| Compound ID |
Compound Name |
Compound Formula |
|
CP0541840
|
US8829200, 3
Show/Hide
|
C27H25N7O
|
1
|
| 1 |
IC50 = 0.91 nM
|
|
|
|
CP0417387
|
3-[4-[3-[1-[4-(2-aminopyrimidin-5-yl)phenyl]cyclobutyl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]propanenitrile
Show/Hide
|
C22H20N8O
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0475862
|
2-[4-[3-[1-[4-(2-aminopyrimidin-5-yl)phenyl]cyclobutyl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]-N-tert-butyl-N-methylacetamide
Show/Hide
|
C26H30N8O2
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0444934
|
2-[4-[3-[(1R)-1-[4-(6-aminopyridin-3-yl)phenyl]-1-cyclopropylethyl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]-N,N-dimethylacetamide
Show/Hide
|
C25H27N7O2
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
|
CP0302590
|
2-[4-[3-[(1R)-1-[4-(5-aminopyrazin-2-yl)phenyl]-1-cyclopropylethyl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]-N,N-dimethylacetamide
Show/Hide
|
C24H26N8O2
|
1
|
| 1 |
IC50 = 1.2 nM
|
|
|
|
CP0326561
|
5-[4-[(1R)-1-cyclopropyl-1-[5-(1-methylpyrazol-4-yl)-1,2,4-oxadiazol-3-yl]ethyl]phenyl]pyrimidin-2-amine
Show/Hide
|
C21H21N7O
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
|
CP0335417
|
5-[4-[1-(5-phenyl-1,2,4-oxadiazol-3-yl)cyclobutyl]phenyl]pyrimidin-2-amine
Show/Hide
|
C22H19N5O
|
1
|
| 1 |
IC50 = 1.4 nM
|
|
|
|
CP0569092
|
US8829200, 22
Show/Hide
|
C27H25N7O
|
1
|
| 1 |
IC50 = 1.5 nM
|
|
|
|
CP0315670
|
5-[5-[(1R)-1-cyclopropyl-1-[5-[1-(oxetan-3-yl)pyrazol-4-yl]-1,2,4-oxadiazol-3-yl]ethyl]pyridin-2-yl]pyrimidin-2-amine
Show/Hide
|
C22H22N8O2
|
1
|
| 1 |
IC50 = 1.5 nM
|
|
|
|
CP0302589
|
5-[4-[(2R)-3-methyl-2-[5-(1-methylpyrazol-4-yl)-1,2,4-oxadiazol-3-yl]butan-2-yl]phenyl]pyrimidin-2-amine
Show/Hide
|
C21H23N7O
|
1
|
| 1 |
IC50 = 1.6 nM
|
|
|
|
CP0029907
|
2-[4-[3-[(1R)-1-[4-(2-aminopyrimidin-5-yl)phenyl]-1-cyclopropylethyl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]-N,N-dimethylacetamide
Show/Hide
|
C24H26N8O2
|
1
|
| 1 |
IC50 = 1.7 nM
|
|
|
|
CP0369521
|
5-[4-[1-[5-(1-methylpyrazol-4-yl)-1,2,4-oxadiazol-3-yl]cyclobutyl]phenyl]pyrimidin-2-amine
Show/Hide
|
C20H19N7O
|
1
|
| 1 |
IC50 = 1.9 nM
|
|
|
|
CP0271149
|
5-[4-[1-[5-[1-(oxetan-3-yl)pyrazol-4-yl]-1,2,4-oxadiazol-3-yl]cyclobutyl]phenyl]pyrimidin-2-amine
Show/Hide
|
C22H21N7O2
|
1
|
| 1 |
IC50 = 1.9 nM
|
|
|
|
CP0350128
|
5-[4-[3-methyl-2-[5-(1-methylpyrazol-4-yl)-1,2,4-oxadiazol-3-yl]butan-2-yl]phenyl]pyrimidin-2-amine
Show/Hide
|
C21H23N7O
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0199283
|
1-[4-[3-[(1R)-1-[4-(2-aminopyrimidin-5-yl)phenyl]-1-cyclopropylethyl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]-2-methylpropan-2-ol
Show/Hide
|
C24H27N7O2
|
1
|
| 1 |
IC50 = 2.1 nM
|
|
|
|
CP0508024
|
5-[4-[1-(5-pyridin-3-yl-1,2,4-oxadiazol-3-yl)cyclobutyl]phenyl]pyrimidin-2-amine
Show/Hide
|
C21H18N6O
|
1
|
| 1 |
IC50 = 2.2 nM
|
|
|
|
CP0551611
|
US8829200, 20
Show/Hide
|
C27H25N7O
|
1
|
| 1 |
IC50 = 2.2 nM
|
|
|
|
CP0316800
|
5-[4-[1-[5-(1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl]cyclobutyl]phenyl]pyrimidin-2-amine
Show/Hide
|
C19H17N7O
|
1
|
| 1 |
IC50 = 2.3 nM
|
|
|
|
CP0238791
|
5-[4-[1-[5-(1H-pyrazol-5-yl)-1,2,4-oxadiazol-3-yl]cyclobutyl]phenyl]pyrimidin-2-amine
Show/Hide
|
C19H17N7O
|
1
|
| 1 |
IC50 = 2.4 nM
|
|
|
|
CP0302588
|
5-[4-[1-[5-[1-(2-methoxyethyl)pyrazol-4-yl]-1,2,4-oxadiazol-3-yl]cyclobutyl]phenyl]pyrimidin-2-amine
Show/Hide
|
C22H23N7O2
|
1
|
| 1 |
IC50 = 2.4 nM
|
|
|
|
CP0324941
|
5-[4-[1-[5-(1,3-thiazol-4-yl)-1,2,4-oxadiazol-3-yl]cyclobutyl]phenyl]pyrimidin-2-amine
Show/Hide
|
C19H16N6OS
|
1
|
| 1 |
IC50 = 2.4 nM
|
|
|
|
CP0369520
|
5-[4-[1-[5-(5-methyl-1H-pyrazol-3-yl)-1,2,4-oxadiazol-3-yl]cyclobutyl]phenyl]pyrimidin-2-amine
Show/Hide
|
C20H19N7O
|
1
|
| 1 |
IC50 = 2.4 nM
|
|
|
|
CP0338909
|
5-[4-[1-[5-(1H-imidazol-5-yl)-1,2,4-oxadiazol-3-yl]cyclobutyl]phenyl]pyrimidin-2-amine
Show/Hide
|
C19H17N7O
|
1
|
| 1 |
IC50 = 2.5 nM
|
|
|
|
CP0177304
|
5-[4-[(1R)-1-cyclobutyl-1-[5-(1-methylpyrazol-4-yl)-1,2,4-oxadiazol-3-yl]ethyl]phenyl]pyrimidin-2-amine
Show/Hide
|
C22H23N7O
|
1
|
| 1 |
IC50 = 2.6 nM
|
|
|
|
CP0566683
|
5-[4-[1-[5-[1-(2-aminoethyl)pyrazol-4-yl]-1,2,4-oxadiazol-3-yl]cyclobutyl]phenyl]pyrimidin-2-amine
Show/Hide
|
C21H22N8O
|
1
|
| 1 |
IC50 = 2.6 nM
|
|
|
|
CP0177300
|
3-[3-[1-[4-(2-aminopyrimidin-5-yl)phenyl]cyclobutyl]-1,2,4-oxadiazol-5-yl]-1H-pyridin-2-one
Show/Hide
|
C21H18N6O2
|
1
|
| 1 |
IC50 = 2.9 nM
|
|
|
|
CP0499953
|
2-[4-[3-[(1R)-1-cyclopropyl-1-[4-[2-(methylamino)pyrimidin-5-yl]phenyl]ethyl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]-N,N-dimethylacetamide
Show/Hide
|
C25H28N8O2
|
1
|
| 1 |
IC50 = 2.9 nM
|
|
|
|
CP0239440
|
2-[4-[3-[(1R)-1-[6-(2-aminopyrimidin-5-yl)pyridin-3-yl]-1-cyclopropylethyl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]-N,N-dimethylacetamide
Show/Hide
|
C23H25N9O2
|
1
|
| 1 |
IC50 = 2.9 nM
|
|
|
|
CP0370073
|
5-[5-[(1R)-1-cyclopropyl-1-[5-(1-methylpyrazol-4-yl)-1,2,4-oxadiazol-3-yl]ethyl]pyridin-2-yl]pyrimidin-2-amine
Show/Hide
|
C20H20N8O
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0183149
|
5-[4-[(1R)-1-cyclopropyl-1-[5-[1-[2-(dimethylamino)ethyl]pyrazol-4-yl]-1,2,4-oxadiazol-3-yl]ethyl]phenyl]pyrimidin-2-amine
Show/Hide
|
C24H28N8O
|
1
|
| 1 |
IC50 = 3.1 nM
|
|
|
|
CP0261517
|
1-[3-[(2R)-2-[4-(2-aminopyrimidin-5-yl)phenyl]-3-methylbutan-2-yl]-1,2,4-oxadiazol-5-yl]-4-methylpiperidin-4-ol
Show/Hide
|
C23H30N6O2
|
1
|
| 1 |
IC50 = 3.1 nM
|
|
|
|
CP0544693
|
US8772304, 22
Show/Hide
|
C22H20ClN9
|
1
|
| 1 |
IC50 = 3.2 nM
|
|
|
|
CP0127412
|
1-[4-[3-[1-[4-(2-aminopyrimidin-5-yl)phenyl]cyclobutyl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]-2-methylpropan-2-ol
Show/Hide
|
C23H25N7O2
|
1
|
| 1 |
IC50 = 3.5 nM
|
|
|
|
CP0245531
|
5-[4-[1-[5-[1-[2-(dimethylamino)ethyl]pyrazol-4-yl]-1,2,4-oxadiazol-3-yl]cyclobutyl]phenyl]pyrimidin-2-amine
Show/Hide
|
C23H26N8O
|
1
|
| 1 |
IC50 = 3.6 nM
|
|
|
|
CP0324942
|
2-[4-[3-[1-[4-(2-aminopyrimidin-5-yl)phenyl]cyclobutyl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]-N,N-dimethylacetamide
Show/Hide
|
C23H24N8O2
|
1
|
| 1 |
IC50 = 3.6 nM
|
|
|
|
CP0127411
|
2-[4-[3-[1-[4-(2-aminopyrimidin-5-yl)phenyl]cyclobutyl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]-N-tert-butylacetamide
Show/Hide
|
C25H28N8O2
|
1
|
| 1 |
IC50 = 3.7 nM
|
|
|
|
CP0521682
|
US8772304, 23
Show/Hide
|
C22H20BrN9
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0541502
|
2-[4-[3-[1-[4-(2-aminopyrimidin-5-yl)phenyl]cyclobutyl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]-2-methylpropan-1-ol
Show/Hide
|
C23H25N7O2
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0521234
|
US8772304, 2
Show/Hide
|
C24H22N10
|
1
|
| 1 |
IC50 = 4.2 nM
|
|
|
|
CP0556148
|
5-[4-[1-[5-(2H-triazol-4-yl)-1,2,4-oxadiazol-3-yl]cyclobutyl]phenyl]pyrimidin-2-amine
Show/Hide
|
C18H16N8O
|
1
|
| 1 |
IC50 = 4.7 nM
|
|
|
|
CP0578726
|
US8829200, 6
Show/Hide
|
C23H23FN6O
|
1
|
| 1 |
IC50 = 5.07 nM
|
|
|
|
CP0237378
|
1-[3-[(1R)-1-[4-(2-aminopyrimidin-5-yl)phenyl]-1-cyclopropylethyl]-1,2,4-oxadiazol-5-yl]piperidin-4-ol
Show/Hide
|
C22H26N6O2
|
1
|
| 1 |
IC50 = 5.2 nM
|
|
|
|
CP0086097
|
US8575201, 80
Show/Hide
|
C19H18N8O
|
1
|
| 1 |
IC50 = 5.5 nM
|
|
|
|
CP0548820
|
1-[3-[(1R)-1-[4-(2-aminopyrimidin-5-yl)phenyl]-1-cyclopropylethyl]-1,2,4-oxadiazol-5-yl]-4-methylpiperidin-4-ol
Show/Hide
|
C23H28N6O2
|
1
|
| 1 |
IC50 = 5.6 nM
|
|
|
|
CP0324939
|
5-[4-[1-(5-pyrazin-2-yl-1,2,4-oxadiazol-3-yl)cyclobutyl]phenyl]pyrimidin-2-amine
Show/Hide
|
C20H17N7O
|
1
|
| 1 |
IC50 = 5.7 nM
|
|
|
|
CP0569779
|
US8772304, 3
Show/Hide
|
C24H22N10
|
1
|
| 1 |
IC50 = 5.9 nM
|
|
|
|
CP0324940
|
5-[4-[1-(5-pyrimidin-5-yl-1,2,4-oxadiazol-3-yl)cyclobutyl]phenyl]pyrimidin-2-amine
Show/Hide
|
C20H17N7O
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0506917
|
US8829200, 10
Show/Hide
|
C24H20N8O
|
1
|
| 1 |
IC50 = 6.09 nM
|
|
|
|
CP0177302
|
5-[4-[2-methyl-1-[5-(1-methylpyrazol-4-yl)-1,2,4-oxadiazol-3-yl]propyl]phenyl]pyrimidin-2-amine
Show/Hide
|
C20H21N7O
|
1
|
| 1 |
IC50 = 6.2 nM
|
|
|
|
CP0367367
|
5-[4-[1-(5-pyridazin-4-yl-1,2,4-oxadiazol-3-yl)cyclobutyl]phenyl]pyrimidin-2-amine
Show/Hide
|
C20H17N7O
|
1
|
| 1 |
IC50 = 6.2 nM
|
|
|
|
CP0370075
|
1-[4-[3-[(1R)-1-[6-(2-aminopyrimidin-5-yl)pyridin-3-yl]-1-cyclopropylethyl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]-2-methylpropan-2-ol
Show/Hide
|
C23H26N8O2
|
1
|
| 1 |
IC50 = 6.3 nM
|
|
|
|
CP0082982
|
5-[4-[1-(5-piperidin-1-yl-1,2,4-oxadiazol-3-yl)cyclobutyl]phenyl]pyrimidin-2-amine
Show/Hide
|
C21H24N6O
|
1
|
| 1 |
IC50 = 6.5 nM
|
|
|
|
CP0239441
|
5-[5-[(2R)-3-methyl-2-[5-[1-(oxetan-3-yl)pyrazol-4-yl]-1,2,4-oxadiazol-3-yl]butan-2-yl]pyridin-2-yl]pyrimidin-2-amine
Show/Hide
|
C22H24N8O2
|
1
|
| 1 |
IC50 = 6.6 nM
|
|
|
|
CP0324943
|
5-[4-[2-[5-(1-methylpyrazol-4-yl)-1,2,4-oxadiazol-3-yl]propan-2-yl]phenyl]pyrimidin-2-amine
Show/Hide
|
C19H19N7O
|
1
|
| 1 |
IC50 = 6.7 nM
|
|
|
|
CP0541829
|
US8772304, 1
Show/Hide
|
C23H20N10
|
1
|
| 1 |
IC50 = 7.1 nM
|
|
|
|
CP0082986
|
1-[3-[(2R)-2-[4-(2-aminopyrimidin-5-yl)phenyl]-3-methylbutan-2-yl]-1,2,4-oxadiazol-5-yl]piperidin-4-ol
Show/Hide
|
C22H28N6O2
|
1
|
| 1 |
IC50 = 7.3 nM
|
|
|
|
CP0554338
|
US8829200, 8
Show/Hide
|
C24H23N7O
|
1
|
| 1 |
IC50 = 7.4 nM
|
|
|
|
CP0326560
|
5-[4-[(2S)-3-methyl-2-[5-(1-methylpyrazol-4-yl)-1,2,4-oxadiazol-3-yl]butan-2-yl]phenyl]pyrimidin-2-amine
Show/Hide
|
C21H23N7O
|
1
|
| 1 |
IC50 = 7.7 nM
|
|
|
|
CP0556268
|
5-[4-[1-[5-(1,3-oxazol-4-yl)-1,2,4-oxadiazol-3-yl]cyclobutyl]phenyl]pyrimidin-2-amine
Show/Hide
|
C19H16N6O2
|
1
|
| 1 |
IC50 = 8.1 nM
|
|
|
|
CP0127452
|
2-[4-[3-[(1R)-1-[6-(2-aminopyrimidin-5-yl)pyridin-3-yl]-1-cyclopropylethyl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]acetonitrile
Show/Hide
|
C21H19N9O
|
1
|
| 1 |
IC50 = 8.1 nM
|
|
|
|
CP0568938
|
5-[4-[1-(5-pyrrolidin-1-yl-1,2,4-oxadiazol-3-yl)cyclobutyl]phenyl]pyrimidin-2-amine
Show/Hide
|
C20H22N6O
|
1
|
| 1 |
IC50 = 8.3 nM
|
|
|
|
CP0566684
|
5-[4-[1-(5-pyridazin-3-yl-1,2,4-oxadiazol-3-yl)cyclobutyl]phenyl]pyrimidin-2-amine
Show/Hide
|
C20H17N7O
|
1
|
| 1 |
IC50 = 8.5 nM
|
|
|
|
CP0129226
|
US8575201, 63
Show/Hide
|
C20H20N8O
|
1
|
| 1 |
IC50 = 8.8 nM
|
|
|
|
CP0550318
|
US8772304, 26
Show/Hide
|
C23H20N10
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0326542
|
3-[1-[4-(2-aminopyrimidin-5-yl)phenyl]cyclobutyl]-N-ethyl-1,2,4-oxadiazol-5-amine
Show/Hide
|
C18H20N6O
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0408352
|
3-[4-[3-[1-[6-(2-aminopyrimidin-5-yl)pyridin-3-yl]cyclobutyl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]propanenitrile
Show/Hide
|
C21H19N9O
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0569090
|
US8829200, 4
Show/Hide
|
C23H24N6O
|
1
|
| 1 |
IC50 = 11.4 nM
|
|
|
|
CP0550317
|
US8772304, 25
Show/Hide
|
C23H23N9
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0489154
|
4-[3-[(1R)-1-[4-(2-aminopyrimidin-5-yl)phenyl]-1-cyclopropylethyl]-1,2,4-oxadiazol-5-yl]-N,N-dimethylpiperazine-1-carboxamide
Show/Hide
|
C24H30N8O2
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0283785
|
5-[4-[1-[5-(1H-1,2,4-triazol-5-yl)-1,2,4-oxadiazol-3-yl]cyclobutyl]phenyl]pyrimidin-2-amine
Show/Hide
|
C18H16N8O
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0379996
|
US8772304, 4
Show/Hide
|
C25H25N9
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0110933
|
US8575201, 55
Show/Hide
|
C21H20N8O2
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0271141
|
US8575201, 102
Show/Hide
|
C19H18N8O
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0541241
|
1-[4-[3-[(2R)-2-[6-(2-aminopyrimidin-5-yl)pyridin-3-yl]-3-methylbutan-2-yl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]-2-methylpropan-2-ol
Show/Hide
|
C23H28N8O2
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0177299
|
5-[4-[1-(5-pyrimidin-4-yl-1,2,4-oxadiazol-3-yl)cyclobutyl]phenyl]pyrimidin-2-amine
Show/Hide
|
C20H17N7O
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0175132
|
US8575201, 144
Show/Hide
|
C24H27N9O2
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0175191
|
US8575201, 143
Show/Hide
|
C25H29N9O2
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0569091
|
US8829200, 21
Show/Hide
|
C26H30N6O
|
1
|
| 1 |
IC50 = 14.7 nM
|
|
|
|
CP0545673
|
US8829200, 34
Show/Hide
|
C23H23FN6O
|
1
|
| 1 |
IC50 = 15.8 nM
|
|
|
|
CP0364379
|
1-[3-[(1R)-1-[4-(2-aminopyrimidin-5-yl)phenyl]-1-cyclopropylethyl]-1,2,4-oxadiazol-5-yl]-3-methylazetidin-3-ol
Show/Hide
|
C21H24N6O2
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0370074
|
5-[5-[(2R)-3-methyl-2-[5-(1-methylpyrazol-4-yl)-1,2,4-oxadiazol-3-yl]butan-2-yl]pyridin-2-yl]pyrimidin-2-amine
Show/Hide
|
C20H22N8O
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0414825
|
US8772304, 28
Show/Hide
|
C23H23N9
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0271150
|
1-[3-[1-[4-(2-aminopyrimidin-5-yl)phenyl]cyclobutyl]-1,2,4-oxadiazol-5-yl]-4-methylpiperidin-4-ol
Show/Hide
|
C22H26N6O2
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0343152
|
US8575201, 28
Show/Hide
|
C21H22N8O2
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0556564
|
US8829200, 23
Show/Hide
|
C24H26N6O
|
1
|
| 1 |
IC50 = 17.4 nM
|
|
|
|
CP0177301
|
2-[4-[3-[1-[4-(2-aminopyrimidin-5-yl)phenyl]cyclobutyl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]acetic acid
Show/Hide
|
C21H19N7O3
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0177303
|
5-[4-[(1S)-1-cyclopropyl-1-[5-(1-methylpyrazol-4-yl)-1,2,4-oxadiazol-3-yl]ethyl]phenyl]pyrimidin-2-amine
Show/Hide
|
C21H21N7O
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0082984
|
1-[3-[1-[4-(2-aminopyrimidin-5-yl)phenyl]cyclobutyl]-1,2,4-oxadiazol-5-yl]piperidin-4-ol
Show/Hide
|
C21H24N6O2
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0179823
|
US8575201, 151
Show/Hide
|
C22H21N9O
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0402718
|
US8829200, 18
Show/Hide
|
C27H30N6O2
|
1
|
| 1 |
IC50 = 18.8 nM
|
|
|
|
CP0535873
|
US8772304, 20
Show/Hide
|
C22H21N9
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0302587
|
3-[1-[4-(2-aminopyrimidin-5-yl)phenyl]cyclobutyl]-1,2,4-oxadiazol-5-amine
Show/Hide
|
C16H16N6O
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0535875
|
US8772304, 21
Show/Hide
|
C22H20FN9
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0554340
|
US8829200, 33
Show/Hide
|
C23H23FN6O
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0110071
|
3-[1-[4-(2-aminopyrimidin-5-yl)phenyl]cyclobutyl]-N,N-dimethyl-1,2,4-oxadiazol-5-amine
Show/Hide
|
C18H20N6O
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0461522
|
US8829200, 7
Show/Hide
|
C24H26N6O2
|
1
|
| 1 |
IC50 = 21.9 nM
|
|
|
|
CP0543810
|
US8829200, 17
Show/Hide
|
C23H23N5O2
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0544694
|
US8772304, 24
Show/Hide
|
C23H23N9
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0544695
|
US8772304, 27
Show/Hide
|
C23H22BrN9
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0315671
|
2-[4-[3-[(2R)-2-[6-(2-aminopyrimidin-5-yl)pyridin-3-yl]-3-methylbutan-2-yl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]acetonitrile
Show/Hide
|
C21H21N9O
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0545672
|
US8829200, 2
Show/Hide
|
C25H26N6O
|
1
|
| 1 |
IC50 = 25.2 nM
|
|
|
|
CP0237377
|
US8575201, 54
Show/Hide
|
C22H24N8O2
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0550157
|
US8772304, 5
Show/Hide
|
C25H22N10
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0271151
|
3-[(1R)-1-[4-(2-aminopyrimidin-5-yl)phenyl]-1-cyclopropylethyl]-N-methyl-N-(1-methylpyrazol-4-yl)-1,2,4-oxadiazol-5-amine
Show/Hide
|
C22H24N8O
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0175129
|
US8575201, 30
Show/Hide
|
C22H24N8O2
|
1
|
| 1 |
IC50 = 33 nM
|
|
|
|
CP0460031
|
US8772304, 33
Show/Hide
|
C22H24N6O
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0578728
|
US8829200, 26
Show/Hide
|
C25H28N6O
|
1
|
| 1 |
IC50 = 34.6 nM
|
|
|
|
CP0350126
|
5-[4-[3,3-dimethyl-1-[5-(1-methylpyrazol-4-yl)-1,2,4-oxadiazol-3-yl]cyclobutyl]phenyl]pyrimidin-2-amine
Show/Hide
|
C22H23N7O
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0461523
|
US8829200, 14
Show/Hide
|
C22H22N6O
|
1
|
| 1 |
IC50 = 35.4 nM
|
|
|
|
CP0568937
|
(3S)-1-[3-[1-[4-(2-aminopyrimidin-5-yl)phenyl]cyclobutyl]-1,2,4-oxadiazol-5-yl]pyrrolidin-3-ol
Show/Hide
|
C20H22N6O2
|
1
|
| 1 |
IC50 = 36 nM
|
|
|
|
CP0237376
|
US8575201, 133
Show/Hide
|
C19H18N8O
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0402399
|
US8829200, 19
Show/Hide
|
C25H28N6O2
|
1
|
| 1 |
IC50 = 43.8 nM
|
|
|
|
CP0526525
|
US8772304, 11
Show/Hide
|
C21H22N6O
|
1
|
| 1 |
IC50 = 46 nM
|
|
|
|
CP0370071
|
[1-[3-[1-[4-(2-aminopyrimidin-5-yl)phenyl]cyclobutyl]-1,2,4-oxadiazol-5-yl]piperidin-4-yl]methanol
Show/Hide
|
C22H26N6O2
|
1
|
| 1 |
IC50 = 46 nM
|
|
|
|
CP0463371
|
5-[4-[1-[5-(4-propan-2-yloxypiperidin-1-yl)-1,2,4-oxadiazol-3-yl]cyclobutyl]phenyl]pyrimidin-2-amine
Show/Hide
|
C24H30N6O2
|
1
|
| 1 |
IC50 = 48 nM
|
|
|
|
CP0551368
|
US8772304, 13
Show/Hide
|
C24H28N6O
|
1
|
| 1 |
IC50 = 51 nM
|
|
|
|
CP0127415
|
1-[4-[3-[(1R)-1-[4-(2-aminopyrimidin-5-yl)phenyl]-1-cyclopropylethyl]-1,2,4-oxadiazol-5-yl]piperazin-1-yl]-2-methylpropan-2-ol
Show/Hide
|
C25H33N7O2
|
1
|
| 1 |
IC50 = 53 nM
|
|
|
|
CP0083001
|
2-[4-[3-[(2R)-2-[6-(2-aminopyrimidin-5-yl)pyridin-3-yl]-3-methylbutan-2-yl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]-N,N-dimethylacetamide
Show/Hide
|
C23H27N9O2
|
1
|
| 1 |
IC50 = 54 nM
|
|
|
|
CP0402397
|
US8829200, 11
Show/Hide
|
C24H23N7O3S
|
1
|
| 1 |
IC50 = 55.6 nM
|
|
|
|
CP0412709
|
US8772304, 17
Show/Hide
|
C21H21FN6O
|
1
|
| 1 |
IC50 = 58 nM
|
|
|
|
CP0237477
|
US8575201, 134
Show/Hide
|
C19H18N8O
|
1
|
| 1 |
IC50 = 81 nM
|
|
|
|
CP0521235
|
US8772304, 6
Show/Hide
|
C25H22N10
|
1
|
| 1 |
IC50 = 86 nM
|
|
|
|
CP0085835
|
US8575201, 76
Show/Hide
|
C19H21N7O
|
1
|
| 1 |
IC50 = 92 nM
|
|
|
|
CP0389228
|
5-[4-[1-[5-[4-(oxolan-2-ylmethyl)piperazin-1-yl]-1,2,4-oxadiazol-3-yl]cyclobutyl]phenyl]pyrimidin-2-amine
Show/Hide
|
C25H31N7O2
|
1
|
| 1 |
IC50 = 92 nM
|
|
|
|
CP0475867
|
1-[3-[(1R)-1-[6-(2-aminopyrimidin-5-yl)pyridin-3-yl]-1-cyclopropylethyl]-1,2,4-oxadiazol-5-yl]-4-methylpiperidin-4-ol
Show/Hide
|
C22H27N7O2
|
1
|
| 1 |
IC50 = 97 nM
|
|
|
|
CP0514453
|
5-[4-[1-[5-(1-methylpyrazol-4-yl)-1,2,4-oxadiazol-3-yl]cyclopropyl]phenyl]pyrimidin-2-amine
Show/Hide
|
C19H17N7O
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0412704
|
US8772304, 9
Show/Hide
|
C23H21N7O2
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0549284
|
US8829200, 9
Show/Hide
|
C24H24N10O
|
1
|
| 1 |
IC50 = 110.9 nM
|
|
|
|
CP0526524
|
US8772304, 10
Show/Hide
|
C23H22N8O
|
1
|
| 1 |
IC50 = 138 nM
|
|
|
|
CP0514450
|
5-[4-[(1S)-1-cyclobutyl-1-[5-(1-methylpyrazol-4-yl)-1,2,4-oxadiazol-3-yl]ethyl]phenyl]pyrimidin-2-amine
Show/Hide
|
C22H23N7O
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0402719
|
US8829200, 24
Show/Hide
|
C26H31N7O
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0370070
|
1-[3-[1-[4-(2-aminopyrimidin-5-yl)phenyl]cyclobutyl]-1,2,4-oxadiazol-5-yl]azetidin-3-ol
Show/Hide
|
C19H20N6O2
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
|
CP0110937
|
US8575201, 154
Show/Hide
|
C20H23N7O2
|
1
|
| 1 |
IC50 = 173 nM
|
|
|
|
CP0521285
|
US8772304, 30
Show/Hide
|
C24H27N7O
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0569093
|
US8829200, 27
Show/Hide
|
C28H27N7O
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0541842
|
US8829200, 29
Show/Hide
|
C24H26N6O
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0462934
|
US8772304, 32
Show/Hide
|
C21H22N6O
|
1
|
| 1 |
IC50 = 220 nM
|
|
|
|
CP0402398
|
US8829200, 15
Show/Hide
|
C22H20FN5O2
|
1
|
| 1 |
IC50 = 220 nM
|
|
|
|
CP0550316
|
US8772304, 19
Show/Hide
|
C20H19BrN6
|
1
|
| 1 |
IC50 = 270 nM
|
|
|
|
CP0544692
|
US8772304, 14
Show/Hide
|
C20H19FN6
|
1
|
| 1 |
IC50 = 279 nM
|
|
|
|
CP0370072
|
US8575201, 15
Show/Hide
|
C17H19N7O
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0517950
|
US8772304, 29
Show/Hide
|
C21H22N6O
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0110935
|
5-[4-[1-(5-piperazin-1-yl-1,2,4-oxadiazol-3-yl)cyclobutyl]phenyl]pyrimidin-2-amine
Show/Hide
|
C20H23N7O
|
1
|
| 1 |
IC50 = 324 nM
|
|
|
|
CP0508025
|
N-[3-[1-[4-(2-aminopyrimidin-5-yl)phenyl]cyclobutyl]-1,2,4-oxadiazol-5-yl]methanesulfonamide
Show/Hide
|
C17H18N6O3S
|
1
|
| 1 |
IC50 = 340 nM
|
|
|
|
CP0245532
|
2-[4-[3-[1-cyclopropyl-1-[4-[2-(ethylamino)pyrimidin-5-yl]phenyl]ethyl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]-N,N-dimethylacetamide
Show/Hide
|
C26H30N8O2
|
1
|
| 1 |
IC50 = 370 nM
|
|
|
|
CP0408841
|
1-[3-[(1R)-1-[6-(2-aminopyrimidin-5-yl)pyridin-3-yl]-1-cyclopropylethyl]-1,2,4-oxadiazol-5-yl]piperidin-4-ol
Show/Hide
|
C21H25N7O2
|
1
|
| 1 |
IC50 = 434 nM
|
|
|
|
CP0550315
|
US8772304, 18
Show/Hide
|
C20H20N6
|
1
|
| 1 |
IC50 = 450 nM
|
|
|
|
CP0541841
|
US8829200, 25
Show/Hide
|
C27H31N7O
|
1
|
| 1 |
IC50 = 460 nM
|
|
|
|
CP0554339
|
US8829200, 28
Show/Hide
|
C26H28N6O2
|
1
|
| 1 |
IC50 = 520 nM
|
|
|
|
CP0535604
|
US8772304, 7
Show/Hide
|
C22H22N6O2
|
1
|
| 1 |
IC50 = 540 nM
|
|
|
|
CP0521236
|
US8772304, 31
Show/Hide
|
C20H20N6
|
1
|
| 1 |
IC50 = 542 nM
|
|
|
|
CP0412746
|
US8829200, 12
Show/Hide
|
C24H25FN6O
|
1
|
| 1 |
IC50 = 610 nM
|
|
|
|
CP0412544
|
US8772304, 8
Show/Hide
|
C22H23N7O
|
1
|
| 1 |
IC50 = 620 nM
|
|
|
|
CP0578727
|
US8829200, 16
Show/Hide
|
C22H21N5O2
|
1
|
| 1 |
IC50 = 644.9 nM
|
|
|
|
CP0550158
|
US8772304, 12
Show/Hide
|
C20H20N6
|
1
|
| 1 |
IC50 = 700 nM
|
|
|
|
CP0412707
|
US8772304, 15
Show/Hide
|
C26H23F2N7
|
1
|
| 1 |
IC50 = 870 nM
|
|
|
|
CP0412708
|
US8772304, 16
Show/Hide
|
C21H22N6O
|
1
|
| 1 |
IC50 = 960 nM
|
|
|
|
CP0450119
|
US8829200, 1
Show/Hide
|
C22H21N5O2
|
1
|
| 1 |
IC50 = 1400 nM
|
|
|
|
CP0541843
|
US8829200, 35
Show/Hide
|
C24H24N4O2
|
1
|
| 1 |
IC50 = 4700 nM
|
|
|
|
CP0350129
|
2-[4-[3-[(1R)-1-cyclopropyl-1-[4-[2-(propan-2-ylamino)pyrimidin-5-yl]phenyl]ethyl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]-N,N-dimethylacetamide
Show/Hide
|
C27H32N8O2
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0519040
|
5-[4-[[5-(1-methylpyrazol-4-yl)-1,2,4-oxadiazol-3-yl]methyl]phenyl]pyrimidin-2-amine
Show/Hide
|
C17H15N7O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
