4-(((3-(1-ethyl-3,3,5-trimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-7-yloxy)propyl)(2-(1-oxoisoquinolin-2(1H)-yl)ethyl)amino)methyl)benzonitrile

4-(((3-(1-ethyl-3,3,5-trimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-7-yloxy)propyl)(2-(7-oxofuro[2,3-c]pyridin-6(7H)-yl)ethyl)amino)methyl)benzonitrile

3-(((3-(1-ethyl-3,3,5-trimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-7-yloxy)propyl)(2-(pyridin-3-yl)ethyl)amino)methyl)benzonitrile

1-ethyl-3,3,5-trimethyl-7-(3-{[2-(1-oxo-1H-isoquinolin-2-yl)ethyl]pyridin-4-ylmethylamino}propoxy)-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione dihydrochloride

1-ethyl-3,3,5-trimethyl-7-(3-((2-(pyridin-3-yl)benzyl)(2-(pyridin-3-yl)ethyl)amino)propoxy)-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione

1-ethyl-3,3,5-trimethyl-7-(3-((2-(7-oxofuro[2,3-c]pyridin-6(7H)-yl)ethyl)(thiophen-2-ylmethyl)amino)propoxy)-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione

1-ethyl-3,3,5-trimethyl-7-(3-((2-(7-oxofuro[2,3-c]pyridin-6(7H)-yl)ethyl)(4-(trifluoromethyl)benzyl)amino)propoxy)-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione

1-ethyl-3,3,5-trimethyl-7-(3-((2-(1-oxoisoquinolin-2(1H)-yl)ethyl)(thiophen-3-ylmethyl)amino)propoxy)-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione

1,3,3,5-tetramethyl-7-{3-[(2-pyridin-3-ylethyl)-(quinolin-4-ylmethyl)amino]propoxy}-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione trihydrochloride

1-ethyl-3,3,5-trimethyl-7-(3-((2-methylbenzyl)(2-(7-oxofuro[2,3-c]pyridin-6(7H)-yl)ethyl)amino)propoxy)-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione

1-Trifluoromethyl-cyclopropanecarboxylic acid{3-[(6-fluoro-1,1-dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-phenyl-amino]-2,2-dimethyl-propyl}-amide

1-ethyl-3,3,5-trimethyl-7-(3-{[2-(2-oxo-2H-quinolin-1-yl)ethyl]pyridin-4-ylmethylamino}propoxy)-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione

1,3,3,5-tetramethyl-7-{3-[(2-methylbenzyl)-(2-pyridin-3-ylethyl)amino]propoxy}-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione dihydrochloride

3,3,3-Trifluoro-N-{3-[(6-fluoro-1,1-dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-phenyl-amino]-2,2-dimethyl-propyl}-propionamide

1-ethyl-7-(3-((furan-2-ylmethyl)(2-(1-oxoisoquinolin-2(1H)-yl)ethyl)amino)propoxy)-3,3,5-trimethyl-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione

1-ethyl-3,3,5-trimethyl-7-{3-[(3-methylpyridin-4-ylmethyl)-(2-pyridin-3-ylethyl)amino]propoxy}-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione trihydrochloride

N-[3-(N-(6-fluoro-1,1-dioxo-1,2-benzothiazol-3-yl)anilino)-2,2-dimethylpropyl]-1,3-thiazole-4-carboxamide

7-(3-(benzyl(2-(pyridin-3-yl)ethyl)amino)propoxy)-1-ethyl-3,3,5-trimethyl-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione

US9212187, 48

1-ethyl-3,3,5-trimethyl-7-{3-[[2-(2-methyl-4-oxo-4H-furo[3,2-c]pyridin-5-yl)ethyl]-(2-propylpyridin-3-ylmethyl)amino]propoxy}-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione dihydrochloride

1-Trifluoromethyl-cyclobutanecarboxylic acid{3-[(6-fluoro-1,1-dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-phenyl-amino]2,2dimethylpropyl}amide

2,2-Difluoro-cyclopropanecarboxylic acid{3-[(6-fluoro-1,1-dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-phenyl-amino]-2,2-dimethyl-propyl}-amide

US9212187, 43

1-ethyl-3,3,5-trimethyl-7-{3-[[2-(2-methyl-4-oxo-4H-furo[3,2-c]pyridin-5-yl)ethyl]-(4-methylpyridin-3-yl methyl)amino]propoxy}-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione

N-[3-(N-(6-fluoro-1,1-dioxo-1,2-benzothiazol-3-yl)anilino)-2,2-dimethylpropyl]pyrrole-1-carboxamide

N-[3-(N-(6-fluoro-1,1-dioxo-1,2-benzothiazol-3-yl)anilino)-2,2-dimethylpropyl]pyrazine-2-carboxamide

N-[3-(N-(6-fluoro-1,1-dioxo-1,2-benzothiazol-3-yl)anilino)-2,2-dimethylpropyl]furan-3-carboxamide

N-[3-(1-ethyl-3,3,5-trimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-7-yloxy)propyl]-N-[2-(1-oxo-1H-isoquinolin-2-yl)ethyl]benzenesulfonamide

N-[3-(N-(6-fluoro-1,1-dioxo-1,2-benzothiazol-3-yl)anilino)-2,2-dimethylpropyl]-3-methoxypyridine-4-carboxamide

1-Methyl-cyclopropanecarboxylic acid{3-[(6-fluoro-1,1-dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-phenyl-amino]-2,2-dimethyl-propyl}-amide

1-ethyl-3,3,5-trimethyl-7-(3-{[2-(7-oxo-7H-thieno[2,3-c]pyridin-6-yl)ethyl]pyridin-4-ylmethylamino}propoxy)-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione

1-ethyl-3,3,5-trimethyl-7-(3-{[2-(4-oxo-4H-furo[3,2-c]pyridin-5-yl)ethyl]pyridin-3-ylmethylamino}-propoxy)-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione

1-ethyl-3,3,5-trimethyl-7-{3-[(2-pyridin-3-ylethyl)pyridin-4-ylmethylamino]propoxy}-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione trihydrochloride

N-[3-(N-(6-fluoro-1,1-dioxo-1,2-benzothiazol-3-yl)anilino)-2,2-dimethylpropyl]furan-2-carboxamide

1-ethyl-3,3,5-trimethyl-7-(3-{[2-(4-oxo-4H-thieno[3,2-c]pyridin-5-yl)ethyl]pyridin-3-ylmethylamino}-propoxy)-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione

N-[3-(N-(6-fluoro-1,1-dioxo-1,2-benzothiazol-3-yl)anilino)-2,2-dimethylpropyl]oxane-2-carboxamide

1-ethyl-3,3,5-trimethyl-7-(3-{[2-(2-methyl-4-oxo-4H-furo[3,2-c]pyridin-5-yl)ethyl]pyridin-4-ylmethyl-amino}propoxy)-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione dihydrochloride

1-ethyl-3,3,5-trimethyl-7-(3-{(2-methylpyridin-3-ylmethyl)-[2-(4-oxo-4H-furo[3,2-c]pyridin-5-yl)ethyl]-amino}propoxy)-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione

1-Hydroxy-cyclohexanecarboxylic acid{3-[(6-fluoro-1,1-dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-phenyl-amino]-2,2-dimethyl-propyl}-amide

3-Hydroxy-pyridine-2-carboxylic acid{3-[(6-fluoro-1,1-dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-phenyl-amino]-2,2-dimethyl-propyl}-amide

1-ethyl-3,3,5-trimethyl-7-(3-{(4-methylpyridin-3-ylmethyl)-[2-(4-oxo-4H-furo[3,2-c]pyridin-5-yl)ethyl]-amino}propoxy)-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione

3,3,3-Trifluoro-N-{3-[(6-fluoro-1,1-dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-phenyl-amino]-2,2-dimethyl-propyl}-2-hydroxy-2-methyl-propionamide

N-[3-(N-(6-fluoro-1,1-dioxo-1,2-benzothiazol-3-yl)anilino)-2,2-dimethylpropyl]cyclopropanecarboxamide

1-ethyl-3,3,5-trimethyl-7-(3-{(2-methylpyridin-3-ylmethyl)-[2-(4-oxo-4H-thieno[3,2-c]pyridin-5-yl)ethyl]-amino}propoxy)-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione

US9212187, 16

1-Methyl-1H-imidazole-2-carboxylic acid{3-[(6-fluoro-1,1-dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-phenyl-amino]-2,2-dimethyl-propyl}-amide

1-Cyano-cyclopropanecarboxylic acid{3-[(6-fluoro-1,1dioxo1H1lambda*6*benzo[d]isothiazol-3-yl)-phenyl-amino]-2,2-dimethyl-propyl}-amide

1,3,3,5-tetramethyl-7-{3-[(2-pyridin-3-ylethyl)pyridin-4-ylmethylamino]propoxy}-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione trihydrochloride

4-Cyano-tetrahydro-pyran-4-carboxylic acid{3-[(6-fluoro-1,1-dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-phenyl-amino]-2,2-dimethyl-propyl}-amide

3,3,5-trimethyl-1-propyl-7-{3-[(2-pyridin-3-ylethyl)pyridin-4-ylmethylamino]propoxy}-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione trihydrochloride

1,5-diethyl-3,3-dimethyl-7-{3-[(2-pyridin-3-ylethyl)pyridin-4-ylmethylamino]propoxy}-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione trihydrochloride

US9212187, 18

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4,4-Difluoro-1-hydroxy-cyclohexanecarboxylic acid{3-[(6-fluoro-1,1-dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-phenyl-amino]-2,2-dimethyl-propyl}-amide

US9212187, 317

N-methyl-N-(2-(pyridin-4-ylmethyl-[3-(1,3,3,5-tetramethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-7-yloxy)propyl]amino)ethyl)benzamide dihydrochloride

1-Hydroxy-cyclopentanecarboxylic acid{3-[(6-fluoro-1,1-dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-phen yl-amino]-2,2-dimethyl-propyl}-amide

7-(3-{(2,6-dimethylpyridin-3-ylmethyl)-[2-(4-oxo-4H-furo[3,2-c]pyridin-5-yl)ethyl]amino}propoxy)-1-ethyl-3,3,5-trimethyl-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione dihydrochloride

N-[3-(N-(6-fluoro-1,1-dioxo-1,2-benzothiazol-3-yl)anilino)-2,2-dimethylpropyl]-2-(oxan-2-yl)acetamide

1-Amino-cyclopropanecarboxylic acid{3-[(6-fluoro-1,1-dioxo-1H-1lambda*6*-benzo[d]isothiazol-3yl)phenyl-amino]-2,2-dimethyl-propyl}-amide

US9212187, 15

N-[3-(N-(6-fluoro-1,1-dioxo-1,2-benzothiazol-3-yl)anilino)-2,2-dimethylpropyl]oxolane-2-carboxamide

US9212187, 330

N-[3-(N-(6-fluoro-1,1-dioxo-1,2-benzothiazol-3-yl)anilino)-2,2-dimethylpropyl]-1,3-oxazole-4-carboxamide

US9212187, 35

3,3-Dimethyl-tetrahydro-pyran-4-carboxylic acid{3-[(6-fluoro-1,1-dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-phenyl-amino]-2,2-dimethyl-propyl}-amide

N-[3-(1-ethyl-3,3,5-trimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-7-yloxy)propyl]-N-(2-pyridin-3-ylethyl)benzenesulfonamide hydrochloride

N-[3-(1-ethyl-3,3,5-trimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-7-yloxy)propyl]-N-(2-pyridin-3-ylethyl)benzamide hydrochloride

N-[3-(N-(6-fluoro-1,1-dioxo-1,2-benzothiazol-3-yl)anilino)-2,2-dimethylpropyl]acetamide

1-ethyl-3,3,5-trimethyl-7-(3-{[2-(7-oxo-7H-furo[2,3-c]pyridin-6-yl)ethyl]pyridin-4-ylmethylamino}propoxy)-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione dihydrochloride

1H-Pyrrole-3-carboxylic acid{3-[(6-fluoro-1,1-dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-phenyl-amino]-2,2-dimethyl-propyl}-amide

1-Hydroxy-cyclopropanecarboxylic ac id{3-[(6-fluoro-1,1-dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-phenyl-amino]-2,2-dimethyl-propyl}-amide

N-[3-(N-(6-fluoro-1,1-dioxo-1,2-benzothiazol-3-yl)anilino)-2,2-dimethylpropyl]-2-(1-methylpyrrol-2-yl)acetamide

US9212187, 104

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4-Hydroxy-tetrahydro-pyran-4-carboxylic acid{3-[(6-fluoro-1,1-dioxo-1 H-1lambda*6*-benzo[d]isothiazol-3-yl)-phenyl-amino]-2,2-dimethyl-propyl}-amide

N-[3-(N-(6-fluoro-1,1-dioxo-1,2-benzothiazol-3-yl)anilino)-2,2-dimethylpropyl]morpholine-3-carboxamide

1-{3-[(6-Fluoro-1,1-dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-pheny l-amino]-2,2-dimethyl-propyl}-3-methyl-urea

1-Amino-cyclopentanecarboxylic acid{3-[(6-fluoro-1,1-dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-phenyl-amino]-2,2-dimethyl-propyl}-amide

1-Methyl-piperidine-2-carboxylic acid{3-[(6-fluoro-1,1-dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-phenyl-amino]-2,2-dimethyl-propyl}-amide

US9212187, 318

4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one

N-[3-(N-(6-fluoro-1,1-dioxo-1,2-benzothiazol-3-yl)anilino)-2,2-dimethylpropyl]piperidine-2-carboxamide

US9212187, 41

N-[3-(N-(6-fluoro-1,1-dioxo-1,2-benzothiazol-3-yl)anilino)-2,2-dimethylpropyl]-2-oxo-1H-pyridine-3-carboxamide

1-Methyl-piperidine-3-carboxylic acid{3-[(6-fluoro-1,1-dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-phenyl-amino]-2,2-dimethyl-propyl}-amide

1-Methyl-1H-imidazole-4-carboxylic acid{3-[(6-fluoro-1,1-dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-phenyl-amino]-2,2-dimethyl-propyl}-amide

Benzofuran-2-carboxylic acid{3-[(6-fluoro-1,1-dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-phenyl-amino]-2,2-dimethyl-propyl}-amide

N-[3-(N-(6-fluoro-1,1-dioxo-1,2-benzothiazol-3-yl)anilino)-2,2-dimethylpropyl]-3-hydroxypyridine-4-carboxamide

1-{3-[(6-Fluoro-1,1-dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-phenyl-amino]-2,2-dimethyl-propylcarbamoyl}-cyclopropanecarboxylicacid

N-[3-(N-(6-fluoro-1,1-dioxo-1,2-benzothiazol-3-yl)anilino)-2,2-dimethylpropyl]piperidine-3-carboxamide

1-Methyl-piperidine-4-carboxylic acid{3-[(6-fluoro-1,1-dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-phenyl-amino]-2,2-dimethyl-propyl}-amide