Brief Information of the Cell Line and Protein
Cell Line ID: CL000050 , HEK293-A
Synonyms
HEK-293A
HEK293A
HEK 293A
293A
QBI-HEK 293A
QBI-293A
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_6910
Protein ID: PT01994 , Metabotropic glutamate receptor 1
Gene Name GRM1
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID Q13255
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000050  Protein ID: PT01994
 
Compound ID Compound Name Compound Formula
CP0176101
3-[(3R)-4-(adamantane-1-carbonyl)-3-methylpiperazin-1-yl]pyridine-2-carbonitrile
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C22H28N4O
 1
1
IC50 = 99 nM
   TI
   LI
   LO
   TS
CP0390726
[(3aS,6aR)-2-(3-fluoropyridin-2-yl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(1-adamantyl)methanone
   Show/Hide
C22H28FN3O
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0397053
cyclooctyl-[(3R)-3-methyl-4-pyridin-2-ylpiperazin-1-yl]methanone
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C19H29N3O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0397668
cuban-1-yl-[(2R)-2-methyl-4-pyridin-2-ylpiperazin-1-yl]methanone
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C19H21N3O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0397680
1-adamantyl-[(3R)-3-methyl-4-pyridin-3-ylpiperazin-1-yl]methanone
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C21H29N3O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0397681
CHEMBL2397362
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C18H27N3O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0397682
1-adamantyl-[(3R)-3-methyl-4-pyrazin-2-ylpiperazin-1-yl]methanone
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C20H28N4O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0403857
1-adamantyl-[(2R)-2-methyl-4-pyridin-4-ylpiperazin-1-yl]methanone
   Show/Hide
C21H29N3O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0407420
1-adamantyl-[(3R)-3-methyl-4-pyrimidin-2-ylpiperazin-1-yl]methanone
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C20H28N4O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0433680
1-adamantyl-[(3R)-3-methyl-4-pyrimidin-4-ylpiperazin-1-yl]methanone
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C20H28N4O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0433681
cycloheptyl-[(2R)-2-methyl-4-pyridin-2-ylpiperazin-1-yl]methanone
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C18H27N3O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0456254
cycloheptyl-[(3R)-3-methyl-4-pyridin-2-ylpiperazin-1-yl]methanone
   Show/Hide
C18H27N3O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0456257
(4-tert-butylcyclohexyl)-[(3R)-3-methyl-4-pyridin-2-ylpiperazin-1-yl]methanone
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C21H33N3O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0456258
3-bicyclo[3.3.1]nonanyl-[(3R)-3-methyl-4-pyridin-2-ylpiperazin-1-yl]methanone
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C20H29N3O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0491650
cyclohexyl-[(2R)-2-methyl-4-pyridin-2-ylpiperazin-1-yl]methanone
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C17H25N3O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0375973
[(3aR,6aS)-2-pyridin-2-yl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-cycloheptylmethanone
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C19H27N3O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0376010
[(3aS,6aR)-2-pyridin-2-yl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(azocan-1-yl)methanone
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C19H28N4O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0376012
[(3aR,6aS)-2-pyridin-2-yl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-cuban-1-ylmethanone
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C20H21N3O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0376014
[(3aR,6aS)-2-(1,3-thiazol-2-yl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(1-adamantyl)methanone
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C20H27N3OS
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0390716
[(3aS,6aR)-2-pyrimidin-2-yl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(1-adamantyl)methanone
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C21H28N4O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0407790
[(3aR,6aS)-2-pyridin-2-yl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(4-methylcyclohexyl)methanone
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C19H27N3O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0431767
[(3aR,6aS)-2-pyridin-2-yl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-cyclooctylmethanone
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C20H29N3O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0456229
CHEMBL2418371
   Show/Hide
C22H33N3O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0456230
[(3aR,6aS)-2-pyridin-2-yl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-cyclohexylmethanone
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C18H25N3O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0466668
4-[(3aS,6aR)-5-(adamantane-1-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]pyridine-3-carbonitrile
   Show/Hide
C23H28N4O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0500915
[(3aR,6aS)-2-pyrimidin-4-yl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(1-adamantyl)methanone
   Show/Hide
C21H28N4O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0504720
1-[(3aS,6aR)-2-pyridin-2-yl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-cyclohexylethanone
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C19H27N3O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS