Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT02202 , Poly [ADP-ribose] polymerase tankyrase-1
Gene Name TNKS
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID O95271
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT02202
 
Compound ID Compound Name Compound Formula
CP0508441
(4-pyrimidin-4-ylpiperazin-1-yl)-[4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)phenyl]methanone
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C23H20N10O
 1
1
IC50 = 6.31 nM
   TI
   LI
   LO
   TS
CP0154599
(4-pyrimidin-2-ylpiperazin-1-yl)-[4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)phenyl]methanone
   Show/Hide
C23H20N10O
 1
1
IC50 = 19.95 nM
   TI
   LI
   LO
   TS
CP0154554
[4-(1-methylimidazole-4-carbonyl)piperazin-1-yl]-[4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)phenyl]methanone
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C24H22N10O2
 1
1
IC50 = 31.62 nM
   TI
   LI
   LO
   TS
CP0458446
(4-pyridin-3-ylpiperazin-1-yl)-[4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)phenyl]methanone
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C24H21N9O
 1
1
IC50 = 63.1 nM
   TI
   LI
   LO
   TS
CP0454432
N-methyl-N-[4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)phenyl]acetamide
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C17H15N7O
 1
1
IC50 = 79.43 nM
   TI
   LI
   LO
   TS
CP0539024
N-(2-methoxyethyl)-N-methyl-4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)benzamide
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C19H19N7O2
 1
1
IC50 = 79.43 nM
   TI
   LI
   LO
   TS
CP0447057
1-[4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)phenyl]pyrrolidin-2-one
   Show/Hide
C18H15N7O
 1
1
IC50 = 100 nM
   TI
   LI
   LO
   TS
CP0454433
4-[4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)phenyl]morpholin-3-one
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C18H15N7O2
 1
1
IC50 = 100 nM
   TI
   LI
   LO
   TS
CP0454455
[4-(1-methylpyrazole-3-carbonyl)piperazin-1-yl]-[4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)phenyl]methanone
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C24H22N10O2
 1
1
IC50 = 100 nM
   TI
   LI
   LO
   TS
CP0492107
(4-pyridin-2-ylpiperazin-1-yl)-[4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)phenyl]methanone
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C24H21N9O
 1
1
IC50 = 100 nM
   TI
   LI
   LO
   TS
CP0432544
(4-pyridin-4-ylpiperazin-1-yl)-[4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)phenyl]methanone
   Show/Hide
C24H21N9O
 1
1
IC50 = 125.89 nM
   TI
   LI
   LO
   TS
CP0462220
1-[4-[4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)benzoyl]piperazin-1-yl]ethanone
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C21H20N8O2
 1
1
IC50 = 125.89 nM
   TI
   LI
   LO
   TS
CP0468722
[4-(1H-pyrazole-5-carbonyl)piperazin-1-yl]-[4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)phenyl]methanone
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C23H20N10O2
 1
1
IC50 = 125.89 nM
   TI
   LI
   LO
   TS
CP0118849
morpholin-4-yl-[4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)phenyl]methanone
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C19H17N7O2
 1
1
IC50 = 158.49 nM
   TI
   LI
   LO
   TS
CP0154596
N-(4-propan-2-ylphenyl)tetrazolo[1,5-a]quinoxalin-4-amine
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C17H16N6
 1
1
IC50 = 199.53 nM
   TI
   LI
   LO
   TS
CP0558598
oxan-4-yl-[4-[4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)benzoyl]piperazin-1-yl]methanone
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C25H26N8O3
 1
1
IC50 = 199.53 nM
   TI
   LI
   LO
   TS
CP0412937
[4-(1H-imidazole-5-carbonyl)piperazin-1-yl]-[4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)phenyl]methanone
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C23H20N10O2
 1
1
IC50 = 251.19 nM
   TI
   LI
   LO
   TS
CP0492105
N-[4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)phenyl]acetamide
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C16H13N7O
 1
1
IC50 = 251.19 nM
   TI
   LI
   LO
   TS
CP0492106
[4-(oxan-4-yl)piperazin-1-yl]-[4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)phenyl]methanone
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C24H26N8O2
 1
1
IC50 = 251.19 nM
   TI
   LI
   LO
   TS
CP0454456
[4-(3-methylimidazole-4-carbonyl)piperazin-1-yl]-[4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)phenyl]methanone
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C24H22N10O2
 1
1
IC50 = 398.11 nM
   TI
   LI
   LO
   TS
CP0533477
[4-(pyrimidine-2-carbonyl)piperazin-1-yl]-[4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)phenyl]methanone
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C24H20N10O2
 1
1
IC50 = 398.11 nM
   TI
   LI
   LO
   TS
CP0432542
piperidin-1-yl-[4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)phenyl]methanone
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C20H19N7O
 1
1
IC50 = 501.19 nM
   TI
   LI
   LO
   TS
CP0558588
N-(2-methoxyethyl)-4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)benzamide
   Show/Hide
C18H17N7O2
 1
1
IC50 = 630.96 nM
   TI
   LI
   LO
   TS
CP0454457
piperazin-1-yl-[4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)phenyl]methanone
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C19H18N8O
 1
1
IC50 = 794.33 nM
   TI
   LI
   LO
   TS
CP0447257
N-(4-chlorophenyl)tetrazolo[1,5-a]quinoxalin-4-amine
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C14H9ClN6
 1
1
IC50 = 1258.93 nM
   TI
   LI
   LO
   TS
CP0447258
4-N,4-N-dimethyl-1-N-(tetrazolo[1,5-a]quinoxalin-4-yl)benzene-1,4-diamine
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C16H15N7
 1
1
IC50 = 1258.93 nM
   TI
   LI
   LO
   TS
CP0565590
N-(4-methylphenyl)tetrazolo[1,5-a]quinoxalin-4-amine
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C15H12N6
 1
1
IC50 = 1258.93 nM
   TI
   LI
   LO
   TS
CP0425188
MLS000686692
   Show/Hide
C14H10N6
 1
1
IC50 = 1995.26 nM
   TI
   LI
   LO
   TS
CP0492104
N-(4-fluorophenyl)tetrazolo[1,5-a]quinoxalin-4-amine
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C14H9FN6
 1
1
IC50 = 3981.07 nM
   TI
   LI
   LO
   TS
CP0432543
cyclopropyl-[4-[4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)benzoyl]piperazin-1-yl]methanone
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C23H22N8O2
 1
1
IC50 = 5011.87 nM
   TI
   LI
   LO
   TS
CP0358921
N-(3-methylphenyl)tetrazolo[1,5-a]quinoxalin-4-amine
   Show/Hide
C15H12N6
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0393904
N-(3-propan-2-ylphenyl)tetrazolo[1,5-a]quinoxalin-4-amine
   Show/Hide
C17H16N6
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0447058
morpholin-4-yl-[3-(tetrazolo[1,5-a]quinoxalin-4-ylamino)phenyl]methanone
   Show/Hide
C19H17N7O2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0454434
[3-fluoro-4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)phenyl]-morpholin-4-ylmethanone
   Show/Hide
C19H16FN7O2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0458578
N-(2-methylphenyl)tetrazolo[1,5-a]quinoxalin-4-amine
   Show/Hide
C15H12N6
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0458580
4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)benzoic acid
   Show/Hide
C15H10N6O2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS