| Compound ID |
Compound Name |
Compound Formula |
|
CP0244121
|
2-[[3-[4-[[2-[[1-[3-[3-(cyclohexylamino)propylamino]propyl]triazol-4-yl]methylamino]-6-methylpyrimidin-4-yl]amino]piperidin-1-yl]-3-oxopropyl]amino]acetic acid
Show/Hide
|
C30H51N11O3
|
1
|
| 1 |
EC50 = 13.7 nM
|
|
|
|
CP0062278
|
N-cyclohexyl-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
Show/Hide
|
C29H42N4
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 75.2 nM
|
|
|
|
CP0062281
|
(E)-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]but-2-ene-1,4-diamine
Show/Hide
|
C23H30N4
|
3
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 129 nM
|
|
|
| 3 |
IC50 = 130 nM
|
|
|
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CP0070322
|
N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
Show/Hide
|
C23H32N4
|
4
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 6 nM
|
|
|
| 3 |
IC50 = 6.25 nM
|
|
|
| 4 |
IC50 = 7 nM
|
|
|
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CP0117855
|
N-(4,4-dimethylcyclohexyl)-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
Show/Hide
|
C31H46N4
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 77.6 nM
|
|
|
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CP0117857
|
N-(oxan-4-ylmethyl)-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
Show/Hide
|
C29H42N4O
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 52.9 nM
|
|
|
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CP0117858
|
N-[(4,4-difluorocyclohexyl)methyl]-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
Show/Hide
|
C30H42F2N4
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 168 nM
|
|
|
|
CP0117859
|
N-(piperidin-4-ylmethyl)-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
Show/Hide
|
C29H43N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 36.5 nM
|
|
|
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CP0117965
|
(E)-N-(oxan-4-ylmethyl)-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]but-2-ene-1,4-diamine
Show/Hide
|
C29H40N4O
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 24.2 nM
|
|
|
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CP0117966
|
(E)-N-(oxan-4-yl)-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]but-2-ene-1,4-diamine
Show/Hide
|
C28H38N4O
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 15.5 nM
|
|
|
|
CP0238067
|
2,2-dimethyl-N-(oxan-4-yl)-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
Show/Hide
|
C30H44N4O
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 36.3 nM
|
|
|
|
CP0238068
|
N-(4,4-dimethylcyclohexyl)-2,2-dimethyl-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
Show/Hide
|
C33H50N4
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 541 nM
|
|
|
|
CP0241356
|
N',N'-dibenzyl-N-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
Show/Hide
|
C37H44N4
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 > 16700 nM
|
|
|
|
CP0241364
|
N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]-N-(thian-4-ylmethyl)butane-1,4-diamine
Show/Hide
|
C29H42N4S
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 69.6 nM
|
|
|
|
CP0249300
|
N-piperidin-4-yl-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
Show/Hide
|
C28H41N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 63.4 nM
|
|
|
|
CP0262922
|
(Z)-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]but-2-ene-1,4-diamine
Show/Hide
|
C23H30N4
|
3
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 9.26 nM
|
|
|
| 3 |
IC50 = 10 nM
|
|
|
|
CP0273272
|
N',N'-bis(pyridin-2-ylmethyl)-N-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
Show/Hide
|
C35H42N6
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 664 nM
|
|
|
|
CP0273273
|
N-(pyridin-3-ylmethyl)-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
Show/Hide
|
C29H37N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 15.3 nM
|
|
|
|
CP0273274
|
(E)-N-(4,4-dimethylcyclohexyl)-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]but-2-ene-1,4-diamine
Show/Hide
|
C31H44N4
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 64.6 nM
|
|
|
|
CP0273276
|
N-[(1,1-dioxothian-4-yl)methyl]-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
Show/Hide
|
C29H42N4O2S
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 17 nM
|
|
|
|
CP0273280
|
N-(1,1-dioxothian-4-yl)-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
Show/Hide
|
C28H40N4O2S
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 45.5 nM
|
|
|
|
CP0313670
|
N-benzyl-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
Show/Hide
|
C30H38N4
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 20.1 nM
|
|
|
|
CP0313671
|
4-methyl-1-N-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-1-N-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]pentane-1,4-diamine
Show/Hide
|
C25H36N4
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 24.6 nM
|
|
|
|
CP0319471
|
(8S)-N-[[4-[(oxan-4-ylamino)methyl]phenyl]methyl]-N-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C32H40N4O
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 90.3 nM
|
|
|
|
CP0347670
|
N',N'-bis(pyridin-3-ylmethyl)-N-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
Show/Hide
|
C35H42N6
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 471 nM
|
|
|
|
CP0347671
|
(8S)-N-[[4-[[(4,4-difluorocyclohexyl)amino]methyl]phenyl]methyl]-N-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C33H40F2N4
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 143 nM
|
|
|
|
CP0347674
|
N-(cyclohexylmethyl)-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
Show/Hide
|
C30H44N4
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 158 nM
|
|
|
|
CP0347675
|
N-(oxan-4-yl)-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
Show/Hide
|
C28H40N4O
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 29.4 nM
|
|
|
|
CP0350428
|
(8S)-N-[[4-[(pyridin-4-ylmethylamino)methyl]phenyl]methyl]-N-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C33H37N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 134 nM
|
|
|
|
CP0350429
|
(E)-N-(4,4-difluorocyclohexyl)-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]but-2-ene-1,4-diamine
Show/Hide
|
C29H38F2N4
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 82.1 nM
|
|
|
|
CP0350430
|
(E)-N-(pyridin-4-ylmethyl)-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]but-2-ene-1,4-diamine
Show/Hide
|
C29H35N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 40.7 nM
|
|
|
|
CP0350432
|
N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]-N-(thian-4-yl)butane-1,4-diamine
Show/Hide
|
C28H40N4S
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 54.7 nM
|
|
|
|
CP0358749
|
N',N'-bis(pyridin-4-ylmethyl)-N-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
Show/Hide
|
C35H42N6
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 832 nM
|
|
|
|
CP0358752
|
(8S)-N-[[4-[(oxan-4-ylmethylamino)methyl]phenyl]methyl]-N-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C33H42N4O
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 183 nM
|
|
|
|
CP0358753
|
(8S)-N-[[4-[(pyridin-3-ylmethylamino)methyl]phenyl]methyl]-N-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C33H37N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 60.5 nM
|
|
|
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CP0358754
|
N-(4,4-difluorocyclohexyl)-2,2-dimethyl-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
Show/Hide
|
C31H44F2N4
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 168 nM
|
|
|
|
CP0358755
|
N-(4,4-difluorocyclohexyl)-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
Show/Hide
|
C29H40F2N4
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 3.71 nM
|
|
|
|
CP0360766
|
N-(pyridin-4-ylmethyl)-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
Show/Hide
|
C29H37N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 22.7 nM
|
|
|
|
CP0383530
|
(8S)-N-[[4-[[(4,4-dimethylcyclohexyl)amino]methyl]phenyl]methyl]-N-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C35H46N4
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 661 nM
|
|
|
|
CP0383531
|
2,2-dimethyl-N-(oxan-4-ylmethyl)-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
Show/Hide
|
C31H46N4O
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 43.8 nM
|
|
|
|
CP0403284
|
(8S)-N-[[3-(aminomethyl)phenyl]methyl]-N-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C27H32N4
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 292 nM
|
|
|
|
CP0412494
|
(8S)-N-[[4-(aminomethyl)phenyl]methyl]-N-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C27H32N4
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 115 nM
|
|
|
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CP0412495
|
(8S)-N-[[4-[(pyridin-2-ylmethylamino)methyl]phenyl]methyl]-N-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C33H37N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 286 nM
|
|
|
|
CP0489051
|
(E)-N-(pyridin-3-ylmethyl)-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]but-2-ene-1,4-diamine
Show/Hide
|
C29H35N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 92.8 nM
|
|
|
|
CP0489179
|
N-(pyridin-2-ylmethyl)-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
Show/Hide
|
C29H37N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 89.5 nM
|
|
|
|
CP0489180
|
2,2-dimethyl-N-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
Show/Hide
|
C25H36N4
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 > 33300 nM
|
|
|
|
CP0515633
|
(8S)-N-[[2-(aminomethyl)phenyl]methyl]-N-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C27H32N4
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 50.8 nM
|
|
|
|
CP0545977
|
(E)-N-(pyridin-2-ylmethyl)-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]but-2-ene-1,4-diamine
Show/Hide
|
C29H35N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 58.3 nM
|
|
|
|
CP0559312
|
2,2-dimethyl-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
Show/Hide
|
C25H36N4
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 69 nM
|
|
|
|
CP0072949
|
(8S)-N-methyl-N-[[(3R)-5-piperazin-1-yl-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C24H33N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 6.08 nM
|
|
|
|
CP0072951
|
(8S)-N-[[(3R)-5-[(1R,4R)-2,5-diazabicyclo[2.2.1]heptan-2-yl]-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C25H33N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 20.7 nM
|
|
|
|
CP0072952
|
(8S)-N-[[(3R)-5-(3,3-dimethylpiperazin-1-yl)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C26H37N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 33.9 nM
|
|
|
|
CP0072954
|
(8S)-N-methyl-N-[[(3R)-5-[4-(pyridin-2-ylmethyl)piperazin-1-yl]-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C30H38N6
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 4.47 nM
|
|
|
|
CP0139968
|
(8S)-N,3-dimethyl-N-[[(3R)-5-piperazin-1-yl-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C25H35N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 16.1 nM
|
|
|
|
CP0144923
|
(8S)-N-methyl-N-[[(3R)-5-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl]-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C27H39N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 14.1 nM
|
|
|
|
CP0144924
|
(8S)-N-[[(3R)-5-[(8aS)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C27H37N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 2.92 nM
|
|
|
|
CP0144925
|
(8S)-N-methyl-N-[[(3R)-2-methyl-5-piperazin-1-yl-3,4-dihydro-1H-isoquinolin-3-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C25H35N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 32 nM
|
|
|
|
CP0145164
|
(8S)-N-[[(3R)-5-piperazin-1-yl-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N-propan-2-yl-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C26H37N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 364 nM
|
|
|
|
CP0145165
|
(8S)-N-methyl-N-[[(3R)-5-(4-propan-2-ylpiperazin-1-yl)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C27H39N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 16.9 nM
|
|
|
|
CP0179920
|
(8S)-N-(2-methoxyethyl)-N-[[(3R)-5-piperazin-1-yl-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C26H37N5O
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 154 nM
|
|
|
|
CP0237516
|
(8S)-N-methyl-N-[[(3R)-5-[4-(oxetan-3-yl)piperazin-1-yl]-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C27H37N5O
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 381 nM
|
|
|
|
CP0240541
|
(8S)-N-(cyclopropylmethyl)-N-[[(3R)-5-piperazin-1-yl-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C27H37N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 26.7 nM
|
|
|
|
CP0240542
|
(4aR,10bS)-1-[[(3R)-5-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-3,4,4a,5,6,10b-hexahydro-2H-1,10-phenanthroline
Show/Hide
|
C27H37N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 25.2 nM
|
|
|
|
CP0262638
|
(8S)-N-[[(3R)-5-(4-ethylpiperazin-1-yl)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C26H37N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 13.8 nM
|
|
|
|
CP0315676
|
(8S)-N-[[(3R)-5-piperazin-1-yl-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N-propyl-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C26H37N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 32.2 nM
|
|
|
|
CP0315677
|
(8S)-N-[[(3R)-5-[(8aR)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C27H37N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 3.59 nM
|
|
|
|
CP0368285
|
(8S)-N-[[(3R)-5-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C26H37N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 61 nM
|
|
|
|
CP0389293
|
(8S)-N-[[(3R)-5-[(1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl]-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C25H33N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 146 nM
|
|
|
|
CP0389332
|
(8S)-N-[[(3R)-5-(4-cyclopropylpiperazin-1-yl)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C27H37N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 23.5 nM
|
|
|
|
CP0389425
|
(8S)-N-(cyclohexylmethyl)-N-[[(3R)-5-piperazin-1-yl-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C30H43N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 715 nM
|
|
|
|
CP0427373
|
(8S)-N-methyl-N-[[(3R)-5-(4-pyridin-2-ylpiperazin-1-yl)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C29H36N6
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 17.9 nM
|
|
|
|
CP0427375
|
(8S)-N-methyl-N-[[(3R)-2-methyl-5-(4-methylpiperazin-1-yl)-3,4-dihydro-1H-isoquinolin-3-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C26H37N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 171 nM
|
|
|
|
CP0427504
|
(8S)-N-methyl-N-[[(3S)-5-piperazin-1-yl-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C24H33N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 313 nM
|
|
|
|
CP0429949
|
(8S)-N-[(4,4-difluorocyclohexyl)methyl]-N-[[(3R)-5-piperazin-1-yl-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C30H41F2N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 498 nM
|
|
|
|
CP0446329
|
2-[[(3R)-5-piperazin-1-yl-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]amino]ethanol
Show/Hide
|
C25H35N5O
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 195 nM
|
|
|
|
CP0451017
|
(8S)-N-methyl-N-[[(3R)-5-(4-pyrimidin-2-ylpiperazin-1-yl)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C28H35N7
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 30.7 nM
|
|
|
|
CP0456217
|
(8S)-N-methyl-N-[[(3R)-5-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C25H35N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 29.6 nM
|
|
|
|
CP0475894
|
(8S)-N-ethyl-N-[[(3R)-5-piperazin-1-yl-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C25H35N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 14.8 nM
|
|
|
|
CP0482335
|
(8S)-N-methyl-N-[[(3R)-5-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C31H36F3N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 > 16700 nM
|
|
|
|
CP0489780
|
N-methyl-N-[(5-methylpyridin-2-yl)methyl]-1-[(3R)-5-piperazin-1-yl-1,2,3,4-tetrahydroisoquinolin-3-yl]methanamine
Show/Hide
|
C22H31N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 510 nM
|
|
|
|
CP0513845
|
N-[(3,5-dimethylpyridin-2-yl)methyl]-N-methyl-1-[(3R)-5-piperazin-1-yl-1,2,3,4-tetrahydroisoquinolin-3-yl]methanamine
Show/Hide
|
C23H33N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 21.4 nM
|
|
|
|
CP0552506
|
N-methyl-N-[(3-methylpyridin-2-yl)methyl]-1-[(3R)-5-piperazin-1-yl-1,2,3,4-tetrahydroisoquinolin-3-yl]methanamine
Show/Hide
|
C22H31N5
|
2
|
| 1 |
EC50 > 30000 nM
|
|
|
| 2 |
IC50 = 91.2 nM
|
|
|
|
CP0539877
|
US9314468, Table 7, Compound 47
Show/Hide
|
C31H39N5O2
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0563327
|
US9314468, Table 7, Compound 147
Show/Hide
|
C35H46N6O
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0069850
|
(6,6-dimethyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-3-yl)methyl N,N'-dicyclohexylimidothiocarbamate
Show/Hide
|
C21H34N4S2
|
2
|
| 1 |
IC50 = 1.1 nM
|
|
|
| 2 |
IC50 = 8 nM
|
|
|
|
CP0496696
|
N-[[4-(aminomethyl)-1,3-oxazol-5-yl]methyl]-N-(1H-benzimidazol-2-ylmethyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C22H24N6O
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
|
CP0463939
|
(4R,7S,10S,13S,16S)-16-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-10-benzyl-13-[3-(diaminomethylideneamino)propyl]-3,3-dimethyl-7-(naphthalen-2-ylmethyl)-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
Show/Hide
|
C47H65N13O9S2
|
1
|
| 1 |
IC50 = 1.5 nM
|
|
|
|
CP0491738
|
1,3-dicycloheptyl-2-((6,6-dimethyl-5,6-dihydroimidazo[2,1-b]thiazol-3-yl)methyl)isothiourea
Show/Hide
|
C23H38N4S2
|
2
|
| 1 |
IC50 = 2.1 nM
|
|
|
| 2 |
IC50 = 8.8 nM
|
|
|
|
CP0387551
|
1,3-dicycloheptyl-2-((5,6-dihydroimidazo[2,1-b]thiazol-3-yl)methyl)isothiourea
Show/Hide
|
C21H34N4S2
|
2
|
| 1 |
IC50 = 3.1 nM
|
|
|
| 2 |
IC50 = 25 nM
|
|
|
|
CP0477965
|
US9314468, Table 7, Compound 121
Show/Hide
|
C32H41N7O
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0516388
|
US9314468, Table 7, Compound 83
Show/Hide
|
C31H40N6O
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0574031
|
US9314468, Table 7, Compound 144
Show/Hide
|
C29H35N5
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0377592
|
4-((((1H-benzo[d]imidazol-2-yl)methyl)(5,6,7,8-tetrahydroquinolin-8-yl)amino)methyl)-3-(aminomethyl)benzaldehyde O-methyl oxime
Show/Hide
|
C27H30N6O
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0527099
|
N-[[2-(aminomethyl)-4-methoxyphenyl]methyl]-N-(1H-benzimidazol-2-ylmethyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C26H29N5O
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0563326
|
US9314468, Table 7, Compound 141
Show/Hide
|
C31H41N7
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0067401
|
(S)-N-((1H-benzo[d]imidazol-2-yl)methyl)-N-(4-aminobutyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C21H27N5
|
3
|
| 1 |
IC50 = 5 nM
|
|
|
| 2 |
IC50 = 5.18 nM
|
|
|
| 3 |
IC50 = 13 nM
|
|
|
|
CP0421795
|
1,3-dicyclooctyl-2-((5,6-dihydroimidazo[2,1-b]thiazol-3-yl)methyl)isothiourea
Show/Hide
|
C23H38N4S2
|
2
|
| 1 |
IC50 = 5.3 nM
|
|
|
| 2 |
IC50 = 27 nM
|
|
|
|
CP0145769
|
1,1''-{1,4-phenylenebis(methylene)}-bis{1,4,8,11-tetraaza-cyclotetradecane}
Show/Hide
|
C28H54N8
|
3
|
| 1 |
IC50 = 6 nM
|
|
|
| 2 |
IC50 = 245 nM
|
|
|
| 3 |
IC50 = 6200 nM
|
|
|
|
CP0402832
|
(4R,7S,10S,13S,16S)-16-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-13-[3-(diaminomethylideneamino)propyl]-7-(1H-imidazol-5-ylmethyl)-3,3-dimethyl-10-(naphthalen-2-ylmethyl)-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
Show/Hide
|
C44H63N15O9S2
|
2
|
| 1 |
IC50 = 6 nM
|
|
|
| 2 |
IC50 = 20 nM
|
|
|
|
CP0565905
|
(4R,7S,10S,13S,16S)-16-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-7-benzyl-13-[3-(diaminomethylideneamino)propyl]-3,3-dimethyl-10-(naphthalen-2-ylmethyl)-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
Show/Hide
|
C47H65N13O9S2
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0519905
|
N'-[(4S)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl]-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]butane-1,4-diamine
Show/Hide
|
C22H30N4O
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0493701
|
1-cycloheptyl-3-cyclohexyl-2-((5,6-dihydroimidazo[2,1-b]thiazol-3-yl)methyl)isothiourea
Show/Hide
|
C20H32N4S2
|
2
|
| 1 |
IC50 = 6.6 nM
|
|
|
| 2 |
IC50 = 28 nM
|
|
|
|
CP0421796
|
1-cyclohexyl-3-cyclooctyl-2-((5,6-dihydroimidazo[2,1-b]thiazol-3-yl)methyl)isothiourea
Show/Hide
|
C21H34N4S2
|
2
|
| 1 |
IC50 = 8 nM
|
|
|
| 2 |
IC50 = 28 nM
|
|
|
|
CP0465579
|
N'-[1-(4-methylpyridin-2-yl)ethyl]-N'-[(3-methylpyridin-2-yl)methyl]butane-1,4-diamine
Show/Hide
|
C19H28N4
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0512751
|
(Z)-2-methyl-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]but-2-ene-1,4-diamine
Show/Hide
|
C24H32N4
|
1
|
| 1 |
IC50 = 8.6 nM
|
|
|
|
CP0537000
|
US9314468, Table 7, Compound 80
Show/Hide
|
C28H31N5
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0537001
|
US9314468, Table 7, Compound 140
Show/Hide
|
C30H37N7O
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0549059
|
(8S)-N-[[(3R)-5-[(3aS,6aR)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C27H37N5
|
1
|
| 1 |
IC50 = 9.56 nM
|
|
|
|
CP0377591
|
N-(1H-benzimidazol-2-ylmethyl)-N-[[2,4-bis(aminomethyl)phenyl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C26H30N6
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0413524
|
US9314468, Table 7, Compound 25
Show/Hide
|
C26H31N5
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0137454
|
(8S)-N-[[(3R)-5-[(3aS,6aR)-2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl]-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C26H35N5
|
1
|
| 1 |
IC50 = 10.3 nM
|
|
|
|
CP0137455
|
(8S)-N-[[(3R)-5-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C26H37N5
|
1
|
| 1 |
IC50 = 10.4 nM
|
|
|
|
CP0516430
|
(S)-N1-((3-aminopyridin-2-yl)methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine
Show/Hide
|
C19H27N5
|
1
|
| 1 |
IC50 = 10.9 nM
|
|
|
|
CP0444486
|
(8S)-N-[[(3R)-5-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C26H37N5
|
1
|
| 1 |
IC50 = 10.9 nM
|
|
|
|
CP0135993
|
1,3-dicyclohexyl-2-((5,6-dihydroimidazo[2,1-b]thiazol-3-yl)methyl)isothiourea
Show/Hide
|
C19H30N4S2
|
2
|
| 1 |
IC50 = 11 nM
|
|
|
| 2 |
IC50 = 48 nM
|
|
|
|
CP0470937
|
N'-(1H-benzimidazol-2-ylmethyl)-N'-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine
Show/Hide
|
C21H27N5
|
2
|
| 1 |
IC50 = 11 nM
|
|
|
| 2 |
IC50 = 22 nM
|
|
|
|
CP0496678
|
[3-(aminomethyl)-4-[[1H-benzimidazol-2-ylmethyl(5,6,7,8-tetrahydroquinolin-8-yl)amino]methyl]phenyl]methanol
Show/Hide
|
C26H29N5O
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0574028
|
US9314468, Table 7, Compound 87
Show/Hide
|
C27H33N5O
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0416449
|
N'-[(8S)-3-methyl-5,6,7,8-tetrahydroquinolin-8-yl]-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]butane-1,4-diamine
Show/Hide
|
C24H34N4
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0322364
|
(8S)-N-[[(3R)-5-[(3aS,6aS)-1-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C27H37N5
|
1
|
| 1 |
IC50 = 11.4 nM
|
|
|
|
CP0508777
|
N-[[3-(aminomethyl)furan-2-yl]methyl]-N-(1H-benzimidazol-2-ylmethyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C23H25N5O
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0401320
|
1-Adamantan-2-yl-3-cyclohexyl-2-(5,6-dihydro-imidazo[2,1-b]thiazol-3-ylmethyl)-isothiourea
Show/Hide
|
C23H34N4S2
|
2
|
| 1 |
IC50 = 13 nM
|
|
|
| 2 |
IC50 = 81 nM
|
|
|
|
CP0878555
|
N-((1H-benzo[d]imidazol-2-yl)methyl)-N-(4-(aminomethyl)thiophen-3-yl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C22H23N5S
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0522227
|
US9314468, Table 7, Compound 119
Show/Hide
|
C32H41N5O
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0471080
|
(3R)-N-methyl-N-(1-methylpiperidin-4-yl)-3-[[methyl-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]amino]methyl]-1,2,3,4-tetrahydroisoquinolin-5-amine
Show/Hide
|
C27H39N5
|
1
|
| 1 |
IC50 = 13.4 nM
|
|
|
|
CP0512337
|
US9314468, Table 7, Compound 145
Show/Hide
|
C32H40N6
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0398816
|
4-((((1H-benzo[d]imidazol-2-yl)methyl)(5,6,7,8-tetrahydroquinolin-8-yl)amino)methyl)-3-(aminomethyl)benzamide
Show/Hide
|
C26H28N6O
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0563412
|
US9314468, Table 7, Compound 62
Show/Hide
|
C29H35N5O2
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0667357
|
(S)-N-(2-((R)-piperidin-3-yl)ethyl)-N-(((R)-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C26H36N4
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0469106
|
(S)-N1-((1H-benzo[d]imidazol-2-yl)methyl)-N1-(1-(pyridin-2-yl)ethyl)butane-1,4-diamine
Show/Hide
|
C19H25N5
|
1
|
| 1 |
IC50 = 16.6 nM
|
|
|
|
CP0667783
|
(S)-N-(3-piperazin-1-yl)propyl)-N-(((R)-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C26H37N5
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0708365
|
(S)-N-(isoquinolin-3-ylmethyl)-N-(3-piperazin-1yl)propyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C26H33N5
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0425560
|
N'-[(3-tert-butylpyridin-2-yl)methyl]-N'-(1-pyridin-2-ylethyl)butane-1,4-diamine
Show/Hide
|
C21H32N4
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0528381
|
N'-[(3-methylpyridin-2-yl)methyl]-N'-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine
Show/Hide
|
C20H28N4
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0922843
|
US9314468, Table 7, Compound 27
Show/Hide
|
C28H34N6
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0565448
|
(3R)-3-[[methyl-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]amino]methyl]-N-piperidin-4-yl-1,2,3,4-tetrahydroisoquinolin-5-amine
Show/Hide
|
C25H35N5
|
1
|
| 1 |
IC50 = 18.1 nM
|
|
|
|
CP0451079
|
(8S)-N-[[(3R)-5-[(3aR,6aR)-1-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C27H37N5
|
1
|
| 1 |
IC50 = 18.7 nM
|
|
|
|
CP0528382
|
N'-[(3,5-dimethylpyridin-2-yl)methyl]-N'-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine
Show/Hide
|
C21H30N4
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0382187
|
(S)-N-((1H-benzo[d]imidazol-2-yl)methyl)-N-((2-(aminomethyl)pyridin-3-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C24H26N6
|
1
|
| 1 |
IC50 = 19.8 nM
|
|
|
|
CP0511436
|
N'-[(3,5-dimethylpyridin-2-yl)methyl]-N'-(1-pyridin-2-ylethyl)butane-1,4-diamine
Show/Hide
|
C19H28N4
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0557378
|
US9314468, Table 7, Compound 143
Show/Hide
|
C28H35N5O
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0564872
|
US9314468, Table 7, Compound 138
Show/Hide
|
C32H41N7O
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0508778
|
N-[[2-(aminomethyl)furan-3-yl]methyl]-N-(1H-benzimidazol-2-ylmethyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C23H25N5O
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0527100
|
N-[[2-(aminomethyl)-4-(methoxymethyl)phenyl]methyl]-N-(1H-benzimidazol-2-ylmethyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C27H31N5O
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0940336
|
N-((1H-benzo[d]imidazol-2-yl)methyl)-N-((2-(aminomethyl)pyridin-3-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C24H26N6
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0494920
|
US9314468, Table 7, Compound 114
Show/Hide
|
C32H40N6O2
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0476995
|
N'-[(3-methylpyridin-2-yl)methyl]-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]butane-1,4-diamine
Show/Hide
|
C21H30N4
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0478039
|
US9314468, Table 7, Compound 31
Show/Hide
|
C26H31N5
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0566756
|
(4R,7S,10S,13S,16S)-16-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-7-benzyl-13-[3-(diaminomethylideneamino)propyl]-3,3-dimethyl-10-(naphthalen-1-ylmethyl)-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
Show/Hide
|
C47H65N13O9S2
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0476597
|
N'-[(3-methylpyridin-2-yl)methyl]-N'-(1-pyridin-2-ylethyl)butane-1,4-diamine
Show/Hide
|
C18H26N4
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0499712
|
US9314468, Table 8, Compound 9
Show/Hide
|
C34H45N7O
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0523361
|
US9314468, Table 7, Compound 106
Show/Hide
|
C34H45N7O
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0519902
|
N'-[(1S)-1-(3-methylpyridin-2-yl)ethyl]-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]butane-1,4-diamine
Show/Hide
|
C22H32N4
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0940337
|
N-((1H-benzo[d]imidazol-2-yl)methyl)-N-(4-(aminomethyl)furan-3-yl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C22H23N5O
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0499707
|
US9314468, Table 7, Compound 127
Show/Hide
|
C35H45N7O2
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0437013
|
N'-[(3-aminopyridin-2-yl)methyl]-N'-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine
Show/Hide
|
C19H27N5
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0496677
|
N-[[2-(aminomethyl)phenyl]methyl]-N-(1H-benzimidazol-2-ylmethyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C25H27N5
|
2
|
| 1 |
IC50 = 28 nM
|
|
|
| 2 |
IC50 = 50 nM
|
|
|
|
CP0262924
|
(E)-3-fluoro-2-methyl-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]but-2-ene-1,4-diamine
Show/Hide
|
C24H31FN4
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0472917
|
(Z)-2-methyl-N-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]but-2-ene-1,4-diamine
Show/Hide
|
C24H32N4
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0529252
|
US9314468, Table 7, Compound 135
Show/Hide
|
C31H39N7O
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0932456
|
US9314468, Table 7, Compound 42
Show/Hide
|
C25H29N5
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0516389
|
US9314468, Table 7, Compound 88
Show/Hide
|
C31H34N6
|
1
|
| 1 |
IC50 = 31 nM
|
|
|
|
CP0854379
|
(S)-N-(3-(4-ethylpiperazin-1-yl)propyl)-N-(((R)-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C28H41N5
|
1
|
| 1 |
IC50 = 33 nM
|
|
|
|
CP0422705
|
(8S)-N-[[(3R)-5-(4-aminopiperidin-1-yl)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C25H35N5
|
1
|
| 1 |
IC50 = 33.4 nM
|
|
|
|
CP0232297
|
4-N-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-4-N-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]cyclohexane-1,4-diamine
Show/Hide
|
C25H34N4
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0469123
|
N'-[(5-methylpyridin-2-yl)methyl]-N'-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine
Show/Hide
|
C20H28N4
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0516431
|
(S)-N1-((3-methylpyridin-2-yl)methyl)-N1-(1-(pyridin-2-yl)ethyl)butane-1,4-diamine
Show/Hide
|
C18H26N4
|
1
|
| 1 |
IC50 = 35.8 nM
|
|
|
|
CP0129672
|
(8S)-N-[[(3R)-5-[4-(dimethylamino)piperidin-1-yl]-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C27H39N5
|
1
|
| 1 |
IC50 = 35.9 nM
|
|
|
|
CP0405087
|
N'-[(4,6-dimethylpyridin-2-yl)methyl]-N'-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine
Show/Hide
|
C21H30N4
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0969651
|
US9314468, Table 7, Compound 16
Show/Hide
|
C28H34N6O
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0532461
|
methyl 3-(aminomethyl)-4-[[1H-benzimidazol-2-ylmethyl(5,6,7,8-tetrahydroquinolin-8-yl)amino]methyl]benzoate
Show/Hide
|
C27H29N5O2
|
1
|
| 1 |
IC50 = 39 nM
|
|
|
|
CP0380488
|
(4R,7S,10S,13S,16S)-16-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-7,10-dibenzyl-13-[3-(diaminomethylideneamino)propyl]-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
Show/Hide
|
C41H59N13O9S2
|
3
|
| 1 |
IC50 = 40 nM
|
|
|
| 2 |
IC50 = 53 nM
|
|
|
| 3 |
IC50 = 338 nM
|
|
|
|
CP0465578
|
N'-[(3-chloropyridin-2-yl)methyl]-N'-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine
Show/Hide
|
C19H25ClN4
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0499708
|
US9314468, Table 7, Compound 134
Show/Hide
|
C39H43N7O2
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0499709
|
US9314468, Table 7, Compound 139
Show/Hide
|
C35H46N8O
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0499711
|
US9314468, Table 9, Compound 6
Show/Hide
|
C35H44N6O2
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0567621
|
US9314468, Table 7, Compound 75
Show/Hide
|
C34H43N7O2
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0232296
|
(Z)-3-fluoro-2-methyl-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]but-2-ene-1,4-diamine
Show/Hide
|
C24H31FN4
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0465991
|
(S)-N-((1H-benzo[d]imidazol-2-yl)methyl)-N-(4-(aminomethyl)furan-3-yl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C22H23N5O
|
1
|
| 1 |
IC50 = 44.5 nM
|
|
|
|
CP0667787
|
(S)-N-((1H-benzo[d]imidazole-2yl)methyl)-N-(3-(piperazine-1yl)propyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C24H32N6
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0522228
|
US9314468, Table 7, Compound 123
Show/Hide
|
C32H35N5
|
1
|
| 1 |
IC50 = 47 nM
|
|
|
|
CP0137453
|
(3S)-N-(4-methylpiperazin-1-yl)-3-[[methyl-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]amino]methyl]-1,2,3,4-tetrahydroisoquinolin-5-amine
Show/Hide
|
C25H36N6
|
1
|
| 1 |
IC50 = 47.4 nM
|
|
|
|
CP0437012
|
N'-[(6-aminopyridin-2-yl)methyl]-N'-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine
Show/Hide
|
C19H27N5
|
1
|
| 1 |
IC50 = 49 nM
|
|
|
|
CP0559905
|
US9314468, Table 7, Compound 146
Show/Hide
|
C31H40N6O
|
1
|
| 1 |
IC50 = 49 nM
|
|
|
|
CP0667788
|
(S)-N-(3-(4-cyclopropylpiperazin-1-yl)propyl)-N-(((R)-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C29H41N5
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0527098
|
N-[[2-(aminomethyl)-4-(trifluoromethyl)phenyl]methyl]-N-(1H-benzimidazol-2-ylmethyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C26H26F3N5
|
1
|
| 1 |
IC50 = 51 nM
|
|
|
|
CP0436598
|
N'-[(6-methylpyridin-2-yl)methyl]-N'-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine
Show/Hide
|
C20H28N4
|
1
|
| 1 |
IC50 = 53 nM
|
|
|
|
CP0398333
|
(4R,7S,10S,13S,16R)-16-[[(2S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-7,10-dibenzyl-13-[3-(diaminomethylideneamino)propyl]-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
Show/Hide
|
C39H57N13O8S2
|
2
|
| 1 |
IC50 = 53 nM
|
|
|
| 2 |
IC50 = 6200 nM
|
|
|
|
CP0499713
|
US9314468, Table 8, Compound 14
Show/Hide
|
C30H38N6O
|
1
|
| 1 |
IC50 = 56 nM
|
|
|
|
CP0559902
|
US9314468, Table 7, Compound 107
Show/Hide
|
C30H38N6O
|
1
|
| 1 |
IC50 = 56 nM
|
|
|
|
CP0471923
|
1,3-dicyclohexyl-2-((6,7-dihydro-5H-thiazolo[3,2-a]pyrimidin-3-yl)methyl)isothiourea
Show/Hide
|
C20H32N4S2
|
2
|
| 1 |
IC50 = 57 nM
|
|
|
| 2 |
IC50 = 185 nM
|
|
|
|
CP0477960
|
US9314468, Table 7, Compound 50
Show/Hide
|
C26H31N5
|
1
|
| 1 |
IC50 = 57 nM
|
|
|
|
CP0437325
|
N-[[2-(aminomethyl)thiophen-3-yl]methyl]-N-(1H-benzimidazol-2-ylmethyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C23H25N5S
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0559903
|
US9314468, Table 7, Compound 109
Show/Hide
|
C31H38N6O2S
|
1
|
| 1 |
IC50 = 61 nM
|
|
|
|
CP0519904
|
N'-[(1S)-1-pyridin-2-ylethyl]-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]butane-1,4-diamine
Show/Hide
|
C21H30N4
|
1
|
| 1 |
IC50 = 62 nM
|
|
|
|
CP0875938
|
(S)-N-(3-(4-isopropylpiperazin-1-yl)propyl)-N-(((R)-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C29H43N5
|
1
|
| 1 |
IC50 = 62 nM
|
|
|
|
CP0524100
|
(S)-N1-((3,5-dimethylpyridin-2-yl)methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine
Show/Hide
|
C21H30N4
|
1
|
| 1 |
IC50 = 62.9 nM
|
|
|
|
CP0508362
|
N'-[(3-propan-2-ylpyridin-2-yl)methyl]-N'-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine
Show/Hide
|
C22H32N4
|
1
|
| 1 |
IC50 = 63 nM
|
|
|
|
CP0887626
|
(S)-N-(piperidin-4-ylmethyl)-N-(((R)-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C25H34N4
|
1
|
| 1 |
IC50 = 65 nM
|
|
|
|
CP0405088
|
N'-[(5-methylpyridin-2-yl)methyl]-N'-(1-pyridin-2-ylethyl)butane-1,4-diamine
Show/Hide
|
C18H26N4
|
1
|
| 1 |
IC50 = 66 nM
|
|
|
|
CP0667784
|
(S)-N-(4-piperazin-1-yl)butyll)-N-(((R)-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C27H39N5
|
1
|
| 1 |
IC50 = 66 nM
|
|
|
|
CP0477654
|
N'-(1H-benzimidazol-2-ylmethyl)-N'-(5,6,7,8-tetrahydroquinolin-8-yl)propane-1,3-diamine
Show/Hide
|
C20H25N5
|
1
|
| 1 |
IC50 = 68 nM
|
|
|
|
CP0957753
|
US9314468, Table 7, Compound 24
Show/Hide
|
C25H29N5
|
1
|
| 1 |
IC50 = 69 nM
|
|
|
|
CP0545490
|
N'-[(3,5-dimethylpyridin-2-yl)methyl]-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]butane-1,4-diamine
Show/Hide
|
C22H32N4
|
1
|
| 1 |
IC50 = 69 nM
|
|
|
|
CP0537272
|
(4R,7S,10S,13S,16S)-16-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-7-benzyl-13-[3-(diaminomethylideneamino)propyl]-10-[(4-hydroxyphenyl)methyl]-3,3-dimethyl-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
Show/Hide
|
C43H63N13O10S2
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0412797
|
N'-[(5-methylpyridin-2-yl)methyl]-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]butane-1,4-diamine
Show/Hide
|
C21H30N4
|
1
|
| 1 |
IC50 = 71 nM
|
|
|
|
CP0504911
|
N'-[(3-aminopyridin-2-yl)methyl]-N'-(1-pyridin-2-ylethyl)butane-1,4-diamine
Show/Hide
|
C17H25N5
|
1
|
| 1 |
IC50 = 72 nM
|
|
|
|
CP0409854
|
(+/-)-N1-(pyridine-2-ylmethyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine
Show/Hide
|
C19H26N4
|
1
|
| 1 |
IC50 = 74 nM
|
|
|
|
CP0542087
|
1-cyclohexyl-2-((5,6-dihydroimidazo[2,1-b]thiazol-3-yl)methyl)-3-hexylisothiourea
Show/Hide
|
C19H32N4S2
|
2
|
| 1 |
IC50 = 75 nM
|
|
|
| 2 |
IC50 = 855 nM
|
|
|
|
CP0504660
|
N'-(1H-benzimidazol-2-ylmethyl)-N'-(5,6,7,8-tetrahydroquinolin-8-yl)hexane-1,6-diamine
Show/Hide
|
C23H31N5
|
1
|
| 1 |
IC50 = 75 nM
|
|
|
|
CP0504662
|
(Z)-N1-((1H-Benzo[d]imidazol-2-yl)methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)but-2-ene-1,4-diamine
Show/Hide
|
C21H25N5
|
1
|
| 1 |
IC50 = 77 nM
|
|
|
|
CP0499706
|
US9314468, Table 7, Compound 122
Show/Hide
|
C31H38N6OS
|
1
|
| 1 |
IC50 = 78 nM
|
|
|
|
CP0465577
|
[2-[[4-aminobutyl(5,6,7,8-tetrahydroquinolin-8-yl)amino]methyl]pyridin-3-yl]methanol
Show/Hide
|
C20H28N4O
|
1
|
| 1 |
IC50 = 79 nM
|
|
|
|
CP0518819
|
(E)-2-fluoro-3-methyl-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]but-2-ene-1,4-diamine
Show/Hide
|
C24H31FN4
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0506231
|
N'-(1H-benzimidazol-2-ylmethyl)-N,N-dimethyl-N'-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine
Show/Hide
|
C23H31N5
|
1
|
| 1 |
IC50 = 87 nM
|
|
|
|
CP0946154
|
US9314468, Table 7, Compound 39
Show/Hide
|
C28H34N6
|
1
|
| 1 |
IC50 = 87 nM
|
|
|
|
CP0376539
|
(S)-N-((1H-benzo[d]imidazol-2-yl)methyl)-N-(4-(aminomethyl)thiophen-3-yl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C22H23N5S
|
1
|
| 1 |
IC50 = 88.9 nM
|
|
|
|
CP0425608
|
N'-[(4-methylpyridin-2-yl)methyl]-N'-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine
Show/Hide
|
C20H28N4
|
1
|
| 1 |
IC50 = 91 nM
|
|
|
|
CP0476598
|
(S)-N1-((6-methylpyridin-2-yl)methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine
Show/Hide
|
C20H28N4
|
1
|
| 1 |
IC50 = 96.1 nM
|
|
|
|
CP0489948
|
(Z)-N-(4,4-difluorocyclohexyl)-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]but-2-ene-1,4-diamine
Show/Hide
|
C29H38F2N4
|
1
|
| 1 |
IC50 = 98 nM
|
|
|
|
CP0946169
|
US9314468, Table 7, Compound 45
Show/Hide
|
C25H29N5
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0387548
|
2-[3-[(2S,5S,8S,14R)-5-[3-(diaminomethylideneamino)propyl]-14-[(4-hydroxyphenyl)methyl]-8-naphthalen-2-yl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]propyl]guanidine
Show/Hide
|
C35H45N11O6
|
1
|
| 1 |
IC50 = 109 nM
|
|
|
|
CP0525266
|
US9314468, Table 7, Compound 66
Show/Hide
|
C32H41N7O
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0525668
|
N'-(1-pyridin-2-ylethyl)-N'-[[3-(trifluoromethyl)pyridin-2-yl]methyl]butane-1,4-diamine
Show/Hide
|
C18H23F3N4
|
1
|
| 1 |
IC50 = 111 nM
|
|
|
|
CP0502808
|
N-[[4-(aminomethyl)phenyl]methyl]-N-(1H-benzimidazol-2-ylmethyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C25H27N5
|
1
|
| 1 |
IC50 = 119 nM
|
|
|
|
CP0556537
|
US9314468, Table 7, Compound 96
Show/Hide
|
C31H34N6
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0494922
|
US9314468, Table 7, Compound 132
Show/Hide
|
C35H44N6O2
|
1
|
| 1 |
IC50 = 124 nM
|
|
|
|
CP0852868
|
(S)-N-(3-(4-methylpiperazin-1-yl)propyl)-N-(((R)-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C27H39N5
|
1
|
| 1 |
IC50 = 125 nM
|
|
|
|
CP0549576
|
4-((((1H-benzo[d]imidazole-2-yl)methyl)(5,6,7,8-tetrahydroquinolin-8-yl)amino)methyl)-3-(aminomethyl)benzoic acid
Show/Hide
|
C26H27N5O2
|
1
|
| 1 |
IC50 = 126 nM
|
|
|
|
CP0499710
|
US9314468, Table 8, Compound 12
Show/Hide
|
C32H41N7O
|
1
|
| 1 |
IC50 = 126 nM
|
|
|
|
CP0473706
|
N'-[(5-fluoro-3-methylpyridin-2-yl)methyl]-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]butane-1,4-diamine
Show/Hide
|
C21H29FN4
|
1
|
| 1 |
IC50 = 127 nM
|
|
|
|
CP0476596
|
2-[[4-aminobutyl(5,6,7,8-tetrahydroquinolin-8-yl)amino]methyl]pyridin-3-ol
Show/Hide
|
C19H26N4O
|
1
|
| 1 |
IC50 = 129 nM
|
|
|
|
CP0398334
|
(4R,7S,10S,13S,16R)-16-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-7,10-dibenzyl-13-[3-(diaminomethylideneamino)propyl]-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
Show/Hide
|
C41H59N13O9S2
|
1
|
| 1 |
IC50 = 131 nM
|
|
|
|
CP0523362
|
US9314468, Table 7, Compound 131
Show/Hide
|
C39H41N7O3
|
1
|
| 1 |
IC50 = 138 nM
|
|
|
|
CP0556535
|
US9314468, Table 7, Compound 79
Show/Hide
|
C24H27N5
|
1
|
| 1 |
IC50 = 142 nM
|
|
|
|
CP0962995
|
US9314468, Table 7, Compound 1
Show/Hide
|
C25H29N5
|
1
|
| 1 |
IC50 = 142 nM
|
|
|
|
CP0708364
|
(S)-N-(2-(piperidin-4-yl)ethyl)-N-(((R)-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C26H36N4
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0545812
|
US9314468, Table 7, Compound 130
Show/Hide
|
C35H40N6
|
1
|
| 1 |
IC50 = 152 nM
|
|
|
|
CP0524339
|
(E)-N1-((1H-Benzo[d]imidazol-2-yl)methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)but-2-ene-1,4-diamine
Show/Hide
|
C21H25N5
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
|
CP0499819
|
N-[[4-(aminomethyl)pyridin-3-yl]methyl]-N-(1H-benzimidazol-2-ylmethyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C24H26N6
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
|
CP0946810
|
(S)-N-(2-((S)-piperidin-3-yl)ethyl)-N-(((R)-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C26H36N4
|
1
|
| 1 |
IC50 = 161 nM
|
|
|
|
CP0412795
|
N'-[(3-cyclopropylpyridin-2-yl)methyl]-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]butane-1,4-diamine
Show/Hide
|
C23H32N4
|
1
|
| 1 |
IC50 = 163 nM
|
|
|
|
CP0917521
|
US9314468, Table 7, Compound 15
Show/Hide
|
C27H33N5
|
1
|
| 1 |
IC50 = 168 nM
|
|
|
|
CP0667785
|
(S)-N-(3-(piperazin-1yl)propyl)-N-(((R)-5,6,7,8-tetrahydro-1,6-naphthyridin-7-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C25H36N6
|
1
|
| 1 |
IC50 = 171 nM
|
|
|
|
CP0507952
|
1-cyclohexyl-3-cyclopentyl-2-((5,6-dihydroimidazo[2,1-b]thiazol-3-yl)methyl)isothiourea
Show/Hide
|
C18H28N4S2
|
2
|
| 1 |
IC50 = 173 nM
|
|
|
| 2 |
IC50 = 372 nM
|
|
|
|
CP0523940
|
US9314468, Table 7, Compound 113
Show/Hide
|
C34H39N7
|
1
|
| 1 |
IC50 = 176 nM
|
|
|
|
CP0447204
|
(4R,7S,10S,13S,16S)-16-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-10-benzyl-13-[3-(diaminomethylideneamino)propyl]-3,3-dimethyl-7-[(4-nitrophenyl)methyl]-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
Show/Hide
|
C43H62N14O11S2
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0425561
|
N'-[(6-methylpyridin-2-yl)methyl]-N'-(1-pyridin-2-ylethyl)butane-1,4-diamine
Show/Hide
|
C18H26N4
|
1
|
| 1 |
IC50 = 183 nM
|
|
|
|
CP0514884
|
N'-(1H-benzimidazol-2-ylmethyl)-N-methyl-N'-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine
Show/Hide
|
C22H29N5
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0507719
|
(R)-N1-((1H-benzo[d]imidazol-2-yl)methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine
Show/Hide
|
C21H27N5
|
1
|
| 1 |
IC50 = 206 nM
|
|
|
|
CP0930475
|
US9314468, Table 7, Compound 105
Show/Hide
|
C29H36N6
|
1
|
| 1 |
IC50 = 206 nM
|
|
|
|
CP0506647
|
(4R,7S,10S,13S,16S)-16-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-7-benzyl-10-[(4-chlorophenyl)methyl]-13-[3-(diaminomethylideneamino)propyl]-3,3-dimethyl-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
Show/Hide
|
C43H62ClN13O9S2
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0472918
|
[(Z)-4-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]amino]but-2-enyl]urea
Show/Hide
|
C24H31N5O
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0494919
|
US9314468, Table 7, Compound 103
Show/Hide
|
C32H40N6O2
|
1
|
| 1 |
IC50 = 212 nM
|
|
|
|
CP0525267
|
US9314468, Table 7, Compound 74
Show/Hide
|
C33H31N5O2
|
1
|
| 1 |
IC50 = 217 nM
|
|
|
|
CP0382186
|
N-[[2-(aminomethyl)-4-fluorophenyl]methyl]-N-(1H-benzimidazol-2-ylmethyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C25H26FN5
|
1
|
| 1 |
IC50 = 219 nM
|
|
|
|
CP0569680
|
N'-(pyridin-2-ylmethyl)-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]butane-1,4-diamine
Show/Hide
|
C20H28N4
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0232295
|
(8S)-N-[[2-(aminomethyl)cyclohexen-1-yl]methyl]-N-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C27H36N4
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0519901
|
N'-[(5-fluoropyridin-2-yl)methyl]-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]butane-1,4-diamine
Show/Hide
|
C20H27FN4
|
1
|
| 1 |
IC50 = 260 nM
|
|
|
|
CP0477966
|
US9314468, Table 7, Compound 128
Show/Hide
|
C32H40N6O
|
1
|
| 1 |
IC50 = 270 nM
|
|
|
|
CP0384845
|
(8S)-N-[(4-aminocyclohexyl)methyl]-N-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C26H36N4
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0421797
|
1-Adamantan-1-yl-3-cyclohexyl-2-(5,6-dihydro-imidazo[2,1-b]thiazol-3-ylmethyl)-isothiourea
Show/Hide
|
C23H34N4S2
|
2
|
| 1 |
IC50 = 304 nM
|
|
|
| 2 |
IC50 = 1873 nM
|
|
|
|
CP0532972
|
N'-[(3-fluoro-5-methylpyridin-2-yl)methyl]-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]butane-1,4-diamine
Show/Hide
|
C21H29FN4
|
1
|
| 1 |
IC50 = 323 nM
|
|
|
|
CP0512326
|
US9314468, Table 7, Compound 77
Show/Hide
|
C32H29N5O2
|
1
|
| 1 |
IC50 = 329 nM
|
|
|
|
CP0952607
|
US9314468, Table 7, Compound 53
Show/Hide
|
C28H34N6
|
1
|
| 1 |
IC50 = 331 nM
|
|
|
|
CP0352403
|
(8S)-N-[[4-(aminomethyl)cyclohexyl]methyl]-N-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C27H38N4
|
1
|
| 1 |
IC50 = 340 nM
|
|
|
|
CP0402829
|
(4R,7S,10S,13S,16S)-16-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-10-benzyl-13-[3-(diaminomethylideneamino)propyl]-7-(1H-imidazol-5-ylmethyl)-3,3-dimethyl-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
Show/Hide
|
C40H61N15O9S2
|
1
|
| 1 |
IC50 = 360 nM
|
|
|
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CP0530605
|
US9314468, Table 7, Compound 129
Show/Hide
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C35H45N7O
|
1
|
| 1 |
IC50 = 405 nM
|
|
|
|
CP0569678
|
N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[[3-(trifluoromethyl)pyridin-2-yl]methyl]butane-1,4-diamine
Show/Hide
|
C21H27F3N4
|
1
|
| 1 |
IC50 = 406 nM
|
|
|
|
CP0563328
|
US9314468, Table 7, Compound 149
Show/Hide
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C29H36N6O2
|
1
|
| 1 |
IC50 = 423 nM
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|
|
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CP0503540
|
1-(4-tert-butylcyclohexyl)-3-cyclohexyl-2-((5,6-dihydroimidazo[2,1-b]thiazol-3-yl)methyl)isothiourea
Show/Hide
|
C23H38N4S2
|
2
|
| 1 |
IC50 = 437 nM
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|
|
| 2 |
IC50 = 1533 nM
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CP0417923
|
5-(((1H-Benzo[d]imidazol-2-yl)methyl)(5,6,7,8-tetrahydroquinolin-8-yl)amino)butanenitrile
Show/Hide
|
C22H25N5
|
1
|
| 1 |
IC50 = 442 nM
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|
|
|
CP0906087
|
US9314468, Table 7, Compound 34
Show/Hide
|
C29H35N5
|
1
|
| 1 |
IC50 = 451 nM
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|
|
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CP0539827
|
US9314468, Table 7, Compound 102
Show/Hide
|
C31H34N6
|
1
|
| 1 |
IC50 = 481 nM
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|
|
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CP0533313
|
N'-[(3-ethenylpyridin-2-yl)methyl]-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]butane-1,4-diamine
Show/Hide
|
C22H30N4
|
1
|
| 1 |
IC50 = 484 nM
|
|
|
|
CP0372577
|
1,3-dicyclopentyl-2-((5,6-dihydroimidazo[2,1-b]thiazol-3-yl)methyl)isothiourea
Show/Hide
|
C17H26N4S2
|
2
|
| 1 |
IC50 = 493 nM
|
|
|
| 2 |
IC50 = 3835 nM
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CP0417921
|
N'-(1H-benzimidazol-2-ylmethyl)-N'-(5,6,7,8-tetrahydroquinolin-8-yl)pentane-1,5-diamine
Show/Hide
|
C22H29N5
|
1
|
| 1 |
IC50 = 514 nM
|
|
|
|
CP0865070
|
(S)-N-(((S)-2-methyl-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl)-N-(3-(4-methylpiperazin-1-yl)propyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C28H41N5
|
1
|
| 1 |
IC50 = 536 nM
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|
|
|
CP0875937
|
(S)-N-(2-(piperazin-1-yl)ethyl)-N-(((R)-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C25H35N5
|
1
|
| 1 |
IC50 = 553 nM
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|
|
|
CP0961944
|
US9314468, Table 7, Compound 12
Show/Hide
|
C25H28FN5
|
1
|
| 1 |
IC50 = 565 nM
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|
|
|
CP0574030
|
US9314468, Table 7, Compound 133
Show/Hide
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C29H36N6O2
|
1
|
| 1 |
IC50 = 583 nM
|
|
|
|
CP0515003
|
US9314468, Table 7, Compound 116
Show/Hide
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C35H45N7O2
|
1
|
| 1 |
IC50 = 628 nM
|
|
|
|
CP0473708
|
N'-[(5-chloropyridin-2-yl)methyl]-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]butane-1,4-diamine
Show/Hide
|
C20H27ClN4
|
1
|
| 1 |
IC50 = 631 nM
|
|
|
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CP0563413
|
US9314468, Table 7, Compound 65
Show/Hide
|
C31H39N7O
|
1
|
| 1 |
IC50 = 663 nM
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|
|
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CP0569679
|
N'-[(4-methylpyridin-2-yl)methyl]-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]butane-1,4-diamine
Show/Hide
|
C21H30N4
|
1
|
| 1 |
IC50 = 698 nM
|
|
|
|
CP0946040
|
US9314468, Table 7, Compound 32
Show/Hide
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C27H33N5
|
1
|
| 1 |
IC50 = 699 nM
|
|
|
|
CP0922842
|
US9314468, Table 7, Compound 14
Show/Hide
|
C29H35N5
|
1
|
| 1 |
IC50 = 729 nM
|
|
|
|
CP0228805
|
4-N-[(3R)-3-[[methyl-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]amino]methyl]-1,2,3,4-tetrahydroisoquinolin-5-yl]cyclohexane-1,4-diamine
Show/Hide
|
C26H37N5
|
1
|
| 1 |
IC50 = 755 nM
|
|
|
|
CP0564084
|
US9314468, Table 7, Compound 55
Show/Hide
|
C27H31N5O2
|
1
|
| 1 |
IC50 = 864 nM
|
|
|
|
CP0493700
|
1,3-dicyclohexyl-2-((5,6-dihydroimidazo[2,1-b]thiazol-3-yl)methyl)-1-methylisothiourea
Show/Hide
|
C20H32N4S2
|
2
|
| 1 |
IC50 = 931 nM
|
|
|
| 2 |
IC50 = 3575 nM
|
|
|
|
CP0413526
|
US9314468, Table 7, Compound 58
Show/Hide
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C31H39N5O2
|
1
|
| 1 |
IC50 = 949 nM
|
|
|
|
CP0915653
|
US9314468, Table 7, Compound 68
Show/Hide
|
C25H27N5
|
1
|
| 1 |
IC50 = 949 nM
|
|
|
|
CP0904009
|
4-3-(((R)-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl)((S)-5,6,7,8-tetrahydroquinolin-8-yl)amino)propyl)piperazin-1-carboxamide
Show/Hide
|
C27H38N6O
|
1
|
| 1 |
IC50 = 959 nM
|
|
|
|
CP0518716
|
N'-(1H-benzimidazol-2-ylmethyl)-N'-(5,6,7,8-tetrahydroquinolin-8-yl)but-2-yne-1,4-diamine
Show/Hide
|
C21H23N5
|
1
|
| 1 |
IC50 = 973 nM
|
|
|
|
CP0561595
|
US9314468, Table 7, Compound 98
Show/Hide
|
C26H31N5
|
1
|
| 1 |
IC50 = 997 nM
|
|
|
|
CP0494918
|
US9314468, Table 7, Compound 78
Show/Hide
|
C25H29N5
|
1
|
| 1 |
IC50 = 1046 nM
|
|
|
|
CP0840066
|
(S)-N-(3-(piperazin-1yl)propyl)-N-(((S)-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C26H37N5
|
1
|
| 1 |
IC50 = 1154 nM
|
|
|
|
CP0922844
|
US9314468, Table 7, Compound 44
Show/Hide
|
C25H29N5
|
1
|
| 1 |
IC50 = 1180 nM
|
|
|
|
CP0887627
|
(S)-N-((1H-benzo[d]thiazol-2yl)methyl)-N-(3-(piperazine-1yl)propyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C24H31N5S
|
1
|
| 1 |
IC50 = 1199 nM
|
|
|
|
CP0380489
|
(4R,7S,10S,13S,16R)-16-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-7,10-dibenzyl-13-[3-(diaminomethylideneamino)propyl]-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxamide
Show/Hide
|
C41H60N14O8S2
|
1
|
| 1 |
IC50 = 1230 nM
|
|
|
|
CP0571755
|
(4R,7S,10S,13S,16S)-16-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-10-benzyl-13-[3-(diaminomethylideneamino)propyl]-7-[(4-hydroxyphenyl)methyl]-3,3-dimethyl-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
Show/Hide
|
C43H63N13O10S2
|
1
|
| 1 |
IC50 = 1250 nM
|
|
|
|
CP0556538
|
US9314468, Table 7, Compound 137
Show/Hide
|
C34H42N6O2
|
1
|
| 1 |
IC50 = 1260 nM
|
|
|
|
CP0865678
|
US9314468, Table 7, Compound 43
Show/Hide
|
C25H29N5
|
1
|
| 1 |
IC50 = 1340 nM
|
|
|
|
CP0522897
|
N'-(1H-benzimidazol-2-ylmethyl)-N'-(5,6,7,8-tetrahydroquinolin-8-yl)ethane-1,2-diamine
Show/Hide
|
C19H23N5
|
1
|
| 1 |
IC50 = 1369 nM
|
|
|
|
CP0494921
|
US9314468, Table 7, Compound 117
Show/Hide
|
C37H43N7O2
|
1
|
| 1 |
IC50 = 1398 nM
|
|
|
|
CP0518715
|
N-[[3-(aminomethyl)phenyl]methyl]-N-(1H-benzimidazol-2-ylmethyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C25H27N5
|
1
|
| 1 |
IC50 = 1402 nM
|
|
|
|
CP0960852
|
US9314468, Table 7, Compound 69
Show/Hide
|
C25H27N5O
|
1
|
| 1 |
IC50 = 1440 nM
|
|
|
|
CP0510822
|
(4R,7S,10S,13S,16S)-16-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-7,10-dibenzyl-13-[3-(diaminomethylideneamino)propyl]-17,17-dimethyl-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
Show/Hide
|
C43H63N13O9S2
|
1
|
| 1 |
IC50 = 1530 nM
|
|
|
|
CP0509709
|
N'-[[6-(methoxymethyl)pyridin-2-yl]methyl]-N'-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine
Show/Hide
|
C21H30N4O
|
1
|
| 1 |
IC50 = 1621 nM
|
|
|
|
CP0555366
|
US9314468, Table 7, Compound 89
Show/Hide
|
C34H33N5O2
|
1
|
| 1 |
IC50 = 1640 nM
|
|
|
|
CP0957752
|
US9314468, Table 7, Compound 3
Show/Hide
|
C28H33N7
|
1
|
| 1 |
IC50 = 1666 nM
|
|
|
|
CP0228804
|
(3S)-3-[[methyl-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]amino]methyl]-N-piperidin-4-yl-1,2,3,4-tetrahydroisoquinolin-5-amine
Show/Hide
|
C25H35N5
|
1
|
| 1 |
IC50 = 1670 nM
|
|
|
|
CP0402756
|
N'-[(1S)-1-(5-methylpyridin-2-yl)ethyl]-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]butane-1,4-diamine
Show/Hide
|
C22H32N4
|
1
|
| 1 |
IC50 = 1710 nM
|
|
|
|
CP0958023
|
US9314468, Table 7, Compound 17
Show/Hide
|
C27H31N5O
|
1
|
| 1 |
IC50 = 1720 nM
|
|
|
|
CP0573628
|
(4R,7S,10S,13S,16S)-16-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-10-benzyl-13-[3-(diaminomethylideneamino)propyl]-3,3-dimethyl-7-(naphthalen-1-ylmethyl)-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
Show/Hide
|
C47H65N13O9S2
|
1
|
| 1 |
IC50 = 1800 nM
|
|
|
|
CP0262923
|
(Z)-2-fluoro-3-methyl-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]but-2-ene-1,4-diamine
Show/Hide
|
C24H31FN4
|
1
|
| 1 |
IC50 = 1800 nM
|
|
|
|
CP0352402
|
4-N-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-4-N-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]cyclohexane-1,4-diamine
Show/Hide
|
C25H34N4
|
1
|
| 1 |
IC50 = 1800 nM
|
|
|
|
CP0935346
|
US9314468, Table 7, Compound 81
Show/Hide
|
C27H30N6O
|
1
|
| 1 |
IC50 = 1810 nM
|
|
|
|
CP0532974
|
N'-[(3-chloropyridin-2-yl)methyl]-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]butane-1,4-diamine
Show/Hide
|
C20H27ClN4
|
1
|
| 1 |
IC50 = 1855 nM
|
|
|
|
CP0952604
|
US9314468, Table 7, Compound 28
Show/Hide
|
C33H42N6O
|
1
|
| 1 |
IC50 = 1930 nM
|
|
|
|
CP0952605
|
US9314468, Table 7, Compound 30
Show/Hide
|
C29H36N6
|
1
|
| 1 |
IC50 = 1955 nM
|
|
|
|
CP0516387
|
US9314468, Table 7, Compound 49
Show/Hide
|
C22H25N5
|
1
|
| 1 |
IC50 = 1970 nM
|
|
|
|
CP0416445
|
N'-[(3-fluoropyridin-2-yl)methyl]-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]butane-1,4-diamine
Show/Hide
|
C20H27FN4
|
1
|
| 1 |
IC50 = 2116 nM
|
|
|
|
CP0571757
|
(4R,7S,10S,13S,16S)-16-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-7-benzyl-13-[3-(diaminomethylideneamino)propyl]-10-(1H-imidazol-5-ylmethyl)-3,3-dimethyl-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
Show/Hide
|
C40H61N15O9S2
|
1
|
| 1 |
IC50 = 2140 nM
|
|
|
|
CP0529253
|
US9314468, Table 7, Compound 136
Show/Hide
|
C34H42N6O2
|
1
|
| 1 |
IC50 = 2150 nM
|
|
|
|
CP0372327
|
1-benzyl-3-cyclohexyl-2-((2,3,5,6-tetrahydroimidazo[2,1-b]thiazol-3-yl)methyl)isothiourea
Show/Hide
|
C20H28N4S2
|
2
|
| 1 |
IC50 = 2220 nM
|
|
|
| 2 |
IC50 = 10000 nM
|
|
|
|
CP0708046
|
(S)-N-(3-(piperazin-1yl)propyl)-N-(((S)-5,6,7,8-tetrahydro-1,6-naphthyridin-7-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C25H36N6
|
1
|
| 1 |
IC50 = 2639 nM
|
|
|
|
CP0413525
|
US9314468, Table 7, Compound 46
Show/Hide
|
C27H30N4O2
|
1
|
| 1 |
IC50 = 2810 nM
|
|
|
|
CP0477964
|
US9314468, Table 7, Compound 118
Show/Hide
|
C37H43N7O2
|
1
|
| 1 |
IC50 = 2830 nM
|
|
|
|
CP0575402
|
N'-[(6-methylpyridin-2-yl)methyl]-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]butane-1,4-diamine
Show/Hide
|
C21H30N4
|
1
|
| 1 |
IC50 = 2902 nM
|
|
|
|
CP0524341
|
4-amino-N-(1H-benzimidazol-2-ylmethyl)-N-(5,6,7,8-tetrahydroquinolin-8-yl)butanamide
Show/Hide
|
C21H25N5O
|
1
|
| 1 |
IC50 = 3200 nM
|
|
|
|
CP0572427
|
US9314468, Table 7, Compound 2
Show/Hide
|
C23H30N6
|
1
|
| 1 |
IC50 = 3200 nM
|
|
|
|
CP0457068
|
(4R,7S,10S,13S,16R)-7,10-dibenzyl-16-[[(2S)-2-[[3-(diaminomethylideneamino)benzoyl]amino]propanoyl]amino]-13-[3-(diaminomethylideneamino)propyl]-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
Show/Hide
|
C41H52N12O8S2
|
1
|
| 1 |
IC50 = 3200 nM
|
|
|
|
CP0473709
|
N'-(isoquinolin-3-ylmethyl)-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]butane-1,4-diamine
Show/Hide
|
C24H30N4
|
1
|
| 1 |
IC50 = 3307 nM
|
|
|
|
CP0413527
|
US9314468, Table 7, Compound 73
Show/Hide
|
C26H31N5
|
1
|
| 1 |
IC50 = 3370 nM
|
|
|
|
CP0935736
|
US9314468, Table 7, Compound 111
Show/Hide
|
C27H31N5
|
1
|
| 1 |
IC50 = 3597 nM
|
|
|
|
CP0407231
|
(4R,7S,10S,13S,16S)-16-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-7-benzyl-13-[3-(diaminomethylideneamino)propyl]-3,3-dimethyl-10-[(4-nitrophenyl)methyl]-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
Show/Hide
|
C43H62N14O11S2
|
1
|
| 1 |
IC50 = 3690 nM
|
|
|
|
CP0915654
|
US9314468, Table 7, Compound 94
Show/Hide
|
C32H34N6
|
1
|
| 1 |
IC50 = 3730 nM
|
|
|
|
CP0667786
|
(S)-N-(3-(piperazin-1yl)propyl)-N-(pyrimidin-2ylmethyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C21H30N6
|
1
|
| 1 |
IC50 = 4316 nM
|
|
|
|
CP0516119
|
US9314468, Table 7, Compound 76
Show/Hide
|
C32H41N7O
|
1
|
| 1 |
IC50 = 4390 nM
|
|
|
|
CP0937433
|
US9314468, Table 7, Compound 4
Show/Hide
|
C31H34N6
|
1
|
| 1 |
IC50 = 5100 nM
|
|
|
|
CP0491737
|
1-cyclohexyl-2-((5,6-dihydroimidazo[2,1-b]thiazol-3-yl)methyl)-3-phenylisothiourea
Show/Hide
|
C19H24N4S2
|
2
|
| 1 |
IC50 = 5275 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0402755
|
N'-(quinolin-2-ylmethyl)-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]butane-1,4-diamine
Show/Hide
|
C24H30N4
|
1
|
| 1 |
IC50 = 5751 nM
|
|
|
|
CP0570864
|
(4S,7S,10S,13S,16R)-16-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-7,10-dibenzyl-13-[3-(diaminomethylideneamino)propyl]-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
Show/Hide
|
C41H59N13O9S2
|
1
|
| 1 |
IC50 = 5900 nM
|
|
|
|
CP0570865
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(4R,7S,10S,13S,16R)-16-[[(2S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-7,10-dibenzyl-13-[3-(diaminomethylideneamino)propyl]-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxamide
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C39H58N14O7S2
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1
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| 1 |
IC50 = 5900 nM
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CP0499705
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US9314468, Table 7, Compound 97
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C36H37N5O2
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1
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| 1 |
IC50 = 6650 nM
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CP0865679
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US9314468, Table 7, Compound 60
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C26H30N6O
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1
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| 1 |
IC50 = 6671 nM
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CP0522188
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2-Benzo[4,5]imidazo[2,1-b]thiazol-3-ylmethyl-1,3-dicyclohexyl-isothiourea
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C23H30N4S2
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2
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| 1 |
IC50 = 8120 nM
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| 2 |
IC50 > 10000 nM
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CP0572442
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US9314468, Table 7, Compound 108
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C27H25N5
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1
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| 1 |
IC50 = 8393 nM
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CP0563324
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US9314468, Table 7, Compound 115
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C37H43N7O2
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1
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| 1 |
IC50 = 8650 nM
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CP0516390
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US9314468, Table 7, Compound 126
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C34H41N7O3
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1
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| 1 |
IC50 = 8720 nM
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CP0545493
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N'-(isoquinolin-1-ylmethyl)-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]butane-1,4-diamine
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C24H30N4
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1
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| 1 |
IC50 = 8721 nM
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CP0574027
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US9314468, Table 7, Compound 86
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C24H27N5
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1
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| 1 |
IC50 = 8890 nM
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CP0496643
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1,3-dicyclohexyl-2-(((E)-3-methyl-2-(methylimino)-2,3-dihydrothiazol-4-yl)methyl)isothiourea
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C19H32N4S2
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2
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| 1 |
IC50 = 9130 nM
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| 2 |
IC50 > 10000 nM
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CP0941766
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US9314468, Table 7, Compound 104
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C30H37N5O2
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1
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| 1 |
IC50 = 9585 nM
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CP0958024
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US9314468, Table 7, Compound 23
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C28H34N6O2S
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1
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| 1 |
IC50 = 9999 nM
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CP0502435
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2-Benzyl-1,3-dicyclohexyl-isothiourea
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C20H30N2S
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1
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| 1 |
IC50 > 10000 nM
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CP0537552
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2-(5,6-Dihydro-imidazo[2,1-b]thiazol-3-ylmethyl)-1,3-diisopropyl-isothiourea
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C13H22N4S2
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1
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| 1 |
IC50 > 10000 nM
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CP0398332
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(4R,7S,10S,13S,16S)-16-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-10-benzyl-13-[3-(diaminomethylideneamino)propyl]-7-methyl-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
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C35H55N13O9S2
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1
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| 1 |
IC50 > 10000 nM
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CP0459415
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(4R,7S,10S,13S,16R)-16-[[(2S)-2-[[(2R)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-7,10-dibenzyl-13-[3-(diaminomethylideneamino)propyl]-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
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C41H59N13O9S2
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1
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| 1 |
IC50 > 10000 nM
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CP0463839
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(4R,7S,10S,13S,16S)-16-[[(2S)-2-[[(2S)-2-acetamidopropanoyl]amino]propanoyl]amino]-7,10-dibenzyl-13-[3-(diaminomethylideneamino)propyl]-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
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C38H52N10O9S2
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1
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| 1 |
IC50 > 10000 nM
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CP0469495
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(4R,7S,10S,13S,16S)-16-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-7,10-dibenzyl-13-methyl-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
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C38H52N10O9S2
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1
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| 1 |
IC50 > 10000 nM
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CP0510215
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(4R,7R,10S,13S,16R)-16-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-7,10-dibenzyl-13-[3-(diaminomethylideneamino)propyl]-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
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C41H59N13O9S2
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1
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| 1 |
IC50 > 10000 nM
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CP0549029
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(4R,7S,10S,13R,16R)-16-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-7,10-dibenzyl-13-[3-(diaminomethylideneamino)propyl]-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
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C41H59N13O9S2
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1
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| 1 |
IC50 > 10000 nM
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CP0554790
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(4R,7S,10R,13S,16R)-16-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-7,10-dibenzyl-13-[3-(diaminomethylideneamino)propyl]-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
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C41H59N13O9S2
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1
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| 1 |
IC50 > 10000 nM
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CP0567584
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(4R,7S,10S,13S,16R)-16-[[(2R)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-7,10-dibenzyl-13-[3-(diaminomethylideneamino)propyl]-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
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C41H59N13O9S2
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1
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| 1 |
IC50 > 10000 nM
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CP0567622
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(4R,7S,10S,13S,16S)-16-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-7-benzyl-13-[3-(diaminomethylideneamino)propyl]-10-methyl-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
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C35H55N13O9S2
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1
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| 1 |
IC50 > 10000 nM
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CP0437120
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(4R,7S,10S,13S,16R)-7,10-dibenzyl-16-[[(2S)-2-[(1-carbamimidoylpiperidine-4-carbonyl)amino]propanoyl]amino]-13-[3-(diaminomethylideneamino)propyl]-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
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C40H56N12O8S2
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1
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| 1 |
IC50 > 10000 nM
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CP0457065
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(4R,7S,10S,13S,16R)-7,10-dibenzyl-16-[[(2S)-2-[4-(diaminomethylideneamino)butanoylamino]propanoyl]amino]-13-[3-(diaminomethylideneamino)propyl]-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
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C38H54N12O8S2
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1
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| 1 |
IC50 > 10000 nM
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CP0457067
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(4R,7S,10S,13S,16R)-16-[[(2S)-2-[[(2R)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-7,10-dibenzyl-13-[3-(diaminomethylideneamino)propyl]-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
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C39H57N13O8S2
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1
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| 1 |
IC50 > 10000 nM
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CP0556043
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(4R,7S,10S,13S,16R)-16-[[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-13-benzyl-7-[3-(diaminomethylideneamino)propyl]-10-methyl-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
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C39H57N13O8S2
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1
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| 1 |
IC50 > 10000 nM
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CP0564231
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(4R,7S,10S,13S,16R)-7,10-dibenzyl-16-[[(2S)-2-[[4-(diaminomethylideneamino)benzoyl]amino]propanoyl]amino]-13-[3-(diaminomethylideneamino)propyl]-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
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C41H52N12O8S2
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1
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| 1 |
IC50 > 10000 nM
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CP0537274
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(4R,7S,10S,13S,16S)-16-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-7,10-dibenzyl-13-[3-(diaminomethylideneamino)propyl]-3,3,17,17-tetramethyl-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
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C45H67N13O9S2
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1
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| 1 |
IC50 > 10000 nM
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CP0565904
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(4R,7S,10S,13S,16S)-16-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-10-benzyl-7-[(4-chlorophenyl)methyl]-13-[3-(diaminomethylideneamino)propyl]-3,3-dimethyl-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
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C43H62ClN13O9S2
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1
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| 1 |
IC50 > 10000 nM
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CP0565906
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(4R,7S,10S,13S,16S)-16-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-7,10-dibenzyl-13-[3-(diaminomethylideneamino)propyl]-3,3-dimethyl-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxylic acid
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C43H63N13O9S2
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1
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| 1 |
IC50 > 10000 nM
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CP0545491
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N'-[(5-methoxypyridin-2-yl)methyl]-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]butane-1,4-diamine
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C21H30N4O
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1
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| 1 |
IC50 > 23000 nM
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CP0473707
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N'-[(3-methoxypyridin-2-yl)methyl]-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]butane-1,4-diamine
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C21H30N4O
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1
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| 1 |
IC50 > 33000 nM
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CP0532973
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N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]-N'-[[5-(trifluoromethyl)pyridin-2-yl]methyl]butane-1,4-diamine
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C21H27F3N4
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1
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| 1 |
IC50 > 33000 nM
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CP0545492
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N'-[(4-chloropyridin-2-yl)methyl]-N'-[[(3R)-1,2,3,4-tetrahydroisoquinolin-3-yl]methyl]butane-1,4-diamine
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C20H27ClN4
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1
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| 1 |
IC50 > 33000 nM
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