Brief Information of the Cell Line and Protein
Cell Line ID: CL000131 , HEK293-F
Synonyms
HEK-293-F
HEK 293-F
HEK-293F
HEK293F
293-F
293 F
293F
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_6642
Protein ID: PT02223 , Protein arginine N-methyltransferase 6
Gene Name PRMT6
Organism Homo sapiens, Human
Protein Classification Epigenetic regulator
Uniprot ID Q96LA8
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000131  Protein ID: PT02223
 
Compound ID Compound Name Compound Formula
CP0453246
N'-methyl-N'-[[5-(4-phenoxyphenyl)-1H-pyrazol-4-yl]methyl]ethane-1,2-diamine
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C19H22N4O
 1
1
IC50 = 2 nM
   TI
   LI
   LO
   TS
CP0499013
N,N-dimethyl-3-[4-[5-[[methyl-[2-(methylamino)ethyl]amino]methyl]-1H-pyrazol-4-yl]phenoxy]benzamide
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C23H29N5O2
 1
1
IC50 = 2 nM
   TI
   LI
   LO
   TS
CP0428503
N,N-dimethyl-3-[4-[4-[[methyl-[2-(methylamino)ethyl]amino]methyl]-1H-pyrazol-5-yl]phenoxy]benzamide
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C23H29N5O2
 1
1
IC50 = 3 nM
   TI
   LI
   LO
   TS
CP0539655
N-methyl-2-[4-[5-[[methyl-[2-(methylamino)ethyl]amino]methyl]-1H-pyrazol-4-yl]phenoxy]benzamide
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C22H27N5O2
 1
1
IC50 = 5 nM
   TI
   LI
   LO
   TS
CP0499010
N'-methyl-N'-[[5-(4-propan-2-yloxyphenyl)-1H-pyrazol-4-yl]methyl]ethane-1,2-diamine
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C16H24N4O
 1
1
IC50 = 7 nM
   TI
   LI
   LO
   TS
CP0382295
N'-[[5-(3-chloro-4-propan-2-yloxyphenyl)-1H-pyrazol-4-yl]methyl]-N'-methylethane-1,2-diamine
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C16H23ClN4O
 1
1
IC50 = 8 nM
   TI
   LI
   LO
   TS
CP0418314
N'-[[5-(3-chloro-4-propan-2-yloxyphenyl)-1H-pyrazol-4-yl]methyl]-N,N'-dimethylethane-1,2-diamine
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C17H25ClN4O
 1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0453248
N'-methyl-N'-[[5-[4-(2-methylpropyl)phenyl]-1H-pyrazol-4-yl]methyl]ethane-1,2-diamine
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C17H26N4
 1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0849394
(trans)-N1,N2-dimethyl-N1-((3-(4-(3-(2-(tetrahydro-2H-pyran-4-yl)ethoxy)cyclobutoxy)phenyl)-1H-pyrazol-4-yl)methyl)ethane-1,2-diamine
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C25H38N4O3
 1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0448921
N'-[[5-(4-fluorophenyl)-1H-pyrazol-4-yl]methyl]-N'-methylethane-1,2-diamine
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C13H17FN4
 1
1
IC50 = 11 nM
   TI
   LI
   LO
   TS
CP0494789
N,N'-dimethyl-N'-[[5-(4-propan-2-yloxyphenyl)-1H-pyrazol-4-yl]methyl]ethane-1,2-diamine
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C17H26N4O
 1
1
IC50 = 11 nM
   TI
   LI
   LO
   TS
CP0531080
N'-methyl-N'-[[5-[4-(3-morpholin-4-ylpropoxy)phenyl]-1H-pyrazol-4-yl]methyl]ethane-1,2-diamine
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C20H31N5O2
 1
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
CP0428504
1-[4-[4-[4-[[2-aminoethyl(methyl)amino]methyl]-1H-pyrazol-5-yl]phenyl]piperazin-1-yl]-2-phenylethanone
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C25H32N6O
 1
1
IC50 = 20 nM
   TI
   LI
   LO
   TS
CP0431443
N'-[[5-(3-chloro-4-propan-2-yloxyphenyl)-1-methylpyrazol-4-yl]methyl]-N,N'-dimethylethane-1,2-diamine
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C18H27ClN4O
 1
1
IC50 = 23 nM
   TI
   LI
   LO
   TS
CP0531081
N'-[[5-(4-ethoxyphenyl)-1H-pyrazol-4-yl]methyl]-N,N'-dimethylethane-1,2-diamine
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C16H24N4O
 1
1
IC50 = 25 nM
   TI
   LI
   LO
   TS
CP0875179
2-(4-(4-((methyl(2-(methylamino)ethyl)amino)methyl)-1H-pyrazol-5-yl)phenoxy)butan-1-ol
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C18H28N4O2
 1
1
IC50 = 25 nM
   TI
   LI
   LO
   TS
CP0917231
3-methyl-2-(4-(4-((methyl(2-(methylamino)ethyl)amino)methyl)-1H-pyrazol-5-yl)phenoxy)butan-1-ol
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C19H30N4O2
 1
1
IC50 = 32 nM
   TI
   LI
   LO
   TS
CP0382294
N'-[[4-[3-chloro-4-propan-2-yloxy-5-(trifluoromethyl)phenyl]-1H-pyrazol-5-yl]methyl]-N'-methylethane-1,2-diamine
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C17H22ClF3N4O
 1
1
IC50 = 320 nM
   TI
   LI
   LO
   TS
CP0382293
N,N'-dimethyl-N'-[[5-[3-(2-phenylethoxy)-5-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl]methyl]ethane-1,2-diamine
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C23H27F3N4O
 1
1
IC50 = 327 nM
   TI
   LI
   LO
   TS
CP0453247
N'-[[5-[3-(2-cyclohexylethoxy)-5-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl]methyl]-N,N'-dimethylethane-1,2-diamine
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C23H33F3N4O
 1
1
IC50 = 461 nM
   TI
   LI
   LO
   TS
CP0873454
4-methyl-2-(3-(4-((methyl(2-(methylamino)ethyl)amino)methyl)-1H-pyrazol-5-yl)-5-(trifluoromethyl)phenoxy)pentan-1-ol
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C21H31F3N4O2
 1
1
IC50 = 1900 nM
   TI
   LI
   LO
   TS