Brief Information of the Cell Line and Protein
Cell Line ID: CL000880 , COS
Category Transformed cell line
Organism
Chlorocebus aethiops (Green monkey)
Cellosaurus ID
CVCL_0223
Protein ID: PT01089 , Alpha-1A adrenergic receptor
Gene Name ADRA1A
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P35348
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000880  Protein ID: PT01089
 
Compound ID Compound Name Compound Formula
CP0404209
1-{5-[4-(2-Propoxy-phenyl)-piperazin-1-ylmethyl]-thiophen-3-ylmethyl}-pyrrolidin-2-one
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C23H31N3O2S
 1
1
Ki = 0.2 nM
   TI
   LI
   LO
   TS
CP0441282
1-{5-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl]-thiophen-2-ylmethyl}-piperidin-2-one; hydrochloride
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C24H33N3O2S
 1
1
Ki = 0.3 nM
   TI
   LI
   LO
   TS
CP0479750
1-{5-[4-(2-Propoxy-phenyl)-piperazin-1-ylmethyl]-thiophen-3-ylmethyl}-piperidin-2-one
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C24H33N3O2S
 1
1
Ki = 0.5 nM
   TI
   LI
   LO
   TS
CP0424607
2-(2-oxopiperidin-1-yl)-N-[3-[4-(2-propan-2-yloxyphenyl)piperazin-1-yl]propyl]acetamide
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C23H36N4O3
 1
1
Ki = 0.66 nM
   TI
   LI
   LO
   TS
CP0049709
2-(4-Furan-2-yl-piperazin-1-yl)-6,7-dimethoxy-quinazolin-4-ylamine
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C18H21N5O3
 1
1
Ki = 1.39 nM
   TI
   LI
   LO
   TS
CP0110274
1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-3,3-diphenyl-propan-1-one
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C29H31N5O3
 1
1
Ki = 1.59 nM
   TI
   LI
   LO
   TS
CP0428734
1-{5-[4-(2-Propoxy-phenyl)-piperazin-1-ylmethyl]-thiophen-3-ylmethyl}-azepan-2-one
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C25H35N3O2S
 1
1
Ki = 1.8 nM
   TI
   LI
   LO
   TS
CP0415583
1-{5-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl]-2H-pyrazol-3-ylmethyl}-piperidin-2-one
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C23H33N5O2
 1
1
Ki = 2.1 nM
   TI
   LI
   LO
   TS
CP0451946
1-{5-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl]-2-methyl-2H-pyrazol-3-ylmethyl}-piperidin-2-one
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C24H35N5O2
 1
1
Ki = 3.7 nM
   TI
   LI
   LO
   TS
CP0380273
1-{3-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl]-isoxazol-5-ylmethyl}-piperidin-2-one
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C23H32N4O3
 1
1
Ki = 3.8 nM
   TI
   LI
   LO
   TS
CP0122632
1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-3-phenyl-propane-1,3-dione
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C23H25N5O4
 1
1
Ki = 8.17 nM
   TI
   LI
   LO
   TS
CP0375998
2-(2-oxopiperidin-1-yl)-N-[2-[4-(2-propan-2-yloxyphenyl)piperazin-1-yl]ethyl]acetamide
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C22H34N4O3
 1
1
Ki = 8.7 nM
   TI
   LI
   LO
   TS
CP0436835
1-{5-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl]-1-methyl-1H-pyrazol-3-ylmethyl}-piperidin-2-one
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C24H35N5O2
 1
1
Ki = 9 nM
   TI
   LI
   LO
   TS
CP0049357
1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-2-(2-isopropyl-6-methoxy-phenoxy)-ethanone
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C26H33N5O5
 1
1
Ki = 10.34 nM
   TI
   LI
   LO
   TS
CP0447216
(S)-1-{5-[4-(2-Methoxy-phenyl)-piperazin-1-ylmethyl]-thiophen-2-ylmethyl}-pyrrolidine-2-carboxylic acid methyl ester
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C23H31N3O3S
 1
1
Ki = 12 nM
   TI
   LI
   LO
   TS
CP0514449
1-{5-[4-(2-Methoxy-phenyl)-piperazin-1-ylmethyl]-thiophen-2-ylmethyl}-piperidin-2-one
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C22H29N3O2S
 1
1
Ki = 14 nM
   TI
   LI
   LO
   TS
CP0497715
2-(2-oxoazepan-1-yl)-N-[2-[4-(2-propan-2-yloxyphenyl)piperazin-1-yl]ethyl]acetamide
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C23H36N4O3
 1
1
Ki = 18 nM
   TI
   LI
   LO
   TS
CP0921505
1-{(E)-5-[4-(2-Isopropoxy-phenyl)-piperazin-1-yl]-2-oxo-pent-3-enyl}-piperidin-2-one
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C23H33N3O3
 1
1
Ki = 18 nM
   TI
   LI
   LO
   TS
CP0460888
1-{5-[4-(2-Methoxy-phenyl)-piperazin-1-ylmethyl]-thiophen-2-ylmethyl}-azepan-2-one
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C23H31N3O2S
 1
1
Ki = 18 nM
   TI
   LI
   LO
   TS
CP0122703
1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-2-(2-methoxy-phenoxy)-ethanone
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C23H27N5O5
 1
1
Ki = 18.95 nM
   TI
   LI
   LO
   TS
CP0096797
1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-4-phenyl-butane-1,4-dione
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C24H27N5O4
 1
1
Ki = 19.38 nM
   TI
   LI
   LO
   TS
CP0501089
1-({2-[4-(2-Isopropoxy-phenyl)-piperazin-1-yl]-ethylcarbamoyl}-methyl)-5-oxo-pyrrolidine-2-carboxylic acid ethyl ester
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C24H36N4O5
 1
1
Ki = 20 nM
   TI
   LI
   LO
   TS
CP0358354
1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-2-(2,6-dimethoxy-phenoxy)-ethanone
   Show/Hide
C24H29N5O6
 1
1
Ki = 23.72 nM
   TI
   LI
   LO
   TS
CP0515889
1-{4-Hydroxy-5-[4-(2-isopropoxy-phenyl)-piperazin-1-yl]-2-oxo-pentyl}-piperidin-2-one
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C23H35N3O4
 1
1
Ki = 28 nM
   TI
   LI
   LO
   TS
CP0441665
(2-Oxo-piperidin-1-yl)-acetic acid 2-[4-(2-isopropoxy-phenyl)-piperazin-1-yl]-ethyl ester
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C22H33N3O4
 1
1
Ki = 38 nM
   TI
   LI
   LO
   TS
CP0418914
1-{5-[4-(2-Methoxy-phenyl)-piperazin-1-ylmethyl]-thiophen-2-ylmethyl}-pyrrolidin-2-one
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C21H27N3O2S
 1
1
Ki = 40 nM
   TI
   LI
   LO
   TS
CP0497205
N-methyl-2-(2-oxopiperidin-1-yl)-N-[2-[4-(2-propan-2-yloxyphenyl)piperazin-1-yl]ethyl]acetamide
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C23H36N4O3
 1
1
Ki = 53 nM
   TI
   LI
   LO
   TS
CP0374743
1-{2-Amino-6-[4-(2-isopropoxy-phenyl)-piperazin-1-ylmethyl]-pyrimidin-4-ylmethyl}-piperidin-2-one
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C24H34N6O2
 1
1
Ki = 79 nM
   TI
   LI
   LO
   TS
CP0419315
N-[2-[4-(4-fluoro-2-propan-2-yloxyphenyl)piperazin-1-yl]ethyl]-2-(2-oxopiperidin-1-yl)acetamide
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C22H33FN4O3
 1
1
Ki = 83 nM
   TI
   LI
   LO
   TS
CP0448732
1-{3-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl]-4,5-dihydro-isoxazol-5-ylmethyl}-piperidin-2-one
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C23H34N4O3
 1
1
Ki = 89 nM
   TI
   LI
   LO
   TS
CP0505644
N-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propyl]-2-(2-oxopiperidin-1-yl)acetamide
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C21H32N4O3
 1
1
Ki = 98 nM
   TI
   LI
   LO
   TS
CP0401646
1-(5-Bromo-thiophen-2-ylmethyl)-4-(2-methoxy-phenyl)-piperazine
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C16H19BrN2OS
 1
1
Ki = 128 nM
   TI
   LI
   LO
   TS
CP0484760
N-[2-[4-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl]ethyl]-2-(2-oxopiperidin-1-yl)acetamide
   Show/Hide
C21H28F4N4O3
 1
1
Ki = 129 nM
   TI
   LI
   LO
   TS
CP0441309
[5-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]thiophen-2-yl]methanol
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C17H22N2O2S
 1
1
Ki = 202 nM
   TI
   LI
   LO
   TS
CP0453097
[5-[[4-(2-propan-2-yloxyphenyl)piperazin-1-yl]methyl]thiophen-3-yl]methanol
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C19H26N2O2S
 1
1
Ki = 331 nM
   TI
   LI
   LO
   TS
CP0399342
1-[4-(2-Isopropoxy-phenyl)-piperazin-1-yl]-5-(2-oxo-piperidin-1-yl)-pentane-2,4-dione
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C23H33N3O4
 1
1
Ki = 417 nM
   TI
   LI
   LO
   TS
CP0437757
1-{5-[4-(2-Methoxy-phenyl)-piperazin-1-ylmethyl]-thiophen-2-ylmethyl}-piperidin-2-ol
   Show/Hide
C22H31N3O2S
 1
1
Ki = 419 nM
   TI
   LI
   LO
   TS
CP0466836
5-[4-(2-Methoxy-phenyl)-piperazin-1-ylmethyl]-thiophene-2-carbaldehyde
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C17H20N2O2S
 1
1
Ki = 578 nM
   TI
   LI
   LO
   TS
CP0270867
1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-2-(2-isopropyl-6-methoxy-phenoxy)-propan-1-one
   Show/Hide
C27H35N5O5
 1
1
Ki = 1112.8 nM
   TI
   LI
   LO
   TS