Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT03033 , Nuclear receptor ROR-beta
Gene Name RORB
Organism Homo sapiens, Human
Protein Classification Transcription factor
Uniprot ID Q92753
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT03033
 
Compound ID Compound Name Compound Formula
CP0234135
N-(2-methylpropyl)-N-[[5-(4-methylsulfonylphenyl)thiophen-2-yl]methyl]-1-phenylmethanesulfonamide
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C23H27NO4S3
 1
1
EC50 = 2200 nM
   TI
   LI
   LO
   TS
CP0257822
N-(2-methylpropyl)-N-[[4-(4-methylsulfonylphenyl)phenyl]methyl]-1-phenylmethanesulfonamide
   Show/Hide
C25H29NO4S2
 1
1
EC50 = 2500 nM
   TI
   LI
   LO
   TS
CP0059785
N-[[4-[4-(methanesulfonamido)phenyl]phenyl]methyl]-N-(2-methylpropyl)-1-phenylmethanesulfonamide
   Show/Hide
C25H30N2O4S2
 1
1
EC50 = 3700 nM
   TI
   LI
   LO
   TS
CP0059780
N-(2-methylpropyl)-N-[[5-(3-methylsulfonylphenyl)thiophen-2-yl]methyl]-1-phenylmethanesulfonamide
   Show/Hide
C23H27NO4S3
 1
1
EC50 = 5000 nM
   TI
   LI
   LO
   TS
CP0168528
4-[4-[[benzylsulfonyl(2-methylpropyl)amino]methyl]phenyl]benzamide
   Show/Hide
C25H28N2O3S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0459436
5-butyl-9-chloro-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenanthridin-6-one
   Show/Hide
C20H16ClF6NO2
 1
1
IC50 = 4900 nM
   TI
   LI
   LO
   TS
CP0481996
2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-5-hexylphenanthridin-6-one
   Show/Hide
C22H21F6NO2
 1
1
IC50 = 5400 nM
   TI
   LI
   LO
   TS
CP0524496
5-butyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-9-hydroxyphenanthridin-6-one
   Show/Hide
C20H17F6NO3
 1
1
IC50 = 5500 nM
   TI
   LI
   LO
   TS
CP0459435
5-butyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-9-(trifluoromethyl)phenanthridin-6-one
   Show/Hide
C21H16F9NO2
 1
1
IC50 = 5600 nM
   TI
   LI
   LO
   TS
CP0380839
5-butyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenanthridin-6-one
   Show/Hide
C20H17F6NO2
 2
1
IC50 = 5700 nM
   TI
   LI
   LO
   TS
2
IC50 = 6500 nM
   TI
   LI
   LO
   TS
CP0389304
2-(5,5-dibutylbenzo[b][1]benzosilol-2-yl)-1,1,1,3,3,3-hexafluoropropan-2-ol
   Show/Hide
C23H26F6OSi
 1
1
IC50 = 6700 nM
   TI
   LI
   LO
   TS
CP0456138
2-(5-butyl-5-methylbenzo[b][1]benzosilol-2-yl)-1,1,1,3,3,3-hexafluoropropan-2-ol
   Show/Hide
C20H20F6OSi
 1
1
IC50 = 7000 nM
   TI
   LI
   LO
   TS
CP0487873
5-butyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-9-methylphenanthridin-6-one
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C21H19F6NO2
 1
1
IC50 = 7100 nM
   TI
   LI
   LO
   TS
CP0473976
5-butyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-10-methoxyphenanthridin-6-one
   Show/Hide
C21H19F6NO3
 1
1
IC50 = 7500 nM
   TI
   LI
   LO
   TS
CP0488049
5-butyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-9-methoxyphenanthridin-6-one
   Show/Hide
C21H19F6NO3
 1
1
IC50 = 7700 nM
   TI
   LI
   LO
   TS
CP0380838
5-butyl-2-ethylphenanthridin-6-one
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C19H21NO
 1
1
IC50 = 7900 nM
   TI
   LI
   LO
   TS
CP0395440
2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-5-propylphenanthridin-6-one
   Show/Hide
C19H15F6NO2
 1
1
IC50 = 8200 nM
   TI
   LI
   LO
   TS
CP0488050
5-(cyclohexylmethyl)-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenanthridin-6-one
   Show/Hide
C23H21F6NO2
 1
1
IC50 = 8800 nM
   TI
   LI
   LO
   TS
CP0467808
2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-5-propan-2-ylphenanthridin-6-one
   Show/Hide
C19H15F6NO2
 1
1
IC50 = 9700 nM
   TI
   LI
   LO
   TS
CP0467810
5-butyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-4-methoxyphenanthridin-6-one
   Show/Hide
C21H19F6NO3
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0116134
2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-N-(4-fluorophenyl)-2-methylpropanamide
   Show/Hide
C26H27FN2O4S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0116135
N-(4-cyanopyridin-2-yl)-2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]-2-fluorophenyl]-2-methylpropanamide
   Show/Hide
C26H25FN4O4S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0116165
N-(2,4-difluorophenyl)-2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]-2-fluorophenyl]-2-methylpropanamide
   Show/Hide
C26H25F3N2O4S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0262113
2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]-2-fluorophenyl]-N-(4-fluorophenyl)-2-methylpropanamide
   Show/Hide
C26H26F2N2O4S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0499213
2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-5-(2,2,2-trifluoroethyl)phenanthridin-6-one
   Show/Hide
C18H10F9NO2
 1
1
IC50 = 10100 nM
   TI
   LI
   LO
   TS
CP0395912
5-butyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-3-methoxyphenanthridin-6-one
   Show/Hide
C21H19F6NO3
 1
1
IC50 = 10900 nM
   TI
   LI
   LO
   TS
CP0459431
5-butyl-2-hexylphenanthridin-6-one
   Show/Hide
C23H29NO
 1
1
IC50 = 11300 nM
   TI
   LI
   LO
   TS
CP0459432
5-(cyclopropylmethyl)-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenanthridin-6-one
   Show/Hide
C20H15F6NO2
 1
1
IC50 = 11800 nM
   TI
   LI
   LO
   TS
CP0487874
5-butyl-2-tert-butylphenanthridin-6-one
   Show/Hide
C21H25NO
 1
1
IC50 = 12800 nM
   TI
   LI
   LO
   TS
CP0417384
5-butylphenanthridin-6-one
   Show/Hide
C17H17NO
 1
1
IC50 = 13400 nM
   TI
   LI
   LO
   TS
CP0467809
5-butyl-2-propan-2-ylphenanthridin-6-one
   Show/Hide
C20H23NO
 1
1
IC50 = 17000 nM
   TI
   LI
   LO
   TS
CP0459433
5-butyl-2-methylphenanthridin-6-one
   Show/Hide
C18H19NO
 1
1
IC50 = 17100 nM
   TI
   LI
   LO
   TS
CP0395918
2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-5-nonylphenanthridin-6-one
   Show/Hide
C25H27F6NO2
 1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0395919
5-ethyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenanthridin-6-one
   Show/Hide
C18H13F6NO2
 1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0397540
2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-5-methylphenanthridin-6-one
   Show/Hide
C17H11F6NO2
 1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0459434
5-butyl-2-(hydroxymethyl)phenanthridin-6-one
   Show/Hide
C18H19NO2
 1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0478004
2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-5H-phenanthridin-6-one
   Show/Hide
C16H9F6NO2
 1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0394583
2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-4-methyl-5H-phenanthridin-6-one
   Show/Hide
C17H11F6NO2
 1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0394584
8-fluoro-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-4-methyl-5H-phenanthridin-6-one
   Show/Hide
C17H10F7NO2
 1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0482005
8-fluoro-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-4,5-dimethylphenanthridin-6-one
   Show/Hide
C18H12F7NO2
 1
1
IC50 > 20000 nM
   TI
   LI
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   TS