Brief Information of the Cell Line and Protein
Cell Line ID: CL000870 , HEK-Blue Null1-v
Category Transformed cell line
Organism
Homo sapiens (Human)
Protein ID: PT03041 , Toll-like receptor 4
Gene Name TLR4
Organism Mus musculus, Mouse
Protein Classification Membrane receptor
Uniprot ID Q9QUK6
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000870  Protein ID: PT03041
 
Compound ID Compound Name Compound Formula
CP0184261
N-cyclohexyl-2-(5-methyl-4-oxo-3,8-diphenylpyrimido[5,4-b]indol-2-yl)sulfanylacetamide
   Show/Hide
C31H30N4O2S
 1
1
EC50 = 820 nM
   TI
   LI
   LO
   TS
CP0127752
N-cyclohexyl-2-(5-methyl-8-naphthalen-2-yl-4-oxo-3-phenylpyrimido[5,4-b]indol-2-yl)sulfanylacetamide
   Show/Hide
C35H32N4O2S
 1
1
EC50 = 2010 nM
   TI
   LI
   LO
   TS
CP0238282
2-(8-bromo-5-methyl-4-oxo-3-phenylpyrimido[5,4-b]indol-2-yl)sulfanyl-N-cyclohexylacetamide
   Show/Hide
C25H25BrN4O2S
 1
1
EC50 = 2450 nM
   TI
   LI
   LO
   TS
CP0201870
N-cyclohexyl-2-(8-iodo-5-methyl-4-oxo-3-phenylpyrimido[5,4-b]indol-2-yl)sulfanylacetamide
   Show/Hide
C25H25IN4O2S
 1
1
EC50 = 2510 nM
   TI
   LI
   LO
   TS
CP0184258
N-cyclohexyl-2-(5-methyl-8-naphthalen-1-yl-4-oxo-3-phenylpyrimido[5,4-b]indol-2-yl)sulfanylacetamide
   Show/Hide
C35H32N4O2S
 1
1
EC50 = 2580 nM
   TI
   LI
   LO
   TS
CP0476463
N-cyclohexyl-2-(8-ethynyl-5-methyl-4-oxo-3-phenylpyrimido[5,4-b]indol-2-yl)sulfanylacetamide
   Show/Hide
C27H26N4O2S
 1
1
EC50 = 2740 nM
   TI
   LI
   LO
   TS
CP0303515
N-cyclohexyl-2-[(6-oxo-5-phenyl-3,5,8-triazatricyclo[7.5.0.02,7]tetradeca-1(9),2(7),3-trien-4-yl)sulfanyl]acetamide
   Show/Hide
C25H30N4O2S
 1
1
EC50 = 2830 nM
   TI
   LI
   LO
   TS
CP0127764
N-cyclohexyl-2-(5-methyl-4-oxo-3-phenylpyrimido[5,4-b]indol-2-yl)sulfanylacetamide
   Show/Hide
C25H26N4O2S
 1
1
EC50 = 3170 nM
   TI
   LI
   LO
   TS
CP0417558
N-cyclohexyl-2-[5-methyl-4-oxo-3-phenyl-8-(2-trimethylsilylethynyl)pyrimido[5,4-b]indol-2-yl]sulfanylacetamide
   Show/Hide
C30H34N4O2SSi
 1
1
EC50 = 3300 nM
   TI
   LI
   LO
   TS
CP0238283
2-(7-bromo-5-methyl-4-oxo-3-phenylpyrimido[5,4-b]indol-2-yl)sulfanyl-N-cyclohexylacetamide
   Show/Hide
C25H25BrN4O2S
 1
1
EC50 = 4890 nM
   TI
   LI
   LO
   TS
CP0127750
N-cyclohexyl-2-[(4-oxo-3-phenyl-6,7,8,9-tetrahydro-5H-pyrimido[5,4-b]indol-2-yl)sulfanyl]acetamide
   Show/Hide
C24H28N4O2S
 1
1
EC50 = 7120 nM
   TI
   LI
   LO
   TS
CP0303517
N-cyclohexyl-2-[(8-methyl-6-oxo-5-phenyl-3,5,8-triazatricyclo[7.5.0.02,7]tetradeca-1(9),2(7),3-trien-4-yl)sulfanyl]acetamide
   Show/Hide
C26H32N4O2S
 1
1
EC50 = 8800 nM
   TI
   LI
   LO
   TS
CP0127749
N-cyclohexyl-2-[(5-methyl-4-oxo-3-phenylpyrimido[5,4-b]indol-2-yl)amino]acetamide
   Show/Hide
C25H27N5O2
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0127751
N-cyclohexyl-2-[(6,7-dimethyl-4-oxo-3-phenyl-5H-pyrrolo[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide
   Show/Hide
C22H26N4O2S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0184256
N-[2-[2-(cyclohexylamino)-2-oxoethyl]sulfanyl-5-methyl-4-oxo-3-phenylpyrimido[5,4-b]indol-8-yl]benzamide
   Show/Hide
C32H31N5O3S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0235985
2-(8-cyano-5-methyl-4-oxo-3-phenylpyrimido[5,4-b]indol-2-yl)sulfanyl-N-cyclohexylacetamide
   Show/Hide
C26H25N5O2S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0238280
N-cyclohexyl-2-[(5-methyl-4-oxo-3-phenyl-6,7,8,9-tetrahydropyrimido[5,4-b]indol-2-yl)sulfanyl]acetamide
   Show/Hide
C25H30N4O2S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0238281
N-cyclohexyl-2-(5-methyl-4-oxo-3-phenylpyrrolo[3,2-d]pyrimidin-2-yl)sulfanylacetamide
   Show/Hide
C21H24N4O2S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0303516
4-[[2-[2-(cyclohexylamino)-2-oxoethyl]sulfanyl-5-methyl-4-oxo-3-phenylpyrimido[5,4-b]indol-8-yl]amino]-4-oxobutanoic acid
   Show/Hide
C29H31N5O5S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0326610
2-(3-cyclohexylpropylsulfanyl)-3-phenyl-5H-pyrimido[5,4-b]indol-4-one
   Show/Hide
C25H27N3OS
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0355546
2-(7-cyano-5-methyl-4-oxo-3-phenylpyrimido[5,4-b]indol-2-yl)sulfanyl-N-cyclohexylacetamide
   Show/Hide
C26H25N5O2S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0417555
N-cyclohexyl-2-[5-methyl-4-oxo-3-phenyl-8-(4-phenylphenyl)pyrimido[5,4-b]indol-2-yl]sulfanylacetamide
   Show/Hide
C37H34N4O2S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0417570
N-[2-[2-(cyclohexylamino)-2-oxoethyl]sulfanyl-5-methyl-4-oxo-3-phenylpyrimido[5,4-b]indol-8-yl]octanamide
   Show/Hide
C33H41N5O3S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0417571
N-cyclohexyl-2-(5-methyl-4-oxo-3-phenylpyrimido[5,4-b]indol-2-yl)sulfonylacetamide
   Show/Hide
C25H26N4O4S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0417572
N-cyclohexyl-2-(5-methyl-4-oxo-3-phenylpyrimido[5,4-b]indol-2-yl)oxyacetamide
   Show/Hide
C25H26N4O3
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0448700
N-cyclohexyl-2-(5,6,7-trimethyl-4-oxo-3-phenylpyrrolo[3,2-d]pyrimidin-2-yl)sulfanylacetamide
   Show/Hide
C23H28N4O2S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0448701
2-(8-amino-5-methyl-4-oxo-3-phenylpyrimido[5,4-b]indol-2-yl)sulfanyl-N-cyclohexylacetamide
   Show/Hide
C25H27N5O2S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0448702
N-cyclohexyl-2-[(4-oxo-3-phenyl-5H-pyrrolo[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide
   Show/Hide
C20H22N4O2S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0475070
N-cyclohexyl-4-[(4-oxo-3-phenyl-5H-pyrimido[5,4-b]indol-2-yl)sulfanyl]butanamide
   Show/Hide
C26H28N4O2S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0476464
N-cyclohexyl-3-[(5-methyl-4-oxo-3-phenylpyrimido[5,4-b]indol-2-yl)amino]propanamide
   Show/Hide
C26H29N5O2
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0519697
N-cyclohexyl-3-[(4-oxo-3-phenyl-5H-pyrimido[5,4-b]indol-2-yl)sulfanyl]propanamide
   Show/Hide
C25H26N4O2S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS