Brief Information of the Cell Line and Protein
Cell Line ID: CL000094 , 1321N1
Synonyms
1321-N1
1321 N1
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0110
Protein ID: PT07329 , Calcitonin gene-related peptide 2
Gene Name CALCB
Organism Homo sapiens, Human
Protein Classification Secreted protein
Uniprot ID P10092
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000094  Protein ID: PT07329
 
Compound ID Compound Name Compound Formula
CP0418498
N-[[2-[(diaminomethylideneamino)methyl]phenyl]methyl]-2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]propanamide
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C31H35N7O3
 1
1
IC50 = 0.631 nM
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CP0549140
N-[[2-[(cyclopropylamino)methyl]phenyl]methyl]-2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]propanamide
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C33H37N5O3
 1
1
IC50 = 1 nM
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CP0572345
N-[[2-(1-aminoethyl)phenyl]methyl]-2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]propanamide
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C31H35N5O3
 1
1
IC50 = 1.259 nM
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CP0572344
N-[[2-(azetidin-1-ylmethyl)phenyl]methyl]-2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]propanamide
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C33H37N5O3
 1
1
IC50 = 1.995 nM
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CP0549141
N-[[2-(2-aminoethyl)phenyl]methyl]-2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]propanamide
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C31H35N5O3
 1
1
IC50 = 2.512 nM
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CP0558402
N-[[2-(imidazol-1-ylmethyl)phenyl]methyl]-2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]propanamide
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C33H34N6O3
 1
1
IC50 = 3.162 nM
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CP0507382
N-[(2-aminophenyl)methyl]-2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]propanamide
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C29H31N5O3
 1
1
IC50 = 3.981 nM
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CP0533804
2,2-dimethyl-N-[[2-(methylaminomethyl)phenyl]methyl]-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]propanamide
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C31H35N5O3
 1
1
IC50 = 3.981 nM
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CP0507380
N-[[2-(hydroxymethyl)phenyl]methyl]-2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]propanamide
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C30H32N4O4
 1
1
IC50 = 5.012 nM
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CP0546386
N-[[2-(aminomethyl)phenyl]methyl]-2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]propanamide
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C30H33N5O3
 1
1
IC50 = 5.012 nM
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CP0959215
N-((1H-Indozol-4-yl)methyl)-N-(2-oxo-2-((2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl)amino)-ethyl)pivalamide
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C30H30N6O3
 1
1
IC50 = 5.012 nM
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CP0418495
2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]-N-[(2-pyrrolidin-3-ylphenyl)methyl]propanamide
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C33H37N5O3
 1
1
IC50 = 7.943 nM
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CP0418497
2,2-dimethyl-N-[[2-(morpholin-4-ylmethyl)phenyl]methyl]-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]propanamide
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C34H39N5O4
 1
1
IC50 = 7.943 nM
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CP0546385
N-[(2-cyanophenyl)methyl]-2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]propanamide
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C30H29N5O3
 1
1
IC50 = 25.12 nM
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CP0531177
2-[[2,2-dimethylpropanoyl-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]amino]methyl]benzamide
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C30H31N5O4
 1
1
IC50 = 50.12 nM
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CP0549138
2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]-N-(pyridin-2-ylmethyl)propanamide
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C28H29N5O3
 1
1
IC50 = 100 nM
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CP0551838
2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]-N-(1,3-thiazol-2-ylmethyl)propanamide
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C26H27N5O3S
 1
1
IC50 = 100 nM
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CP0558403
2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]-N-[(2-phenylpyrazol-3-yl)methyl]propanamide
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C32H32N6O3
 1
1
IC50 = 100 nM
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CP0558401
2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]-N-(1,2,3,4-tetrahydroisoquinolin-8-ylmethyl)propanamide
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C32H35N5O3
 1
1
IC50 = 125.89 nM
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CP0507383
N-[1-[2-(aminomethyl)phenyl]ethyl]-2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]propanamide
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C31H35N5O3
 1
1
IC50 = 199.53 nM
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CP0546384
2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]-N-[(2-pyridin-3-ylphenyl)methyl]propanamide
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C34H33N5O3
 1
1
IC50 = 398.11 nM
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CP0507381
N-[[3-(aminomethyl)pyridin-2-yl]methyl]-2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]propanamide
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C29H32N6O3
 1
1
IC50 = 501.19 nM
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CP0418496
N-[[3-(aminomethyl)phenyl]methyl]-2,2-dimethyl-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]propanamide
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C30H33N5O3
 1
1
IC50 = 794.33 nM
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CP0572343
2,2-dimethyl-N-[(1-methylpiperidin-3-yl)methyl]-N-[2-oxo-2-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]ethyl]propanamide
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C29H37N5O3
 1
1
IC50 = 3162.28 nM
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