Brief Information of the Cell Line and Protein
Cell Line ID: CL000134 , DLD-1
 Cell Line Info 
Synonyms
DLD 1
DLD1
CoCL3
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0248
Protein ID: PT04417 , Son of sevenless homolog 1
 Protein Info 
Gene Name SOS1
Organism Homo sapiens, Human
Protein Classification Unclassified protein
Uniprot ID Q07889
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000134
 Cell Line Info 
 Protein ID: PT04417
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0576629
 Compound Info 
[(7S)-17-[[(1R)-1-[3-(difluoromethyl)-2-fluorophenyl]ethyl]amino]-15-methyl-10-oxa-2,5,14,16-tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(11),12,14,16,18-pentaen-5-yl]-[(3R)-oxolan-3-yl]methanone
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C29H32F3N5O3
  1
1
IC50 = 10 nM
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CP0562636
 Compound Info 
(7S)-N-[(1R)-1-[3-(difluoromethyl)-2-fluorophenyl]ethyl]-5-(2-methoxyethyl)-15-methyl-10-oxa-2,5,14,16-tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(11),12,14,16,18-pentaen-17-amine
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C27H32F3N5O2
  1
1
IC50 = 11 nM
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CP0494968
 Compound Info 
[(7S)-17-[[(1R)-1-[3-(difluoromethyl)-2-fluorophenyl]ethyl]amino]-15-methyl-10-oxa-2,5,14,16-tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(11),12,14,16,18-pentaen-5-yl]-(oxetan-3-yl)methanone
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C28H30F3N5O3
  1
1
IC50 = 13 nM
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CP0542805
 Compound Info 
1-[(7R)-16-[[(1R)-1-[3-(difluoromethyl)-2-fluorophenyl]ethyl]amino]-14-methyl-9-oxa-2,5,13,15-tetrazatetracyclo[8.8.0.02,7.012,17]octadeca-1(10),11,13,15,17-pentaene-5-carbonyl]cyclopropane-1-carbonitrile
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C28H27F3N6O2
  1
1
IC50 = 13 nM
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CP0554105
 Compound Info 
(7S)-N-[(1R)-1-[3-(difluoromethyl)-2-fluorophenyl]ethyl]-15-methyl-5-(2,2,2-trifluoroethyl)-10-oxa-2,5,14,16-tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(11),12,14,16,18-pentaen-17-amine
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C26H27F6N5O
  1
1
IC50 = 16 nM
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CP0533722
 Compound Info 
1-[(7S)-17-[[(1R)-1-[3-(difluoromethyl)-2-fluorophenyl]ethyl]amino]-15-methyl-10-oxa-2,5,14,16-tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(11),12,14,16,18-pentaene-5-carbonyl]cyclopropane-1-carbonitrile
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C29H29F3N6O2
  1
1
IC50 = 19 nM
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CP0574918
 Compound Info 
(7S)-N-[(1R)-1-[3-(difluoromethyl)-2-fluorophenyl]ethyl]-15-methyl-5-(oxetan-3-ylmethyl)-10-oxa-2,5,14,16-tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(11),12,14,16,18-pentaen-17-amine
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C28H32F3N5O2
  1
1
IC50 = 29 nM
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CP0575070
 Compound Info 
(7S)-N-[(1R)-1-[3-(difluoromethyl)-2-fluorophenyl]ethyl]-5,15-dimethyl-10-oxa-2,5,14,16-tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(11),12,14,16,18-pentaen-17-amine
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C25H28F3N5O
  1
1
IC50 = 30 nM
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CP0273407
 Compound Info 
4-[[(1R)-1-[3-amino-5-(trifluoromethyl)phenyl]ethyl]amino]-2-methyl-6-[(3S)-oxolan-3-yl]oxyquinazolin-7-ol
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C22H23F3N4O3
  1
1
IC50 = 34 nM
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CP0569970
 Compound Info 
(7S)-N-[(1R)-1-[3-(difluoromethyl)-2-fluorophenyl]ethyl]-15-methyl-5-(2-methylpyrazol-3-yl)-10-oxa-2,5,14,16-tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(11),12,14,16,18-pentaen-17-amine
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C28H30F3N7O
  1
1
IC50 = 34 nM
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CP0575069
 Compound Info 
[(7S)-17-[[(1R)-1-[3-(difluoromethyl)-2-fluorophenyl]ethyl]amino]-15-methyl-10-oxa-2,5,14,16-tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(11),12,14,16,18-pentaen-5-yl]-(2-methylpyrazol-3-yl)methanone
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C29H30F3N7O2
  1
1
IC50 = 40 nM
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CP0569968
 Compound Info 
1-[(7S)-17-[[(1R)-1-[3-(difluoromethyl)-2-fluorophenyl]ethyl]amino]-15-methyl-10-oxa-2,5,14,16-tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(11),12,14,16,18-pentaen-5-yl]-2,2-dimethylpropan-1-one
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C29H34F3N5O2
  1
1
IC50 = 49 nM
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CP0576630
 Compound Info 
[(7S)-17-[[(1R)-1-[3-(difluoromethyl)-2-fluorophenyl]ethyl]amino]-15-methyl-10-oxa-2,5,14,16-tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(11),12,14,16,18-pentaen-5-yl]-pyridin-3-ylmethanone
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C30H29F3N6O2
  1
1
IC50 = 51 nM
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CP0579395
 Compound Info 
(7S)-N-[(1R)-1-[3-(difluoromethyl)-2-fluorophenyl]ethyl]-15-methyl-5-[(3S)-oxolan-3-yl]-10-oxa-2,5,14,16-tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(11),12,14,16,18-pentaen-17-amine
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C28H32F3N5O2
  1
1
IC50 = 53 nM
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CP0574917
 Compound Info 
2-[(7S)-17-[[(1R)-1-[3-(difluoromethyl)-2-fluorophenyl]ethyl]amino]-15-methyl-10-oxa-2,5,14,16-tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(11),12,14,16,18-pentaen-5-yl]acetonitrile
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C26H27F3N6O
  1
1
IC50 = 70 nM
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CP0574916
 Compound Info 
(7S)-N-[(1R)-1-[3-(difluoromethyl)-2-fluorophenyl]ethyl]-15-methyl-5-propan-2-yl-10-oxa-2,5,14,16-tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(11),12,14,16,18-pentaen-17-amine
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C27H32F3N5O
  1
1
IC50 = 75 nM
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CP0574915
 Compound Info 
oxetan-3-yl (7S)-17-[[(1R)-1-[3-(difluoromethyl)-2-fluorophenyl]ethyl]amino]-15-methyl-10-oxa-2,5,14,16-tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(11),12,14,16,18-pentaene-5-carboxylate
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C28H30F3N5O4
  1
1
IC50 = 78 nM
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CP0574914
 Compound Info 
(7S)-17-[[(1R)-1-[3-(difluoromethyl)-2-fluorophenyl]ethyl]amino]-15-methyl-10-oxa-2,5,14,16-tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(11),12,14,16,18-pentaene-5-carboxamide
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C25H27F3N6O2
  1
1
IC50 = 88 nM
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