| Compound ID |
Compound Name |
Compound Formula |
|
CP0382561
|
US9085531, 102
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|
C21H24N2S
|
2
|
| 1 |
IC50 = 4.4 nM
|
|
|
| 2 |
Ki = 3.4 nM
|
|
|
|
CP0494543
|
4-[4-(1-benzothiophen-6-yl)-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]morpholine
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|
C22H24N2OS
|
1
|
| 1 |
IC50 = 4.5 nM
|
|
|
|
CP0140304
|
4-(1-benzothiophen-5-yl)-2,7-dimethyl-3,4-dihydro-1H-isoquinoline
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|
C19H19NS
|
1
|
| 1 |
IC50 = 4.9 nM
|
|
|
|
CP0105627
|
4-(1-benzothiophen-5-yl)-7-methoxy-2-methyl-3,4-dihydro-1H-isoquinoline
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|
C19H19NOS
|
1
|
| 1 |
IC50 = 5.3 nM
|
|
|
|
CP0411811
|
4-(1-benzothiophen-5-yl)-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol
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|
C18H17NOS
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0396823
|
US9085531, 14
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|
C18H17NO
|
2
|
| 1 |
IC50 = 24 nM
|
|
|
| 2 |
Ki = 19.2 nM
|
|
|
|
CP0411812
|
[4-(1-benzothiophen-5-yl)-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]methanamine
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|
C19H20N2S
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0414291
|
4-(1-benzofuran-4-yl)-2-methyl-3,4-dihydro-1H-isoquinoline
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|
C18H17NO
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0414289
|
US9085531, 19
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|
C18H17NO
|
2
|
| 1 |
IC50 = 31 nM
|
|
|
| 2 |
Ki = 19.2 nM
|
|
|
|
CP0407606
|
US9085531, 21
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|
C18H17NS
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0379916
|
BDBM50054527
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|
C23H26N2S
|
2
|
| 1 |
IC50 = 38 nM
|
|
|
| 2 |
Ki = 30.4 nM
|
|
|
|
CP0487942
|
4-(1-benzothiophen-6-yl)-2-methyl-3,4-dihydro-1H-isoquinoline
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|
C18H17NS
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0488293
|
4-(1-benzofuran-3-yl)-2-methyl-3,4-dihydro-1H-isoquinoline
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|
C18H17NO
|
1
|
| 1 |
IC50 = 67 nM
|
|
|
|
CP0105628
|
US9085531, 40
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|
C18H17NS
|
1
|
| 1 |
IC50 = 69 nM
|
|
|
|
CP0384782
|
US9085531, 2
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|
C18H17NO
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0409636
|
BDBM50054534
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|
C18H17NS
|
2
|
| 1 |
IC50 = 130 nM
|
|
|
| 2 |
Ki = 40.3 nM
|
|
|
|
CP0862386
|
(+/-)-4-(1H-indol-5-yl)-2-methyl-1,2,3,4-tetrahydroisoquinoline
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|
C18H18N2
|
2
|
| 1 |
IC50 = 170 nM
|
|
|
| 2 |
Ki = 137 nM
|
|
|
|
CP0396824
|
US9085531, 17
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|
C18H17NO
|
2
|
| 1 |
IC50 = 250 nM
|
|
|
| 2 |
Ki = 254 nM
|
|
|
|
CP0536634
|
2-[[4-(1-benzothiophen-5-yl)-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]amino]ethanol
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|
C20H22N2OS
|
1
|
| 1 |
IC50 = 2500 nM
|
|
|
|
CP0415903
|
US9085531, 97
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|
C22H19N3S
|
1
|
| 1 |
Ki = 2.2 nM
|
|
|
|
CP0416412
|
US9085531, 70
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|
C22H19N3S
|
1
|
| 1 |
Ki = 2.2 nM
|
|
|
|
CP0545728
|
US9085531, 137
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|
C24H21N3
|
1
|
| 1 |
Ki < 3 nM
|
|
|
|
CP0407673
|
US9085531, 78
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|
C23H26N2OS
|
1
|
| 1 |
Ki = 3.3 nM
|
|
|
|
CP0554208
|
US9085531, 56
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|
C21H21N
|
1
|
| 1 |
Ki = 3.4 nM
|
|
|
|
CP0538925
|
US9085531, 117
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|
C22H19N3O
|
1
|
| 1 |
Ki = 4.1 nM
|
|
|
|
CP0409884
|
US9085531, 82
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|
C19H19NOS
|
1
|
| 1 |
Ki = 4.3 nM
|
|
|
|
CP0483271
|
US9085531, 142
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|
C25H28N2O
|
1
|
| 1 |
Ki = 5.2 nM
|
|
|
|
CP0459699
|
BDBM50054521
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|
C22H24N2OS
|
1
|
| 1 |
Ki = 6.7 nM
|
|
|
|
CP0389390
|
US9085531, 100
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|
C22H24N2OS
|
1
|
| 1 |
Ki = 7.1 nM
|
|
|
|
CP0538207
|
US9085531, 135
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|
C17H16N2S
|
1
|
| 1 |
Ki = 10.4 nM
|
|
|
|
CP0429723
|
US9085531, 84
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|
C24H23N3OS
|
1
|
| 1 |
Ki = 12.9 nM
|
|
|
|
CP0857555
|
(+)-4-(1H-indol-6-yl)-2-methyl-1,2,3,4-tetrahydroisoquinoline
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|
C18H18N2
|
1
|
| 1 |
Ki = 13.9 nM
|
|
|
|
CP0867810
|
US9085531, 125
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|
C17H16ClN3
|
1
|
| 1 |
Ki = 21.3 nM
|
|
|
|
CP0859202
|
US9085531, 130
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|
C18H19N3
|
1
|
| 1 |
Ki = 22.5 nM
|
|
|
|
CP0863203
|
(+)-4-(1H-indazol-6-yl)-2-methyl-1,2,3,4-tetrahydroisoquinoline
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|
C17H17N3
|
1
|
| 1 |
Ki = 22.8 nM
|
|
|
|
CP0407192
|
US9085531, 11
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|
C19H19NO2
|
1
|
| 1 |
Ki = 26.8 nM
|
|
|
|
CP0468434
|
US9085531, 71
Show/Hide
|
C22H19N3S
|
1
|
| 1 |
Ki = 91 nM
|
|
|
|
CP0458987
|
US9085531, 73
Show/Hide
|
C22H19N3S
|
1
|
| 1 |
Ki = 93 nM
|
|
|
|
CP0857556
|
(+)-4-(1H-indazol-5-yl)-2-methyl-1,2,3,4-tetrahydroisoquinoline
Show/Hide
|
C17H17N3
|
1
|
| 1 |
Ki = 180 nM
|
|
|
|
CP0396822
|
BDBM50054516
Show/Hide
|
C17H16N2S
|
1
|
| 1 |
Ki = 205 nM
|
|
|
|
CP0474037
|
4-(4-fluorophenyl)-2,7-dimethyl-3,4-dihydro-1H-isoquinoline
Show/Hide
|
C17H18FN
|
1
|
| 1 |
Ki = 230 nM
|
|
|
|
CP0431464
|
US9085531, 6-methoxy-pyridin-3-yl
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|
C16H18N2O
|
1
|
| 1 |
Ki = 470 nM
|
|
|
|
CP0523321
|
US9085531, 4-(3,5-dimethyl-isoxazol-4-yl
Show/Hide
|
C15H18N2O
|
1
|
| 1 |
Ki = 1400 nM
|
|
|
|
CP0463174
|
US9085531, thiophen-2-yl
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|
C14H15NS
|
1
|
| 1 |
Ki = 2450 nM
|
|
|
|
CP0403475
|
US9085531, 4-methyl-thiophen-2-yl
Show/Hide
|
C15H17NS
|
1
|
| 1 |
Ki = 3170 nM
|
|
|
|
CP0413981
|
US9085531, 5-methyl-furan-2-yl
Show/Hide
|
C15H17NO
|
1
|
| 1 |
Ki = 7530 nM
|
|
|
|
CP0287226
|
methyl 2-phenyl-2-piperidin-2-ylacetate
Show/Hide
|
C14H19NO2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
