Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT02025 , Prostaglandin E synthase
Gene Name PTGES
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID O14684
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT02025
 
Compound ID Compound Name Compound Formula
CP0092312
2-[2-[(1S,2S)-2-[[1-(8-methylquinolin-2-yl)piperidine-4-carbonyl]amino]cyclopentyl]ethyl]benzoic acid
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C30H35N3O3
 1
1
IC50 = 1 nM
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CP0113791
4-methyl-2-[2-[(1S,2S)-2-[[1-[4-(trifluoromethyl)phenyl]piperidine-4-carbonyl]amino]cyclopentyl]ethyl]benzoic acid
   Show/Hide
C28H33F3N2O3
 1
1
IC50 = 1 nM
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CP0126743
4-fluoro-2-[2-[(1S,2S)-2-[[1-[4-(trifluoromethyl)phenyl]piperidine-4-carbonyl]amino]cyclopentyl]ethyl]benzoic acid
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C27H30F4N2O3
 1
1
IC50 = 1 nM
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CP0196736
2-[2-[(1S,2S)-2-[[1-[4-(trifluoromethoxy)phenyl]piperidine-4-carbonyl]amino]cyclopentyl]ethyl]benzoic acid
   Show/Hide
C27H31F3N2O4
 1
1
IC50 = 1 nM
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CP0526264
4-chloro-2-[2-[(1S,2S)-2-[[1-[4-(trifluoromethyl)phenyl]piperidine-4-carbonyl]amino]cyclopentyl]ethyl]benzoic acid
   Show/Hide
C27H30ClF3N2O3
 1
1
IC50 = 1 nM
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CP0115746
4-chloro-2-[[(1S,2S)-2-[(1-phenylpiperidine-4-carbonyl)amino]cyclopentyl]methylamino]benzoic acid
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C25H30ClN3O3
 1
1
IC50 = 2 nM
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CP0190357
2-[2-[(1S,2S)-2-[[1-[5-(trifluoromethyl)pyridin-2-yl]piperidine-4-carbonyl]amino]cyclopentyl]ethyl]benzoic acid
   Show/Hide
C26H30F3N3O3
 1
1
IC50 = 2 nM
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CP0196729
2-[2-[(1S,2S)-2-[[1-[4-(trifluoromethyl)phenyl]piperidine-4-carbonyl]amino]cyclopentyl]ethyl]benzoic acid
   Show/Hide
C27H31F3N2O3
 1
1
IC50 = 2 nM
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CP0359657
4-chloro-2-[[(1R,2S)-2-[[1-[4-(trifluoromethyl)phenyl]piperidine-4-carbonyl]amino]cyclopentyl]methoxy]benzoic acid
   Show/Hide
C26H28ClF3N2O4
 1
1
IC50 = 2 nM
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CP0396678
2-(2-chloro-6-fluorophenyl)-7-(3-chlorophenyl)-3,5-dihydroimidazo[4,5-c]quinolin-4-one
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C22H12Cl2FN3O
 1
1
IC50 = 2.5 nM
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CP0446273
2-(2-chloro-6-fluorophenyl)-7-(4-chlorophenyl)-3,5-dihydroimidazo[4,5-c]quinolin-4-one
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C22H12Cl2FN3O
 1
1
IC50 = 3.3 nM
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CP0201007
4-chloro-2-[[(1S,2S)-2-[[1-[4-(trifluoromethyl)phenyl]piperidine-4-carbonyl]amino]cyclopentyl]methylamino]benzoic acid
   Show/Hide
C26H29ClF3N3O3
 1
1
IC50 = 4 nM
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CP0156847
2-(2-chloro-6-fluorophenyl)-7-phenyl-3,5-dihydroimidazo[4,5-c]quinolin-4-one
   Show/Hide
C22H13ClFN3O
 1
1
IC50 = 4.1 nM
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CP0047355
2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)isophthalonitrile
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C23H11ClN4
 1
1
IC50 = 4.3 nM
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CP0446274
2-(2-chloro-6-fluorophenyl)-7-(2-chlorophenyl)-3,5-dihydroimidazo[4,5-c]quinolin-4-one
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C22H12Cl2FN3O
 1
1
IC50 = 4.3 nM
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CP0468608
2-(2-chloro-6-fluorophenyl)-7-(3-methylphenyl)-3,5-dihydroimidazo[4,5-c]quinolin-4-one
   Show/Hide
C23H15ClFN3O
 1
1
IC50 = 4.5 nM
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CP0196752
2-[2-[(1S,2S)-2-[[1-[4-(trifluoromethyl)phenyl]piperidine-4-carbonyl]amino]cyclopentyl]ethyl]pyridine-3-carboxylic acid
   Show/Hide
C26H30F3N3O3
 1
1
IC50 = 6 nM
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CP0514254
2-(2-chlorophenyl)-7-phenyl-3,5-dihydroimidazo[4,5-c]quinolin-4-one
   Show/Hide
C22H14ClN3O
 1
1
IC50 = 7.9 nM
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CP0399363
2-(2-chloro-6-fluorophenyl)-7-(4-methylphenyl)-3,5-dihydroimidazo[4,5-c]quinolin-4-one
   Show/Hide
C23H15ClFN3O
 1
1
IC50 = 8.3 nM
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CP0085702
7-bromo-2-(2-chlorophenyl)-3,5-dihydroimidazo[4,5-c]quinolin-4-one
   Show/Hide
C16H9BrClN3O
 1
1
IC50 = 9.1 nM
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CP0514255
2-(2-chloro-6-fluorophenyl)-7-(2-methylphenyl)-3,5-dihydroimidazo[4,5-c]quinolin-4-one
   Show/Hide
C23H15ClFN3O
 1
1
IC50 = 9.9 nM
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CP0446275
2-(2-chloro-6-nitrophenyl)-7-phenyl-3,5-dihydroimidazo[4,5-c]quinolin-4-one
   Show/Hide
C22H13ClN4O3
 1
1
IC50 = 10 nM
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CP0397688
2-(2-chloro-6-methylphenyl)-7-phenyl-3,5-dihydroimidazo[4,5-c]quinolin-4-one
   Show/Hide
C23H16ClN3O
 1
1
IC50 = 12 nM
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CP0491728
2-[2-chloro-6-(trifluoromethyl)phenyl]-7-phenyl-3,5-dihydroimidazo[4,5-c]quinolin-4-one
   Show/Hide
C23H13ClF3N3O
 1
1
IC50 = 12 nM
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CP0396208
7-benzyl-2-(2-chlorophenyl)-3,5-dihydroimidazo[4,5-c]quinolin-4-one
   Show/Hide
C23H16ClN3O
 1
1
IC50 = 17 nM
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CP0396679
7-butyl-2-(2-chlorophenyl)-3,5-dihydroimidazo[4,5-c]quinolin-4-one
   Show/Hide
C20H18ClN3O
 1
1
IC50 = 17 nM
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CP0396682
2-(2-chlorophenyl)-7-(2-phenylethyl)-3,5-dihydroimidazo[4,5-c]quinolin-4-one
   Show/Hide
C24H18ClN3O
 1
1
IC50 = 21 nM
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CP0482263
2-(2-chlorophenyl)-7-thiophen-2-yl-3,5-dihydroimidazo[4,5-c]quinolin-4-one
   Show/Hide
C20H12ClN3OS
 1
1
IC50 = 21 nM
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CP0374983
2-(2-chlorophenyl)-7-(furan-2-yl)-3,5-dihydroimidazo[4,5-c]quinolin-4-one
   Show/Hide
C20H12ClN3O2
 1
1
IC50 = 22 nM
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CP0433645
7-chloro-2-(2-chlorophenyl)-3,5-dihydroimidazo[4,5-c]quinolin-4-one
   Show/Hide
C16H9Cl2N3O
 1
1
IC50 = 27 nM
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CP0415020
7-bromo-2-(2-chlorophenyl)-4-methylsulfanyl-3H-imidazo[4,5-c]quinoline
   Show/Hide
C17H11BrClN3S
 1
1
IC50 = 31 nM
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CP0556276
2-(2-chlorophenyl)-7-naphthalen-2-yl-3,5-dihydroimidazo[4,5-c]quinolin-4-one
   Show/Hide
C26H16ClN3O
 1
1
IC50 = 32 nM
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CP0526263
4-chloro-2-[[(1S,2S)-2-(2,2-dimethylpropanoylamino)cyclopentyl]methylamino]benzoic acid
   Show/Hide
C18H25ClN2O3
 1
1
IC50 = 43 nM
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CP0396206
2-(2-chlorophenyl)-7-propyl-3,5-dihydroimidazo[4,5-c]quinolin-4-one
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C19H16ClN3O
 1
1
IC50 = 47 nM
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CP0396680
2-(2-chlorophenyl)-7-pentyl-3,5-dihydroimidazo[4,5-c]quinolin-4-one
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C21H20ClN3O
 1
1
IC50 = 53 nM
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CP0449320
7-bromo-2-(2-chlorophenyl)-4-ethylsulfanyl-3H-imidazo[4,5-c]quinoline
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C18H13BrClN3S
 1
1
IC50 = 59 nM
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CP0474564
7-bromo-2-(2-chlorophenyl)-4-methoxy-3H-imidazo[4,5-c]quinoline
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C17H11BrClN3O
 1
1
IC50 = 62 nM
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CP0396681
2-(2-chlorophenyl)-7-hexyl-3,5-dihydroimidazo[4,5-c]quinolin-4-one
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C22H22ClN3O
 1
1
IC50 = 70 nM
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CP0513273
7-bromo-2-(2-chlorophenyl)-3,5-dihydroimidazo[4,5-c]quinoline-4-thione
   Show/Hide
C16H9BrClN3S
 1
1
IC50 = 83 nM
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CP0415019
7-bromo-2-(2-chlorophenyl)-5-methyl-3H-imidazo[4,5-c]quinolin-4-one
   Show/Hide
C17H11BrClN3O
 1
1
IC50 = 85 nM
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CP0449562
2-(2-chlorophenyl)-7-ethyl-3,5-dihydroimidazo[4,5-c]quinolin-4-one
   Show/Hide
C18H14ClN3O
 1
1
IC50 = 98 nM
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CP0452368
7-bromo-2-(2-chlorophenyl)-5-ethyl-3H-imidazo[4,5-c]quinolin-4-one
   Show/Hide
C18H13BrClN3O
 1
1
IC50 = 106 nM
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CP0392452
7-bromo-2-(2-chlorophenyl)-4-ethoxy-3H-imidazo[4,5-c]quinoline
   Show/Hide
C18H13BrClN3O
 1
1
IC50 = 108 nM
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CP0392450
7-bromo-2-(2-chlorophenyl)-4-phenylmethoxy-3H-imidazo[4,5-c]quinoline
   Show/Hide
C23H15BrClN3O
 1
1
IC50 = 172 nM
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CP0556275
8-bromo-2-(2-chlorophenyl)-3,5-dihydroimidazo[4,5-c]quinolin-4-one
   Show/Hide
C16H9BrClN3O
 1
1
IC50 = 198 nM
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CP0523711
5-benzyl-7-bromo-2-(2-chlorophenyl)-3H-imidazo[4,5-c]quinolin-4-one
   Show/Hide
C23H15BrClN3O
 1
1
IC50 = 226 nM
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CP0491791
2-(2-chlorophenyl)-7-methyl-3,5-dihydroimidazo[4,5-c]quinolin-4-one
   Show/Hide
C17H12ClN3O
 1
1
IC50 = 241 nM
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CP0401160
7-bromo-2-(2-chlorophenyl)-3H-imidazo[4,5-c]quinoline
   Show/Hide
C16H9BrClN3
 1
1
IC50 = 251 nM
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CP0503530
7-bromo-2-(2-chlorophenyl)-4-cyclohexyloxy-3H-imidazo[4,5-c]quinoline
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C22H19BrClN3O
 1
1
IC50 = 306 nM
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CP0396070
7-bromo-2-(2-chlorophenyl)-4-phenoxy-3H-imidazo[4,5-c]quinoline
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C22H13BrClN3O
 1
1
IC50 = 330 nM
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CP0480249
7-bromo-2-(2-chlorophenyl)-N,N-dimethyl-3H-imidazo[4,5-c]quinolin-4-amine
   Show/Hide
C18H14BrClN4
 1
1
IC50 = 387 nM
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CP0401161
7-bromo-2-(2-methylphenyl)-3H-imidazo[4,5-c]quinoline
   Show/Hide
C17H12BrN3
 1
1
IC50 = 395 nM
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CP0514253
8-chloro-2-(2-chlorophenyl)-3,5-dihydroimidazo[4,5-c]quinolin-4-one
   Show/Hide
C16H9Cl2N3O
 1
1
IC50 = 434 nM
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CP0461622
7-bromo-2-(2-bromophenyl)-3H-imidazo[4,5-c]quinoline
   Show/Hide
C16H9Br2N3
 1
1
IC50 = 506 nM
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CP0452369
7-bromo-2-(2-chlorophenyl)-N-methyl-3H-imidazo[4,5-c]quinolin-4-amine
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C17H12BrClN4
 1
1
IC50 = 631 nM
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CP0493782
7-bromo-2-(2-nitrophenyl)-3H-imidazo[4,5-c]quinoline
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C16H9BrN4O2
 1
1
IC50 = 669 nM
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CP0508903
2-(7-bromo-3H-imidazo[4,5-c]quinolin-2-yl)benzonitrile
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C17H9BrN4
 1
1
IC50 = 687 nM
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CP0376540
7-bromo-2-(3-chlorophenyl)-3H-imidazo[4,5-c]quinoline
   Show/Hide
C16H9BrClN3
 1
1
IC50 = 859 nM
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CP0396204
2-(2-chlorophenyl)-3,5-dihydroimidazo[4,5-c]quinolin-4-one
   Show/Hide
C16H10ClN3O
 1
1
IC50 = 891 nM
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CP0482466
2-(2-chlorophenyl)-7-pyridin-3-yl-3,5-dihydroimidazo[4,5-c]quinolin-4-one
   Show/Hide
C21H13ClN4O
 1
1
IC50 = 908 nM
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CP0524660
7-bromo-2-[2-(trifluoromethyl)phenyl]-3H-imidazo[4,5-c]quinoline
   Show/Hide
C17H9BrF3N3
 1
1
IC50 = 1000 nM
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CP0452370
7-bromo-2-(2-chlorophenyl)-3H-imidazo[4,5-c]quinolin-4-amine
   Show/Hide
C16H10BrClN4
 1
1
IC50 = 1068 nM
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CP0433646
2-(2-chlorophenyl)-7-pyridin-4-yl-3,5-dihydroimidazo[4,5-c]quinolin-4-one
   Show/Hide
C21H13ClN4O
 1
1
IC50 = 1128 nM
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CP0461960
7-bromo-2-(3-methylphenyl)-3H-imidazo[4,5-c]quinoline
   Show/Hide
C17H12BrN3
 1
1
IC50 = 1490 nM
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CP0392448
2-(7-bromo-3H-imidazo[4,5-c]quinolin-2-yl)phenol
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C16H10BrN3O
 1
1
IC50 = 4116 nM
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CP0508902
7-bromo-2-(2-phenylphenyl)-3H-imidazo[4,5-c]quinoline
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C22H14BrN3
 1
1
IC50 = 4620 nM
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CP0549846
2-(7-bromo-3H-imidazo[4,5-c]quinolin-2-yl)-N,N-dimethylaniline
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C18H15BrN4
 1
1
IC50 = 6264 nM
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CP0459952
7-bromo-2-(2-fluorophenyl)-3H-imidazo[4,5-c]quinoline
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C16H9BrFN3
 1
1
IC50 = 6970 nM
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CP0457169
7-bromo-2-phenyl-3H-imidazo[4,5-c]quinoline
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C16H10BrN3
 1
1
IC50 = 9500 nM
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CP0415017
7-bromo-2-(2-chlorophenyl)-3-methyl-5H-imidazo[4,5-c]quinolin-4-one
   Show/Hide
C17H11BrClN3O
 1
1
IC50 = 9810 nM
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CP0398348
7-bromo-2-(4-methylphenyl)-3H-imidazo[4,5-c]quinoline
   Show/Hide
C17H12BrN3
 1
1
IC50 > 10000 nM
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CP0461620
7-bromo-2-(4-chlorophenyl)-3H-imidazo[4,5-c]quinoline
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C16H9BrClN3
 1
1
IC50 > 10000 nM
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CP0415018
7-bromo-2-(2-chlorophenyl)-1-methyl-5H-imidazo[4,5-c]quinolin-4-one
   Show/Hide
C17H11BrClN3O
 1
1
IC50 > 10000 nM
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CP0452367
7-bromo-2-(2-chlorophenyl)-3,5-dimethylimidazo[4,5-c]quinolin-4-one
   Show/Hide
C18H13BrClN3O
 1
1
IC50 > 10000 nM
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CP0514905
3-benzyl-7-bromo-2-(2-chlorophenyl)-5H-imidazo[4,5-c]quinolin-4-one
   Show/Hide
C23H15BrClN3O
 1
1
IC50 > 10000 nM
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