Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT03089 , Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Gene Name HCN4
Organism Homo sapiens, Human
Protein Classification Ion channel
Uniprot ID Q9Y3Q4
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT03089
 
Compound ID Compound Name Compound Formula
CP0415351
3-[3-[[(7S)-3,4-dimethoxy-7-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one
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C27H36N2O5
 1
1
EC50 = 4280 nM
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CP0387683
3-((Z)-4-((3,4-dimethoxyphenethyl)(methyl)amino)but-2-enyl)-7,8-dimethoxy-1H-benzo[d]azepin-2(3H)-one
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C27H34N2O5
 1
1
EC50 = 7140 nM
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CP0372749
3-((E)-4-((3,4-dimethoxyphenethyl)(methyl)amino)but-2-enyl)-7,8-dimethoxy-1H-benzo[d]azepin-2(3H)-one
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C27H34N2O5
 1
1
EC50 = 7230 nM
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CP0497219
3-(3-{[2-(3,4-Dimethoxy-phenyl)-ethyl]-methyl-amino}-propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-benzo[d]azepin-2-one
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C26H36N2O5
 1
1
EC50 = 8570 nM
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CP0384202
3-((Z)-4-(((R)-2-(3,4-dimethoxyphenyl)propyl)(methyl)amino)but-2-enyl)-7,8-dimethoxy-1H-benzo[d]azepin-2(3H)-one
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C28H36N2O5
 1
1
EC50 = 24940 nM
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CP0489458
3-((Z)-4-(((S)-2-(3,4-dimethoxyphenyl)propyl)(methyl)amino)but-2-enyl)-7,8-dimethoxy-1H-benzo[d]azepin-2(3H)-one
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C28H36N2O5
 1
1
EC50 = 31590 nM
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CP0371749
3,3'-((2Z,2'Z)-4,4'-(3,4-dimethoxyphenethylazanediyl)bis(but-2-ene-4,1-diyl))bis(7,8-dimethoxy-1H-benzo[d]azepin-2(3H)-one)
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C42H49N3O8
 1
1
EC50 = 70670 nM
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CP0888597
N-ethyl-1,2-dimethyl-6-(methylimino)-N-phenyl-1,6-dihydropyrimidin-4-amine hydrochloride
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C15H21ClN4
 1
1
IC50 = 31.62 nM
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CP0490002
2-ethoxy-N-[[1-(4-ethylpiperazin-1-yl)cyclohexyl]methyl]benzamide
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C22H35N3O2
 1
1
IC50 = 158.49 nM
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CP0389054
2-ethoxy-N-[[1-(4-propan-2-ylpiperazin-1-yl)cyclohexyl]methyl]benzamide
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C23H37N3O2
 1
1
IC50 = 316.23 nM
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CP0505841
N-[[1-(4-cyclopropylpiperazin-1-yl)cyclohexyl]methyl]-2-ethoxybenzamide
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C23H35N3O2
 1
1
IC50 = 316.23 nM
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CP0397889
N-[[1-(4-cyclopentylpiperazin-1-yl)cyclohexyl]methyl]-2-ethoxybenzamide
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C25H39N3O2
 1
1
IC50 = 794.33 nM
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CP0452466
2-methoxy-N-[[1-(4-propan-2-ylpiperazin-1-yl)cyclohexyl]methyl]benzamide
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C22H35N3O2
 1
1
IC50 = 794.33 nM
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CP0505471
N-[[1-(4-cyclobutylpiperazin-1-yl)cyclohexyl]methyl]-2-ethoxybenzamide
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C24H37N3O2
 1
1
IC50 = 794.33 nM
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CP0512573
2-ethoxy-N-[[1-(4-methylpiperazin-1-yl)cyclohexyl]methyl]benzamide
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C21H33N3O2
 1
1
IC50 = 1258.93 nM
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CP0505470
2-propan-2-yloxy-N-[[1-(4-propan-2-ylpiperazin-1-yl)cyclohexyl]methyl]benzamide
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C24H39N3O2
 1
1
IC50 = 1584.89 nM
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CP0494247
N-[[2-(4-methylpiperazin-1-yl)-1,3-dihydroinden-2-yl]methyl]-2-phenylmethoxybenzamide
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C29H33N3O2
 1
1
IC50 = 2511.89 nM
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CP0512571
2-ethoxy-N-[[2-(4-propan-2-ylpiperazin-1-yl)-1,3-dihydroinden-2-yl]methyl]benzamide
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C26H35N3O2
 1
1
IC50 = 3162.28 nM
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CP0452497
2-ethoxy-N-[[4-(4-propan-2-ylpiperazin-1-yl)oxan-4-yl]methyl]benzamide
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C22H35N3O3
 1
1
IC50 = 3981.07 nM
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CP0456075
2-ethoxy-N-[(1-piperazin-1-ylcyclohexyl)methyl]benzamide
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C20H31N3O2
 1
1
IC50 = 3981.07 nM
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CP0426126
2-methoxy-N-[[1-phenyl-4-(4-propan-2-ylpiperazin-1-yl)piperidin-4-yl]methyl]benzamide
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C27H38N4O2
 1
1
IC50 = 5011.87 nM
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CP0431255
2-methoxy-N-[[1-(4-methylpiperazin-1-yl)cyclohexyl]methyl]benzamide
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C20H31N3O2
 1
1
IC50 = 5011.87 nM
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CP0452462
2-ethoxy-N-[[2-(4-methylpiperazin-1-yl)-1,3-dihydroinden-2-yl]methyl]benzamide
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C24H31N3O2
 1
1
IC50 = 5011.87 nM
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CP0505468
2-ethoxy-N-[[1-(4-methylpiperazin-1-yl)cyclopentyl]methyl]benzamide
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C20H31N3O2
 1
1
IC50 = 5011.87 nM
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CP0429849
2-methoxy-N-[[2-(4-methylpiperazin-1-yl)-3,4-dihydro-1H-naphthalen-2-yl]methyl]benzamide
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C24H31N3O2
 1
1
IC50 = 6309.57 nM
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CP0389055
2-methoxy-N-[[2-(4-methylpiperazin-1-yl)-1,3-dihydroinden-2-yl]methyl]benzamide
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C23H29N3O2
 1
1
IC50 = 19952.62 nM
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CP0505469
2-methoxy-N-[2-(4-methylphenyl)-2-(4-methylpiperazin-1-yl)ethyl]benzamide
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C22H29N3O2
 1
1
IC50 = 19952.62 nM
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CP0452465
2-chloro-N-[[1-(4-methylpiperazin-1-yl)cyclohexyl]methyl]benzamide
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C19H28ClN3O
 1
1
IC50 = 31622.78 nM
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CP0431254
2-ethoxy-N-[(2-piperidin-1-yl-1,3-dihydroinden-2-yl)methyl]benzamide
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C24H30N2O2
 1
1
IC50 = 39810.72 nM
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CP0490003
2-ethoxy-N-[(1-piperidin-1-ylcyclohexyl)methyl]benzamide
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C21H32N2O2
 1
1
IC50 = 39810.72 nM
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CP0494553
2-methoxy-N-[(1-morpholin-4-ylcyclohexyl)methyl]benzamide
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C19H28N2O3
 1
1
IC50 = 50118.72 nM
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CP0389056
2-ethyl-N-[[1-(4-propan-2-ylpiperazin-1-yl)cyclohexyl]methyl]benzamide
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C23H37N3O
 1
1
IC50 = 79432.82 nM
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CP0452467
2-ethoxy-N-[[1-(4-phenylpiperazin-1-yl)cyclohexyl]methyl]benzamide
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C26H35N3O2
 1
1
IC50 = 100000 nM
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