| Compound ID |
Compound Name |
Compound Formula |
|
CP0129278
|
US10463663, Example 40
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|
C11H9ClN2O2
|
1
|
| 1 |
EC50 = 4.2 nM
|
|
|
|
CP0574281
|
5-[(3R)-7-chloro-3-methyl-2H-1,4-benzoxathiin-3-yl]-1,4-dihydropyrazine-2,3-dione
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|
C13H11ClN2O3S
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0579480
|
(3R)-3-(5,6-dioxo-1,4-dihydropyrazin-2-yl)-3-methyl-2H-1,4-benzoxathiine-7-carbonitrile
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|
C14H11N3O3S
|
1
|
| 1 |
EC50 = 120 nM
|
|
|
|
CP0546647
|
5-[(3R)-7-chloro-2,3-dihydro-1,4-benzoxathiin-3-yl]-1,4-dihydropyrazine-2,3-dione
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|
C12H9ClN2O3S
|
1
|
| 1 |
EC50 = 220 nM
|
|
|
|
CP0546645
|
5-[[4-(trifluoromethyl)phenyl]methylsulfanyl]-1,4-dihydropyrazine-2,3-dione
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|
C12H9F3N2O2S
|
1
|
| 1 |
EC50 = 240 nM
|
|
|
|
CP0578767
|
5-(3-methyl-2H-1,4-benzoxathiin-3-yl)-1,4-dihydropyrazine-2,3-dione
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|
C13H12N2O3S
|
1
|
| 1 |
EC50 = 250 nM
|
|
|
|
CP0579643
|
5-[(3R)-3-methyl-7-(trifluoromethyl)-2H-1,4-benzoxathiin-3-yl]-1,4-dihydropyrazine-2,3-dione
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|
C14H11F3N2O3S
|
1
|
| 1 |
EC50 = 260 nM
|
|
|
|
CP0578758
|
5-[(3R)-7-(difluoromethyl)-2,3-dihydro-1,4-benzoxathiin-3-yl]-1,4-dihydropyrazine-2,3-dione
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|
C13H10F2N2O3S
|
1
|
| 1 |
EC50 = 290 nM
|
|
|
|
CP0572801
|
4-[(5,6-dioxo-1,4-dihydropyrazin-2-yl)sulfanylmethyl]benzonitrile
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|
C12H9N3O2S
|
1
|
| 1 |
EC50 = 310 nM
|
|
|
|
CP0579103
|
5,6-dioxo-3-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,4-dihydropyrazine-2-carbonitrile
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|
C14H10F3N3O2
|
1
|
| 1 |
EC50 = 340 nM
|
|
|
|
CP0579105
|
5-[(4-chlorophenyl)sulfanylmethyl]-1,4-dihydropyrazine-2,3-dione
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|
C11H9ClN2O2S
|
1
|
| 1 |
EC50 = 390 nM
|
|
|
|
CP0576992
|
5-[7-(trifluoromethyl)-2,3-dihydro-1,4-benzoxathiin-3-yl]-1,4-dihydropyrazine-2,3-dione
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|
C13H9F3N2O3S
|
1
|
| 1 |
EC50 = 430 nM
|
|
|
|
CP0569387
|
5-[[4-(pentafluoro-lambda6-sulfanyl)phenyl]methylsulfanyl]-1,4-dihydropyrazine-2,3-dione
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|
C11H9F5N2O2S2
|
1
|
| 1 |
EC50 = 500 nM
|
|
|
|
CP0569386
|
5-[(4-chlorophenyl)methylsulfanyl]-1,4-dihydropyrazine-2,3-dione
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|
C11H9ClN2O2S
|
1
|
| 1 |
EC50 = 510 nM
|
|
|
|
CP0579104
|
5-[[4-(trifluoromethyl)phenyl]sulfanylmethyl]-1,4-dihydropyrazine-2,3-dione
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|
C12H9F3N2O2S
|
1
|
| 1 |
EC50 = 510 nM
|
|
|
|
CP0570422
|
5-[(3R)-7-fluoro-2,3-dihydro-1,4-benzoxathiin-3-yl]-1,4-dihydropyrazine-2,3-dione
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|
C12H9FN2O3S
|
1
|
| 1 |
EC50 = 540 nM
|
|
|
|
CP0576368
|
5-[(4-methylsulfonylphenyl)methylsulfanyl]-1,4-dihydropyrazine-2,3-dione
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|
C12H12N2O4S2
|
1
|
| 1 |
EC50 = 540 nM
|
|
|
|
CP0546651
|
2-chloro-4-[(5,6-dioxo-1,4-dihydropyrazin-2-yl)methylsulfanyl]benzonitrile
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|
C12H8ClN3O2S
|
1
|
| 1 |
EC50 = 560 nM
|
|
|
|
CP0569210
|
5-[[6-(trifluoromethyl)pyridin-3-yl]methylsulfanyl]-1,4-dihydropyrazine-2,3-dione
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|
C11H8F3N3O2S
|
1
|
| 1 |
EC50 = 590 nM
|
|
|
|
CP0579837
|
5-[[4-(difluoromethyl)phenyl]methylsulfanyl]-1,4-dihydropyrazine-2,3-dione
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|
C12H10F2N2O2S
|
1
|
| 1 |
EC50 = 590 nM
|
|
|
|
CP0546650
|
5-[[4-(difluoromethyl)phenyl]sulfanylmethyl]-1,4-dihydropyrazine-2,3-dione
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|
C12H10F2N2O2S
|
1
|
| 1 |
EC50 = 620 nM
|
|
|
|
CP0578757
|
4-[(5,6-dioxo-1,4-dihydropyrazin-2-yl)sulfanylmethyl]-2-fluorobenzonitrile
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|
C12H8FN3O2S
|
1
|
| 1 |
EC50 = 680 nM
|
|
|
|
CP0546654
|
5-(2,3-dihydro-1,4-benzoxathiin-3-yl)-1,4-dihydropyrazine-2,3-dione
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|
C12H10N2O3S
|
1
|
| 1 |
EC50 = 720 nM
|
|
|
|
CP0546648
|
(3R)-3-(5,6-dioxo-1,4-dihydropyrazin-2-yl)-2,3-dihydro-1,4-benzoxathiine-7-carbonitrile
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|
C13H9N3O3S
|
1
|
| 1 |
EC50 = 780 nM
|
|
|
|
CP0579106
|
5-[[4-(pentafluoro-lambda6-sulfanyl)phenyl]sulfanylmethyl]-1,4-dihydropyrazine-2,3-dione
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|
C11H9F5N2O2S2
|
1
|
| 1 |
EC50 = 790 nM
|
|
|
|
CP0546666
|
4-[(5,6-dioxo-1,4-dihydropyrazin-2-yl)methylsulfanyl]-2-fluorobenzonitrile
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|
C12H8FN3O2S
|
1
|
| 1 |
EC50 = 970 nM
|
|
|
|
CP0576993
|
5-[(3R)-7-methylsulfonyl-2,3-dihydro-1,4-benzoxathiin-3-yl]-1,4-dihydropyrazine-2,3-dione
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|
C13H12N2O5S2
|
1
|
| 1 |
EC50 = 1200 nM
|
|
|
|
CP0579836
|
5-[(7-chloroquinolin-3-yl)sulfanylmethyl]-1,4-dihydropyrazine-2,3-dione
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|
C14H10ClN3O2S
|
1
|
| 1 |
EC50 = 1400 nM
|
|
|
|
CP0546649
|
5-[(3R)-3-methyl-7-methylsulfonyl-2H-1,4-benzoxathiin-3-yl]-1,4-dihydropyrazine-2,3-dione
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|
C14H14N2O5S2
|
1
|
| 1 |
EC50 = 1500 nM
|
|
|
|
CP0570177
|
4-[2-(5,6-dioxo-1,4-dihydropyrazin-2-yl)ethyl]benzonitrile
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|
C13H11N3O2
|
1
|
| 1 |
EC50 = 1500 nM
|
|
|
|
CP0546642
|
5-[2-[3-fluoro-4-(5-oxo-1,2-dihydropyrazol-3-yl)phenyl]ethyl]-1,4-dihydropyrazine-2,3-dione
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|
C15H13FN4O3
|
1
|
| 1 |
EC50 = 1800 nM
|
|
|
|
CP0568248
|
5-[(4-methylsulfonylphenyl)sulfanylmethyl]-1,4-dihydropyrazine-2,3-dione
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|
C12H12N2O4S2
|
1
|
| 1 |
EC50 = 2300 nM
|
|
|
|
CP0569208
|
5-[2-(3-methyl-2H-indazol-6-yl)ethyl]-1,4-dihydropyrazine-2,3-dione
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|
C14H14N4O2
|
1
|
| 1 |
EC50 = 4300 nM
|
|
|
