Brief Information of the Cell Line and Protein
Cell Line ID: CL000880 , COS
Category Transformed cell line
Organism
Chlorocebus aethiops (Green monkey)
Cellosaurus ID
CVCL_0223
Protein ID: PT00901 , Prostaglandin G/H synthase 2
Gene Name PTGS2
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID P35354
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000880  Protein ID: PT00901
 
Compound ID Compound Name Compound Formula
CP0452665
N-benzyl-4-(4-methylsulfonylphenyl)-6-(trifluoromethyl)pyrimidin-2-amine
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C19H16F3N3O2S
 1
1
IC50 = 0.25 nM
   TI
   LI
   LO
   TS
CP0492568
N-[(4-fluorophenyl)methyl]-4-(4-methylsulfonylphenyl)-6-(trifluoromethyl)pyrimidin-2-amine
   Show/Hide
C19H15F4N3O2S
 1
1
IC50 = 0.28 nM
   TI
   LI
   LO
   TS
CP0498487
4-[2-(4-Ethoxy-phenyl)-pyrazolo[1,5-b]pyridazin-3-yl]-benzenesulfonamide
   Show/Hide
C20H18N4O3S
 1
1
IC50 = 0.44 nM
   TI
   LI
   LO
   TS
CP0492565
N-cyclohexyl-4-(4-methylsulfonylphenyl)-6-(trifluoromethyl)pyrimidin-2-amine
   Show/Hide
C18H20F3N3O2S
 1
1
IC50 = 0.5 nM
   TI
   LI
   LO
   TS
CP0452664
N-butyl-4-(4-methylsulfonylphenyl)-6-(trifluoromethyl)pyrimidin-2-amine
   Show/Hide
C16H18F3N3O2S
 1
1
IC50 = 1.3 nM
   TI
   LI
   LO
   TS
CP0472128
4-(2-(butylamino)-6-(trifluoromethyl)pyrimidin-4-yl)benzenesulfonamide
   Show/Hide
C15H17F3N4O2S
 1
1
IC50 < 1.4 nM
   TI
   LI
   LO
   TS
CP0451843
3-(4-Methanesulfonyl-phenyl)-2-phenyl-pyrazolo[1,5-b]pyridazine
   Show/Hide
C19H15N3O2S
 1
1
IC50 = 2 nM
   TI
   LI
   LO
   TS
CP0396906
N-butan-2-yl-4-(4-methylsulfonylphenyl)-6-(trifluoromethyl)pyrimidin-2-amine
   Show/Hide
C16H18F3N3O2S
 1
1
IC50 = 2 nM
   TI
   LI
   LO
   TS
CP0061060
5-Bromo-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-thiophene
   Show/Hide
C17H12BrFO2S2
 1
1
IC50 = 2 nM
   TI
   LI
   LO
   TS
CP0452663
4-(2-(cyclohexylamino)-6-(trifluoromethyl)pyrimidin-4-yl)benzenesulfonamide
   Show/Hide
C17H19F3N4O2S
 1
1
IC50 = 2.4 nM
   TI
   LI
   LO
   TS
CP0392520
2-(4-Ethoxy-phenyl)-3-(4-methanesulfonyl-phenyl)-pyrazolo[1,5-b]pyridazine
   Show/Hide
C21H19N3O3S
 1
1
IC50 = 3 nM
   TI
   LI
   LO
   TS
CP0485346
N-methyl-N-(4-methylphenyl)-4-(4-methylsulfonylphenyl)-6-(trifluoromethyl)pyrimidin-2-amine
   Show/Hide
C20H18F3N3O2S
 1
1
IC50 = 3 nM
   TI
   LI
   LO
   TS
CP0457428
4-(4-(methylsulfonyl)phenyl)-N-((tetrahydro-2H-pyran-4-yl)methyl)-6-(trifluoromethyl)pyrimidin-2-amine
   Show/Hide
C18H20F3N3O3S
 1
1
IC50 = 5 nM
   TI
   LI
   LO
   TS
CP0524034
4-(4-(methylsulfonyl)phenyl)-N-propyl-6-(trifluoromethyl)pyrimidin-2-amine
   Show/Hide
C15H16F3N3O2S
 1
1
IC50 = 5 nM
   TI
   LI
   LO
   TS
CP0509358
4-(4-(methylsulfonyl)phenyl)-N-phenyl-6-(trifluoromethyl)pyrimidin-2-amine
   Show/Hide
C18H14F3N3O2S
 1
1
IC50 = 5.6 nM
   TI
   LI
   LO
   TS
CP0492572
N-(4-fluorophenyl)-4-(4-methylsulfonylphenyl)-6-(trifluoromethyl)pyrimidin-2-amine
   Show/Hide
C18H13F4N3O2S
 1
1
IC50 = 7.2 nM
   TI
   LI
   LO
   TS
CP0404720
4-[2-(4-Fluoro-phenyl)-pyrazolo[1,5-b]pyridazin-3-yl]-benzenesulfonamide
   Show/Hide
C18H13FN4O2S
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0451844
3-(4-Methanesulfonyl-phenyl)-2-(4-methoxy-phenyl)-pyrazolo[1,5-b]pyridazine
   Show/Hide
C20H17N3O3S
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0457430
N-[(4-methylphenyl)methyl]-4-(4-methylsulfonylphenyl)-6-(trifluoromethyl)pyrimidin-2-amine
   Show/Hide
C20H18F3N3O2S
 1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS
CP0524035
4-(4-(methylsulfonyl)phenyl)-N-p-tolyl-6-(trifluoromethyl)pyrimidin-2-amine
   Show/Hide
C19H16F3N3O2S
 1
1
IC50 = 11 nM
   TI
   LI
   LO
   TS
CP0457431
2-(cyclohexylmethyl)-4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)pyrimidine
   Show/Hide
C24H25FN2O2S
 1
1
IC50 = 12 nM
   TI
   LI
   LO
   TS
CP0497006
4-[2-(4-Ethoxy-phenyl)-6-methylsulfanyl-pyrazolo[1,5-b]pyridazin-3-yl]-benzenesulfonamide
   Show/Hide
C21H20N4O3S2
 1
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
CP0452661
N-cyclohexyl-4-(4-methylsulfonylphenyl)-6-(2,2,2-trifluoroethoxy)pyrimidin-2-amine
   Show/Hide
C19H22F3N3O3S
 1
1
IC50 = 16 nM
   TI
   LI
   LO
   TS
CP0404719
3-(4-Methanesulfonyl-phenyl)-2-p-tolyl-pyrazolo[1,5-b]pyridazine
   Show/Hide
C20H17N3O2S
 1
1
IC50 = 17 nM
   TI
   LI
   LO
   TS
CP0485347
4-(4-(methylsulfonyl)phenyl)-N-(tetrahydro-2H-pyran-4-yl)-6-(trifluoromethyl)pyrimidin-2-amine
   Show/Hide
C17H18F3N3O3S
 1
1
IC50 = 18 nM
   TI
   LI
   LO
   TS
CP0452666
4-(4-fluorophenyl)-2-((1-methyl-1H-pyrrol-2-yl)methyl)-5-(4-(methylsulfonyl)phenyl)pyrimidine
   Show/Hide
C23H20FN3O2S
 1
1
IC50 = 23 nM
   TI
   LI
   LO
   TS
CP0496838
2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-6-methyl-pyrazolo[1,5-b]pyridazine
   Show/Hide
C20H16FN3O2S
 1
1
IC50 = 24 nM
   TI
   LI
   LO
   TS
CP0469539
4-[2-(4-Fluoro-phenyl)-6-methoxy-pyrazolo[1,5-b]pyridazin-3-yl]-benzenesulfonamide
   Show/Hide
C19H15FN4O3S
 1
1
IC50 = 26 nM
   TI
   LI
   LO
   TS
CP0457429
N-(cyclohexylmethyl)-4-(4-methylsulfonylphenyl)-6-(trifluoromethyl)pyrimidin-2-amine
   Show/Hide
C19H22F3N3O2S
 1
1
IC50 = 29 nM
   TI
   LI
   LO
   TS
CP0496845
3-(4-Methanesulfonyl-phenyl)-6-methyl-2-phenyl-pyrazolo[1,5-b]pyridazine
   Show/Hide
C20H17N3O2S
 1
1
IC50 < 31 nM
   TI
   LI
   LO
   TS
CP0037144
4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofuran-2-one
   Show/Hide
C17H14O4S
 1
1
IC50 = 32 nM
   TI
   LI
   LO
   TS
CP0497450
2-(3-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-pyrazolo[1,5-b]pyridazine
   Show/Hide
C19H14FN3O2S
 1
1
IC50 = 34 nM
   TI
   LI
   LO
   TS
CP0497959
2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-pyrazolo[1,5-b]pyridazine
   Show/Hide
C19H14FN3O2S
 1
1
IC50 = 39 nM
   TI
   LI
   LO
   TS
CP0469542
6-Ethoxy-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-pyrazolo[1,5-b]pyridazine
   Show/Hide
C21H18FN3O3S
 1
1
IC50 = 43 nM
   TI
   LI
   LO
   TS
CP0422094
2-((4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)pyrimidin-2-yl)methyl)phenol
   Show/Hide
C24H19FN2O3S
 1
1
IC50 = 43 nM
   TI
   LI
   LO
   TS
CP0430083
6-Ethyl-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-pyrazolo[1,5-b]pyridazine
   Show/Hide
C21H18FN3O2S
 1
1
IC50 = 48 nM
   TI
   LI
   LO
   TS
CP0498492
3-(4-Methanesulfonyl-phenyl)-6-methoxy-2-p-tolyl-pyrazolo[1,5-b]pyridazine
   Show/Hide
C21H19N3O3S
 1
1
IC50 = 50 nM
   TI
   LI
   LO
   TS
CP0469538
2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-6-methoxy-pyrazolo[1,5-b]pyridazine
   Show/Hide
C20H16FN3O3S
 1
1
IC50 = 51 nM
   TI
   LI
   LO
   TS
CP0492579
4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)-N-phenylpyrimidin-2-amine
   Show/Hide
C23H18FN3O2S
 1
1
IC50 = 56 nM
   TI
   LI
   LO
   TS
CP0469546
2-(4-Fluoro-phenyl)-6-isopropoxy-3-(4-methanesulfonyl-phenyl)-pyrazolo[1,5-b]pyridazine
   Show/Hide
C22H20FN3O3S
 1
1
IC50 = 57 nM
   TI
   LI
   LO
   TS
CP0492586
(4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)pyrimidin-2-yl)(phenyl)methanol
   Show/Hide
C24H19FN2O3S
 1
1
IC50 = 57 nM
   TI
   LI
   LO
   TS
CP0097394
5-(4-Fluoro-phenyl)-1-(4-methanesulfonyl-phenyl)-3-trifluoromethyl-1H-pyrazole
   Show/Hide
C17H12F4N2O2S
 1
1
IC50 = 66 nM
   TI
   LI
   LO
   TS
CP0011191
4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzene-1-sulfonamide
   Show/Hide
C17H14F3N3O2S
 1
1
IC50 = 68 nM
   TI
   LI
   LO
   TS
CP0517116
4-(4-fluorophenyl)-N-methyl-5-(4-(methylsulfonyl)phenyl)-N-phenylpyrimidin-2-amine
   Show/Hide
C24H20FN3O2S
 1
1
IC50 = 85 nM
   TI
   LI
   LO
   TS
CP0492581
2-benzyl-4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)pyrimidine
   Show/Hide
C24H19FN2O2S
 1
1
IC50 = 104 nM
   TI
   LI
   LO
   TS
CP0455242
2-(2,4-difluorobenzyl)-4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)pyrimidine
   Show/Hide
C24H17F3N2O2S
 1
1
IC50 = 114 nM
   TI
   LI
   LO
   TS
CP0040447
4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzene-1-sulfonamide
   Show/Hide
C16H14N2O3S
 1
1
IC50 = 183 nM
   TI
   LI
   LO
   TS
CP0496866
4-[2-(4-Ethoxy-phenyl)-6-methanesulfonyl-pyrazolo[1,5-b]pyridazin-3-yl]-benzenesulfonamide
   Show/Hide
C21H20N4O5S2
 1
1
IC50 = 264 nM
   TI
   LI
   LO
   TS
CP0492566
4-(4-(methylsulfonyl)phenyl)-6-(trifluoromethyl)pyrimidin-2-amine
   Show/Hide
C12H10F3N3O2S
 1
1
IC50 = 272 nM
   TI
   LI
   LO
   TS
CP0422086
2-(4-fluorobenzyl)-4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)pyrimidine
   Show/Hide
C24H18F2N2O2S
 1
1
IC50 = 277 nM
   TI
   LI
   LO
   TS
CP0132427
5-Chloro-3-(4-methanesulfonyl-phenyl)-6''-methyl-[2,3'']bipyridinyl
   Show/Hide
C18H15ClN2O2S
 1
1
IC50 = 347 nM
   TI
   LI
   LO
   TS
CP0496865
2-(4-Fluoro-phenyl)-6-methanesulfonyl-3-(4-methanesulfonyl-phenyl)-pyrazolo[1,5-b]pyridazine
   Show/Hide
C20H16FN3O4S2
 1
1
IC50 = 370 nM
   TI
   LI
   LO
   TS
CP0500754
4-[2-(4-Trifluoromethoxy-phenyl)-pyrazolo[1,5-b]pyridazin-3-yl]-benzenesulfonamide
   Show/Hide
C19H13F3N4O3S
 1
1
IC50 = 388 nM
   TI
   LI
   LO
   TS
CP0473841
N-benzyl-4-(4-fluorophenyl)-5-(4-methylsulfonylphenyl)pyrimidin-2-amine
   Show/Hide
C24H20FN3O2S
 1
1
IC50 = 686 nM
   TI
   LI
   LO
   TS
CP0537979
2-Benzyl-4-(4-fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-pyrimidine 3-oxide
   Show/Hide
C24H19FN2O3S
 1
1
IC50 = 717 nM
   TI
   LI
   LO
   TS
CP0492582
4-(4-fluorophenyl)-2-isopropyl-5-(4-(methylsulfonyl)phenyl)pyrimidine
   Show/Hide
C20H19FN2O2S
 1
1
IC50 = 1135 nM
   TI
   LI
   LO
   TS
CP0504274
N-cyclohexyl-4-methyl-6-(4-methylsulfonylphenyl)pyrimidin-2-amine
   Show/Hide
C18H23N3O2S
 1
1
IC50 = 1683 nM
   TI
   LI
   LO
   TS
CP0505880
4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)-2-phenethylpyrimidine
   Show/Hide
C25H21FN2O2S
 1
1
IC50 = 5263 nM
   TI
   LI
   LO
   TS
CP0502249
4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)-2-(pyridin-2-ylmethyl)pyrimidine
   Show/Hide
C23H18FN3O2S
 1
1
IC50 = 6323 nM
   TI
   LI
   LO
   TS
CP0428840
2-N-cyclohexyl-6-(4-methylsulfonylphenyl)pyrimidine-2,4-diamine
   Show/Hide
C17H22N4O2S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0428841
4-(4-(methylsulfonyl)phenyl)-N-(piperidin-4-yl)-6-(trifluoromethyl)pyrimidin-2-amine
   Show/Hide
C17H19F3N4O2S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0452662
4-Trifluoromethyl-13-thia-5,7,19-triaza-tricyclo[12.2.2.1*2,6*]nonadeca-1(17),2,4,6(19),14(18),15-hexaene 13,13-dioxide
   Show/Hide
C16H16F3N3O2S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0472127
2-(cyclohexylamino)-6-(4-(methylsulfonyl)phenyl)pyrimidine-4-carboxylic acid
   Show/Hide
C18H21N3O4S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0485344
2-(cyclohexylamino)-6-(4-(methylsulfonyl)phenyl)pyrimidine-4-carboxamide
   Show/Hide
C18H22N4O3S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0485345
N-cyclohexyl-5-methyl-4-(4-methylsulfonylphenyl)-6-(trifluoromethyl)pyrimidin-2-amine
   Show/Hide
C19H22F3N3O2S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0509353
N-cyclohexyl-4-(4-methylsulfonylphenyl)pyrimidin-2-amine
   Show/Hide
C17H21N3O2S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0509354
N-cyclohexyl-5-methyl-4-(4-methylsulfonylphenyl)pyrimidin-2-amine
   Show/Hide
C18H23N3O2S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0422091
4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)-2-phenoxypyrimidine
   Show/Hide
C23H17FN2O3S
 1
1
IC50 > 4640 nM
   TI
   LI
   LO
   TS
CP0422087
4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)-2-(phenylthio)pyrimidine
   Show/Hide
C23H17FN2O2S2
 1
1
IC50 > 7200 nM
   TI
   LI
   LO
   TS