Brief Information of the Cell Line and Protein
Cell Line ID: CL000017 , HeLa
Synonyms
HELA
Hela
He La
He-La
HeLa-CCL2
Henrietta Lacks cells
Helacyton gartleri
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0030
Protein ID: PT01202 , 5-hydroxytryptamine receptor 1B
Gene Name HTR1B
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P28222
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000017  Protein ID: PT01202
 
Compound ID Compound Name Compound Formula
CP0017968
3-cyano-4-[2-[2-[(2-piperidin-4-ylethylamino)methyl]pyridin-4-yl]-4-[3-(trifluoromethyl)phenyl]phenoxy]-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide
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C35H32F3N7O3S2
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0376628
1-(2-{4-[1-(4-Fluoro-phenyl)-5-(3-methyl-3H-[1,2,3]triazol-4-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
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C27H30FN7O
 1
1
Ki = 2.8 nM
   TI
   LI
   LO
   TS
CP0453890
1-(2-{4-[1-(4-Fluoro-phenyl)-5-pyrimidin-5-yl-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
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C28H29FN6O
 1
1
Ki = 4.2 nM
   TI
   LI
   LO
   TS
CP0001238
14C-5-hydroxy tryptamine creatinine disulfate
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C10H12N2O
 1
1
Ki = 4.8 nM
   TI
   LI
   LO
   TS
CP0448256
1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-pyrazol-3-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
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C28H31FN6O
 1
1
Ki = 5.9 nM
   TI
   LI
   LO
   TS
CP0459887
1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-[1,2,4]triazol-3-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
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C27H30FN7O
 1
1
Ki = 6.5 nM
   TI
   LI
   LO
   TS
CP0492027
1-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-imidazol-2-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
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C28H31FN6O
 1
1
Ki = 11 nM
   TI
   LI
   LO
   TS
CP0126862
1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-4-methylpiperazine
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C24H23FN4
 1
1
Ki = 13 nM
   TI
   LI
   LO
   TS
CP0490676
1-(2-{4-[1-(4-Fluoro-phenyl)-5-pyridin-3-yl-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
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C29H30FN5O
 1
1
Ki = 14 nM
   TI
   LI
   LO
   TS
CP0404715
1-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-tetrazol-5-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
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C26H29FN8O
 1
1
Ki = 20 nM
   TI
   LI
   LO
   TS
CP0429995
1-(2-{4-[1-(4-Fluoro-phenyl)-5-(4-methyl-4H-[1,2,4]triazol-3-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
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C27H30FN7O
 1
1
Ki = 20 nM
   TI
   LI
   LO
   TS
CP0382930
1-(2-{4-[5-(1-Ethyl-1H-[1,2,3]triazol-4-yl)-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
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C28H32FN7O
 1
1
Ki = 28 nM
   TI
   LI
   LO
   TS
CP0392710
1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2H-[1,2,3]triazol-4-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
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C26H28FN7O
 1
1
Ki = 31 nM
   TI
   LI
   LO
   TS
CP0126860
1-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-[1,2,3]triazol-4-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
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C27H30FN7O
 1
1
Ki = 36 nM
   TI
   LI
   LO
   TS
CP0502318
1-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-pyrazol-4-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
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C28H31FN6O
 1
1
Ki = 45 nM
   TI
   LI
   LO
   TS
CP0228798
1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-tetrazol-5-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
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C26H29FN8O
 1
1
Ki = 48 nM
   TI
   LI
   LO
   TS
CP0046703
1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]piperidin-1-yl}ethyl)imidazolidin-2-one
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C24H26ClFN4O
 1
1
Ki = 56 nM
   TI
   LI
   LO
   TS
CP0384143
1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-[1,2,3]triazol-4-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
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C27H30FN7O
 1
1
Ki = 67 nM
   TI
   LI
   LO
   TS
CP0151333
1-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-[1,2,4]triazol-3-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
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C27H30FN7O
 1
1
Ki = 68 nM
   TI
   LI
   LO
   TS
CP0382893
1-(2-{4-[1-(4-Fluoro-phenyl)-5-pyrimidin-2-yl-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
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C28H29FN6O
 1
1
Ki = 76 nM
   TI
   LI
   LO
   TS
CP0320413
3-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-[1,2,4]triazol-3-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-1-methyl-pyrrolidin-2-one
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C29H33FN6O
 1
1
Ki = 100 nM
   TI
   LI
   LO
   TS
CP0277576
1-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-pyrazol-3-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
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C28H31FN6O
 1
1
Ki = 110 nM
   TI
   LI
   LO
   TS
CP0105167
3-{4-[1-(4-Fluoro-phenyl)-5-pyrimidin-2-yl-1H-indol-3-yl]-piperidin-1-yl}-propionitrile
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C26H24FN5
 1
1
Ki = 200 nM
   TI
   LI
   LO
   TS
CP0406243
1-(2-{4-[5-(2-Ethyl-2H-[1,2,3]triazol-4-yl)-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
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C28H32FN7O
 1
1
Ki = 208 nM
   TI
   LI
   LO
   TS
CP0267173
3-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-tetrazol-5-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-oxazolidin-2-one
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C26H28FN7O2
 1
1
Ki = 220 nM
   TI
   LI
   LO
   TS
CP0163622
3-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-[1,2,4]triazol-3-yl)-1H-indol-3-yl]-piperidin-1-yl}-propionitrile
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C25H25FN6
 1
1
Ki = 340 nM
   TI
   LI
   LO
   TS
CP0134581
3-(2-{4-[1-(4-Fluoro-phenyl)-5-pyrimidin-2-yl-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-oxazolidin-2-one
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C28H28FN5O2
 1
1
Ki = 360 nM
   TI
   LI
   LO
   TS
CP0343878
3-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-[1,2,4]triazol-3-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-oxazolidin-2-one
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C27H29FN6O2
 1
1
Ki = 480 nM
   TI
   LI
   LO
   TS
CP0333143
3-(2-{4-[1-(4-Fluoro-phenyl)-5-(1-methyl-1H-[1,2,4]triazol-3-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-1H-quinazoline-2,4-dione
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C32H30FN7O2
 1
1
Ki = 560 nM
   TI
   LI
   LO
   TS
CP0379546
1-methyl-3-(naphthalen-1-ylsulfonyl)-5-(piperazin-1-yl)-1H-indazole
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C22H22N4O2S
 1
1
Ki = 3624 nM
   TI
   LI
   LO
   TS
CP0072419
(SNAP-8719)[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-octahydro-quinoxalin-1-yl]-furan-2-yl-methanone
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C22H28F3N3O2
 1
1
Ki = 7700 nM
   TI
   LI
   LO
   TS
CP0379542
5-(4-Methylpiperazin-1-yl)-3-(1-naphthalenesulfonyl)-1H-indazole
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C22H22N4O2S
 1
1
Ki > 5000 nM
   TI
   LI
   LO
   TS
CP0379544
5-(4-methylpiperazin-1-yl)-3-(phenylsulfonyl)-1H-indazole
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C18H20N4O2S
 1
1
Ki > 5000 nM
   TI
   LI
   LO
   TS
CP0379545
3-(Naphthalen-1-ylsulfonyl)-5-(piperazin-1-yl)-1H-indazole
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C21H20N4O2S
 1
1
Ki > 5000 nM
   TI
   LI
   LO
   TS
CP0379601
1-isopropyl-3-(naphthalen-1-ylsulfonyl)-5-(piperazin-1-yl)-1H-indazole
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C24H26N4O2S
 1
1
Ki > 5000 nM
   TI
   LI
   LO
   TS
CP0406091
1-benzyl-3-(naphthalen-1-ylsulfonyl)-5-(piperazin-1-yl)-1H-indazole
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C28H26N4O2S
 1
1
Ki > 5000 nM
   TI
   LI
   LO
   TS
CP0479094
1-isobutyl-3-(naphthalen-1-ylsulfonyl)-5-(piperazin-1-yl)-1H-indazole
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C25H28N4O2S
 1
1
Ki > 5000 nM
   TI
   LI
   LO
   TS
CP0040814
[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone
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C19H21N5O4
 1
1
Ki > 7700 nM
   TI
   LI
   LO
   TS