Brief Information of the Cell Line and Protein
Cell Line ID: CL000247 , MT-4
Synonyms
MT4
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_2632
Protein ID: PT00021 , Protease
Gene Name PROTEASE
Organism Human immunodeficiency virus 1
Protein Classification Enzyme
Uniprot ID Q9YQ12
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000247  Protein ID: PT00021
 
Compound ID Compound Name Compound Formula
CP0354600
(4R)-N-[(2,6-dimethylphenyl)methyl]-3-[(2S,3S)-2-hydroxy-3-[[(2S)-2-[(7-methoxy-1-benzofuran-2-carbonyl)amino]-2-[(3R)-oxolan-3-yl]acetyl]amino]-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide
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C41H48N4O8S
 1
1
EC50 = 25 nM
   TI
   LI
   LO
   TS
CP0478515
(2S)-2-(1-benzofuran-2-carbonylamino)-N-[(2S,3S)-4-[(4R)-4-[(2,6-dimethylphenyl)methylcarbamoyl]-5,5-dimethyl-1,3-thiazolidin-3-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]butanediamide
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C38H43N5O7S
 1
1
EC50 = 61 nM
   TI
   LI
   LO
   TS
CP0353831
(2S)-N-[(2S,3S)-4-[(4R)-4-[(2,6-dimethylphenyl)methylcarbamoyl]-5,5-dimethyl-1,3-thiazolidin-3-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]-2-[(7-methoxy-1-benzofuran-2-carbonyl)amino]butanediamide
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C39H45N5O8S
 1
1
EC50 = 84 nM
   TI
   LI
   LO
   TS
CP0354599
(4R)-3-[(2S,3S)-2-hydroxy-3-[[(2S)-2-[(3R)-oxolan-3-yl]-2-(quinoxaline-2-carbonylamino)acetyl]amino]-4-phenylbutanoyl]-5,5-dimethyl-N-[(2-methylphenyl)methyl]-1,3-thiazolidine-4-carboxamide
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C39H44N6O6S
 1
1
EC50 = 95 nM
   TI
   LI
   LO
   TS
CP0063016
(4R)-3-[(2S,3S)-3-[[(2S)-2-[[2-[3-(dimethylamino)phenoxy]acetyl]amino]-2-[(3R)-oxolan-3-yl]acetyl]amino]-2-hydroxy-4-phenylbutanoyl]-N-[(2,6-dimethylphenyl)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide
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C41H53N5O7S
 1
1
EC50 = 165 nM
   TI
   LI
   LO
   TS
CP0353830
(4R)-3-[(2S,3S)-3-[[(2S)-2-[[2-(3-anilinophenoxy)acetyl]amino]-2-[(3R)-oxolan-3-yl]acetyl]amino]-2-hydroxy-4-phenylbutanoyl]-N-[(2,6-dimethylphenyl)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide
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C45H53N5O7S
 1
1
EC50 = 226 nM
   TI
   LI
   LO
   TS
CP0466675
(4R)-N-[(2,6-dimethylphenyl)methyl]-3-[(2S,3S)-2-hydroxy-3-[[(2S)-2-[(7-methoxy-1-benzofuran-2-carbonyl)amino]-3-methylbutanoyl]amino]-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide
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C40H48N4O7S
 1
1
EC50 = 309 nM
   TI
   LI
   LO
   TS
CP0241924
(4R)-3-[(2S,3S)-3-[[(2S)-2-(1-benzofuran-2-carbonylamino)-2-[(3R)-oxolan-3-yl]acetyl]amino]-2-hydroxy-4-phenylbutanoyl]-N-[(2,6-dimethylphenyl)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide
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C40H46N4O7S
 1
1
EC50 = 678 nM
   TI
   LI
   LO
   TS
CP0533337
(4R)-3-[(2S,3S)-3-[[(2S)-2-(1-benzofuran-2-carbonylamino)-3-methylbutanoyl]amino]-2-hydroxy-4-phenylbutanoyl]-N-[(2,6-dimethylphenyl)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide
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C39H46N4O6S
 1
1
EC50 = 1100 nM
   TI
   LI
   LO
   TS
CP0080761
(2S)-N-[(2S,4S,5S)-5-[2-(2,6-dimethylphenoxy)acetamido]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide
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C37H48N4O5
 1
1
EC50 = 1160 nM
   TI
   LI
   LO
   TS
CP0095094
(4R)-3-[(2S,3S)-2-hydroxy-3-[(3-hydroxy-2-methylphenyl)formamido]-4-phenylbutanoyl]-5,5-dimethyl-N-[(2-methylphenyl)methyl]-1,3-thiazolidine-4-carboxamide
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C32H37N3O5S
 1
1
EC50 = 2730 nM
   TI
   LI
   LO
   TS