Brief Information of the Cell Line and Protein
Cell Line ID: CL000083 , MCF-7
Synonyms
MCF 7
MCF.7
MCF7
Michigan Cancer Foundation-7
ssMCF-7
ssMCF7
MCF7/WT
MCF7-CTRL
IBMF-7
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0031
Protein ID: PT02259 , Neuropeptide Y receptor type 1
Gene Name NPY1R
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P25929
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000083  Protein ID: PT02259
 
Compound ID Compound Name Compound Formula
CP0391738
(2R)-5-[[amino-[2-(2,3-ditritiopropanoylamino)ethylcarbamoylamino]methylidene]amino]-2-[(2,2-diphenylacetyl)amino]-N-[(4-hydroxyphenyl)methyl]pentanamide
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C33H41N7O5
 2
1
Kd = 0.074 nM
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2
Kd = 0.14 nM
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CP0871818
3-((R)-9-Amino-4-(2,2-diphenylacetamido)-1-(4-hydroxyphenyl)-3,11,18-trioxo-2,8,10,12,17-pentaazahenicos-9-en-21-yl)-2-((1E,3E)-4-(4-(dimethylamino)phenyl)buta-1,3-enyl)benzo[d]thiazol-3-ium hydrotrifluoroacetate
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C57H64F3N9O7S
 1
1
Kd = 5 nM
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CP0419095
(R)-Nalpha-(2,2-diphenylacetyl)-N-(4-hydroxybenzyl)-N-omega-propanoylargininamide
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C30H35N5O4
 1
1
Ki = 1.2 nM
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CP0421780
(4S)-4-[[2-[[(2S)-1-[(2S)-4-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-carboxypropanoyl]amino]-4-oxobutanoyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-5-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
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C137H198N38O44S
 1
1
Ki = 3.1 nM
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CP0501371
(3S,6S,9S,12S,15S,18S)-1-((S)-1-((S)-4-amino-2-((2S,3S)-2-amino-3-methylpentanamido)-4-oxobutanoyl)pyrrolidin-2-yl)-3-(4-aminobutyl)-9,15-bis(3-guanidinopropyl)-6,18-bis(4-hydroxybenzyl)-12-isobutyl-1,4,7,10,13,16-hexaoxo-2,5,8,11,14,17-hexaazanonadecan-19-oic acid
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C57H91N17O13
 1
1
Ki = 7 nM
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CP0870337
(R,R)-N,N-Bis[N-(N-{8-[4-diphenylacetylamino-4-(4-hydroxybenzylaminocarbonyl)butyl]amino-(amino)methyleneamino-carbonylamino-3,6-dioxaoctyl}-4-amino-4-oxobutanoyl)-2-aminoethyl]ethane-1,2-diamine tetra(hydrotrifluoroacetate)
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C84H113F3N18O18
 1
1
Ki = 37 nM
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CP0853428
(R,R)-N,N-Bis[N-(N-{8-[4-diphenylacetylamino-4-(4-hydroxybenzylaminocarbonyl)butyl]amino-(amino)methyleneamino-carbonylamino-3,6-dioxaoctyl}-4-aminocarbonylbenzoyl)-2-aminoethyl]ethane-1,2-diamine tetra(hydrotrifluoroacetate)
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C92H113F3N18O18
 1
1
Ki = 48 nM
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CP0915112
(R,R)-N,N-Bis[N-(N-{8-[4-diphenylacetylamino-4-(4-hydroxybenzylaminocarbonyl)butyl]amino-(amino)methyleneamino-carbonylamino-3,6-dioxaoctyl}-5-amino-5-oxopentanoyl)-2-aminoethyl]ethane-1,2-diamine tetra(hydrotrifluoroacetate)
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C86H117F3N18O18
 1
1
Ki = 50 nM
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CP0371823
2,2',2''-(10-((6S,9S,12S,15S,18S)-1-amino-18-((S)-1-((S)-4-amino-2-((2S,3S)-2-amino-3-methylpentanamido)-4-oxobutanoyl)pyrrolidine-2-carboxamido)-6-((S)-1-carboxy-2-(4-hydroxyphenyl)ethylcarbamoyl)-12-(3-guanidinopropyl)-15-(4-hydroxybenzyl)-1-imino-9-isobutyl-8,11,14,17,24-pentaoxo-2,7,10,13,16,23-hexaazapentacosan-25-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid
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C73H117N21O20
 1
1
Ki = 63 nM
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CP0903765
N1,N1'-(2,2'-(2-propionamidoethylazanediyl)bis(ethane-2,1-diyl))bis(N4-((R,Z)-9-amino-4-(2,2-diphenylacetamido)-1-(4-hydroxyphenyl)-3,11-dioxo-15,18-dioxa-2,8,10,12-tetraazaicos-9-en-20-yl)terephthalamide)tris(hydrotrifluoroacetate)
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C95H117F3N18O19
 1
1
Ki = 110 nM
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CP0501370
(3S,6S,9S,12S,15S,18S)-1-((S)-1-((S)-6-amino-2-((2S,3S)-2-amino-3-methylpentanamido)hexanoyl)pyrrolidin-2-yl)-3-sec-butyl-9,15-bis(3-guanidinopropyl)-6,18-bis(4-hydroxybenzyl)-12-isobutyl-1,4,7,10,13,16-hexaoxo-2,5,8,11,14,17-hexaazanonadecan-19-oic acid
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C59H96N16O12
 1
1
Ki = 128 nM
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CP0853471
(R,R)-N,N-Bis{N-[N-(8-{4-diphenylacetylamino-4-[4-(ureidomethyl)benzylaminocarbonyl]butyl}amino-(amino)methyleneamino-carbonylamino-3,6-dioxaoctyl)-4-amino-4-oxo-butanoyl]-2-aminoethyl}ethane-1,2-diamine tetra(hydrotrifluoroacetate)
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C88H121F3N22O18
 1
1
Ki = 210 nM
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CP0853466
N-{N-[N-(6-{[(4R)-4-Diphenylacetylamino-4-(4-hydroxybenzylaminocarbonyl)butyl]amino-(amino)methylene-aminocarbonyl}aminohexyl)-4-amino-4-oxo-butanoyl]-2-aminoethyl}-N-(N-{N-[6-({(4S)-5-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethylamino]-5-oxo-4-[2-(1-{2-oxo-2-[4-(6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-11-yl)piperazin-1-yl]ethyl}cyclopentyl)acetamido]pentyl}-amino-(amino)methylene-aminocarbonyl)aminohexyl]-aminocarbonylpropanoyl}-2-aminoethyl)ethane-1,2-diamine tetra(hydrotrifluoroacetate)
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C106H139F3N24O17
 1
1
Ki = 260 nM
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CP0371824
(3S,6S,9S,12S,15S,18S)-1-((S)-1-((S)-2-((2S,3S)-2-acetamido-3-methylpentanamido)-4-amino-4-oxobutanoyl)pyrrolidin-2-yl)-3-(4-aminobutyl)-12-sec-butyl-9,15-bis(3-guanidinopropyl)-6,18-bis(4-hydroxybenzyl)-1,4,7,10,13,16-hexaoxo-2,5,8,11,14,17-hexaazanonadecan-19-oic acid
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C75H119N21O21
 1
1
Ki = 275 nM
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CP0475519
(2R,7R)-2-amino-N-[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-N'-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-7-(propanoylamino)octanediamide
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C83H128N26O17
 1
1
Ki = 290 nM
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CP0423824
N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-N'-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-5-[[(E)-N'-[4-(propanoylamino)butylcarbamoyl]carbamimidoyl]amino]pentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]octanediamide
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C88H136N26O18
 1
1
Ki = 360 nM
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CP0529436
(2S,7S)-2-amino-N,N'-bis[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-7-(propanoylamino)octanediamide
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C83H128N26O17
 1
1
Ki = 400 nM
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CP0420443
N'-[(2S)-1-[[(2S)-5-[[(E)-N'-(4-aminobutylcarbamoyl)carbamimidoyl]amino]-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]octanediamide
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C85H132N26O17
 1
1
Ki = 410 nM
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CP0873882
(R,R)-N,N-Bis(N-{N-[N-(4-{N-[2-diphenylacetylamino-2-(3-guanidinopro pyl)acetyl]aminomethyl}benzyl)aminocarbonylaminobutyl]-aminocarbonylbutanoyl}-2-aminoethyl)ethane-1,2-diamine tetra(hydrotrifluoroacetate)
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C84H115F3N20O12
 1
1
Ki = 430 nM
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CP0420444
(2R,7R)-2,7-diamino-N,N'-bis[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]octanediamide
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C80H124N26O16
 1
1
Ki = 440 nM
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CP0482449
N,N'-bis[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]octanediamide
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C80H122N24O16
 1
1
Ki = 720 nM
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CP0423825
(2S,7S)-2,7-diamino-N,N'-bis[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]octanediamide
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C80H124N26O16
 1
1
Ki = 930 nM
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CP0482448
N'-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]octanediamide
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C77H115N21O16
 1
1
Ki = 1400 nM
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CP0446419
N'-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]octanediamide
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C77H115N21O16
 1
1
Ki = 1600 nM
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CP0476160
8-{2-[4-({[(5S)-5-{[(2S)-1-[(2S)-2-[(2S,3S)-2-amino-3-methylpentanamido]-3-carbamoylpropanoyl]pyrrolidin-2-yl]formamido}-5-{[(1S)-1-{[(1S)-4-carbamimidamido-1-{[(1S)-1-{[(1S)-4-carbamimidamido-1-{[(1S)-1-carboxy-2-(4-hydroxyphenyl)ethyl]carbamoyl}butyl]carbamoyl}-3-methylbutyl]carbamoyl}butyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}pentyl]carbamoyl}methyl)-7,10-bis({[(7-carboxyheptyl)carbamoyl]methyl})-1,4,7,10-tetraazacyclododecan-1-yl]acetamido}octanoic acid
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C97H162N24O23
 1
1
Ki = 4507 nM
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CP0530735
(2S)-2-amino-N,N'-bis[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]octanediamide
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C74H109N19O16
 1
1
Ki > 10000 nM
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CP0489960
N,N'-bis[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]octanediamide
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C74H108N18O16
 1
1
Ki > 3000 nM
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