| Compound ID |
Compound Name |
Compound Formula |
|
CP0034575
|
4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]-2,5-difluorophenyl]-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one
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|
C27H37F2N7O
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0567512
|
9-(2-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-1,4,9-triazaspiro[5.5]undecan-2-one
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|
C28H36ClN7O
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0574748
|
9-[6-(benzylamino)pyrimidin-4-yl]-4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-1,4,9-triazaspiro[5.5]undecan-2-one
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|
C33H43N7O
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0567513
|
4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]-3-fluorophenyl]-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one
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|
C27H38FN7O
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0578976
|
9-[6-(benzylamino)pyrimidin-4-yl]-4-[6-[(4,4-dimethylpiperidin-1-yl)methyl]pyridin-3-yl]-1,4,9-triazaspiro[5.5]undecan-2-one
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|
C32H42N8O
|
1
|
| 1 |
IC50 = 37 nM
|
|
|
|
CP0488721
|
4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]-2-fluorophenyl]-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one
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|
C27H38FN7O
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0573583
|
4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-9-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,4,9-triazaspiro[5.5]undecan-2-one
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|
C28H37N7O
|
1
|
| 1 |
IC50 = 61 nM
|
|
|
|
CP0567396
|
9-[6-(cyclopropylamino)pyrimidin-4-yl]-4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-1,4,9-triazaspiro[5.5]undecan-2-one
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|
C29H41N7O
|
1
|
| 1 |
IC50 = 84 nM
|
|
|
|
CP0572954
|
4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one
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|
C27H39N7O
|
1
|
| 1 |
IC50 = 89 nM
|
|
|
|
CP0562025
|
N-benzyl-6-[4-[6-[(4,4-dimethylpiperidin-1-yl)methyl]pyridin-3-yl]-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]pyrimidin-4-amine
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|
C32H43N7O
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0574893
|
4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-9-[6-(propan-2-ylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one
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|
C29H43N7O
|
1
|
| 1 |
IC50 = 330 nM
|
|
|
|
CP0562026
|
8-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-2-[6-(methylamino)pyrimidin-4-yl]-2,5,8-triazaspiro[3.5]nonan-6-one
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|
C25H35N7O
|
1
|
| 1 |
IC50 = 440 nM
|
|
|
|
CP0011023
|
AdoHcy
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|
C14H20N6O5S
|
1
|
| 1 |
IC50 = 590 nM
|
|
|
|
CP0562024
|
1-[6-(benzylamino)pyrimidin-4-yl]-4-[[[6-[(4,4-dimethylpiperidin-1-yl)methyl]pyridin-3-yl]amino]methyl]piperidin-4-ol
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|
C30H41N7O
|
1
|
| 1 |
IC50 = 790 nM
|
|
|
|
CP0574355
|
9-[6-(dimethylamino)pyrimidin-4-yl]-4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-1,4,9-triazaspiro[5.5]undecan-2-one
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|
C28H41N7O
|
1
|
| 1 |
IC50 = 970 nM
|
|
|
|
CP0562027
|
4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-1-methyl-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one
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|
C28H41N7O
|
1
|
| 1 |
IC50 = 1500 nM
|
|
|
|
CP0567395
|
3-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-8-[6-(methylamino)pyrimidin-4-yl]-1,3,8-triazaspiro[4.5]decan-2-one
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|
C26H37N7O
|
1
|
| 1 |
IC50 = 1800 nM
|
|
|
|
CP0574892
|
N-[1-[6-(benzylamino)pyrimidin-4-yl]piperidin-4-yl]-6-[(4,4-dimethylpiperidin-1-yl)methyl]pyridine-3-carboxamide
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|
C30H39N7O
|
1
|
| 1 |
IC50 = 3600 nM
|
|
|
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CP0572955
|
4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-9-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1,4,9-triazaspiro[5.5]undecan-2-one
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|
C29H38N6O
|
1
|
| 1 |
IC50 = 4500 nM
|
|
|
|
CP0576670
|
4-[[[5-[(4,4-dimethylpiperidin-1-yl)methyl]pyridin-2-yl]amino]methyl]-1-[6-(methylamino)pyrimidin-4-yl]piperidin-4-ol
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|
C24H37N7O
|
1
|
| 1 |
IC50 = 4600 nM
|
|
|
|
CP0547124
|
4-[[4-[(4,4-dimethylpiperidin-1-yl)methyl]anilino]methyl]-1-[6-(methylamino)pyrimidin-4-yl]piperidin-4-ol
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|
C25H38N6O
|
1
|
| 1 |
IC50 = 5000 nM
|
|
|
|
CP0571969
|
4-[[[6-[(4,4-dimethylpiperidin-1-yl)methyl]pyridin-3-yl]amino]methyl]-1-[6-(methylamino)pyrimidin-4-yl]piperidin-4-ol
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|
C24H37N7O
|
1
|
| 1 |
IC50 = 5800 nM
|
|
|
|
CP0577038
|
4-[(4,4-dimethylpiperidin-1-yl)methyl]-N-[[3-hydroxy-1-[6-(methylamino)pyrimidin-4-yl]piperidin-3-yl]methyl]benzamide
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|
C26H38N6O2
|
1
|
| 1 |
IC50 = 7000 nM
|
|
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