| Compound ID |
Compound Name |
Compound Formula |
|
CP0579841
|
US10906888, Example 147
Show/Hide
|
C18H22N6O2
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0549311
|
8-oxa-2-azaspiro[4.5]dec-2-yl(2-{[1-(pyrimidin-5-yl)cyclopropyl]amino}pyrimidin-5-yl)methanone
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|
C20H24N6O2
|
1
|
| 1 |
IC50 = 1020 nM
|
|
|
|
CP0546334
|
7-oxa-2-azaspiro[3.5]non-2-yl(2-{[2-(pyrazin-2-yl)propan-2-yl]amino}pyrimidin-5-yl)methanone
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|
C19H24N6O2
|
1
|
| 1 |
IC50 = 1200 nM
|
|
|
|
CP0549313
|
US10906888, Example 133
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|
C20H24N6O3
|
1
|
| 1 |
IC50 = 1300 nM
|
|
|
|
CP0579711
|
8-oxa-2-azaspiro[4.5]dec-2-yl(2-{[2-(pyrimidin-5-yl)propan-2-yl]amino}pyrimidin-5-yl)methanone
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|
C20H26N6O2
|
1
|
| 1 |
IC50 = 1900 nM
|
|
|
|
CP0579840
|
8-oxa-2-azaspiro[4.5]dec-2-yl(2-{[(1S)-1-(pyrazin-2-yl)ethyl]amino}pyrimidin-5-yl)methanone
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|
C19H24N6O2
|
1
|
| 1 |
IC50 = 2800 nM
|
|
|
|
CP0573882
|
8-oxa-2-azaspiro[4.5]dec-2-yl(2-{[2-(pyrazin-2-yl)propan-2-yl]amino}pyrimidin-5-yl)methanone
Show/Hide
|
C20H26N6O2
|
1
|
| 1 |
IC50 = 3600 nM
|
|
|
|
CP0573141
|
US10906888, Example 135
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|
C17H20N6O2
|
1
|
| 1 |
IC50 = 7400 nM
|
|
|
|
CP0546331
|
8-oxa-2-azaspiro[4.5]decan-2-yl-[2-[(1-pyrazin-2-ylcyclobutyl)amino]pyrimidin-5-yl]methanone
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|
C21H26N6O2
|
1
|
| 1 |
IC50 = 8900 nM
|
|
|
|
CP0491746
|
US10906888, Example 185
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|
C18H22N6O2
|
1
|
| 1 |
IC50 = 11000 nM
|
|
|
|
CP0491744
|
US10906888, Example 1
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|
C19H23N5O2
|
1
|
| 1 |
IC50 = 11300 nM
|
|
|
|
CP0491743
|
(3R)-1-[2-[(1-pyrimidin-5-ylcyclopropyl)amino]pyrimidine-5-carbonyl]piperidine-3-carbonitrile
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|
C18H19N7O
|
1
|
| 1 |
IC50 = 12700 nM
|
|
|
|
CP0571521
|
US10906888, Example 198
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|
C18H22N6O3S
|
1
|
| 1 |
IC50 > 13000 nM
|
|
|
|
CP0280569
|
US10906888, Example 190
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|
C17H20N6O
|
1
|
| 1 |
IC50 = 18000 nM
|
|
|
|
CP0266746
|
3-[(2-{[1-(pyrimidin-5-yl)cyclopropyl]amino}pyrimidin-5-yl)carbonyl]benzonitrile
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|
C19H14N6O
|
1
|
| 1 |
IC50 = 24000 nM
|
|
|
|
CP0229469
|
8-oxa-2-azaspiro[4.5]dec l{2-[(pyrazin-2-ylmethyl)amino]pyrimidin-5-yl}methanone
Show/Hide
|
C18H22N6O2
|
1
|
| 1 |
IC50 > 50000 nM
|
|
|
|
CP0546333
|
US10906888, Example 150
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|
C19H24N6O2
|
1
|
| 1 |
IC50 > 50000 nM
|
|
|
|
CP0573139
|
US10906888, Example 146
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|
C19H24N6O2
|
1
|
| 1 |
IC50 > 50000 nM
|
|
|
|
CP0491748
|
US10906888, Example 195
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|
C18H19N7O
|
1
|
| 1 |
IC50 = 53000 nM
|
|
|
|
CP0491747
|
[(3R)-3-methylsulfonylpiperidin-1-yl]-[2-[(1-pyrimidin-5-ylcyclopropyl)amino]pyrimidin-5-yl]methanone
Show/Hide
|
C18H22N6O3S
|
1
|
| 1 |
IC50 = 62000 nM
|
|
|
