Brief Information of the Cell Line and Protein
Cell Line ID: CL000186 , RPMI-8226
 Cell Line Info 
Synonyms
RPMI 8226
RPMI.8226
RPMI8226
RPMI no. 8226
RPMI no 8226
RPMI #8226
8226
RPMI 8226/S
RPMI-8226S
RPMI8226/S
8226/S
Roswell Park Memorial Institute 8226
GM02132
GM2132
GM 2132
GM02132C
Simpson
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0014
Protein ID: PT03168 , Proteasome subunit beta type-8
 Protein Info 
Gene Name PSMB8
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID P28062
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000186
 Cell Line Info 
 Protein ID: PT03168
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0062987
 Compound Info 
(2S)-3-(4-methoxyphenyl)-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide
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C31H40N4O7
  1
1
IC50 = 18 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0847941
 Compound Info 
N-((R)-1-((S)-3-(1H-indol-3-yl)-1-((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-ylamino)-1-oxopropan-2-ylamino)-1-oxopropan-2-yl)-3-methyl-1H-indene-2-carboxamide
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C37H38N4O5
  1
1
IC50 = 25 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0885679
 Compound Info 
(S)-N-((S)-3-cyclohexyl-1-((R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-(4-methoxyphenyl)-2-((S)-2-(2-morpholinoacetamido)propanamido)propanamide
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C31H46N4O7
  1
1
IC50 = 44 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0864816
 Compound Info 
(S)-N-((S)-3-cyclohexyl-1-((R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-(1H-indol-3-yl)-2-((R)-2-(2-morpholinoacetamido)propanamido)propanamide
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C32H45N5O6
  1
1
IC50 = 59 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0386861
 Compound Info 
(2S)-N-[(2S)-3-cyclohexyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-(4-methoxyphenyl)-2-[[(2R)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide
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C31H46N4O7
  1
1
IC50 = 100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0868641
 Compound Info 
N-((R)-1-((S)-1-((S)-3-cyclohexyl-1-((R)-2-methyloxiran-2-yl)-1-oxopropan-2-ylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-ylamino)-1-oxopropan-2-yl)-3-methyl-1H-indene-2-carboxamide
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C37H44N4O5
  1
1
IC50 = 230 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0411613
 Compound Info 
N-[(2R)-1-[[(2S)-1-[[(2S)-3-cyclohexyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]amino]-3-(4-methoxyphenyl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]-3-methyl-1H-indene-2-carboxamide
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C36H45N3O6
  1
1
IC50 = 370 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0850423
 Compound Info 
N-((R)-1-((S)-3-(1H-indol-3-yl)-1-((S)-4-(methylsulfonyl)-1-phenylbut-3-en-2-ylamino)-1-oxopropan-2-ylamino)-1-oxopropan-2-yl)-3-methyl-1H-indene-2-carboxamide
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C36H38N4O5S
  1
1
IC50 = 390 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS