Brief Information of the Cell Line and Protein
Cell Line ID: CL000141 , LNCaP
 Cell Line Info 
Synonyms
LNCAP
LNCap
Ln-Cap
Lymph Node Carcinoma of the prostate
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0395
Protein ID: PT01462 , Bromodomain-containing protein 4
 Protein Info 
Gene Name BRD4
Organism Homo sapiens, Human
Protein Classification Epigenetic regulator
Uniprot ID O60885
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000141
 Cell Line Info 
 Protein ID: PT01462
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0143638
 Compound Info 
(3R)-4-[2-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]phenoxy]ethyl]-1,3-dimethylpiperazin-2-one
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C25H33N7O3
  1
1
IC50 = 19.95 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0213782
 Compound Info 
(3R)-1,3-dimethyl-4-[2-[4-[1-(3-methylsulfanyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]phenoxy]ethyl]piperazin-2-one
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C25H33N7O2S
  1
1
IC50 = 25.12 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0236893
 Compound Info 
(3R)-4-[2-[4-[1-(3-chloro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]phenoxy]ethyl]-1,3-dimethylpiperazin-2-one
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C24H30ClN7O2
  1
1
IC50 = 25.12 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0236899
 Compound Info 
(3R)-4-[2-[4-[1-[3-(dimethylamino)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl]phenoxy]ethyl]-1,3-dimethylpiperazin-2-one
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C26H36N8O2
  1
1
IC50 = 25.12 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0480263
 Compound Info 
(3R)-1,3-dimethyl-4-[2-[4-[1-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl]phenoxy]ethyl]piperazin-2-one
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C25H30F3N7O2
  1
1
IC50 = 39.81 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0213778
 Compound Info 
1-methyl-4-[2-[4-[1-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl]phenoxy]ethyl]piperazin-2-one
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C24H28F3N7O2
  1
1
IC50 = 316.23 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0249897
 Compound Info 
1-[4-[2-[4-[1-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl]phenoxy]ethyl]piperazin-1-yl]ethanone
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C25H30F3N7O2
  1
1
IC50 = 316.23 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0180784
 Compound Info 
(3R)-1,3-dimethyl-4-[2-[4-[1-([1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]phenoxy]ethyl]piperazin-2-one
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C24H31N7O2
  1
1
IC50 = 1584.89 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS