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C27H32N4O5
 1
1
Ki = 9700 nM
   TI
   LI
   LO
   TS
CP0430164
(+/-)-N-(3-cyanobenzyl)-N-(2-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidine-4,2'-indene]-5'-ylamino)-2-oxoethyl)pivalamide
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C27H29N5O4
 1
1
Ki = 13000 nM
   TI
   LI
   LO
   TS
CP0388352
2,2-dimethyl-N-[2-[[(2S)-1'-methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl]amino]-2-oxoethyl]-N-[(1S)-1-phenylethyl]propanamide
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C27H32N4O4
 1
1
Ki = 16000 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line