Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT02768 , Potassium voltage-gated channel subfamily A member 5
Gene Name KCNA5
Organism Homo sapiens, Human
Protein Classification Ion channel
Uniprot ID P22460
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT02768
 
Compound ID Compound Name Compound Formula
CP0388305
N-(2,4-difluorophenyl)-2-[3-[(E)-[(4-methylphenyl)sulfonylhydrazinylidene]methyl]indol-1-yl]acetamide
   Show/Hide
C24H20F2N4O3S
 1
1
IC50 = 250 nM
   TI
   LI
   LO
   TS
CP0387967
N-(4-chlorophenyl)-2-[5-methoxy-3-[(E)-[(4-methylphenyl)sulfonylhydrazinylidene]methyl]indol-1-yl]acetamide
   Show/Hide
C25H23ClN4O4S
 1
1
IC50 = 510 nM
   TI
   LI
   LO
   TS
CP0542197
[4-[2-(4-chlorophenoxy)ethyl]piperazin-1-yl]-thiophen-2-ylmethanone
   Show/Hide
C17H19ClN2O2S
 1
1
IC50 = 720 nM
   TI
   LI
   LO
   TS
CP0388306
N-(2-chlorophenyl)-2-[3-[(E)-[(4-methylphenyl)sulfonylhydrazinylidene]methyl]indol-1-yl]acetamide
   Show/Hide
C24H21ClN4O3S
 1
1
IC50 = 740 nM
   TI
   LI
   LO
   TS
CP0523029
2-[3-[(E)-[(4-methylphenyl)sulfonylhydrazinylidene]methyl]indol-1-yl]-N-phenylacetamide
   Show/Hide
C24H22N4O3S
 1
1
IC50 = 810 nM
   TI
   LI
   LO
   TS
CP0383323
2-[4-[2-(4-cyanophenoxy)ethyl]piperazin-1-yl]-N-(1,3-thiazol-2-yl)acetamide
   Show/Hide
C18H21N5O2S
 1
1
IC50 = 970 nM
   TI
   LI
   LO
   TS
CP0557407
2-[4-[2-(2-methylphenoxy)ethyl]piperazin-1-yl]-N-(1,3-thiazol-2-yl)acetamide
   Show/Hide
C18H24N4O2S
 1
1
IC50 = 1240 nM
   TI
   LI
   LO
   TS
CP0377693
[4-[2-(2,4-dichlorophenoxy)ethyl]piperazin-1-yl]-thiophen-2-ylmethanone
   Show/Hide
C17H18Cl2N2O2S
 1
1
IC50 = 1480 nM
   TI
   LI
   LO
   TS
CP0525588
2-[3-[(E)-[(4-methylphenyl)sulfonylhydrazinylidene]methyl]indol-1-yl]-N-[4-(trifluoromethoxy)phenyl]acetamide
   Show/Hide
C25H21F3N4O4S
 1
1
IC50 = 1520 nM
   TI
   LI
   LO
   TS
CP0558840
[4-[2-(4-methylphenoxy)ethyl]piperazin-1-yl]-thiophen-2-ylmethanone
   Show/Hide
C18H22N2O2S
 1
1
IC50 = 1520 nM
   TI
   LI
   LO
   TS
CP0375176
N-(4-methoxyphenyl)-2-[3-[2-[(4-methoxyphenyl)sulfonylamino]ethyl]indol-1-yl]acetamide
   Show/Hide
C26H27N3O5S
 1
1
IC50 = 1720 nM
   TI
   LI
   LO
   TS
CP0429051
N-(2,5-dimethylphenyl)-2-[3-[(E)-[(4-methylphenyl)sulfonylhydrazinylidene]methyl]indol-1-yl]acetamide
   Show/Hide
C26H26N4O3S
 1
1
IC50 = 1770 nM
   TI
   LI
   LO
   TS
CP0432896
N-(4-chlorophenyl)-2-[3-[(E)-[(4-methylphenyl)sulfonylhydrazinylidene]methyl]indol-1-yl]acetamide
   Show/Hide
C24H21ClN4O3S
 1
1
IC50 = 1900 nM
   TI
   LI
   LO
   TS
CP0858821
7-hydroxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-5-yl 4-methoxybenzoate
   Show/Hide
C24H18O7
 1
1
IC50 = 2040 nM
   TI
   LI
   LO
   TS
CP0387968
[4-[[2-[3-[(E)-[(4-methylphenyl)sulfonylhydrazinylidene]methyl]indol-1-yl]acetyl]amino]phenyl] propanoate
   Show/Hide
C27H26N4O5S
 1
1
IC50 = 2140 nM
   TI
   LI
   LO
   TS
CP0493821
N-(2,4-difluorophenyl)-2-[5-methoxy-3-[(E)-[(4-methylphenyl)sulfonylhydrazinylidene]methyl]indol-1-yl]acetamide
   Show/Hide
C25H22F2N4O4S
 1
1
IC50 = 2180 nM
   TI
   LI
   LO
   TS
CP0395249
methyl 2-[(4-bromophenyl)sulfonylamino]-3-(1H-indol-3-yl)propanoate
   Show/Hide
C18H17BrN2O4S
 1
1
IC50 = 2250 nM
   TI
   LI
   LO
   TS
CP0377691
N-(1,3-thiazol-2-yl)-2-[4-[2-[4-(trifluoromethoxy)phenoxy]ethyl]piperazin-1-yl]acetamide
   Show/Hide
C18H21F3N4O3S
 1
1
IC50 = 2290 nM
   TI
   LI
   LO
   TS
CP0866931
DRONEDARONE HYDROCHLORIDE
   Show/Hide
C31H45ClN2O5S
 1
1
IC50 = 2370 nM
   TI
   LI
   LO
   TS
CP0462103
methyl 2-[(4-cyclopentyloxyphenyl)sulfonylamino]-3-(1H-indol-3-yl)propanoate
   Show/Hide
C23H26N2O5S
 1
1
IC50 = 2380 nM
   TI
   LI
   LO
   TS
CP0434788
2-[4-[2-(4-chlorophenoxy)ethyl]piperazin-1-yl]-N-(4-methoxyphenyl)acetamide
   Show/Hide
C21H26ClN3O3
 1
1
IC50 = 2620 nM
   TI
   LI
   LO
   TS
CP0406304
N-(4-chlorophenyl)-2-[3-[2-[(4-methoxyphenyl)sulfonylamino]ethyl]indol-1-yl]acetamide
   Show/Hide
C25H24ClN3O4S
 1
1
IC50 = 3140 nM
   TI
   LI
   LO
   TS
CP0851203
VERNAKALANT HYDROCHLORIDE
   Show/Hide
C20H32ClNO4
 1
1
IC50 = 3200 nM
   TI
   LI
   LO
   TS
CP0399164
2-[4-[2-(2-chlorophenoxy)ethyl]piperazin-1-yl]-N-(1,3-thiazol-2-yl)acetamide
   Show/Hide
C17H21ClN4O2S
 1
1
IC50 = 3390 nM
   TI
   LI
   LO
   TS
CP0003663
5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one
   Show/Hide
C16H12O5
 1
1
IC50 = 3400 nM
   TI
   LI
   LO
   TS
CP0484720
methyl 3-(1H-indol-3-yl)-2-[[4-(2-methylpropoxy)phenyl]sulfonylamino]propanoate
   Show/Hide
C22H26N2O5S
 1
1
IC50 = 3560 nM
   TI
   LI
   LO
   TS
CP0419334
2-[4-[2-(4-chlorophenoxy)ethyl]piperazin-1-yl]-N-(2-chlorophenyl)acetamide
   Show/Hide
C20H23Cl2N3O2
 1
1
IC50 = 3590 nM
   TI
   LI
   LO
   TS
CP0443755
2-[5-methoxy-3-[(E)-[(4-methylphenyl)sulfonylhydrazinylidene]methyl]indol-1-yl]-N-phenylacetamide
   Show/Hide
C25H24N4O4S
 1
1
IC50 = 3730 nM
   TI
   LI
   LO
   TS
CP0471649
methyl 3-(1H-indol-3-yl)-2-[(4-propan-2-yloxyphenyl)sulfonylamino]propanoate
   Show/Hide
C21H24N2O5S
 1
1
IC50 = 3930 nM
   TI
   LI
   LO
   TS
CP0434787
[4-[2-(4-chlorophenoxy)ethyl]piperazin-1-yl]-phenylmethanone
   Show/Hide
C19H21ClN2O2
 1
1
IC50 = 3970 nM
   TI
   LI
   LO
   TS
CP0557402
4-[2-(4-benzoylpiperazin-1-yl)ethoxy]benzonitrile
   Show/Hide
C20H21N3O2
 1
1
IC50 = 4230 nM
   TI
   LI
   LO
   TS
CP0557403
2-[4-[2-(4-chlorophenoxy)ethyl]piperazin-1-yl]-N-phenylacetamide
   Show/Hide
C20H24ClN3O2
 1
1
IC50 = 4380 nM
   TI
   LI
   LO
   TS
CP0397365
2-[4-[2-(4-cyanophenoxy)ethyl]piperazin-1-yl]-N-(4-methylphenyl)acetamide
   Show/Hide
C22H26N4O2
 1
1
IC50 = 4490 nM
   TI
   LI
   LO
   TS
CP0381551
[4-[2-(4-chlorophenoxy)ethyl]piperazin-1-yl]-(4-methylphenyl)methanone
   Show/Hide
C20H23ClN2O2
 1
1
IC50 = 4510 nM
   TI
   LI
   LO
   TS
CP0432926
methyl 3-(1H-indol-3-yl)-2-[(4-methylphenyl)sulfonylamino]propanoate
   Show/Hide
C19H20N2O4S
 1
1
IC50 = 4720 nM
   TI
   LI
   LO
   TS
CP0875566
(1R,2R)/(1S,2S)-2-(3R)/(3S)-Hydroxypyrrolidinyl]-1-(3,4-dimethoxyphenethoxy)cyclohexane monohydrochloride
   Show/Hide
C20H32ClNO4
 1
1
IC50 = 5000 nM
   TI
   LI
   LO
   TS
CP0557404
2-[4-[2-(4-chlorophenoxy)ethyl]piperazin-1-yl]-N-(4-methylphenyl)acetamide
   Show/Hide
C21H26ClN3O2
 1
1
IC50 = 5020 nM
   TI
   LI
   LO
   TS
CP0419340
2-[4-[2-(4-chlorophenoxy)ethyl]piperazin-1-yl]-N-(1,3-thiazol-2-yl)acetamide
   Show/Hide
C17H21ClN4O2S
 1
1
IC50 = 5180 nM
   TI
   LI
   LO
   TS
CP0487333
methyl 3-(1H-indol-3-yl)-2-[(4-methoxyphenyl)sulfonylamino]propanoate
   Show/Hide
C19H20N2O5S
 1
1
IC50 = 5450 nM
   TI
   LI
   LO
   TS
CP0415799
[4-[2-(4-chlorophenoxy)ethyl]piperazin-1-yl]-(4-methoxyphenyl)methanone
   Show/Hide
C20H23ClN2O3
 1
1
IC50 = 5500 nM
   TI
   LI
   LO
   TS
CP0872999
(1S,2S)-2-[(3S)-hydroxypyrrolidinyl]-l-(3,4-dimethoxyphenethoxy)cyclohexane monohydrochloride
   Show/Hide
C20H32ClNO4
 1
1
IC50 = 6000 nM
   TI
   LI
   LO
   TS
CP0895639
(1R,2R)-2-[(3S)-Hydroxypyrrolidinyl]-1-(3,4-dimethoxyphenethoxy)cyclohexane monohydrochloride
   Show/Hide
C20H32ClNO4
 1
1
IC50 = 6000 nM
   TI
   LI
   LO
   TS
CP0901759
(1S,2S)-2-[(3R)-Hydroxypyrrolidinyl]-1-(3,4-dimethoxyphenethoxy)-cyclohexane monohydrochloride
   Show/Hide
C20H32ClNO4
 1
1
IC50 = 6000 nM
   TI
   LI
   LO
   TS
CP0406302
2-[3-[2-[(4-butoxyphenyl)sulfonylamino]ethyl]indol-1-yl]-N-(4-methoxyphenyl)acetamide
   Show/Hide
C29H33N3O5S
 1
1
IC50 = 6210 nM
   TI
   LI
   LO
   TS
CP0434786
thiophen-2-yl-[4-[2-[4-(trifluoromethoxy)phenoxy]ethyl]piperazin-1-yl]methanone
   Show/Hide
C18H19F3N2O3S
 1
1
IC50 = 6440 nM
   TI
   LI
   LO
   TS
CP0406305
methyl 2-[(4-fluorophenyl)sulfonylamino]-3-(1H-indol-3-yl)propanoate
   Show/Hide
C18H17FN2O4S
 1
1
IC50 = 6450 nM
   TI
   LI
   LO
   TS
CP0397364
(4-methylphenyl)-[4-(2-phenoxyethyl)piperazin-1-yl]methanone
   Show/Hide
C20H24N2O2
 1
1
IC50 = 7140 nM
   TI
   LI
   LO
   TS
CP0558843
N-phenyl-2-[4-[2-[4-(trifluoromethoxy)phenoxy]ethyl]piperazin-1-yl]acetamide
   Show/Hide
C21H24F3N3O3
 1
1
IC50 = 7330 nM
   TI
   LI
   LO
   TS
CP0446995
methyl 2-[(4-butoxyphenyl)sulfonylamino]-3-(1H-indol-3-yl)propanoate
   Show/Hide
C22H26N2O5S
 1
1
IC50 = 8370 nM
   TI
   LI
   LO
   TS
CP0557405
2-[4-[2-(4-methylphenoxy)ethyl]piperazin-1-yl]-N-(1,3-thiazol-2-yl)acetamide
   Show/Hide
C18H24N4O2S
 1
1
IC50 = 8930 nM
   TI
   LI
   LO
   TS
CP0077590
2-(4-Methoxy-phenyl)-chromen-4-one
   Show/Hide
C16H12O3
 1
1
IC50 = 9000 nM
   TI
   LI
   LO
   TS
CP0382364
2-[4-[2-(4-cyanophenoxy)ethyl]piperazin-1-yl]-N-phenylacetamide
   Show/Hide
C21H24N4O2
 1
1
IC50 = 9100 nM
   TI
   LI
   LO
   TS
CP0556320
2-[4-[2-(4-methoxyphenoxy)ethyl]piperazin-1-yl]-N-(1,3-thiazol-2-yl)acetamide
   Show/Hide
C18H24N4O3S
 1
1
IC50 = 9130 nM
   TI
   LI
   LO
   TS
CP0574494
[4-[2-(2-chlorophenoxy)ethyl]piperazin-1-yl]-thiophen-2-ylmethanone
   Show/Hide
C17H19ClN2O2S
 1
1
IC50 = 9740 nM
   TI
   LI
   LO
   TS
CP0420196
4-butoxy-N-[2-(1H-indol-3-yl)ethyl]benzenesulfonamide
   Show/Hide
C20H24N2O3S
 1
1
IC50 = 9950 nM
   TI
   LI
   LO
   TS
CP0415005
N-(4-methoxyphenyl)-2-[4-(2-phenoxyethyl)piperazin-1-yl]acetamide
   Show/Hide
C21H27N3O3
 1
1
IC50 = 10130 nM
   TI
   LI
   LO
   TS
CP0410732
4-[2-[4-(thiophene-2-carbonyl)piperazin-1-yl]ethoxy]benzonitrile
   Show/Hide
C18H19N3O2S
 1
1
IC50 = 10170 nM
   TI
   LI
   LO
   TS
CP0434468
N-(3,4-dimethylphenyl)-2-[3-[(E)-[(4-methylphenyl)sulfonylhydrazinylidene]methyl]indol-1-yl]acetamide
   Show/Hide
C26H26N4O3S
 1
1
IC50 = 11240 nM
   TI
   LI
   LO
   TS
CP0377690
2-[4-[2-(2-methylphenoxy)ethyl]piperazin-1-yl]-N-phenylacetamide
   Show/Hide
C21H27N3O2
 1
1
IC50 = 11820 nM
   TI
   LI
   LO
   TS
CP0434789
[4-[2-(4-bromophenoxy)ethyl]piperazin-1-yl]-thiophen-2-ylmethanone
   Show/Hide
C17H19BrN2O2S
 1
1
IC50 = 12180 nM
   TI
   LI
   LO
   TS
CP0556321
[4-[2-(4-fluorophenoxy)ethyl]piperazin-1-yl]-thiophen-2-ylmethanone
   Show/Hide
C17H19FN2O2S
 1
1
IC50 = 12710 nM
   TI
   LI
   LO
   TS
CP0484721
N-(4-chlorophenyl)-2-[3-[2-[(4-methylphenyl)sulfonylamino]ethyl]indol-1-yl]acetamide
   Show/Hide
C25H24ClN3O3S
 1
1
IC50 = 12920 nM
   TI
   LI
   LO
   TS
CP0399162
[4-[2-(2-methylphenoxy)ethyl]piperazin-1-yl]-thiophen-2-ylmethanone
   Show/Hide
C18H22N2O2S
 1
1
IC50 = 13530 nM
   TI
   LI
   LO
   TS
CP0888303
2-(4-methoxyphenyl)-6-methyl-4H-chromen-4-one
   Show/Hide
C17H14O3
 1
1
IC50 = 13700 nM
   TI
   LI
   LO
   TS
CP0572281
2-[4-[2-(4-cyanophenoxy)ethyl]piperazin-1-yl]-N-(4-methoxyphenyl)acetamide
   Show/Hide
C22H26N4O3
 1
1
IC50 = 14460 nM
   TI
   LI
   LO
   TS
CP0422654
(4-methoxyphenyl)-[4-(2-phenoxyethyl)piperazin-1-yl]methanone
   Show/Hide
C20H24N2O3
 1
1
IC50 = 16070 nM
   TI
   LI
   LO
   TS
CP0574490
N-(4-methylphenyl)-2-[4-(2-phenoxyethyl)piperazin-1-yl]acetamide
   Show/Hide
C21H27N3O2
 1
1
IC50 = 16110 nM
   TI
   LI
   LO
   TS
CP0470457
N-(4-methoxyphenyl)-2-[3-[(E)-[(4-methylphenyl)sulfonylhydrazinylidene]methyl]indol-1-yl]acetamide
   Show/Hide
C25H24N4O4S
 1
1
IC50 = 16910 nM
   TI
   LI
   LO
   TS
CP0383320
2-[4-[2-(2,4-dimethylphenoxy)ethyl]piperazin-1-yl]-N-(1,3-thiazol-2-yl)acetamide
   Show/Hide
C19H26N4O2S
 1
1
IC50 = 17160 nM
   TI
   LI
   LO
   TS
CP0557401
[4-[2-(4-methoxyphenoxy)ethyl]piperazin-1-yl]-thiophen-2-ylmethanone
   Show/Hide
C18H22N2O3S
 1
1
IC50 = 21920 nM
   TI
   LI
   LO
   TS
CP0851367
6-chloro-2-(4-methoxyphenyl)-4H-chromen-4-one
   Show/Hide
C16H11ClO3
 1
1
IC50 = 23500 nM
   TI
   LI
   LO
   TS
CP0430081
N-(2,4-dimethylphenyl)-2-[3-[(E)-[(4-methylphenyl)sulfonylhydrazinylidene]methyl]indol-1-yl]acetamide
   Show/Hide
C26H26N4O3S
 1
1
IC50 = 24010 nM
   TI
   LI
   LO
   TS
CP0572280
[4-[2-(4-methylphenoxy)ethyl]piperazin-1-yl]-phenylmethanone
   Show/Hide
C20H24N2O2
 1
1
IC50 = 25270 nM
   TI
   LI
   LO
   TS
CP0382363
2-[4-(2-phenoxyethyl)piperazin-1-yl]-N-phenylacetamide
   Show/Hide
C20H25N3O2
 1
1
IC50 = 28570 nM
   TI
   LI
   LO
   TS
CP0419336
2-[4-(2-phenoxyethyl)piperazin-1-yl]-N-(1,3-thiazol-2-yl)acetamide
   Show/Hide
C17H22N4O2S
 1
1
IC50 = 29340 nM
   TI
   LI
   LO
   TS
CP0419332
N-(2-chlorophenyl)-2-[4-(2-phenoxyethyl)piperazin-1-yl]acetamide
   Show/Hide
C20H24ClN3O2
 1
1
IC50 = 29420 nM
   TI
   LI
   LO
   TS
CP0381550
[4-(2-phenoxyethyl)piperazin-1-yl]-thiophen-2-ylmethanone
   Show/Hide
C17H20N2O2S
 1
1
IC50 = 37500 nM
   TI
   LI
   LO
   TS
CP0525589
N-(4-methoxyphenyl)-2-[3-[2-[(4-methylphenyl)sulfonylamino]ethyl]indol-1-yl]acetamide
   Show/Hide
C26H27N3O4S
 1
1
IC50 = 38730 nM
   TI
   LI
   LO
   TS
CP0558841
[4-(2-phenoxyethyl)piperazin-1-yl]-phenylmethanone
   Show/Hide
C19H22N2O2
 1
1
IC50 = 38780 nM
   TI
   LI
   LO
   TS
CP0383318
thiophen-2-yl-[4-[4-(trifluoromethoxy)phenyl]piperazin-1-yl]methanone
   Show/Hide
C16H15F3N2O2S
 1
1
IC50 = 48360 nM
   TI
   LI
   LO
   TS
CP0400317
2-[4-[2-(3,4-dimethylphenoxy)ethyl]piperazin-1-yl]-N-(1,3-thiazol-2-yl)acetamide
   Show/Hide
C19H26N4O2S
 1
1
IC50 = 50240 nM
   TI
   LI
   LO
   TS
CP0558842
(2-chlorophenyl)-[4-(2-phenoxyethyl)piperazin-1-yl]methanone
   Show/Hide
C19H21ClN2O2
 1
1
IC50 = 56750 nM
   TI
   LI
   LO
   TS
CP0419338
2-[4-[2-(4-tert-butylphenoxy)ethyl]piperazin-1-yl]-N-(1,3-thiazol-2-yl)acetamide
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C21H30N4O2S
 1
1
IC50 = 63180 nM
   TI
   LI
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CP0388309
2-[(4-butoxyphenyl)sulfonylamino]-3-(1H-indol-3-yl)propanoic acid
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C21H24N2O5S
 1
1
IC50 = 65420 nM
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CP0383324
2-[4-(2-naphthalen-2-yloxyethyl)piperazin-1-yl]-N-(1,3-thiazol-2-yl)acetamide
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C21H24N4O2S
 1
1
IC50 = 68030 nM
   TI
   LI
   LO
   TS
CP0382366
2-[4-[2-(2,6-dimethylphenoxy)ethyl]piperazin-1-yl]-N-(1,3-thiazol-2-yl)acetamide
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C19H26N4O2S
 1
1
IC50 = 85930 nM
   TI
   LI
   LO
   TS