General Information of the Cell Line
Cell Line ID
CL000295
Cell Line Name
L6
Synonyms
L-6
L-6 myoblast
Category
Transformed cell line
Organism
Rattus norvegicus (Rat)
Cellosaurus ID
CVCL_0385
Tissue Information
Skeletal muscle
Disease None
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT03643, Glycogen synthase kinase-3 beta
 Protein Info 
Compound ID Compound Name Compound Formula
CP0022878
 Compound Info 
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-{pyrazolo[1,5-a]pyridazin-3-yl}pyrimidin-2-amine
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C18H14N6O2
  1
1
EC50 = 800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0106633
 Compound Info 
N-(3,5-dichlorophenyl)-4-{pyrazolo[1,5-a]pyridazin-3-yl}pyrimidin-2-amine
   Show/Hide
C16H10Cl2N6
  1
1
EC50 = 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0253873
 Compound Info 
N-(3,5-difluorophenyl)-4-{pyrazolo[1,5-a]pyridazin-3-yl}pyrimidin-2-amine
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C16H10F2N6
  1
1
EC50 = 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0257838
 Compound Info 
N-[4-chloro-3-(trifluoromethyl)phenyl]-4-{pyrazolo[1,5-a]pyridazin-3-yl}pyrimidin-2-amine
   Show/Hide
C17H10ClF3N6
  1
1
EC50 = 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0246051
 Compound Info 
N-[3-methoxy-5-(trifluoromethyl)phenyl]-4-{pyrazolo[1,5-a]pyridazin-3-yl}pyrimidin-2-amine
   Show/Hide
C18H13F3N6O
  1
1
EC50 = 1200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0019675
 Compound Info 
N-(3-methoxyphenyl)-4-{pyrazolo[1,5-a]pyridazin-3-yl}pyrimidin-2-amine
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C17H14N6O
  1
1
EC50 = 1300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0159615
 Compound Info 
N-(3,4-dimethoxyphenyl)-4-{pyrazolo[1,5-a]pyridazin-3-yl}pyrimidin-2-amine
   Show/Hide
C18H16N6O2
  1
1
EC50 = 1500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0083046
 Compound Info 
N-phenyl-4-{2-phenylpyrazolo[1,5-a]pyridazin-3-yl}pyrimidin-2-amine
   Show/Hide
C22H16N6
  1
1
EC50 = 1600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0159629
 Compound Info 
N-(3,5-dimethylphenyl)-4-{pyrazolo[1,5-a]pyridazin-3-yl}pyrimidin-2-amine
   Show/Hide
C18H16N6
  1
1
EC50 = 1800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0253817
 Compound Info 
4-{2-phenylpyrazolo[1,5-a]pyridazin-3-yl}-N-[3-(trifluoromethyl)phenyl]pyrimidin-2-amine
   Show/Hide
C23H15F3N6
  1
1
EC50 = 2100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0267141
 Compound Info 
4-[2-(4-fluorophenyl)pyrazolo[1,5-a]pyridazin-3-yl]-N-[3-(trifluoromethyl)phenyl]pyrimidin-2-amine
   Show/Hide
C23H14F4N6
  1
1
EC50 = 2800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0069036
 Compound Info 
N-phenyl-4-{pyrazolo[1,5-a]pyridazin-3-yl}pyrimidin-2-amine
   Show/Hide
C16H12N6
  1
1
EC50 = 2900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0268960
 Compound Info 
N-(3,4-difluorophenyl)-4-{6-methyl-2-phenylpyrazolo[1,5-a]pyridazin-3-yl}pyrimidin-2-amine
   Show/Hide
C23H16F2N6
  1
1
EC50 = 3400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0225315
 Compound Info 
4-(6-Methyl-2-phenylpyrazolo[1,5-b]pyridazin-3-yl)-N-phenyl-2-pyrimidinamine
   Show/Hide
C23H18N6
  1
1
EC50 = 3600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0340056
 Compound Info 
N-(3,4-difluorophenyl)-4-{2-phenylpyrazolo[1,5-a]pyridazin-3-yl}pyrimidin-2-amine
   Show/Hide
C22H14F2N6
  1
1
EC50 = 4200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0166225
 Compound Info 
4-[2-(4-fluorophenyl)-6-methylpyrazolo[1,5-a]pyridazin-3-yl]-N-[3-(trifluoromethyl)phenyl]pyrimidin-2-amine
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C24H16F4N6
  1
1
EC50 = 6800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein ID: PT05515, Glucose transporter type 1
 Protein Info 
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0499576
 Compound Info 
N-[4-(aminomethyl)-1,3-thiazol-2-yl]-2-benzyl-5-tert-butylpyrazole-3-carboxamide
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 C19H23N5OS  1
1
IC50 = 4900 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Skeletal muscle)
Cell Line Name Organism Disease
Hs 746.T
 Cell Line Info 
Homo sapiens (Human) Gastric adenocarcinoma
C2C12
 Cell Line Info 
Mus musculus (Mouse) -