| Compound ID |
Compound Name |
Compound Formula |
|
CP0763406
|
4-Amino-6-(((1S)-1-(6-fluoro-3-phenyl-4-(1-piperazinylcarbonyl)-2-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile
Show/Hide
|
C27H25FN8O
|
1
|
| 1 |
IC50 = 22.5 nM
|
|
|
|
CP0735509
|
4-Amino-6-(((1S)-1-(4-((1,1-dioxido-4-thiomorpholinyl)carbonyl)-6-fluoro-3-phenyl-2-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile
Show/Hide
|
C27H24FN7O3S
|
1
|
| 1 |
IC50 = 35.4 nM
|
|
|
|
CP0010704
|
4-amino-6-[[(1S)-1-[6-fluoro-1-(3-fluorophenyl)benzimidazol-2-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C20H15F2N7
|
1
|
| 1 |
IC50 = 118 nM
|
|
|
|
CP0011796
|
4-amino-6-[[(1S)-1-(1-cyclopropyl-6-fluorobenzimidazol-2-yl)ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C17H16FN7
|
1
|
| 1 |
IC50 = 144 nM
|
|
|
|
CP0705621
|
2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro-N,N-dimethyl-3-phenyl-4-quinolinecarboxamide
Show/Hide
|
C25H22FN7O
|
1
|
| 1 |
IC50 = 146 nM
|
|
|
|
CP0014717
|
4-amino-6-[[(1S)-1-[6-fluoro-1-(4-fluorophenyl)benzimidazol-2-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C20H15F2N7
|
1
|
| 1 |
IC50 = 191 nM
|
|
|
|
CP0013270
|
4-amino-6-[[(1S)-1-[1-(3,5-difluorophenyl)-6-fluorobenzimidazol-2-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C20H14F3N7
|
1
|
| 1 |
IC50 = 270 nM
|
|
|
|
CP0740357
|
2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro-3-phenyl-4-quinolinecarboxamide
Show/Hide
|
C23H18FN7O
|
1
|
| 1 |
IC50 = 301 nM
|
|
|
|
CP0735510
|
4-Amino-6-(((1S)-1-(6-fluoro-4-((3-hydroxy-1-azetidinyl)-carbonyl)-3-phenyl-2-quinolinyl)ethyl)amino)-5-pyrimidinecarbonitrile
Show/Hide
|
C26H22FN7O2
|
1
|
| 1 |
IC50 = 507 nM
|
|
|
|
CP0720960
|
2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro-N-methyl-3-phenyl-4-quinolinecarboxamide
Show/Hide
|
C24H20FN7O
|
1
|
| 1 |
IC50 = 634 nM
|
|
|
|
CP0013647
|
1-(7-fluoro-3-methyl-2-pyridin-2-ylquinolin-4-yl)-6-morpholin-4-ylspiro[2H-pyrrolo[3,2-b]pyridine-3,4'-oxane]
Show/Hide
|
C30H30FN5O2
|
1
|
| 1 |
IC50 = 825 nM
|
|
|
|
CP0053343
|
4-amino-6-[[(1S)-1-(6-fluoro-3,4-dipyridin-2-ylquinolin-2-yl)ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C26H19FN8
|
1
|
| 1 |
IC50 = 850 nM
|
|
|
|
CP0720958
|
AMG319
Show/Hide
|
C21H16FN7
|
1
|
| 1 |
IC50 = 850 nM
|
|
|
|
CP0698893
|
2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro-N-(1-methylethyl)-3-phenyl-4-quinolinecarboxamide
Show/Hide
|
C26H24FN7O
|
1
|
| 1 |
IC50 = 853 nM
|
|
|
|
CP0776506
|
Rac-4-Amino-6-(1-(6-fluoro-4-(piperazine-1-carbonyl)-3-(pyridin-2-yl)quinolin-2-yl)ethylamino)pyrimidine-5-carbonitrile
Show/Hide
|
C26H24FN9O
|
1
|
| 1 |
IC50 = 964 nM
|
|
|
|
CP0015018
|
4-amino-6-[[(1S)-1-(6-fluoro-1-phenylbenzimidazol-2-yl)ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C20H16FN7
|
1
|
| 1 |
IC50 = 1400 nM
|
|
|
|
CP0012717
|
4-amino-6-[[(1S)-1-[6-fluoro-3-(4-fluorophenyl)imidazo[1,2-a]pyridin-2-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C20H15F2N7
|
1
|
| 1 |
IC50 = 1420 nM
|
|
|
|
CP0011797
|
4-amino-6-[[(1S)-1-[6-fluoro-1-(3-methylsulfonylphenyl)benzimidazol-2-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C21H18FN7O2S
|
1
|
| 1 |
IC50 = 2880 nM
|
|
|
|
CP0735511
|
2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-5-fluoro-N-methyl-3-(2-pyridinyl)-4-quinolinecarboxamide
Show/Hide
|
C23H19FN8O
|
1
|
| 1 |
IC50 = 3220 nM
|
|
|
|
CP0010992
|
4-amino-6-[[(1S)-1-[6-fluoro-3-(3-methylsulfonylphenyl)imidazo[1,2-a]pyridin-2-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C21H18FN7O2S
|
1
|
| 1 |
IC50 = 3340 nM
|
|
|
|
CP0830605
|
2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro-N-methyl-3-(2-pyridinyl)-4-quinolinecarboxamide
Show/Hide
|
C23H19FN8O
|
1
|
| 1 |
IC50 = 3530 nM
|
|
|
|
CP0011795
|
4-amino-6-[[(1S)-1-[3-(3,5-difluorophenyl)-6-fluoroimidazo[1,2-a]pyridin-2-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C20H14F3N7
|
1
|
| 1 |
IC50 = 3550 nM
|
|
|
|
CP0830604
|
Rac-4-Amino-6-(1-(6-fluoro-4-(3-hydroxyazetidine-1-carbonyl)-3-(pyridin-2-yl)quinolin-2-yl)ethylamino)pyrimidine-5-carbonitrile
Show/Hide
|
C25H21FN8O2
|
1
|
| 1 |
IC50 = 3590 nM
|
|
|
|
CP0725929
|
2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-N-ethyl-6-fluoro-3-phenyl-4-quinolinecarboxamide
Show/Hide
|
C25H22FN7O
|
1
|
| 1 |
IC50 = 4650 nM
|
|
|
|
CP0698894
|
2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-N-ethyl-6-fluoro-3-(2-pyridinyl)-4-quinolinecarboxamide
Show/Hide
|
C24H21FN8O
|
1
|
| 1 |
IC50 = 5360 nM
|
|
|
|
CP0013101
|
4-amino-6-[[(1S)-1-(6-fluoro-1-pyridin-3-ylbenzimidazol-2-yl)ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C19H15FN8
|
1
|
| 1 |
IC50 = 5800 nM
|
|
|
|
CP0010702
|
4-amino-6-[[(1S)-1-[6-fluoro-1-(5-fluoropyridin-3-yl)benzimidazol-2-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C19H14F2N8
|
1
|
| 1 |
IC50 = 5900 nM
|
|
|
|
CP0010993
|
4-amino-6-[[(1S)-1-(6-fluoro-3-pyridin-2-ylimidazo[1,2-a]pyridin-2-yl)ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C19H15FN8
|
1
|
| 1 |
IC50 = 7920 nM
|
|
|
|
CP0776505
|
2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro-N-(2-(methylamino)ethyl)-3-phenyl-4-quinolinecarboxamide
Show/Hide
|
C26H25FN8O
|
1
|
| 1 |
IC50 = 9550 nM
|
|
|
|
CP0003969
|
4-amino-6-[[(1S)-1-(6-fluoro-1-pyridin-2-ylbenzimidazol-2-yl)ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C19H15FN8
|
1
|
| 1 |
IC50 = 12600 nM
|
|
|
|
CP0010706
|
4-amino-6-[[(1S)-1-[5-fluoro-1-(3-methylsulfonylphenyl)benzimidazol-2-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C21H18FN7O2S
|
1
|
| 1 |
IC50 = 14000 nM
|
|
|
|
CP0720957
|
2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-N-(2-(dimethylamino)ethyl)-6-fluoro-3-(2-pyridinyl)-4-quinolinecarboxamide
Show/Hide
|
C25H24FN9O
|
1
|
| 1 |
IC50 = 23200 nM
|
|
|
|
CP0011794
|
4-amino-6-[[(1S)-1-[6-fluoro-3-(5-fluoropyridin-3-yl)imidazo[1,2-a]pyridin-2-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C19H14F2N8
|
1
|
| 1 |
IC50 = 24800 nM
|
|
|
|
CP0013646
|
4-amino-6-[[(1S)-1-(6-fluoro-3-phenylimidazo[1,2-a]pyridin-2-yl)ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C20H16FN7
|
1
|
| 1 |
IC50 = 27500 nM
|
|
|
|
CP0003968
|
4-amino-6-[[(1R)-1-[6-fluoro-1-(3-methylsulfonylphenyl)benzimidazol-2-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C21H18FN7O2S
|
1
|
| 1 |
IC50 = 29500 nM
|
|
|
|
CP0010705
|
4-amino-6-[[(1S)-1-[6-fluoro-1-(2-methylsulfonylphenyl)benzimidazol-2-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C21H18FN7O2S
|
1
|
| 1 |
IC50 = 61900 nM
|
|
|
|
CP0010701
|
4-amino-6-[[(1S)-1-[6-fluoro-3-(2-methylsulfonylphenyl)imidazo[1,2-a]pyridin-2-yl]ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C21H18FN7O2S
|
1
|
| 1 |
IC50 = 63400 nM
|
|
|
|
CP0013100
|
4-amino-6-[[(1S)-1-(6-fluoro-3-pyridin-3-ylimidazo[1,2-a]pyridin-2-yl)ethyl]amino]pyrimidine-5-carbonitrile
Show/Hide
|
C19H15FN8
|
1
|
| 1 |
IC50 = 82500 nM
|
|
|
|
CP0005472
|
4-[2-[(5-fluoro-6-methoxypyridin-3-yl)amino]-5-[(1R)-1-(4-methylsulfonylpiperazin-1-yl)ethyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C22H28FN9O3S
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0057249
|
2-amino-4-[5-chloro-2-[[6-chloro-5-(dimethylsulfamoylamino)pyridin-3-yl]amino]pyridin-3-yl]-6-methyl-1,3,5-triazine
Show/Hide
|
C16H17Cl2N9O2S
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0218104
|
2-amino-4-[2-[[6-chloro-5-(dimethylsulfamoylamino)pyridin-3-yl]amino]-5-methoxypyridin-3-yl]-6-methyl-1,3,5-triazine
Show/Hide
|
C17H20ClN9O3S
|
1
|
| 1 |
Ki = 2.2 nM
|
|
|
|
CP0283801
|
N-[5-[[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)pyridin-2-yl]amino]-2-chloropyridin-3-yl]methanesulfonamide
Show/Hide
|
C15H15ClN8O2S
|
1
|
| 1 |
Ki = 2.4 nM
|
|
|
|
CP0000561
|
4-[2-[(5-fluoro-6-methoxypyridin-3-yl)amino]-5-[(1S)-1-(4-methylsulfonylpiperazin-1-yl)ethyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C22H28FN9O3S
|
1
|
| 1 |
Ki = 7 nM
|
|
|
|
CP0000894
|
4-[2-[(5-methoxypyridin-3-yl)amino]-5-[(4-methylsulfonylpiperazin-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C21H27N9O3S
|
1
|
| 1 |
Ki = 7 nM
|
|
|
|
CP0009370
|
4-[2-[(6-methoxypyridin-3-yl)amino]-5-[(4-methylsulfonylpiperazin-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C21H27N9O3S
|
1
|
| 1 |
Ki = 8 nM
|
|
|
|
CP0012062
|
4-[2-[(5-fluoro-6-methoxypyridin-3-yl)amino]-5-[(1R)-1-[(2S)-2-methyl-4-methylsulfonylpiperazin-1-yl]ethyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C23H30FN9O3S
|
1
|
| 1 |
Ki = 8 nM
|
|
|
|
CP0000560
|
4-[2-[(5-fluoro-6-methoxypyridin-3-yl)amino]-5-[2-(4-methylsulfonylpiperazin-1-yl)propan-2-yl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C23H30FN9O3S
|
1
|
| 1 |
Ki = 9 nM
|
|
|
|
CP0001490
|
4-[2-[(5-fluoro-6-methoxypyridin-3-yl)amino]-5-[(1S)-1-[(2S)-2-methyl-4-methylsulfonylpiperazin-1-yl]ethyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C23H30FN9O3S
|
1
|
| 1 |
Ki = 9 nM
|
|
|
|
CP0003272
|
4-[2-[(5-fluoro-6-methoxypyridin-3-yl)amino]-5-[[(2R)-2-methyl-4-methylsulfonylpiperazin-1-yl]methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C22H28FN9O3S
|
1
|
| 1 |
Ki = 9 nM
|
|
|
|
CP0007358
|
4-[2-[(5-fluoro-6-methoxypyridin-3-yl)amino]-5-[[(2S)-2-methyl-4-methylsulfonylpiperazin-1-yl]methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C22H28FN9O3S
|
1
|
| 1 |
Ki = 9 nM
|
|
|
|
CP0001491
|
4-[2-[(5-fluoro-6-methoxypyridin-3-yl)amino]-5-[(1R)-1-[(2R)-2-methyl-4-methylsulfonylpiperazin-1-yl]ethyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C23H30FN9O3S
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0008566
|
4-[2-[(5-fluoro-6-methoxypyridin-3-yl)amino]-5-[(1S)-1-[(2R)-2-methyl-4-methylsulfonylpiperazin-1-yl]ethyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C23H30FN9O3S
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0279598
|
N-[5-[[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-5-(2-methoxyethoxy)pyridin-2-yl]amino]-2-chloropyridin-3-yl]methanesulfonamide
Show/Hide
|
C18H21ClN8O4S
|
1
|
| 1 |
Ki = 14 nM
|
|
|
|
CP0012228
|
4-[2-[(2-methoxypyrimidin-5-yl)amino]-5-[(4-methylsulfonylpiperazin-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C20H26N10O3S
|
1
|
| 1 |
Ki = 16 nM
|
|
|
|
CP0001492
|
4-[2-[(5-fluoro-6-methoxypyridin-3-yl)amino]-5-[(1R)-2,2,2-trifluoro-1-(4-methylsulfonylpiperazin-1-yl)ethyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C22H25F4N9O3S
|
1
|
| 1 |
Ki = 20 nM
|
|
|
|
CP0005570
|
4-[2-[(5-fluoro-6-methoxypyridin-3-yl)amino]-5-[(4-methylsulfonylpiperazin-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C21H26FN9O3S
|
1
|
| 1 |
Ki = 21 nM
|
|
|
|
CP0008076
|
4-[2-[(6-chloropyridin-3-yl)amino]-5-[(4-methylsulfonylpiperazin-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C20H24ClN9O2S
|
1
|
| 1 |
Ki = 21 nM
|
|
|
|
CP0001493
|
4-[2-[(5-fluoropyridin-3-yl)amino]-5-[(4-methylsulfonylpiperazin-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C20H24FN9O2S
|
1
|
| 1 |
Ki = 24 nM
|
|
|
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CP0007778
|
4-methyl-6-[2-[(6-methylpyridin-3-yl)amino]-5-[(4-methylsulfonylpiperazin-1-yl)methyl]pyridin-3-yl]-1,3,5-triazin-2-amine
Show/Hide
|
C21H27N9O2S
|
1
|
| 1 |
Ki = 31 nM
|
|
|
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CP0002987
|
4-[2-[(5-fluoro-6-methoxypyridin-3-yl)amino]-5-[(1S)-2,2,2-trifluoro-1-(4-methylsulfonylpiperazin-1-yl)ethyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C22H25F4N9O3S
|
1
|
| 1 |
Ki = 34 nM
|
|
|
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CP0000562
|
4-methyl-6-[5-[(4-methylsulfonylpiperazin-1-yl)methyl]-2-[[6-(trifluoromethyl)pyridin-3-yl]amino]pyridin-3-yl]-1,3,5-triazin-2-amine
Show/Hide
|
C21H24F3N9O2S
|
1
|
| 1 |
Ki = 136 nM
|
|
|
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CP0007779
|
5-[[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-5-[(4-methylsulfonylpiperazin-1-yl)methyl]pyridin-2-yl]amino]-1H-pyridin-2-one
Show/Hide
|
C20H25N9O3S
|
1
|
| 1 |
Ki = 2350 nM
|
|
|
