Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT05439 , Nuclear receptor ROR-gamma
Gene Name RORC
Organism Mus musculus, Mouse
Protein Classification Transcription factor
Uniprot ID P51450
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT05439
 
Compound ID Compound Name Compound Formula
CP0116135
N-(4-cyanopyridin-2-yl)-2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]-2-fluorophenyl]-2-methylpropanamide
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C26H25FN4O4S
 1
1
IC50 = 74 nM
   TI
   LI
   LO
   TS
CP0440462
2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-2-methyl-N-[4-(trifluoromethyl)pyridin-2-yl]propanamide
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C26H26F3N3O4S
 1
1
IC50 = 78 nM
   TI
   LI
   LO
   TS
CP0411472
2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-N-(2-fluorophenyl)-2-methylpropanamide
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C26H27FN2O4S
 1
1
IC50 = 100 nM
   TI
   LI
   LO
   TS
CP0489514
N-(4-chloropyridin-2-yl)-2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-2-methylpropanamide
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C25H26ClN3O4S
 1
1
IC50 = 100 nM
   TI
   LI
   LO
   TS
CP0262112
N-[4-[1-(2,3-dihydroindol-1-yl)-2-methyl-1-oxopropan-2-yl]phenyl]-2-(4-ethylsulfonylphenyl)acetamide
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C28H30N2O4S
 1
1
IC50 = 110 nM
   TI
   LI
   LO
   TS
CP0262113
2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]-2-fluorophenyl]-N-(4-fluorophenyl)-2-methylpropanamide
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C26H26F2N2O4S
 1
1
IC50 = 250 nM
   TI
   LI
   LO
   TS
CP0411477
2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-N-(3-fluorophenyl)-2-methylpropanamide
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C26H27FN2O4S
 1
1
IC50 = 260 nM
   TI
   LI
   LO
   TS
CP0407819
N-(4-cyanopyridin-2-yl)-2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-2-methylpropanamide
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C26H26N4O4S
 1
1
IC50 = 290 nM
   TI
   LI
   LO
   TS
CP0411468
2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-N-(4-fluoropyridin-2-yl)-2-methylpropanamide
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C25H26FN3O4S
 1
1
IC50 = 320 nM
   TI
   LI
   LO
   TS
CP0262111
2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-N,2-dimethyl-N-phenylpropanamide
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C27H30N2O4S
 1
1
IC50 = 330 nM
   TI
   LI
   LO
   TS
CP0116165
N-(2,4-difluorophenyl)-2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]-2-fluorophenyl]-2-methylpropanamide
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C26H25F3N2O4S
 1
1
IC50 = 340 nM
   TI
   LI
   LO
   TS
CP0168881
2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-2-methyl-N-phenylpropanamide
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C26H28N2O4S
 1
1
IC50 = 470 nM
   TI
   LI
   LO
   TS
CP0116134
2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-N-(4-fluorophenyl)-2-methylpropanamide
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C26H27FN2O4S
 1
1
IC50 = 550 nM
   TI
   LI
   LO
   TS
CP0392911
2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-2-methyl-N-pyridin-2-ylpropanamide
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C25H27N3O4S
 1
1
IC50 = 1300 nM
   TI
   LI
   LO
   TS
CP0440463
N-(2,4-difluorophenyl)-2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-2-methylpropanamide
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C26H26F2N2O4S
 1
1
IC50 = 1800 nM
   TI
   LI
   LO
   TS
CP0361258
N-[4-[1-(1,3-dihydroisoindol-2-yl)-2-methyl-1-oxopropan-2-yl]phenyl]-2-(4-ethylsulfonylphenyl)acetamide
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C28H30N2O4S
 1
1
IC50 = 1900 nM
   TI
   LI
   LO
   TS
CP0116164
ethyl 2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-2-methylpropanoate
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C22H27NO5S
 1
1
IC50 = 3100 nM
   TI
   LI
   LO
   TS
CP0440464
2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-2-methyl-N-pyridin-3-ylpropanamide
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C25H27N3O4S
 1
1
IC50 = 4500 nM
   TI
   LI
   LO
   TS
CP0536883
2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-2-methyl-N-[6-(trifluoromethyl)pyridin-2-yl]propanamide
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C26H26F3N3O4S
 1
1
IC50 = 5400 nM
   TI
   LI
   LO
   TS
CP0411464
2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-2-methyl-N-(2-methylphenyl)propanamide
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C27H30N2O4S
 1
1
IC50 = 6800 nM
   TI
   LI
   LO
   TS
CP0085610
2-(4-ethylsulfonylphenyl)-N-[4-(2-methyl-1-oxo-1-piperidin-1-ylpropan-2-yl)phenyl]acetamide
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C25H32N2O4S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0243406
N-[4-[1-(azetidin-1-yl)-2-methyl-1-oxopropan-2-yl]phenyl]-2-(4-ethylsulfonylphenyl)acetamide
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C23H28N2O4S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0361257
N-[4-[1-(2-azaspiro[3.3]heptan-2-yl)-2-methyl-1-oxopropan-2-yl]phenyl]-2-(4-ethylsulfonylphenyl)acetamide
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C26H32N2O4S
 1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0396018
2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-N-(3-fluoropyridin-2-yl)-2-methylpropanamide
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C25H26FN3O4S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0407763
2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-N,N,2-trimethylpropanamide
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C22H28N2O4S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0411475
2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-2-methyl-N-pyridin-4-ylpropanamide
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C25H27N3O4S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS