Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT02042 , Cystic fibrosis transmembrane conductance regulator
Gene Name CFTR
Organism Homo sapiens, Human
Protein Classification Ion channel
Uniprot ID P13569
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT02042
 
Compound ID Compound Name Compound Formula
CP0890392
N-(3-carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-2-yl)-4-chloro-1H-pyrazole-3-carboxamide
   Show/Hide
C16H19ClN4O3S
 1
1
EC50 = 81 nM
   TI
   LI
   LO
   TS
CP0890391
N-(3-carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-2-yl)-4-methyl-1H-pyrazole-3-carboxamide
   Show/Hide
C17H22N4O3S
 1
1
EC50 = 123 nM
   TI
   LI
   LO
   TS
CP0890393
N-(3-carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-2-yl)-5-(trifluoromethyl)-1H-pyrazole-3-carboxamide
   Show/Hide
C17H19F3N4O3S
 1
1
EC50 = 130 nM
   TI
   LI
   LO
   TS
CP0852982
2-(2-hydroxybenzamido)-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide
   Show/Hide
C19H22N2O4S
 1
1
EC50 = 162 nM
   TI
   LI
   LO
   TS
CP0860496
N-(3-carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-2-yl)-4-chloro-5-methyl-1H-pyrazole-3-carboxamide
   Show/Hide
C17H21ClN4O3S
 1
1
EC50 = 199 nM
   TI
   LI
   LO
   TS
CP0852623
2-(2-hydroxybenzamido)-5,7-dimethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide
   Show/Hide
C17H18N2O4S
 1
1
EC50 = 236 nM
   TI
   LI
   LO
   TS
CP0138270
N-(3-carbamoyl-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-2-yl)-1H-pyrazole-5-carboxamide
   Show/Hide
C16H20N4O3S
 1
1
EC50 = 339 nM
   TI
   LI
   LO
   TS
CP0878183
2-[[(2S)-2-Hydroxy-3,3-dimethyl-butanoyl]amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide
   Show/Hide
C18H28N2O4S
 1
1
EC50 = 421 nM
   TI
   LI
   LO
   TS
CP0472502
2-[(2-hydroxy-2-methylpropanoyl)amino]-5-(4-methoxyphenyl)sulfonylthiophene-3-carboxamide
   Show/Hide
C16H18N2O6S2
 1
1
EC50 = 478 nM
   TI
   LI
   LO
   TS
CP0890488
2-(2-hydroxybenzamido)-5,5-dimethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide
   Show/Hide
C17H18N2O4S
 1
1
EC50 = 490 nM
   TI
   LI
   LO
   TS
CP0878190
N-(3-carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-2-yl)-5-methyl-1H-pyrazole-3-carboxamide
   Show/Hide
C17H22N4O3S
 1
1
EC50 = 590 nM
   TI
   LI
   LO
   TS
CP0949236
2-[(2-hydroxy-4,4-dimethyl-pentanoyl)amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide
   Show/Hide
C19H30N2O4S
 1
1
EC50 = 981 nM
   TI
   LI
   LO
   TS
CP0088272
CHEBI:66901
   Show/Hide
C24H28N2O3
 1
1
EC50 = 1300 nM
   TI
   LI
   LO
   TS
CP0852634
2-(1-(Hydroxymethyl)cyclopropanecarboxamido)-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide
   Show/Hide
C17H24N2O4S
 1
1
EC50 = 1320 nM
   TI
   LI
   LO
   TS
CP0892582
2-[[(2R)-2-hydroxy-3,3-dimethyl-butanoyl]amino]-5,5,7,7-tetramethyl-4H-thieno[2,3-c]pyran-3-carboxamide
   Show/Hide
C18H28N2O4S
 1
1
EC50 = 7777 nM
   TI
   LI
   LO
   TS
CP0285441
2-(2-chlorobenzamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide
   Show/Hide
C16H15ClN2O2S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS