Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT01667 , MAP/microtubule affinity-regulating kinase 4
Gene Name MARK4
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID Q96L34
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT01667
 
Compound ID Compound Name Compound Formula
CP0496360
N-[3-[[5-bromo-4-[3-(cyclobutanecarbonylamino)propylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide
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C23H30BrN7O2
 1
1
IC50 = 72 nM
   TI
   LI
   LO
   TS
CP0275665
5-bromo-4-N-[2-(1H-imidazol-5-yl)ethyl]-2-N-[3-(morpholin-4-ylmethyl)phenyl]pyrimidine-2,4-diamine
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C20H24BrN7O
 1
1
IC50 = 214 nM
   TI
   LI
   LO
   TS
CP0201442
N-[3-[[5-cyclopropyl-2-[3-(morpholin-4-ylmethyl)anilino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide
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C26H36N6O2
 1
1
IC50 = 319 nM
   TI
   LI
   LO
   TS
CP0237749
BX-912
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C20H23BrN8O
 1
1
IC50 = 338 nM
   TI
   LI
   LO
   TS
CP0275666
N-[3-[[4-[3-(cyclobutanecarbonylamino)propylamino]-5-cyclopropylpyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide
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C26H35N7O2
 1
1
IC50 = 509 nM
   TI
   LI
   LO
   TS
CP0275671
5-cyclopropyl-4-N-[2-(1H-imidazol-5-yl)ethyl]-2-N-[3-(morpholin-4-ylmethyl)phenyl]pyrimidine-2,4-diamine
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C23H29N7O
 1
1
IC50 = 808 nM
   TI
   LI
   LO
   TS
CP0496361
N-[3-[[5-bromo-2-[[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide
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C18H23BrF3N7O
 1
1
IC50 = 3537 nM
   TI
   LI
   LO
   TS
CP0496362
5-bromo-4-N-[2-(1H-imidazol-5-yl)ethyl]-2-N-[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyrimidine-2,4-diamine
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C15H16BrF3N8
 1
1
IC50 = 8445 nM
   TI
   LI
   LO
   TS
CP0169053
4-[[[5-bromo-2-[[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]amino]methyl]benzenesulfonamide
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C17H17BrF3N7O2S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0260709
4-N-[2-(1H-imidazol-5-yl)ethyl]-2-N-[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyrimidine-2,4-diamine
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C15H17F3N8
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0273555
4-[[[5-cyclopropyl-2-[3-(morpholin-4-ylmethyl)anilino]pyrimidin-4-yl]amino]methyl]benzenesulfonamide
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C25H30N6O3S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0275668
4-[[[5-bromo-2-[3-(morpholin-4-ylmethyl)anilino]pyrimidin-4-yl]amino]methyl]benzenesulfonamide
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C22H25BrN6O3S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0275670
4-[[[2-[3-(morpholin-4-ylmethyl)anilino]pyrimidin-4-yl]amino]methyl]benzenesulfonamide
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C22H26N6O3S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0275672
N-[3-[[4-[3-(cyclobutanecarbonylamino)propylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide
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C23H31N7O2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0275673
N-[3-[[5-bromo-4-[(4-sulfamoylphenyl)methylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide
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C22H24BrN7O3S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0275674
5-cyclopropyl-4-N-[2-(1H-imidazol-5-yl)ethyl]-2-N-[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyrimidine-2,4-diamine
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C18H21F3N8
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0344151
4-N-[2-(1H-imidazol-5-yl)ethyl]-2-N-[3-(morpholin-4-ylmethyl)phenyl]pyrimidine-2,4-diamine
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C20H25N7O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0496364
4-[[[2-[[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]amino]methyl]benzenesulfonamide
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C17H18F3N7O2S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0543933
N-[3-[[5-cyclopropyl-4-[(4-sulfamoylphenyl)methylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide
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C25H29N7O3S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0551443
4-[[[5-cyclopropyl-2-[[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]amino]methyl]benzenesulfonamide
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C20H22F3N7O2S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0551444
N-[3-[[4-[(4-sulfamoylphenyl)methylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide
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C22H25N7O3S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0567307
N-[3-[[5-cyclopropyl-2-[[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide
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C21H28F3N7O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0571203
N-[3-[[2-[[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide
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C18H24F3N7O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS