Brief Information of the Cell Line and Protein
Cell Line ID: CL000091 , MV4-11
 Cell Line Info 
Synonyms
MV-4-11
MV-4:11
MV4:11
MV 4;11
MV4;11
MV411
MV(4;11)
MV4II
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0064
Protein ID: PT02678 , Histone-lysine N-methyltransferase, H3 lysine-79 specific
 Protein Info 
Gene Name DOT1L
Organism Homo sapiens, Human
Protein Classification Epigenetic regulator
Uniprot ID Q8TEK3
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000091
 Cell Line Info 
 Protein ID: PT02678
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0416983
 Compound Info 
6-(1,3-benzodioxol-5-yl)-3-(benzotriazol-1-ylmethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
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C17H11N7O2S
  1
1
IC50 = 6750 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0567136
 Compound Info 
3-(benzotriazol-1-ylmethyl)-6-(4-fluorophenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
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C16H10FN7S
  1
1
IC50 = 8000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0465737
 Compound Info 
3-(benzotriazol-1-ylmethyl)-6-(4-tert-butylphenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
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C20H19N7S
  1
1
IC50 = 13050 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0320291
 Compound Info 
3-(benzotriazol-1-ylmethyl)-6-(3-fluorophenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
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C16H10FN7S
  1
1
IC50 = 21910 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0441205
 Compound Info 
3-(benzimidazol-1-ylmethyl)-6-(3-bromophenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
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C17H11BrN6S
  1
1
IC50 = 26780 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0570203
 Compound Info 
1-{[6-(2,3-dihydro-1,4-benzodioxin-6-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl]methyl}-1H-1,2,3-benzotriazole
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C18H13N7O2S
  1
1
IC50 = 40730 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0260316
 Compound Info 
3-(1-benzotriazolylmethyl)-6-(phenylmethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
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C17H13N7S
  1
1
IC50 = 48800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0566569
 Compound Info 
3-(benzimidazol-1-ylmethyl)-6-(3,4-dimethylphenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
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C19H16N6S
  1
1
IC50 = 63970 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0478449
 Compound Info 
3-(benzotriazol-1-ylmethyl)-6-(3-methoxyphenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
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C17H13N7OS
  1
1
IC50 = 64150 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS