Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT06663 , G-protein coupled receptor 4
 Protein Info 
Gene Name GPR4
Organism Rattus norvegicus, Rat
Protein Classification Membrane receptor
Uniprot ID Q4KLH9
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006
 Cell Line Info 
 Protein ID: PT06663
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0456411
 Compound Info 
1-[2-[1-[4-[[2,2-dimethylpropyl-(2,6-dimethylpyrimidin-4-yl)amino]methyl]phenyl]triazol-4-yl]ethyl]piperidin-4-ol
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C27H39N7O
  1
1
IC50 = 480 nM
 Bioactivity Info 
   TI
   LI
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CP0411513
 Compound Info 
4-[(E)-3-[4-[(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]prop-2-enyl]piperazin-2-one
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C24H29N5O
  1
1
IC50 = 740 nM
 Bioactivity Info 
   TI
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CP0314508
 Compound Info 
US8748435, 40
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C27H37N5
  1
1
IC50 = 800 nM
 Bioactivity Info 
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CP0408534
 Compound Info 
(2R)-3-[4-[(E)-3-[4-[(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]prop-2-enyl]piperazin-1-yl]propane-1,2-diol
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C27H37N5O2
  1
1
IC50 = 860 nM
 Bioactivity Info 
   TI
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CP0538713
 Compound Info 
N-[4-(dimethylamino)butyl]-4-[[2,2-dimethylpropyl-(2,6-dimethylpyrimidin-4-yl)amino]methyl]benzamide
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C25H39N5O
  1
1
IC50 = 1260 nM
 Bioactivity Info 
   TI
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   LO
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CP0476126
 Compound Info 
N-(2,2-dimethylpropyl)-2,6-dimethyl-N-[[4-[(E)-3-(4-propan-2-ylpiperazin-1-yl)prop-1-enyl]phenyl]methyl]pyrimidin-4-amine
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C28H43N5
  1
1
IC50 = 1590 nM
 Bioactivity Info 
   TI
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CP0493671
 Compound Info 
2,5,7-trimethyl-3-[[4-[(E)-3-(4-propan-2-ylpiperazin-1-yl)prop-1-enyl]phenyl]methyl]imidazo[4,5-b]pyridine
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C26H35N5
  1
1
IC50 = 1840 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0392109
 Compound Info 
US8748435, 35
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C24H28N6O
  1
1
IC50 = 1840 nM
 Bioactivity Info 
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CP0493673
 Compound Info 
5-(dimethylamino)-N-[4-[[2,2-dimethylpropyl-(2,6-dimethylpyrimidin-4-yl)amino]methyl]phenyl]pentanamide
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C25H39N5O
  1
1
IC50 = 1990 nM
 Bioactivity Info 
   TI
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CP0560423
 Compound Info 
5,7-dimethyl-3-[[4-[(E)-3-(4-propan-2-ylpiperazin-1-yl)prop-1-enyl]phenyl]methyl]-2-propylimidazo[4,5-b]pyridine
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C28H39N5
  1
1
IC50 = 5220 nM
 Bioactivity Info 
   TI
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CP0408465
 Compound Info 
5,7-dimethyl-2-propan-2-yl-3-[[4-[(E)-3-(4-propan-2-ylpiperazin-1-yl)prop-1-enyl]phenyl]methyl]imidazo[4,5-b]pyridine
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C28H39N5
  1
1
IC50 = 17240 nM
 Bioactivity Info 
   TI
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CP0493672
 Compound Info 
2-ethyl-3-[[4-[(E)-3-(4-propan-2-ylpiperazin-1-yl)prop-1-enyl]phenyl]methyl]imidazo[4,5-b]pyridine
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C25H33N5
  1
1
IC50 > 20000 nM
 Bioactivity Info 
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CP0558235
 Compound Info 
5,7-dimethyl-2-(2-methylpropyl)-3-[[4-[(E)-3-(4-propan-2-ylpiperazin-1-yl)prop-1-enyl]phenyl]methyl]imidazo[4,5-b]pyridine
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C29H41N5
  1
1
IC50 > 20000 nM
 Bioactivity Info 
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