Brief Information of the Cell Line and Protein
Cell Line ID: CL000131 , HEK293-F
Synonyms
HEK-293-F
HEK 293-F
HEK-293F
HEK293F
293-F
293 F
293F
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_6642
Protein ID: PT06380 , Palmitoleoyl-protein carboxylesterase NOTUM
Gene Name NOTUM
Organism Mus musculus, Mouse
Protein Classification Enzyme
Uniprot ID Q8R116
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000131  Protein ID: PT06380
 
Compound ID Compound Name Compound Formula
CP0414627
6,9-difluoro-8-methyl-4,5-dihydrobenzo[g][1]benzothiole-2-carboxylic acid
   Show/Hide
C14H10F2O2S
 1
1
EC50 = 6 nM
   TI
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   TS
CP0511152
6,8-difluoro-4H-thieno[3,2-c]thiochromene-2-carboxylic acid
   Show/Hide
C12H6F2O2S2
 1
1
EC50 = 6 nM
   TI
   LI
   LO
   TS
CP0406188
3-thiatricyclo[8.4.0.02,6]tetradeca-1(14),2(6),4,10,12-pentaene-4-carboxamide
   Show/Hide
C14H13NOS
 1
1
EC50 = 7 nM
   TI
   LI
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   TS
CP0495741
5-methyl-4,5-dihydrobenzo[g][1]benzothiole-2-carboxamide
   Show/Hide
C14H13NOS
 1
1
EC50 = 7 nM
   TI
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   TS
CP0534345
5,5-dimethyl-4H-benzo[g][1]benzothiole-2-carboxamide
   Show/Hide
C15H15NOS
 1
1
EC50 = 7 nM
   TI
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   TS
CP0407494
4,5-dihydrothieno[3,2-d][1]benzoxepine-2-carboxamide
   Show/Hide
C13H11NO2S
 1
1
EC50 = 8 nM
   TI
   LI
   LO
   TS
CP0511153
6,7,8-trifluoro-4H-thieno[3,2-c]thiochromene-2-carboxylic acid
   Show/Hide
C12H5F3O2S2
 1
1
EC50 = 8 nM
   TI
   LI
   LO
   TS
CP0420081
6-fluoro-8-methyl-4,5-dihydrobenzo[g][1]benzothiole-2-carboxylic acid
   Show/Hide
C14H11FO2S
 1
1
EC50 = 9 nM
   TI
   LI
   LO
   TS
CP0401678
6,7-dichloro-4,5-dihydrobenzo[g][1]benzothiole-2-carboxylic acid
   Show/Hide
C13H8Cl2O2S
 1
1
EC50 = 12 nM
   TI
   LI
   LO
   TS
CP0406186
6-chloro-8-fluoro-4,5-dihydrobenzo[g][1]benzothiole-2-carboxylic acid
   Show/Hide
C13H8ClFO2S
 1
1
EC50 = 13 nM
   TI
   LI
   LO
   TS
CP0549216
4,5-dihydrobenzo[g][1]benzothiole-2-carboxamide
   Show/Hide
C13H11NOS
 1
1
EC50 = 13 nM
   TI
   LI
   LO
   TS
CP0472651
4-methyl-4,5-dihydrobenzo[g][1]benzothiole-2-carboxamide
   Show/Hide
C14H13NOS
 1
1
EC50 = 14 nM
   TI
   LI
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   TS
CP0511165
8-chloro-6-fluoro-4H-thieno[3,2-c]chromene-2-carboxylic acid
   Show/Hide
C12H6ClFO3S
 1
1
EC50 = 16 nM
   TI
   LI
   LO
   TS
CP0406187
6-cyano-7-methyl-4,5-dihydrobenzo[g][1]benzothiole-2-carboxylic acid
   Show/Hide
C15H11NO2S
 1
1
EC50 = 17 nM
   TI
   LI
   LO
   TS
CP0462760
6,7-difluoro-4,5-dihydrobenzo[g][1]benzothiole-2-carboxylic acid
   Show/Hide
C13H8F2O2S
 1
1
EC50 = 17 nM
   TI
   LI
   LO
   TS
CP0414628
6-fluoro-8-methyl-4H-thieno[3,2-c]chromene-2-carboxylic acid
   Show/Hide
C13H9FO3S
 1
1
EC50 = 18 nM
   TI
   LI
   LO
   TS
CP0534346
6-chloro-8-methyl-4,5-dihydrobenzo[g][1]benzothiole-2-carboxylic acid
   Show/Hide
C14H11ClO2S
 1
1
EC50 = 19 nM
   TI
   LI
   LO
   TS
CP0462761
6,8-dichloro-4,5-dihydrobenzo[g][1]benzothiole-2-carboxylic acid
   Show/Hide
C13H8Cl2O2S
 1
1
EC50 = 20 nM
   TI
   LI
   LO
   TS
CP0468104
6-cyano-7-fluoro-4,5-dihydrobenzo[g][1]benzothiole-2-carboxylic acid
   Show/Hide
C14H8FNO2S
 1
1
EC50 = 21 nM
   TI
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   TS
CP0511169
6-chloro-7-methoxy-4,5-dihydrobenzo[g][1]benzothiole-2-carboxylic acid
   Show/Hide
C14H11ClO3S
 1
1
EC50 = 23 nM
   TI
   LI
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   TS
CP0511151
6-chloro-8-fluoro-4H-thieno[3,2-c]chromene-2-carboxylic acid
   Show/Hide
C12H6ClFO3S
 1
1
EC50 = 27 nM
   TI
   LI
   LO
   TS
CP0406184
5,5-dioxo-4H-thieno[3,2-c]thiochromene-2-carboxylic acid
   Show/Hide
C12H8O4S2
 1
1
EC50 = 28 nM
   TI
   LI
   LO
   TS
CP0455455
6-cyano-8-fluoro-4H-thieno[3,2-c]chromene-2-carboxylic acid
   Show/Hide
C13H6FNO3S
 1
1
EC50 = 31 nM
   TI
   LI
   LO
   TS
CP0414589
6-cyano-7-methoxy-4,5-dihydrobenzo[g][1]benzothiole-2-carboxylic acid
   Show/Hide
C15H11NO3S
 1
1
EC50 = 36 nM
   TI
   LI
   LO
   TS
CP0414629
7,8,9-trifluoro-4H-thieno[3,2-c]chromene-2-carboxylic acid
   Show/Hide
C12H5F3O3S
 1
1
EC50 = 38 nM
   TI
   LI
   LO
   TS
CP0406185
6,9-difluoro-4H-thieno[3,2-c]thiochromene-2-carboxylic acid
   Show/Hide
C12H6F2O2S2
 1
1
EC50 = 39 nM
   TI
   LI
   LO
   TS
CP0420082
6,7-dichloro-4H-thieno[3,2-c]chromene-2-carboxylic acid
   Show/Hide
C12H6Cl2O3S
 1
1
EC50 = 39 nM
   TI
   LI
   LO
   TS
CP0511164
6,8-dichloro-4H-thieno[3,2-c]chromene-2-carboxylic acid
   Show/Hide
C12H6Cl2O3S
 1
1
EC50 = 41 nM
   TI
   LI
   LO
   TS
CP0512395
2-[7-cyclopropyl-6-(trifluoromethyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid
   Show/Hide
C12H9F3N2O2S2
 1
1
EC50 = 43 nM
   TI
   LI
   LO
   TS
CP0472947
6-chloro-7-fluoro-4,5-dihydrobenzo[g][1]benzothiole-2-carboxylic acid
   Show/Hide
C13H8ClFO2S
 1
1
EC50 = 46 nM
   TI
   LI
   LO
   TS
CP0459964
7-chloro-8-fluoro-4H-thieno[3,2-c]chromene-2-carboxylic acid
   Show/Hide
C12H6ClFO3S
 1
1
EC50 = 49 nM
   TI
   LI
   LO
   TS
CP0447120
6-fluoro-4H-thieno[3,2-c]thiochromene-2-carboxylic acid
   Show/Hide
C12H7FO2S2
 1
1
EC50 = 53 nM
   TI
   LI
   LO
   TS
CP0344327
2-(6-chloro-7-cyclopropylthieno[3,2-d]pyrimidin-4-yl)sulfanylacetic acid
   Show/Hide
C11H9ClN2O2S2
 1
1
EC50 = 55 nM
   TI
   LI
   LO
   TS
CP0553202
8-fluoro-4H-thieno[3,2-c]thiochromene-2-carboxylic acid
   Show/Hide
C12H7FO2S2
 1
1
EC50 = 59 nM
   TI
   LI
   LO
   TS
CP0420084
6-cyano-4,5-dihydrobenzo[g][1]benzothiole-2-carboxylic acid
   Show/Hide
C14H9NO2S
 1
1
EC50 = 67 nM
   TI
   LI
   LO
   TS
CP0420083
6-chloro-7-fluoro-4H-thieno[3,2-c]chromene-2-carboxylic acid
   Show/Hide
C12H6ClFO3S
 1
1
EC50 = 77 nM
   TI
   LI
   LO
   TS
CP0549215
6-fluoro-5,5-dioxo-4H-thieno[3,2-c]thiochromene-2-carboxylic acid
   Show/Hide
C12H7FO4S2
 1
1
EC50 = 84 nM
   TI
   LI
   LO
   TS
CP0545030
8-chloro-4H-thieno[3,2-c]chromene-2-carboxylic acid
   Show/Hide
C12H7ClO3S
 1
1
EC50 = 133 nM
   TI
   LI
   LO
   TS
CP0447145
8-fluoro-4H-thieno[3,2-c]chromene-2-carboxylic acid
   Show/Hide
C12H7FO3S
 1
1
EC50 = 175 nM
   TI
   LI
   LO
   TS
CP0553200
4H-thieno[3,2-c]thiochromene-2-carboxylic acid
   Show/Hide
C12H8O2S2
 1
1
EC50 = 243 nM
   TI
   LI
   LO
   TS
CP0385487
2-(5-chloro-6-propylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetic acid
   Show/Hide
C11H11ClN2O2S2
 1
1
EC50 = 342 nM
   TI
   LI
   LO
   TS
CP0407493
4,5-dihydrobenzo[g][1]benzothiole-2-carboxylic acid
   Show/Hide
C13H10O2S
 1
1
EC50 = 361 nM
   TI
   LI
   LO
   TS
CP0385488
2-(5-bromo-6-methylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetic acid
   Show/Hide
C9H7BrN2O2S2
 1
1
EC50 = 375 nM
   TI
   LI
   LO
   TS
CP0512394
2-(7-cyclopropyl-6-methylthieno[3,2-d]pyrimidin-4-yl)sulfanylacetic acid
   Show/Hide
C12H12N2O2S2
 1
1
EC50 = 408 nM
   TI
   LI
   LO
   TS
CP0385489
2-(5-chloro-6-methylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetic acid
   Show/Hide
C9H7ClN2O2S2
 1
1
EC50 = 409 nM
   TI
   LI
   LO
   TS
CP0455149
2-(6-bromo-5-methylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetic acid
   Show/Hide
C9H7BrN2O2S2
 1
1
EC50 = 485 nM
   TI
   LI
   LO
   TS
CP0459963
9-fluoro-4H-thieno[3,2-c]chromene-2-carboxylic acid
   Show/Hide
C12H7FO3S
 1
1
EC50 = 706 nM
   TI
   LI
   LO
   TS
CP0516469
2-(5-chloro-6-propan-2-ylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetic acid
   Show/Hide
C11H11ClN2O2S2
 1
1
EC50 = 828 nM
   TI
   LI
   LO
   TS
CP0550461
2-(5-chloro-6-cyclopropylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetic acid
   Show/Hide
C11H9ClN2O2S2
 1
1
EC50 = 1006 nM
   TI
   LI
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   TS
CP0421067
2-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetic acid
   Show/Hide
C10H10N2O2S2
 1
1
EC50 = 1020 nM
   TI
   LI
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   TS
CP0406183
5-oxo-4H-thieno[3,2-c]thiochromene-2-carboxylic acid
   Show/Hide
C12H8O3S2
 1
1
EC50 = 1185 nM
   TI
   LI
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   TS
CP0167846
4H-thieno[3,2-c]chromene-2-carboxylic acid
   Show/Hide
C12H8O3S
 1
1
EC50 = 1360 nM
   TI
   LI
   LO
   TS
CP0561078
2-(6-bromo-7-methylthieno[3,2-d]pyrimidin-4-yl)sulfanylacetic acid
   Show/Hide
C9H7BrN2O2S2
 1
1
EC50 = 1360 nM
   TI
   LI
   LO
   TS
CP0385490
2-(5-chloro-6-ethylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetic acid
   Show/Hide
C10H9ClN2O2S2
 1
1
EC50 = 1442 nM
   TI
   LI
   LO
   TS
CP0434382
2-(6-chloro-7-methylthieno[3,2-d]pyrimidin-4-yl)sulfanylacetic acid
   Show/Hide
C9H7ClN2O2S2
 1
1
EC50 = 1444 nM
   TI
   LI
   LO
   TS
CP0459446
2-(6-chloro-5-methylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetic acid
   Show/Hide
C9H7ClN2O2S2
 1
1
EC50 = 2561 nM
   TI
   LI
   LO
   TS
CP0385486
2-(6-ethyl-5-methylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetic acid
   Show/Hide
C11H12N2O2S2
 1
1
EC50 = 2637 nM
   TI
   LI
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   TS
CP0452379
2-(6,7-dimethylthieno[3,2-d]pyrimidin-4-yl)sulfanylacetic acid
   Show/Hide
C10H10N2O2S2
 1
1
EC50 = 4468 nM
   TI
   LI
   LO
   TS
CP0520427
2-(7-chloro-6-methylthieno[3,2-d]pyrimidin-4-yl)sulfanylacetic acid
   Show/Hide
C9H7ClN2O2S2
 1
1
EC50 = 5508 nM
   TI
   LI
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   TS
CP0452378
2-(5-ethyl-6-methylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetic acid
   Show/Hide
C11H12N2O2S2
 1
1
EC50 = 65394 nM
   TI
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   TS