Brief Information of the Cell Line and Protein
Cell Line ID: CL000026 , CHO-K1
Synonyms
CHO K1
CHOK1
CHO cell clone K1
GM15452
Category Spontaneously immortalized cell line
Organism
Cricetulus griseus (Chinese hamster)
Cellosaurus ID
CVCL_0214
Protein ID: PT02663 , Nuclear receptor ROR-gamma
Gene Name RORC
Organism Homo sapiens, Human
Protein Classification Transcription factor
Uniprot ID P51449
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000026  Protein ID: PT02663
 
Compound ID Compound Name Compound Formula
CP0536538
sodium;(4S)-6-(2-chloro-4-fluoroanilino)-4-[4-cyclopropyl-5-[5-(1,1-difluoro-2,2-dimethylpropyl)-1,2-oxazol-3-yl]-1,2-oxazol-3-yl]-6-oxohexanoate
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C26H26ClF3N3NaO5
 1
1
EC50 = 6 nM
   TI
   LI
   LO
   TS
CP0546922
sodium;(4S)-6-(2-chloro-4-methylanilino)-4-[4-cyclopropyl-5-[5-(1,1-difluoro-2,2-dimethylpropyl)-1,2-oxazol-3-yl]-1,2-oxazol-3-yl]-6-oxohexanoate
   Show/Hide
C27H29ClF2N3NaO5
 1
1
EC50 = 6 nM
   TI
   LI
   LO
   TS
CP0536537
sodium;(4S)-6-(2-chloro-4-methylanilino)-4-[4-cyclopropyl-5-[5-(2,2-dimethylpropyl)-1,2-oxazol-3-yl]-1,2-oxazol-3-yl]-6-oxohexanoate
   Show/Hide
C27H31ClN3NaO5
 1
1
EC50 = 7 nM
   TI
   LI
   LO
   TS
CP0542756
sodium;(4S)-6-(2-chloro-4-methylanilino)-4-[4-cyclopropyl-5-[5-(1,1-difluoro-2-methylpropyl)-1,2-oxazol-3-yl]-1,2-oxazol-3-yl]-6-oxohexanoate
   Show/Hide
C26H27ClF2N3NaO5
 1
1
EC50 = 7 nM
   TI
   LI
   LO
   TS
CP0546923
sodium;(4S)-6-(4-chloro-2-fluoroanilino)-4-[4-cyclopropyl-5-[5-(1,1-difluoro-2,2-dimethylpropyl)-1,2-oxazol-3-yl]-1,2-oxazol-3-yl]-6-oxohexanoate
   Show/Hide
C26H26ClF3N3NaO5
 1
1
EC50 = 7 nM
   TI
   LI
   LO
   TS
CP0528301
sodium;(4S)-6-(2-chloro-4-methylanilino)-4-[4-cyclopropyl-5-[5-(1,1-difluoro-3-methylbutyl)-1,2-oxazol-3-yl]-1,2-oxazol-3-yl]-6-oxohexanoate
   Show/Hide
C27H29ClF2N3NaO5
 1
1
EC50 = 8 nM
   TI
   LI
   LO
   TS
CP0559600
sodium;(4S)-6-(2-chloro-4-methylanilino)-4-[4-cyclopropyl-5-[5-(3-methylbutyl)-1,2-oxazol-3-yl]-1,2-oxazol-3-yl]-6-oxohexanoate
   Show/Hide
C27H31ClN3NaO5
 1
1
EC50 = 8 nM
   TI
   LI
   LO
   TS
CP0189687
sodium;(4S)-4-[4-cyclopropyl-5-[5-(2,2-dimethylpropyl)-1,2-oxazol-3-yl]-1,2-oxazol-3-yl]-6-(2,4-dichloroanilino)-6-oxohexanoate
   Show/Hide
C26H28Cl2N3NaO5
 1
1
EC50 = 9 nM
   TI
   LI
   LO
   TS
CP0482671
sodium;(4S)-6-(2-chloro-4-methylanilino)-4-[4-cyclopropyl-5-[3-(2-methylpropyl)-1,2-oxazol-5-yl]-1,2-oxazol-3-yl]-6-oxohexanoate
   Show/Hide
C26H29ClN3NaO5
 1
1
EC50 = 12 nM
   TI
   LI
   LO
   TS
CP0556867
sodium;(4S)-6-(2-chloro-4-methylanilino)-4-[4-cyclopropyl-5-[5-(2-methylpropyl)-1,2-oxazol-3-yl]-1,2-oxazol-3-yl]-6-oxohexanoate
   Show/Hide
C26H29ClN3NaO5
 1
1
EC50 = 14 nM
   TI
   LI
   LO
   TS
CP0482672
sodium;(4S)-6-(2-chloro-4-methylanilino)-4-[4-cyclopropyl-5-[2-(2-methylpropyl)-1,3-thiazol-5-yl]-1,2-oxazol-3-yl]-6-oxohexanoate
   Show/Hide
C26H29ClN3NaO4S
 1
1
EC50 = 17 nM
   TI
   LI
   LO
   TS
CP0058361
CHEMBL3774855
   Show/Hide
C28H39N5O2
 1
1
EC50 = 34 nM
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   TS
CP0571262
(4S)-6-(2-chloro-4-methylanilino)-4-[4-cyclopropyl-5-[4-(2-methylpropyl)phenyl]-1,2-oxazol-3-yl]-6-oxohexanoic acid
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C29H33ClN2O4
 1
1
EC50 = 44 nM
   TI
   LI
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   TS
CP0528300
sodium;(4S)-6-(2-chloro-4-methylanilino)-4-[4-cyclopropyl-5-[5-(2-methylpropyl)-1,3,4-thiadiazol-2-yl]-1,2-oxazol-3-yl]-6-oxohexanoate
   Show/Hide
C25H28ClN4NaO4S
 1
1
EC50 = 56 nM
   TI
   LI
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   TS
CP0556868
sodium;(4S)-6-(2-chloro-4-methylanilino)-4-[4-cyclopropyl-5-[5-(2-methylpropyl)-1,2,4-oxadiazol-3-yl]-1,2-oxazol-3-yl]-6-oxohexanoate
   Show/Hide
C25H28ClN4NaO5
 1
1
EC50 = 62 nM
   TI
   LI
   LO
   TS
CP0459830
(1S,2S,4S)-2-[4-cyclopropyl-5-[3-(2-methylpropyl)cyclobutyl]-1,2,4-triazol-3-yl]-N-(2,4-dimethylphenyl)-4-hydroxycyclopentane-1-carboxamide
   Show/Hide
C27H38N4O2
 1
1
EC50 = 98 nM
   TI
   LI
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   TS
CP0536535
sodium;(4S)-6-(2-chloro-4-methylanilino)-4-[4-cyclopropyl-5-[5-(2-methylpropyl)-1,3-thiazol-2-yl]-1,2-oxazol-3-yl]-6-oxohexanoate
   Show/Hide
C26H29ClN3NaO4S
 1
1
EC50 = 120 nM
   TI
   LI
   LO
   TS
CP0414833
3-[4-cyclopropyl-5-[3-(2-methylpropyl)cyclobutyl]-1,2,4-triazol-3-yl]-N-(2,4-dimethylphenyl)propanamide
   Show/Hide
C24H34N4O
 1
1
EC50 = 140 nM
   TI
   LI
   LO
   TS
CP0546924
N-ethyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-4-nitrobenzenesulfonamide
   Show/Hide
C17H14F6N2O5S
 1
1
EC50 = 190 nM
   TI
   LI
   LO
   TS
CP0559971
(3R,4S)-4-[4-cyclopropyl-5-[3-(2-methylpropyl)cyclobutyl]-1,2,4-triazol-3-yl]-N-(2,4-dimethylphenyl)-1-methylpiperidine-3-carboxamide
   Show/Hide
C28H41N5O
 1
1
EC50 = 230 nM
   TI
   LI
   LO
   TS
CP0458491
3-[4-cyclopropyl-5-[3-(2-methylpropyl)cyclobutyl]-1,2,4-triazol-3-yl]-N-(2,4-dimethylphenyl)propanamide
   Show/Hide
C24H34N4O
 1
1
EC50 = 400 nM
   TI
   LI
   LO
   TS
CP0556866
3-[4-cyclopropyl-5-(4-methylpentyl)-1,2,4-triazol-3-yl]-N-(2,4-dimethylphenyl)-5-hydroxypentanamide
   Show/Hide
C24H36N4O2
 1
1
EC50 = 440 nM
   TI
   LI
   LO
   TS
CP0551795
3-[4-cyclopropyl-5-[5-(2-methylpropyl)-1,2-oxazol-3-yl]-1,2,4-triazol-3-yl]-N-(2,4-dimethylphenyl)propanamide
   Show/Hide
C23H29N5O2
 1
1
EC50 = 450 nM
   TI
   LI
   LO
   TS
CP0571263
sodium;(4S)-6-(2-chloro-4-methylanilino)-4-[4-cyclopropyl-5-[5-(2-methylpropyl)-1,3-oxazol-2-yl]-1,2-oxazol-3-yl]-6-oxohexanoate
   Show/Hide
C26H29ClN3NaO5
 1
1
EC50 = 660 nM
   TI
   LI
   LO
   TS
CP0555703
3-[5-(2-cyclohexylethyl)-4-ethyl-1,2,4-triazol-3-yl]-N-naphthalen-1-ylpropanamide
   Show/Hide
C25H32N4O
 1
1
EC50 = 820 nM
   TI
   LI
   LO
   TS
CP0181318
3-[5-(2-cyclohexylethyl)-4-ethyl-1,2,4-triazol-3-yl]-N-(2,4-dimethylphenyl)propanamide
   Show/Hide
C23H34N4O
 1
1
EC50 = 900 nM
   TI
   LI
   LO
   TS
CP0397886
3-[5-(2-cyclohexylethyl)-4-(2,2-difluorocyclopropyl)-1,2,4-triazol-3-yl]-N-(2,4-dimethylphenyl)propanamide
   Show/Hide
C24H32F2N4O
 1
1
EC50 = 920 nM
   TI
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   TS
CP0381787
N-(3-chloro-2-methylphenyl)-3-[5-(2-cyclohexylethyl)-4-ethyl-1,2,4-triazol-3-yl]propanamide
   Show/Hide
C22H31ClN4O
 1
1
EC50 = 960 nM
   TI
   LI
   LO
   TS
CP0551794
3-[5-(2-cyclohexylethyl)-4-cyclopropyl-1,2,4-triazol-3-yl]-N-(2,4-dimethylphenyl)propanamide
   Show/Hide
C24H34N4O
 1
1
EC50 = 980 nM
   TI
   LI
   LO
   TS
CP0414830
3-[5-(2,3-dihydro-1H-inden-2-yl)-4-ethyl-1,2,4-triazol-3-yl]-N-naphthalen-1-ylpropanamide
   Show/Hide
C26H26N4O
 1
1
EC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0455009
3-[5-(2,3-dihydro-1H-inden-2-yl)-4-ethyl-1,2,4-triazol-3-yl]-2-methyl-N-naphthalen-1-ylpropanamide
   Show/Hide
C27H28N4O
 1
1
EC50 = 1300 nM
   TI
   LI
   LO
   TS
CP0360184
2-[[5-(2,3-dihydro-1H-inden-2-yl)-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-N-naphthalen-1-ylacetamide
   Show/Hide
C25H24N4OS
 1
1
EC50 = 1700 nM
   TI
   LI
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   TS
CP0542045
3-[4-cyclopropyl-5-(4-methylpentyl)-1,2,4-triazol-3-yl]-N-(2,4-dimethylphenyl)propanamide
   Show/Hide
C22H32N4O
 1
1
EC50 = 1700 nM
   TI
   LI
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   TS
CP0555702
3-[5-(2,3-dihydro-1H-inden-2-yl)-4-ethyl-1,2,4-triazol-3-yl]-N-naphthalen-1-ylbutanamide
   Show/Hide
C27H28N4O
 1
1
EC50 = 1700 nM
   TI
   LI
   LO
   TS
CP0414832
3-[4-cyclopropyl-5-[4-(2-methylpropyl)phenyl]-1,2,4-triazol-3-yl]-N-(2,4-dimethylphenyl)propanamide
   Show/Hide
C26H32N4O
 1
1
EC50 = 1800 nM
   TI
   LI
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   TS
CP0414834
3-[4-ethyl-5-(2-phenylethyl)-1,2,4-triazol-3-yl]-N-naphthalen-1-ylpropanamide
   Show/Hide
C25H26N4O
 1
1
EC50 = 2500 nM
   TI
   LI
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   TS
CP0536518
3-[4-cyclopropyl-5-(4-methylpentyl)-1,2,4-triazol-3-yl]-N-(2,4-dimethylphenyl)-N',N'-dimethylhexanediamide
   Show/Hide
C27H41N5O2
 1
1
EC50 = 2700 nM
   TI
   LI
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   TS
CP0414831
3-[4-cyclopropyl-5-(4,4-dimethylpentyl)-1,2,4-triazol-3-yl]-N-(2,4-dimethylphenyl)propanamide
   Show/Hide
C23H34N4O
 1
1
EC50 = 2800 nM
   TI
   LI
   LO
   TS
CP0381794
3-[5-(2-cyclohexylethyl)-4-ethyl-1,2,4-triazol-3-yl]-N-(3,5-dimethylphenyl)propanamide
   Show/Hide
C23H34N4O
 1
1
EC50 = 2900 nM
   TI
   LI
   LO
   TS
CP0536536
sodium;(4S)-6-(2-chloro-4-methylanilino)-4-[4-cyclopropyl-5-[2-(2-methylpropyl)-1,3-thiazol-4-yl]-1,2-oxazol-3-yl]-6-oxohexanoate
   Show/Hide
C26H29ClN3NaO4S
 1
1
EC50 = 3800 nM
   TI
   LI
   LO
   TS
CP0375786
3-[4-cyclopropyl-5-(3-methylpentyl)-1,2,4-triazol-3-yl]-N-(2,4-dimethylphenyl)propanamide
   Show/Hide
C22H32N4O
 1
1
EC50 = 3900 nM
   TI
   LI
   LO
   TS
CP0451204
3-[4-cyclopropyl-5-(4-methylpentyl)-1,2,4-triazol-3-yl]-N-(2,4-dimethylphenyl)-N'-methylhexanediamide
   Show/Hide
C26H39N5O2
 1
1
EC50 = 6400 nM
   TI
   LI
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   TS
CP0555704
3-[5-(3,3-dimethylbutyl)-4-ethyl-1,2,4-triazol-3-yl]-N-naphthalen-1-ylpropanamide
   Show/Hide
C23H30N4O
 1
1
EC50 = 6700 nM
   TI
   LI
   LO
   TS
CP0375787
3-[4-cyclobutyl-5-(2-cyclohexylethyl)-1,2,4-triazol-3-yl]-N-(2,4-dimethylphenyl)propanamide
   Show/Hide
C25H36N4O
 1
1
EC50 = 9500 nM
   TI
   LI
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   TS
CP0488163
5-acetamido-3-[4-cyclopropyl-5-(4-methylpentyl)-1,2,4-triazol-3-yl]-N-(2,4-dimethylphenyl)pentanamide
   Show/Hide
C26H39N5O2
 1
1
EC50 = 11000 nM
   TI
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   TS
CP0375785
3-[4-ethyl-5-(3-methylbutyl)-1,2,4-triazol-3-yl]-N-naphthalen-1-ylpropanamide
   Show/Hide
C22H28N4O
 1
1
EC50 = 13000 nM
   TI
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   LO
   TS
CP0397884
3-[5-(cyclohexylmethyl)-4-ethyl-1,2,4-triazol-3-yl]-N-naphthalen-1-ylpropanamide
   Show/Hide
C24H30N4O
 1
1
EC50 = 14000 nM
   TI
   LI
   LO
   TS
CP0536517
3-[4-cyclopropyl-5-(4-methylpentyl)-1,2,4-triazol-3-yl]-N-(2,4-dimethylphenyl)hexanediamide
   Show/Hide
C25H37N5O2
 1
1
EC50 = 16000 nM
   TI
   LI
   LO
   TS
CP0550671
3-[4-cyclopropyl-5-(4-methylpentyl)-1,2,4-triazol-3-yl]-5-(dimethylamino)-N-(2,4-dimethylphenyl)pentanamide
   Show/Hide
C26H41N5O
 1
1
EC50 = 19000 nM
   TI
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   TS
CP0414829
2-[[5-(2,3-dihydro-1H-inden-2-yl)-4-ethyl-1,2,4-triazol-3-yl]oxy]-N-naphthalen-1-ylacetamide
   Show/Hide
C25H24N4O2
 1
1
EC50 > 20000 nM
   TI
   LI
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   TS
CP0474191
3-[5-(2,3-dihydro-1H-inden-2-yl)-4-ethyl-1,2,4-triazol-3-yl]-3-hydroxy-N-naphthalen-1-ylpropanamide
   Show/Hide
C26H26N4O2
 1
1
EC50 > 20000 nM
   TI
   LI
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   TS
CP0561097
3-(5-cyclohexyl-4-ethyl-1,2,4-triazol-3-yl)-N-naphthalen-1-ylpropanamide
   Show/Hide
C23H28N4O
 1
1
EC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0528299
4-[4-cyclopropyl-5-(4-methylpentyl)-1,2,4-triazol-3-yl]-6-(2,4-dimethylanilino)-6-oxohexanoic acid
   Show/Hide
C25H36N4O3
 1
1
EC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0537901
5-amino-3-[4-cyclopropyl-5-(4-methylpentyl)-1,2,4-triazol-3-yl]-N-(2,4-dimethylphenyl)pentanamide
   Show/Hide
C24H37N5O
 1
1
EC50 > 20000 nM
   TI
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   TS