Brief Information of the Cell Line and Protein
Cell Line ID: CL000026 , CHO-K1
Synonyms
CHO K1
CHOK1
CHO cell clone K1
GM15452
Category Spontaneously immortalized cell line
Organism
Cricetulus griseus (Chinese hamster)
Cellosaurus ID
CVCL_0214
Protein ID: PT02190 , Cannabinoid receptor 1
Gene Name CNR1
Organism Rattus norvegicus, Rat
Protein Classification Membrane receptor
Uniprot ID P20272
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000026  Protein ID: PT02190
 
Compound ID Compound Name Compound Formula
CP0048192
2-((1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl)-5-(2-methyloctan-2-yl)phenol
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C24H40O3
 1
1
EC50 = 0.16 nM
   TI
   LI
   LO
   TS
CP0397077
(2R,4R)-9-(2,4-difluorophenyl)-N-(1-phenylcyclopropyl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
   Show/Hide
C23H19F2N3O
 1
1
EC50 = 19 nM
   TI
   LI
   LO
   TS
CP0375333
(2R,4R)-9-(2,4-difluorophenyl)-N-(2-pyridin-2-ylpropan-2-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
   Show/Hide
C22H20F2N4O
 1
1
EC50 = 43 nM
   TI
   LI
   LO
   TS
CP0375332
(2R,4R)-9-(2,4-difluorophenyl)-N-(2-phenylpropan-2-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
   Show/Hide
C23H21F2N3O
 1
1
EC50 = 59 nM
   TI
   LI
   LO
   TS
CP0437500
6-Chloro-N-(3-(3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)propyl)quinolin-3-amine
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C20H15Cl2FN4O
 1
1
EC50 = 77 nM
   TI
   LI
   LO
   TS
CP0379011
6-Chloro-3-(3-(3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)propoxy)quinoline
   Show/Hide
C20H14Cl2FN3O2
 1
1
EC50 = 83 nM
   TI
   LI
   LO
   TS
CP0388581
N-[3-[3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl]propyl]-3-(trifluoromethoxy)quinolin-6-amine
   Show/Hide
C21H15ClF4N4O2
 1
1
EC50 = 130 nM
   TI
   LI
   LO
   TS
CP0388674
3-(3-(2-Chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)-N-(6-chloroquinolin-3-yl)propanamide
   Show/Hide
C20H13Cl2FN4O2
 1
1
EC50 = 130 nM
   TI
   LI
   LO
   TS
CP0388675
N-(9-ethylcarbazol-3-yl)-3-[3-(oxan-4-yl)-1,2,4-oxadiazol-5-yl]propanamide
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C24H26N4O3
 1
1
EC50 = 150 nM
   TI
   LI
   LO
   TS
CP0381508
(2R,4R)-9-(2,4-difluorophenyl)-N-[1-(hydroxymethyl)cyclopentyl]-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
   Show/Hide
C20H21F2N3O2
 1
1
EC50 = 150 nM
   TI
   LI
   LO
   TS
CP0423248
N-(5-tert-butyl-1,2-oxazol-3-yl)-3-[3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl]propanamide
   Show/Hide
C18H18ClFN4O3
 1
1
EC50 = 170 nM
   TI
   LI
   LO
   TS
CP0379014
3-[3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-N-(6-chloro-1,8-naphthyridin-3-yl)propanamide
   Show/Hide
C19H12Cl2FN5O2
 1
1
EC50 = 220 nM
   TI
   LI
   LO
   TS
CP0437003
3-(3-(2-Chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)-N-(5-(piperidin-1-yl)-1,3,4-thiadiazol-2-yl)propanamide
   Show/Hide
C18H18ClFN6O2S
 1
1
EC50 = 220 nM
   TI
   LI
   LO
   TS
CP0379012
N-[3-[3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl]propyl]quinolin-6-amine
   Show/Hide
C20H16ClFN4O
 1
1
EC50 = 240 nM
   TI
   LI
   LO
   TS
CP0420845
3-(3-(2-Cyano-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)-N-(9-ethyl-9H-carbazol-3-yl)propanamide
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C26H20FN5O2
 1
1
EC50 = 240 nM
   TI
   LI
   LO
   TS
CP0388577
N-(9-ethylcarbazol-3-yl)-3-[3-(4-fluoro-2-methylphenyl)-1,2,4-oxadiazol-5-yl]propanamide
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C26H23FN4O2
 1
1
EC50 = 280 nM
   TI
   LI
   LO
   TS
CP0423249
3-(3-(2-Chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)-N-(9-ethyl-9H-carbazol-3-yl)propanamide
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C25H20ClFN4O2
 1
1
EC50 = 330 nM
   TI
   LI
   LO
   TS
CP0396917
(2R,4R)-9-(2,4-difluorophenyl)-N-[(1R,2R,4S)-1,3,3-trimethyl-2-bicyclo[2.2.1]heptanyl]-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
   Show/Hide
C24H27F2N3O
 1
1
EC50 = 498 nM
   TI
   LI
   LO
   TS
CP0423250
2-tert-Butyl-5-(3-(3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)propoxy)pyrimidine
   Show/Hide
C19H20ClFN4O2
 1
1
EC50 = 540 nM
   TI
   LI
   LO
   TS
CP0388583
N-(2-tert-butylpyrimidin-5-yl)-3-[3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl]propanamide
   Show/Hide
C19H19ClFN5O2
 1
1
EC50 = 570 nM
   TI
   LI
   LO
   TS
CP0375336
(2R,4R)-9-(2,5-difluorophenyl)-N-(1-hydroxy-2-methylpropan-2-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
   Show/Hide
C18H19F2N3O2
 1
1
EC50 = 639 nM
   TI
   LI
   LO
   TS
CP0379010
N-(9-ethylcarbazol-3-yl)-3-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]propanamide
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C25H21FN4O2
 1
1
EC50 = 650 nM
   TI
   LI
   LO
   TS
CP0397078
(2R,4R)-N-tert-butyl-9-(2,4-difluorophenyl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
   Show/Hide
C18H19F2N3O
 1
1
EC50 = 768 nM
   TI
   LI
   LO
   TS
CP0483740
(2R,4R)-9-(2,4-difluorophenyl)-N-(1-fluoro-2-methylpropan-2-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
   Show/Hide
C18H18F3N3O
 1
1
EC50 = 855 nM
   TI
   LI
   LO
   TS
CP0379008
3-(4-(3-(2-Chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)butyl)quinoline
   Show/Hide
C21H17ClFN3O
 1
1
EC50 = 1600 nM
   TI
   LI
   LO
   TS
CP0474275
(2R,4R)-9-(2,4-difluorophenyl)-N-[1-(hydroxymethyl)cyclobutyl]-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
   Show/Hide
C19H19F2N3O2
 1
1
EC50 = 1900 nM
   TI
   LI
   LO
   TS
CP0397080
(2R,4R)-9-(2,4-difluorophenyl)-N-[(1S)-2-hydroxy-1-phenylethyl]-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
   Show/Hide
C22H19F2N3O2
 1
1
EC50 = 5000 nM
   TI
   LI
   LO
   TS
CP0396919
(2R,4R)-9-(2,4-difluorophenyl)-N-(2-pyridin-3-ylpropan-2-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
   Show/Hide
C22H20F2N4O
 1
1
EC50 = 5400 nM
   TI
   LI
   LO
   TS
CP0381504
(2S,4S)-N-tert-butyl-9-(2,4-difluorophenyl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
   Show/Hide
C18H19F2N3O
 1
1
EC50 = 8900 nM
   TI
   LI
   LO
   TS
CP0155571
(2R,4R)-9-(2,4-difluorophenyl)-N-(1-hydroxy-2-methylpropan-2-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
   Show/Hide
C18H19F2N3O2
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0375335
(2R,4R)-N-(1-hydroxy-2-methylpropan-2-yl)-9-phenyl-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
   Show/Hide
C18H21N3O2
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0379951
(2S,4S)-9-(2,4-difluorophenyl)-N-(oxan-4-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
   Show/Hide
C19H19F2N3O2
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0379970
(2S,4S)-9-(2,4-difluorophenyl)-N-(1-hydroxy-2-methylpropan-2-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
   Show/Hide
C18H19F2N3O2
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0381505
(2S,4S)-9-(2,4-difluorophenyl)-N-(oxan-4-ylmethyl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
   Show/Hide
C20H21F2N3O2
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0396918
(2R,4R)-9-(2,4-difluorophenyl)-N-(oxan-4-ylmethyl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
   Show/Hide
C20H21F2N3O2
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0396920
(2R,4R)-9-(2,6-difluorophenyl)-N-(1-hydroxy-2-methylpropan-2-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
   Show/Hide
C18H19F2N3O2
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0396921
(2R,4R)-9-(2-fluorophenyl)-N-(1-hydroxy-2-methylpropan-2-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
   Show/Hide
C18H20FN3O2
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0397081
(2S,4S)-9-(2,4-difluorophenyl)-N-[1-(hydroxymethyl)cyclopropyl]-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
   Show/Hide
C18H17F2N3O2
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0400313
(2R,4R)-N-(1-hydroxy-2-methylpropan-2-yl)-9-pyridin-2-yl-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
   Show/Hide
C17H20N4O2
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0406642
(2R,4R)-N-(1-hydroxy-2-methylpropan-2-yl)-9-pyrimidin-4-yl-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
   Show/Hide
C16H19N5O2
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0410471
(2R,4R)-9-(3-fluorophenyl)-N-(1-hydroxy-2-methylpropan-2-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
   Show/Hide
C18H20FN3O2
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0410473
(2R,4R)-9-(4-fluorophenyl)-N-(1-hydroxy-2-methylpropan-2-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
   Show/Hide
C18H20FN3O2
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0410476
(2R,4R)-9-(2,4-difluorophenyl)-N-(oxan-4-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
   Show/Hide
C19H19F2N3O2
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0410712
(2R,4R)-9-(2,4-difluorophenyl)-N-(2-methyl-1-morpholin-4-ylpropan-2-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
   Show/Hide
C22H26F2N4O2
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0456395
(2R,4R)-N-(1-hydroxy-2-methylpropan-2-yl)-9-pyridin-3-yl-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
   Show/Hide
C17H20N4O2
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0474269
(2R,4R)-9-(2,4-difluorophenyl)-N-[(1R)-2-hydroxy-1-phenylethyl]-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
   Show/Hide
C22H19F2N3O2
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0474274
(2R,4R)-9-(2,4-dichlorophenyl)-N-(1-hydroxy-2-methylpropan-2-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
   Show/Hide
C18H19Cl2N3O2
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0483738
(2R,4R)-9-(2,4-difluorophenyl)-N-[1-(hydroxymethyl)cyclopropyl]-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
   Show/Hide
C18H17F2N3O2
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0487953
(2R,4R)-N-(1-hydroxy-2-methylpropan-2-yl)-9-pyrazin-2-yl-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene-7-carboxamide
   Show/Hide
C16H19N5O2
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0379009
3-(3-(2-Chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)-N-(6-(trifluoromethyl)pyridin-3-yl)propanamide
   Show/Hide
C17H11ClF4N4O2
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0388568
N-(9-ethylcarbazol-3-yl)-3-[3-(2-fluorophenyl)-1,2,4-oxadiazol-5-yl]propanamide
   Show/Hide
C25H21FN4O2
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0388576
3-(3-(2-Chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)-N-(6-(trifluoromethoxy)benzo[d]thiazol-2-yl)propanamide
   Show/Hide
C19H11ClF4N4O3S
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0388582
5-tert-Butyl-N-(3-(3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)propyl)isoxazol-3-amine
   Show/Hide
C18H20ClFN4O2
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0388584
3-(3-(2-Chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)-N-(5-cyano-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)propanamide
   Show/Hide
C19H12ClF4N5O3
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0388585
3-(3-(2-Chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)-N-(4-(trifluoromethyl)phenyl)propanamide
   Show/Hide
C18H12ClF4N3O2
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0423239
N-(9-ethylcarbazol-3-yl)-3-[5-(2-fluorophenyl)tetrazol-2-yl]propanamide
   Show/Hide
C24H21FN6O
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0423243
5-(3-(3-(2-Chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)propylamino)-2-(2,2,2-trifluoroethoxy)nicotinonitrile
   Show/Hide
C19H14ClF4N5O2
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0423247
3-(3-(3-Cyanopyridin-4-yl)-1,2,4-oxadiazol-5-yl)-N-(9-ethyl-9Hcarbazol-3-yl)propanamide
   Show/Hide
C25H20N6O2
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0437503
6-Chloro-N-(3-(3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)propyl)benzo[d]thiazol-2-amine
   Show/Hide
C18H13Cl2FN4OS
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0457650
3-[3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-N-[3-chloro-4-(trifluoromethyl)phenyl]propanamide
   Show/Hide
C18H11Cl2F4N3O2
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0456330
(2,3-dichlorophenyl)(1-(morpholinomethyl)imidazo[1,5-a]pyridin-3-yl)methanone
   Show/Hide
C19H17Cl2N3O2
 1
1
IC50 = 1068 nM
   TI
   LI
   LO
   TS
CP0442068
((4S,4aR,8aS)-4-hydroxy-4-phenyloctahydroquinolin-1(2H)-yl)(6-methylpyridin-3-yl)methanone
   Show/Hide
C22H26N2O2
 1
1
IC50 = 1887 nM
   TI
   LI
   LO
   TS
CP0436035
N-[[1-(hydroxymethyl)cyclopentyl]methyl]-3-morpholin-4-ylimidazo[1,5-a]pyridine-1-carboxamide
   Show/Hide
C19H26N4O3
 1
1
IC50 > 17000 nM
   TI
   LI
   LO
   TS
CP0436298
((4S,4aR,8aS)-4-hydroxy-4-phenyloctahydroquinolin-1(2H)-yl)((S)-4-methylmorpholin-3-yl)methanone
   Show/Hide
C21H30N2O3
 1
1
IC50 > 17000 nM
   TI
   LI
   LO
   TS