| Compound ID |
Compound Name |
Compound Formula |
|
CP0390362
|
[4-(6-fluoro-1,3-benzoxazol-2-yl)piperazin-1-yl]-[(1S,2S,4R)-4-[[1-(4-methoxyphenyl)cyclobutyl]amino]-2-thiophen-3-ylcyclohexyl]methanone
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C33H37FN4O3S
|
2
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| 1 |
IC50 = 0.18 nM
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| 2 |
IC50 = 1.3 nM
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CP0462707
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[4-(5-fluoro-1,3-benzoxazol-2-yl)piperazin-1-yl]-[(1S,2S,4R)-4-[[1-(4-methoxyphenyl)cyclobutyl]amino]-2-thiophen-3-ylcyclohexyl]methanone
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|
C33H37FN4O3S
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2
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| 1 |
IC50 = 0.2 nM
|
|
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| 2 |
IC50 = 0.86 nM
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CP0392057
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[4-(1,3-benzothiazol-2-yl)piperazin-1-yl]-[(1S,2S,4R)-4-[[1-(4-methoxyphenyl)cyclobutyl]amino]-2-thiophen-3-ylcyclohexyl]methanone
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|
C33H38N4O2S2
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2
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| 1 |
IC50 = 0.33 nM
|
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| 2 |
IC50 = 1.8 nM
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CP0428501
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[4-(6-fluoro-1H-benzimidazol-2-yl)piperazin-1-yl]-[(1S,2S,4R)-4-[[1-(4-methoxyphenyl)cyclobutyl]amino]-2-thiophen-3-ylcyclohexyl]methanone
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|
C33H38FN5O2S
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2
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| 1 |
IC50 = 0.42 nM
|
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| 2 |
IC50 = 0.66 nM
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CP0439844
|
[(1S,2S,4R)-4-[[1-(4-methoxyphenyl)cyclobutyl]amino]-2-thiophen-3-ylcyclohexyl]-[4-(5-methyl-1,3-benzoxazol-2-yl)piperazin-1-yl]methanone
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|
C34H40N4O3S
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2
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| 1 |
IC50 = 0.43 nM
|
|
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| 2 |
IC50 = 3.9 nM
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CP0385417
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[4-(1,3-benzoxazol-2-yl)piperazin-1-yl]-[(1S,2S,4R)-4-[[1-(4-methoxyphenyl)cyclobutyl]amino]-2-thiophen-3-ylcyclohexyl]methanone
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|
C33H38N4O3S
|
2
|
| 1 |
IC50 = 0.69 nM
|
|
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| 2 |
IC50 = 5.9 nM
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CP0387995
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[4-(1H-benzimidazol-2-yl)piperazin-1-yl]-[(1S,2S,4R)-4-[[1-(4-methoxyphenyl)cyclobutyl]amino]-2-thiophen-3-ylcyclohexyl]methanone
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|
C33H39N5O2S
|
2
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| 1 |
IC50 = 1.1 nM
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|
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| 2 |
IC50 = 3 nM
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CP0496008
|
[4-(1,3-benzoxazol-2-yl)piperazin-1-yl]-[(1S,2S,4R)-4-[2-(4-methoxyphenyl)propan-2-ylamino]-2-thiophen-3-ylcyclohexyl]methanone
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|
C32H38N4O3S
|
2
|
| 1 |
IC50 = 1.9 nM
|
|
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| 2 |
IC50 = 9.2 nM
|
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CP0385430
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[(1S,2S,4R)-4-[[1-(4-methoxyphenyl)cyclobutyl]amino]-2-thiophen-3-ylcyclohexyl]-[4-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]piperazin-1-yl]methanone
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|
C29H34F3N5O2S2
|
2
|
| 1 |
IC50 = 2.2 nM
|
|
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| 2 |
IC50 = 14 nM
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CP0385416
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[4-(1H-benzimidazol-2-yl)piperazin-1-yl]-[(1S,2S,4R)-4-[2-(4-methoxyphenyl)propan-2-ylamino]-2-thiophen-3-ylcyclohexyl]methanone
Show/Hide
|
C32H39N5O2S
|
2
|
| 1 |
IC50 = 2.4 nM
|
|
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| 2 |
IC50 = 4.6 nM
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CP0385415
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[4-(5-bromo-1,3,4-thiadiazol-2-yl)piperazin-1-yl]-[(1S,2S,4R)-4-[[1-(4-methoxyphenyl)cyclobutyl]amino]-2-thiophen-3-ylcyclohexyl]methanone
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|
C28H34BrN5O2S2
|
2
|
| 1 |
IC50 = 2.6 nM
|
|
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| 2 |
IC50 = 12 nM
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CP0418913
|
[4-(1,3-benzothiazol-2-yl)piperazin-1-yl]-[(1S,2S,4R)-4-[[(1R)-1-(4-methoxyphenyl)ethyl]amino]-2-thiophen-3-ylcyclohexyl]methanone
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|
C31H36N4O2S2
|
2
|
| 1 |
IC50 = 2.8 nM
|
|
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| 2 |
IC50 = 24 nM
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CP0393721
|
[4-(5-chloropyridin-2-yl)piperazin-1-yl]-[(1S,2S,4R)-4-[[1-(4-methoxyphenyl)cyclobutyl]amino]-2-thiophen-3-ylcyclohexyl]methanone
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|
C31H37ClN4O2S
|
2
|
| 1 |
IC50 = 3.1 nM
|
|
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| 2 |
IC50 = 20 nM
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CP0387996
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[(1S,2S,4R)-4-[[(1R)-1-(4-methoxyphenyl)ethyl]amino]-2-thiophen-3-ylcyclohexyl]-[4-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]piperazin-1-yl]methanone
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|
C27H32F3N5O2S2
|
2
|
| 1 |
IC50 = 4.5 nM
|
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| 2 |
IC50 = 115 nM
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CP0441216
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[4-(1H-benzimidazol-2-yl)piperazin-1-yl]-[(1S,2S,4R)-4-[[(1R)-1-(4-methoxyphenyl)ethyl]amino]-2-thiophen-3-ylcyclohexyl]methanone
Show/Hide
|
C31H37N5O2S
|
2
|
| 1 |
IC50 = 4.5 nM
|
|
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| 2 |
IC50 = 20 nM
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CP0393718
|
[4-(1,3-benzoxazol-2-yl)piperazin-1-yl]-[(1S,2S,4R)-4-[[(1R)-1-(4-methoxyphenyl)ethyl]amino]-2-thiophen-3-ylcyclohexyl]methanone
Show/Hide
|
C31H36N4O3S
|
2
|
| 1 |
IC50 = 8.3 nM
|
|
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| 2 |
IC50 = 18 nM
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CP0395770
|
[4-(5-chloropyridin-2-yl)piperazin-1-yl]-[(1S,2S,4R)-4-[2-(4-methoxyphenyl)propan-2-ylamino]-2-thiophen-3-ylcyclohexyl]methanone
Show/Hide
|
C30H37ClN4O2S
|
2
|
| 1 |
IC50 = 11 nM
|
|
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| 2 |
IC50 = 43 nM
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CP0392035
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[(1S,2S,4R)-4-[[(1R)-1-(4-methoxyphenyl)ethyl]amino]-2-thiophen-3-ylcyclohexyl]-[4-(1,3-thiazol-2-yl)piperazin-1-yl]methanone
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|
C27H34N4O2S2
|
2
|
| 1 |
IC50 = 14 nM
|
|
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| 2 |
IC50 = 207 nM
|
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CP0461675
|
[4-(5-chloropyridin-2-yl)piperazin-1-yl]-[(1S,2S,4R)-4-[2-(4-methylphenyl)propan-2-ylamino]-2-thiophen-3-ylcyclohexyl]methanone
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|
C30H37ClN4OS
|
2
|
| 1 |
IC50 = 16 nM
|
|
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| 2 |
IC50 = 211 nM
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CP0478403
|
[4-(5-chloropyridin-2-yl)piperazin-1-yl]-[(1S,2S,4R)-4-[2-(4-fluorophenyl)propan-2-ylamino]-2-thiophen-3-ylcyclohexyl]methanone
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|
C29H34ClFN4OS
|
2
|
| 1 |
IC50 = 17 nM
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| 2 |
IC50 = 320 nM
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CP0393719
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[(1S,2S,4R)-4-[[(1R)-1-(4-methoxyphenyl)ethyl]amino]-2-thiophen-3-ylcyclohexyl]-[4-(5-methylpyridin-2-yl)piperazin-1-yl]methanone
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|
C30H38N4O2S
|
2
|
| 1 |
IC50 = 18 nM
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| 2 |
IC50 = 400 nM
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CP0427428
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[4-(5-chloropyridin-2-yl)piperazin-1-yl]-[(1S,2S,4R)-4-[[(1R)-1-(4-methoxyphenyl)ethyl]amino]-2-thiophen-3-ylcyclohexyl]methanone
Show/Hide
|
C29H35ClN4O2S
|
2
|
| 1 |
IC50 = 25 nM
|
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| 2 |
IC50 = 360 nM
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CP0395774
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[(1S,2S,4R)-4-[2-(4-chlorophenyl)propan-2-ylamino]-2-thiophen-3-ylcyclohexyl]-[4-(5-chloropyridin-2-yl)piperazin-1-yl]methanone
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|
C29H34Cl2N4OS
|
2
|
| 1 |
IC50 = 27 nM
|
|
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| 2 |
IC50 = 1700 nM
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CP0452076
|
[4-(5-bromo-1,3-thiazol-2-yl)piperazin-1-yl]-[(1S,2S,4R)-4-[[(1R)-1-(4-methoxyphenyl)ethyl]amino]-2-thiophen-3-ylcyclohexyl]methanone
Show/Hide
|
C27H33BrN4O2S2
|
2
|
| 1 |
IC50 = 42 nM
|
|
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| 2 |
IC50 = 55 nM
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CP0506682
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[4-(5-chloropyridin-2-yl)piperazin-1-yl]-[(1S,2S,4R)-4-[[1-(4-methoxyphenyl)cyclopropyl]amino]-2-thiophen-3-ylcyclohexyl]methanone
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|
C30H35ClN4O2S
|
2
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| 1 |
IC50 = 56 nM
|
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| 2 |
IC50 = 523 nM
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CP0517626
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[4-(6-chloropyridin-2-yl)piperazin-1-yl]-[(1S,2S,4R)-4-[[(1R)-1-(4-methoxyphenyl)ethyl]amino]-2-thiophen-3-ylcyclohexyl]methanone
Show/Hide
|
C29H35ClN4O2S
|
2
|
| 1 |
IC50 = 74 nM
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| 2 |
IC50 = 7486 nM
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CP0461677
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[(1S,2S,4R)-4-[[1-(4-bromophenyl)cyclobutyl]amino]-2-thiophen-3-ylcyclohexyl]-[4-(5-chloropyridin-2-yl)piperazin-1-yl]methanone
Show/Hide
|
C30H34BrClN4OS
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2
|
| 1 |
IC50 = 82 nM
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| 2 |
IC50 = 601 nM
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CP0452075
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[4-(5-chloropyridin-2-yl)piperazin-1-yl]-[(1S,2S,4R)-4-[2-(4-nitrophenyl)propan-2-ylamino]-2-thiophen-3-ylcyclohexyl]methanone
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|
C29H34ClN5O3S
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2
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| 1 |
IC50 = 100 nM
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| 2 |
IC50 = 1100 nM
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CP0461676
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[4-(5-chloropyridin-2-yl)piperazin-1-yl]-[(1S,2S,4R)-4-[[1-(3-methoxyphenyl)cyclobutyl]amino]-2-thiophen-3-ylcyclohexyl]methanone
Show/Hide
|
C31H37ClN4O2S
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2
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| 1 |
IC50 = 118 nM
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| 2 |
IC50 = 1020 nM
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CP0428505
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[(1S,2S,4R)-4-[[(1R)-1-(4-bromophenyl)ethyl]amino]-2-thiophen-3-ylcyclohexyl]-[4-(5-chloropyridin-2-yl)piperazin-1-yl]methanone
Show/Hide
|
C28H32BrClN4OS
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2
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| 1 |
IC50 = 134 nM
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| 2 |
IC50 = 2628 nM
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CP0392077
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[(1S,2S,4R)-4-[[1-(3-bromophenyl)cyclobutyl]amino]-2-thiophen-3-ylcyclohexyl]-[4-(5-chloropyridin-2-yl)piperazin-1-yl]methanone
Show/Hide
|
C30H34BrClN4OS
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2
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| 1 |
IC50 = 160 nM
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| 2 |
IC50 = 972 nM
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CP0462708
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6-[4-[(1S,2S,4R)-4-[[(1R)-1-(4-methoxyphenyl)ethyl]amino]-2-thiophen-3-ylcyclohexanecarbonyl]piperazin-1-yl]pyridine-3-carbonitrile
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|
C30H35N5O2S
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2
|
| 1 |
IC50 = 194 nM
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| 2 |
IC50 = 7054 nM
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CP0462709
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[(1S,2S,4R)-4-[[(1R)-1-(4-methoxyphenyl)ethyl]amino]-2-thiophen-3-ylcyclohexyl]-[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methanone
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|
C30H35F3N4O2S
|
1
|
| 1 |
IC50 = 200 nM
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CP0392033
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[4-(5-chloropyridin-2-yl)piperazin-1-yl]-[(1S,2S,4R)-4-[[(1R)-1-phenylethyl]amino]-2-thiophen-3-ylcyclohexyl]methanone
Show/Hide
|
C28H33ClN4OS
|
2
|
| 1 |
IC50 = 217 nM
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| 2 |
IC50 = 981 nM
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CP0393720
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[(1S,2S,4R)-4-[[(1R)-1-(4-methoxyphenyl)ethyl]amino]-2-thiophen-3-ylcyclohexyl]-(4-pyridin-2-ylpiperazin-1-yl)methanone
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|
C29H36N4O2S
|
1
|
| 1 |
IC50 = 330 nM
|
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CP0496034
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[(1S,2S,4R)-4-[[(1R)-1-(4-methoxyphenyl)ethyl]amino]-2-thiophen-3-ylcyclohexyl]-[4-(5-methoxypyridin-2-yl)piperazin-1-yl]methanone
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|
C30H38N4O3S
|
2
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| 1 |
IC50 = 1140 nM
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| 2 |
IC50 = 7303 nM
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CP0395772
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[4-(5-chloropyridin-2-yl)piperazin-1-yl]-[(1S,2S,4R)-4-[(4-methoxyphenyl)methylamino]-2-thiophen-3-ylcyclohexyl]methanone
Show/Hide
|
C28H33ClN4O2S
|
2
|
| 1 |
IC50 = 1525 nM
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| 2 |
IC50 = 3595 nM
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CP0393722
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[4-(4-chloropyridin-2-yl)piperazin-1-yl]-[(1S,2S,4R)-4-[[(1R)-1-(4-methoxyphenyl)ethyl]amino]-2-thiophen-3-ylcyclohexyl]methanone
Show/Hide
|
C29H35ClN4O2S
|
1
|
| 1 |
IC50 = 2143 nM
|
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CP0465766
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[(1S,2S,4R)-4-[[1-(2-bromophenyl)cyclobutyl]amino]-2-thiophen-3-ylcyclohexyl]-[4-(5-chloropyridin-2-yl)piperazin-1-yl]methanone
Show/Hide
|
C30H34BrClN4OS
|
2
|
| 1 |
IC50 = 2196 nM
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| 2 |
IC50 = 2208 nM
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CP0395773
|
[4-(4-chlorophenyl)piperazin-1-yl]-[(1S,2S,4R)-4-[[(1R)-1-(4-methoxyphenyl)ethyl]amino]-2-thiophen-3-ylcyclohexyl]methanone
Show/Hide
|
C30H36ClN3O2S
|
2
|
| 1 |
IC50 = 3715 nM
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| 2 |
IC50 = 3865 nM
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CP0461678
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[4-(3-chloropyridin-2-yl)piperazin-1-yl]-[(1S,2S,4R)-4-[[(1R)-1-(4-methoxyphenyl)ethyl]amino]-2-thiophen-3-ylcyclohexyl]methanone
Show/Hide
|
C29H35ClN4O2S
|
1
|
| 1 |
IC50 > 32000 nM
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