(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide

(2S,3S,4R,5R)-5-[6-[[(1R,2R)-2-(2-chlorophenoxy)cyclopentyl]amino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide

(2S,3S,4R,5R)-N-ethyl-3,4-dihydroxy-5-[6-[[(1R,2R)-2-phenoxycyclopentyl]amino]purin-9-yl]oxolane-2-carboxamide

(2S,3S,4R,5R)-5-[6-[[(1R,2R)-2-(3-chlorophenoxy)cyclopentyl]amino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide

(2S,3S,4R,5R)-5-[6-[[(1R,2R)-2-(3-bromophenoxy)cyclopentyl]amino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide

(2S,3S,4R,5R)-5-[6-[[(1R,2R)-2-[(2-chlorophenyl)methoxy]cyclopentyl]amino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide

(2R,3R,4S,5R)-2-[6-[[(1R,2R)-2-(2-chlorophenoxy)cyclopentyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol

(2R,3R,4S,5R)-2-[6-[[(1R,2R)-2-(3-chlorophenoxy)cyclopentyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol

(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-N-cyclopropyl-3,4-dihydroxyoxolane-2-carboxamide

(2S,3S,4R,5R)-N-ethyl-3,4-dihydroxy-5-[6-[[(1R,2R)-2-(3-methoxyphenoxy)cyclopentyl]amino]purin-9-yl]oxolane-2-carboxamide

(2S,3S,4R,5R)-5-[6-[[(1R,2R)-2-(4-chlorophenoxy)cyclopentyl]amino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide

(2S,3S,4R,5R)-3,4-Dihydroxy-5-[6-(3-iodo-benzylamino)-purin-9-yl]-tetrahydro-furan-2-carboxylic acid methylamide

(2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-[[(1R,2R)-2-phenoxycyclopentyl]amino]purin-9-yl]oxolane-3,4-diol

5-(6-Amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-carbothioic acid cyclopropylamide

5-(6-Amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-carbothioic acid ethylamide

(2S,3S,4R,5R)-5-[6-[[(1R,2R)-2-(4-tert-butylphenoxy)cyclopentyl]amino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide

(2S,3S,4R,5R)-5-[6-[[(1R,2R)-2-[(3-chlorophenyl)methoxy]cyclopentyl]amino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide

(2R,3R,4S,5R)-2-[6-[[(1R,2R)-2-(3-bromophenoxy)cyclopentyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol

(2R,3R,4S,5R)-2-[6-[[(1R,2R)-2-[(2-chlorophenyl)methoxy]cyclopentyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol

(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-N-propyloxolane-2-carboxamide

5-(6-Amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-carboxylic acid (3,3,3-trifluoro-propyl)-amide

(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-N-(2-chloroethyl)-3,4-dihydroxyoxolane-2-carboxamide

(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-N-cyclobutyl-3,4-dihydroxyoxolane-2-carboxamide

(2S,3S,4R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-N-propan-2-yloxolane-2-carboxamide

(2S,3S,4R,5R)-N-ethyl-3,4-dihydroxy-5-[6-[[(1R,2R)-2-[(3-methoxyphenyl)methoxy]cyclopentyl]amino]purin-9-yl]oxolane-2-carboxamide

(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-N-methyloxolane-2-carboxamide

(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-N-methoxyoxolane-2-carboxamide

(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-N-cyclopentyl-3,4-dihydroxyoxolane-2-carboxamide

2-[(3-fluoropyridin-2-yl)methyl]-7-phenyl-8-pyridazin-4-yl-[1,2,4]triazolo[1,5-c]pyrimidin-5-amine

[6-(methylamino)-2-(pyridin-3-ylmethylamino)thieno[3,2-d]pyrimidin-4-yl]-thiophen-2-ylmethanone

5-[5-amino-2-[(3-chloro-5-fluoropyridin-2-yl)methyl]-7-phenyl-[1,2,4]triazolo[1,5-c]pyrimidin-8-yl]-1H-pyridin-2-one

5-[5-amino-2-[(3-fluoropyridin-2-yl)methyl]-7-phenyl-[1,2,4]triazolo[1,5-c]pyrimidin-8-yl]-1-methylpyridin-2-one

5-[5-amino-2-[(R)-(3-fluoropyridin-2-yl)-hydroxymethyl]-7-phenyl-[1,2,4]triazolo[1,5-c]pyrimidin-8-yl]-1-methylpyridin-2-one

5-[5-amino-7-(4-fluorophenyl)-2-[(5-fluoropyridin-2-yl)methyl]-[1,2,4]triazolo[1,5-c]pyrimidin-8-yl]-1H-pyridin-2-one

(+/-)-[2-(1-Pyridin-3-yl-ethylamino)-thieno[3,2-d]pyrimidin-4-yl]-pyrrolidin-1-yl-methanone

1-(6-Amino-8-furan-2-yl-9-methyl-9H-purin-2-ylethynyl)-cyclohexanol

[6-chloro-2-(pyridin-3-ylmethylamino)thieno[3,2-d]pyrimidin-4-yl]-thiophen-2-ylmethanone

(5-methylthiophen-2-yl)(2-(1-(pyridin-3-yl)ethylamino)thieno[3,2-d]pyrimidin-4-yl)methanone

(S)-[2-(1-Pyridin-3-yl-ethylamino)-thieno[3,2-d]pyrimidin-4-yl]-pyrrolidin-1-yl-methanone

(2-(pyridin-3-ylmethylamino)thieno[3,2-d]pyrimidin-4-yl)(thiophen-2-yl)methanone

[6-(ethylamino)-2-(pyridin-3-ylmethylamino)thieno[3,2-d]pyrimidin-4-yl]-thiophen-2-ylmethanone

(5-methylthiophen-2-yl)(2-(1-(pyridin-2-yl)ethylamino)thieno[3,2-d]pyrimidin-4-yl)methanone

1-[6-Amino-8-(3-fluoro-phenyl)-9-methyl-9H-purin-2-ylethynyl]-cyclohexanol

5-[5-amino-7-(4-fluorophenyl)-2-[(R)-(3-fluoropyridin-2-yl)-hydroxymethyl]-[1,2,4]triazolo[1,5-c]pyrimidin-8-yl]-1-methylpyridin-2-one

[6-amino-2-(pyridin-3-ylmethylamino)thieno[3,2-d]pyrimidin-4-yl]-thiophen-2-ylmethanone

[6-(dimethylamino)-2-(pyridin-3-ylmethylamino)thieno[3,2-d]pyrimidin-4-yl]-thiophen-2-ylmethanone

(5-methylthiophen-2-yl)(2-(pyridin-2-ylmethylamino)thieno[3,2-d]pyrimidin-4-yl)methanone

1-[6-Amino-8-(3-fluoro-phenyl)-9-methyl-9H-purin-2-ylethynyl]-cycloheptanol

(5-methylthiophen-2-yl)(2-(pyridin-3-ylmethylamino)thieno[3,2-d]pyrimidin-4-yl)methanone

5-[5-amino-2-[(5-methoxypyridin-2-yl)methyl]-7-phenyl-[1,2,4]triazolo[1,5-c]pyrimidin-8-yl]-1-methylpyridin-2-one

1-[6-Amino-8-(3-fluoro-phenyl)-9-methyl-9H-purin-2-ylethynyl]-cyclopentanol

3-[6-Amino-2-(1-hydroxy-cyclohexylethynyl)-9-methyl-9H-purin-8-yl]-benzonitrile

1-[6-Amino-8-(2-fluoro-phenyl)-9-methyl-9H-purin-2-ylethynyl]-cyclohexanol

2-(oxolan-2-ylmethyl)-7-phenyl-8-pyridazin-4-yl-[1,2,4]triazolo[1,5-c]pyrimidin-5-amine

(5-methylthiophen-2-yl)(2-(pyrimidin-4-ylmethylamino)thieno[3,2-d]pyrimidin-4-yl)methanone

pyridin-3-yl-[2-(pyridin-3-ylmethylamino)thieno[3,2-d]pyrimidin-4-yl]methanone

2-[(Pyridin-3-ylmethyl)-amino]-thieno[3,2-d]pyrimidine-4-carboxylic acid ethyl-amide

5-[5-amino-7-(4-fluorophenyl)-2-(piperidin-1-ylmethyl)-[1,2,4]triazolo[1,5-c]pyrimidin-8-yl]-3-methyl-1H-pyridin-2-one

1-[6-Amino-8-(3-fluoro-phenyl)-9-methyl-9H-purin-2-yl]-3-ethyl-pent-1-yn-3-ol

(2-(pyridin-3-ylmethylamino)thieno[3,2-d]pyrimidin-4-yl)(thiophen-3-yl)methanone

(2-(pyridin-3-ylmethylamino)thieno[3,2-d]pyrimidin-4-yl)(thiazol-5-yl)methanone

4-[6-Amino-8-(3-fluoro-phenyl)-9-methyl-9H-purin-2-yl]-2-methyl-but-3-yn-2-ol

1-[6-Amino-8-(4-fluoro-phenyl)-9-methyl-9H-purin-2-ylethynyl]-cyclohexanol

(2-(pyridin-3-ylmethylamino)thieno[3,2-d]pyrimidin-4-yl)(thiazol-2-yl)methanone

[2-(pyridin-3-ylmethylamino)thieno[3,2-d]pyrimidin-4-yl]-pyrrolidin-1-ylmethanone

1,3-Dimethyl-8-phenyl-3,9-dihydro-purine-2,6-dione

(2-(pyridin-3-ylmethylamino)thieno[3,2-d]pyrimidin-4-yl)(p-tolyl)methanone

2-[(Pyridin-3-ylmethyl)-amino]-thieno[3,2-d]pyrimidine-4-carboxylic acid cyclo-propylamide

5-[5-amino-7-(4-fluorophenyl)-2-(3,3,3-trifluoropropyl)-[1,2,4]triazolo[1,5-c]pyrimidin-8-yl]-1H-pyridin-2-one

N-[4-(5-methylthiophene-2-carbonyl)thieno[3,2-d]pyrimidin-2-yl]pyridine-3-carboxamide

2-[(Pyridin-3-ylmethyl)-amino]-thieno[3,2-d]pyrimidine-4-carboxylic acid iso-propylamide

(5-methylthiophen-2-yl)(2-(1-phenylethylamino)thieno[3,2-d]pyrimidin-4-yl)methanone

(5-methylthiophen-2-yl)(2-(2-(pyridin-3-yl)ethylamino)thieno[3,2-d]pyrimidin-4-yl)methanone

(5-methylfuran-2-yl)(2-(pyridin-3-ylmethylamino)thieno[3,2-d]pyrimidin-4-yl)methanone

(5-chlorothiophen-2-yl)(2-(pyridin-3-ylmethylamino)thieno[3,2-d]pyrimidin-4-yl)methanone

2-[(Pyridin-3-ylmethyl)-amino]-thieno[3,2-d]pyrimidine-4-carboxylic acid methyl-amide

1-[6-Amino-8-(4-chloro-phenyl)-9-methyl-9H-purin-2-ylethynyl]-cyclohexanol

phenyl-[2-(pyridin-3-ylmethylamino)thieno[3,2-d]pyrimidin-4-yl]methanone

2-[(Pyridin-3-ylmethyl)-amino]-thieno[3,2-d]pyrimidine-4-carboxylic acid cyclo-hexylamide

(2-aminothieno[3,2-d]pyrimidin-4-yl)(5-methylthiophen-2-yl)methanone

(2-(pyridin-3-ylmethylamino)thieno[3,2-d]pyrimidin-4-yl)(pyridin-4-yl)methanone

(5-methylthiophen-2-yl)(2-(2-(pyridin-2-yl)ethylamino)thieno[3,2-d]pyrimidin-4-yl)methanone

(E)-1-[(R)-2-(2-Hydroxy-ethyl)-piperidin-1-yl]-3-(2-phenyl-pyrazolo[1,5-a]pyridin-3-yl)-propenone

(2-(ethylamino)thieno[3,2-d]pyrimidin-4-yl)(5-methylthiophen-2-yl)methanone

(4-methoxyphenyl)(2-(pyridin-3-ylmethylamino)thieno[3,2-d]pyrimidin-4-yl)methanone

8-[(E)-2-(3,4-Dimethoxy-phenyl)-vinyl]-7-methyl-1,3-dipropyl-3,7-dihydro-purine-2,6-dione

9-Methyl-2-phenyl-5,9-dihydro-[1,2,4]triazolo[5,1-a][2,7]naphthyridine-6-carboxylic acid methyl ester

(R)-[2-(1-Pyridin-3-yl-ethylamino)-thieno[3,2-d]pyrimidin-4-yl]-pyrrolidin-1-yl-methanone

(2-ethylthieno[3,2-d]pyrimidin-4-yl)(5-methylthiophen-2-yl)methanone

(2-(methyl(pyridin-3-ylmethyl)amino)thieno[3,2-d]pyrimidin-4-yl)(5-methylthiophen-2-yl)methanone

(5-methylthiophen-2-yl)(thieno[3,2-d]pyrimidin-4-yl)methanone

(2-(benzylamino)thieno[3,2-d]pyrimidin-4-yl)(5-methylthiophen-2-yl)methanone

1-[6-Amino-9-methyl-8-(3-trifluoromethyl-phenyl)-9H-purin-2-ylethynyl]-cyclohexanol

(2-(cyclohexylmethylamino)thieno[3,2-d]pyrimidin-4-yl)(5-methylthiophen-2-yl)methanone

(2-methylthieno[3,2-d]pyrimidin-4-yl)(5-methylthiophen-2-yl)methanone

N-(4-chlorophenyl)-7-(4-methylpiperazin-1-yl)-[1,3]thiazolo[5,4-d]pyrimidin-2-amine

[(2S)-1-[2-(4-methylanilino)-[1,3]thiazolo[5,4-d]pyrimidin-7-yl]pyrrolidin-2-yl]methanol

[(2S)-1-[2-(3-bromoanilino)-[1,3]thiazolo[5,4-d]pyrimidin-7-yl]pyrrolidin-2-yl]methanol

N-(4-nitrophenyl)-7-pyrrolidin-1-yl-[1,3]thiazolo[5,4-d]pyrimidin-2-amine

7-chloro-N-(4-methylphenyl)-[1,3]thiazolo[5,4-d]pyrimidin-2-amine

[(2S)-1-[2-(3,4,5-trimethoxyanilino)-[1,3]thiazolo[5,4-d]pyrimidin-7-yl]pyrrolidin-2-yl]methanol

N-(2,6-difluorophenyl)-7-pyrrolidin-1-yl-[1,3]thiazolo[5,4-d]pyrimidin-2-amine

2-N-(4-chlorophenyl)-7-N,7-N-dimethyl-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine

N-(4-methylphenyl)-7-pyrrolidin-1-yl-[1,3]thiazolo[5,4-d]pyrimidin-2-amine

[(2S)-1-(2-anilino-[1,3]thiazolo[5,4-d]pyrimidin-7-yl)pyrrolidin-2-yl]methanol

[(2S)-1-[2-(2,6-difluoroanilino)-[1,3]thiazolo[5,4-d]pyrimidin-7-yl]pyrrolidin-2-yl]methanol

7-chloro-N-phenyl-[1,3]thiazolo[5,4-d]pyrimidin-2-amine

7-chloro-N-(2-morpholin-4-ylethyl)-[1,3]thiazolo[5,4-d]pyrimidin-2-amine

7-chloro-N-(4-nitrophenyl)-[1,3]thiazolo[5,4-d]pyrimidin-2-amine

1,3-dibenzyl-1-(7-chloro-[1,3]thiazolo[5,4-d]pyrimidin-2-yl)thiourea

7-morpholin-4-yl-N-phenyl-[1,3]thiazolo[5,4-d]pyrimidin-2-amine

7-chloro-N-(4-chlorophenyl)-[1,3]thiazolo[5,4-d]pyrimidin-2-amine

7-N,7-N-dimethyl-2-N-phenyl-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine

N-(4-chlorophenyl)-7-piperidin-1-yl-[1,3]thiazolo[5,4-d]pyrimidin-2-amine

7-(4-ethylpiperazin-1-yl)-N-phenyl-[1,3]thiazolo[5,4-d]pyrimidin-2-amine

N-(3-bromophenyl)-7-pyrrolidin-1-yl-[1,3]thiazolo[5,4-d]pyrimidin-2-amine

7-pyrrolidin-1-yl-N-(3,4,5-trimethoxyphenyl)-[1,3]thiazolo[5,4-d]pyrimidin-2-amine

N-(3-bromophenyl)-7-chloro-[1,3]thiazolo[5,4-d]pyrimidin-2-amine

N-phenyl-7-(4-piperidin-1-ylpiperidin-1-yl)-[1,3]thiazolo[5,4-d]pyrimidin-2-amine

7-chloro-N-(2,6-difluorophenyl)-[1,3]thiazolo[5,4-d]pyrimidin-2-amine

2-N-(4-chlorophenyl)-7-N,7-N-diethyl-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine

7-(4-methylpiperazin-1-yl)-N-phenyl-[1,3]thiazolo[5,4-d]pyrimidin-2-amine

N-phenyl-7-piperidin-1-yl-[1,3]thiazolo[5,4-d]pyrimidin-2-amine

7-N,7-N-diethyl-2-N-phenyl-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine

7-chloro-N-(4-methoxyphenyl)-[1,3]thiazolo[5,4-d]pyrimidin-2-amine

[(2S)-1-[2-(4-chloroanilino)-[1,3]thiazolo[5,4-d]pyrimidin-7-yl]pyrrolidin-2-yl]methanol

N-(4-chlorophenyl)-7-pyrrolidin-1-yl-[1,3]thiazolo[5,4-d]pyrimidin-2-amine

[(2S)-1-[2-(4-methoxyanilino)-[1,3]thiazolo[5,4-d]pyrimidin-7-yl]pyrrolidin-2-yl]methanol

7-chloro-N-(3,4,5-trimethoxyphenyl)-[1,3]thiazolo[5,4-d]pyrimidin-2-amine

N-phenyl-7-pyrrolidin-1-yl-[1,3]thiazolo[5,4-d]pyrimidin-2-amine

N-(7-chloro-[1,3]thiazolo[5,4-d]pyrimidin-2-yl)benzamide

N-phenyl-7-piperazin-1-yl-[1,3]thiazolo[5,4-d]pyrimidin-2-amine

N-(4-chlorophenyl)-7-morpholin-4-yl-[1,3]thiazolo[5,4-d]pyrimidin-2-amine