Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT01508 , C-C chemokine receptor type 4
Gene Name CCR4
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P51679
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT01508
 
Compound ID Compound Name Compound Formula
CP0247516
2,3-dichloro-N-(5-fluoro-3-methoxypyrazin-2-yl)benzenesulfonamide
   Show/Hide
C11H8Cl2FN3O3S
 1
1
IC50 = 3.981 nM
   TI
   LI
   LO
   TS
CP0405317
(S)-(4-(4-(2,4-dichlorobenzylamino)pyrido[2,3-d]pyrimidin-2-yl)piperazin-1-yl)(piperidin-2-yl)methanone
   Show/Hide
C24H27Cl2N7O
 1
1
IC50 = 20 nM
   TI
   LI
   LO
   TS
CP0415094
5,7-Dihydroxy-4-methyl-3-(4-methylpiperazin-1-yl)-2H-chromen-2-one
   Show/Hide
C15H18N2O4
 1
1
IC50 = 21.2 nM
   TI
   LI
   LO
   TS
CP0234241
(R)-(4-(4-(2,4-dichlorobenzylamino)pyrimidin-2-yl)piperazin-1-yl)(piperidin-2-yl)methanone
   Show/Hide
C21H26Cl2N6O
 1
1
IC50 = 50 nM
   TI
   LI
   LO
   TS
CP0502756
(R)-(4-(4-(2,4-dichlorobenzylamino)pyrimidin-2-yl)piperazin-1-yl)(pyrrolidin-2-yl)methanone
   Show/Hide
C20H24Cl2N6O
 1
1
IC50 = 60 nM
   TI
   LI
   LO
   TS
CP0440385
(S)-(4-(4-(2,4-dichlorobenzylamino)pyrido[2,3-d]pyrimidin-2-yl)piperazin-1-yl)(pyrrolidin-2-yl)methanone
   Show/Hide
C23H25Cl2N7O
 1
1
IC50 = 80 nM
   TI
   LI
   LO
   TS
CP0430736
4-(5,7-Dihydroxy-4-methyl-2-oxo-2H-chromen-3-yl)-N-(4-(trifluoromethoxy)phenyl)piperazine-1-carboxamide
   Show/Hide
C22H20F3N3O6
 1
1
IC50 = 110 nM
   TI
   LI
   LO
   TS
CP0387424
3-(4-Ethylpiperazin-1-yl)-5,7-dihydroxy-4-methyl-2H-chromen-2-one
   Show/Hide
C16H20N2O4
 1
1
IC50 = 131 nM
   TI
   LI
   LO
   TS
CP0405313
4-N-[(2,4-dichlorophenyl)methyl]-2-N-[5-(diethylamino)pentan-2-yl]pyrido[2,3-d]pyrimidine-2,4-diamine
   Show/Hide
C23H30Cl2N6
 1
1
IC50 = 140 nM
   TI
   LI
   LO
   TS
CP0510490
4-Methyl-3-(4-methylpiperazin-1-yl)-7-(2-(piperidin-1-yl)ethoxy)-2H-chromen-2-one
   Show/Hide
C22H31N3O3
 1
1
IC50 = 196 nM
   TI
   LI
   LO
   TS
CP0465234
1-(2,4-dichlorobenzyl)-N-(5-(diethylamino)pentan-2-yl)-1H-pyrazolo[3,4-b]pyridin-6-amine
   Show/Hide
C22H29Cl2N5
 1
1
IC50 = 280 nM
   TI
   LI
   LO
   TS
CP0894039
N4-(2,4-dichlorobenzyl)-N2-(4-(diethylamino)pentyl)pyrimidine-2,4-diamine
   Show/Hide
C20H32Cl2N6
 1
1
IC50 = 280 nM
   TI
   LI
   LO
   TS
CP0442868
(4-(2-(2,4-dichlorobenzylamino)pyrimidin-4-yl)piperazin-1-yl)(1-methylpiperidin-3-yl)methanone
   Show/Hide
C22H28Cl2N6O
 1
1
IC50 = 300 nM
   TI
   LI
   LO
   TS
CP0501384
5-Hydroxy-7-methoxy-4-methyl-3-(4-methylpiperazin-1-yl)-2H-chromen-2-one
   Show/Hide
C16H20N2O4
 1
1
IC50 = 389 nM
   TI
   LI
   LO
   TS
CP0387428
8-Methyl-7-(4-methylpiperazin-1-yl)-6H-[1,3]dioxolo[4,5-g]-chromen-6-one
   Show/Hide
C16H18N2O4
 1
1
IC50 = 420 nM
   TI
   LI
   LO
   TS
CP0497041
5,7-Dimethoxy-4-methyl-3-(4-methylpiperazin-1-yl)-2H-chromen-2-one
   Show/Hide
C17H22N2O4
 1
1
IC50 = 478 nM
   TI
   LI
   LO
   TS
CP0435635
4-N-[(2,4-dichlorophenyl)methyl]-2-N-[5-(diethylamino)pentan-2-yl]quinazoline-2,4-diamine
   Show/Hide
C24H31Cl2N5
 1
1
IC50 = 500 nM
   TI
   LI
   LO
   TS
CP0423569
4-Methyl-3-(4-methylpiperazin-1-yl)-7-(2-(thiophen-2-yl)ethoxy)-2H-chromen-2-one
   Show/Hide
C21H24N2O3S
 1
1
IC50 = 527 nM
   TI
   LI
   LO
   TS
CP0517554
4-(5,7-Dihydroxy-4-methyl-2-oxo-2H-chromen-3-yl)-N-heptylpiperazine-1-carboxamide
   Show/Hide
C22H31N3O5
 1
1
IC50 = 539 nM
   TI
   LI
   LO
   TS
CP0494418
4-Methyl-3-(4-methylpiperazin-1-yl)-7-(2-morpholinoethoxy)-2H-chromen-2-one
   Show/Hide
C21H29N3O4
 1
1
IC50 = 671 nM
   TI
   LI
   LO
   TS
CP0523168
(4-(4-(2,4-dichlorobenzylamino)pyrimidin-2-yl)piperazin-1-yl)(1-methylpiperidin-3-yl)methanone
   Show/Hide
C22H28Cl2N6O
 1
1
IC50 = 700 nM
   TI
   LI
   LO
   TS
CP0430739
7-Hydroxy-4-methyl-3-(4-methylpiperazin-1-yl)-2H-chromen-2-one
   Show/Hide
C15H18N2O3
 1
1
IC50 = 775 nM
   TI
   LI
   LO
   TS
CP0464678
(4-(4-(2,4-dichlorobenzylamino)pyrimidin-2-yl)piperazin-1-yl)(piperidin-3-yl)methanone
   Show/Hide
C21H26Cl2N6O
 1
1
IC50 = 800 nM
   TI
   LI
   LO
   TS
CP0458918
9-(2,4-dichlorobenzyl)-N-(5-(diethylamino)pentan-2-yl)-9H-purin-2-amine
   Show/Hide
C21H28Cl2N6
 1
1
IC50 = 820 nM
   TI
   LI
   LO
   TS
CP0405316
7-(2,4-dichlorobenzyl)-N-(5-(diethylamino)pentan-2-yl)-7H-purin-2-amine
   Show/Hide
C21H28Cl2N6
 1
1
IC50 = 830 nM
   TI
   LI
   LO
   TS
CP0453765
(S)-(4-(4-(2,4-dichlorobenzylamino)pyrimidin-2-yl)piperazin-1-yl)(piperidin-2-yl)methanone
   Show/Hide
C21H26Cl2N6O
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0509884
6-N-[(2,4-dichlorophenyl)methyl]-2-N-[5-(diethylamino)pentan-2-yl]-7-ethylpurine-2,6-diamine
   Show/Hide
C23H33Cl2N7
 1
1
IC50 = 1100 nM
   TI
   LI
   LO
   TS
CP0469578
5-Hydroxy-4,7-dimethyl-3-(4-methylpiperazin-1-yl)-2H-chromen-2-one
   Show/Hide
C16H20N2O3
 1
1
IC50 = 1130 nM
   TI
   LI
   LO
   TS
CP0516020
(4-(4-(2,4-dichlorobenzyloxy)pyrimidin-2-yl)piperazin-1-yl)(1-methylpiperidin-3-yl)methanone
   Show/Hide
C22H27Cl2N5O2
 1
1
IC50 = 1200 nM
   TI
   LI
   LO
   TS
CP0510480
4-(5,7-Dihydroxy-4-methyl-2-oxo-2H-chromen-3-yl)-N-(4-isopropylphenyl)piperazine-1-carboxamide
   Show/Hide
C24H27N3O5
 1
1
IC50 = 1320 nM
   TI
   LI
   LO
   TS
CP0387434
4-Methyl-3-(4-methylpiperazin-1-yl)-7-(2-(pyrrolidin-1-yl)-ethoxy)-2H-chromen-2-one
   Show/Hide
C21H29N3O3
 1
1
IC50 = 1510 nM
   TI
   LI
   LO
   TS
CP0517596
3-(4-cinnamoylpiperazin-1-yl)-5,7-dihydroxy-4-methyl-2H-chromen-2-one
   Show/Hide
C23H22N2O5
 1
1
IC50 = 1570 nM
   TI
   LI
   LO
   TS
CP0510482
N-benzyl-4-(5,7-dihydroxy-4-methyl-2-oxochromen-3-yl)piperazine-1-carboxamide
   Show/Hide
C22H23N3O5
 1
1
IC50 = 1590 nM
   TI
   LI
   LO
   TS
CP0501386
7-Ethoxy-4-methyl-3-(4-methylpiperazin-1-yl)-2H-chromen-2-one
   Show/Hide
C17H22N2O3
 1
1
IC50 = 1640 nM
   TI
   LI
   LO
   TS
CP0437113
2-N-[(2,4-dichlorophenyl)methyl]-4-N-[5-(diethylamino)pentan-2-yl]quinazoline-2,4-diamine
   Show/Hide
C24H31Cl2N5
 1
1
IC50 = 1910 nM
   TI
   LI
   LO
   TS
CP0405365
2-N-[(2,4-dichlorophenyl)methyl]-6-N-[5-(diethylamino)pentan-2-yl]-7H-purine-2,6-diamine
   Show/Hide
C21H29Cl2N7
 1
1
IC50 = 2100 nM
   TI
   LI
   LO
   TS
CP0517598
N-[4-[4-(5,7-dihydroxy-4-methyl-2-oxochromen-3-yl)piperazin-1-yl]sulfonylphenyl]acetamide
   Show/Hide
C22H23N3O7S
 1
1
IC50 = 2560 nM
   TI
   LI
   LO
   TS
CP0449314
2-N-[(2,4-dichlorophenyl)methyl]-6-N-[5-(diethylamino)pentan-2-yl]-7-ethylpurine-2,6-diamine
   Show/Hide
C23H33Cl2N7
 1
1
IC50 = 2600 nM
   TI
   LI
   LO
   TS
CP0501387
7-(4-Ethylcyclohexyloxy)-4-methyl-3-(4-methylpiperazin-1-yl)-2H-chromen-2-one
   Show/Hide
C23H32N2O3
 1
1
IC50 = 3120 nM
   TI
   LI
   LO
   TS
CP0535902
4-N-[(2,4-dichlorophenyl)methyl]-2-N-[5-(diethylamino)pentan-2-yl]-6-N-methyl-1,3,5-triazine-2,4,6-triamine
   Show/Hide
C20H31Cl2N7
 1
1
IC50 = 3600 nM
   TI
   LI
   LO
   TS
CP0517597
3-(4-Acryloylpiperazin-1-yl)-5,7-dihydroxy-4-methyl-2H-chromen-2-one
   Show/Hide
C17H18N2O5
 1
1
IC50 = 4240 nM
   TI
   LI
   LO
   TS
CP0494417
3-(4-benzoylpiperazin-1-yl)-5,7-dihydroxy-4-methyl-2H-chromen-2-one
   Show/Hide
C21H20N2O5
 1
1
IC50 = 4360 nM
   TI
   LI
   LO
   TS
CP0510491
5,7-Dihydroxy-4-methyl-3-(piperazin-1-yl)-2H-chromen-2-one
   Show/Hide
C14H16N2O4
 1
1
IC50 = 4360 nM
   TI
   LI
   LO
   TS
CP0387431
7-(Dimethylamino)-4-methyl-3-(4-methylpiperazin-1-yl)-2Hchromen-2-one
   Show/Hide
C17H23N3O2
 1
1
IC50 = 4760 nM
   TI
   LI
   LO
   TS
CP0425630
6-N-[(2,4-dichlorophenyl)methyl]-2-N-[5-(diethylamino)pentan-2-yl]-7H-purine-2,6-diamine
   Show/Hide
C21H29Cl2N7
 1
1
IC50 = 4900 nM
   TI
   LI
   LO
   TS
CP0501385
7-Methoxy-4-methyl-3-(4-methylpiperazin-1-yl)-2H-chromen-2-one
   Show/Hide
C16H20N2O3
 1
1
IC50 = 5210 nM
   TI
   LI
   LO
   TS
CP0456936
N-[(2S)-1-[[4-[(2,4-dichlorophenyl)methoxy]pyrimidin-2-yl]amino]-3-methylbutan-2-yl]-1-methylpiperidine-3-carboxamide
   Show/Hide
C23H31Cl2N5O2
 1
1
IC50 = 5600 nM
   TI
   LI
   LO
   TS
CP0510481
4-(5,7-Dihydroxy-4-methyl-2-oxo-2H-chromen-3-yl)-N-(2-phenoxyphenyl)piperazine-1-carboxamide
   Show/Hide
C27H25N3O6
 1
1
IC50 = 6000 nM
   TI
   LI
   LO
   TS
CP0510479
5,7-Dihydroxy-4-methyl-3-(4-(phenylsulfonyl)piperazin-1-yl)-2H-chromen-2-one
   Show/Hide
C20H20N2O6S
 1
1
IC50 = 6040 nM
   TI
   LI
   LO
   TS
CP0541630
7-(4-Methoxybenzyloxy)-4-methyl-3-(4-methylpiperazin-1-yl)-2H-chromen-2-one
   Show/Hide
C23H26N2O4
 1
1
IC50 = 7320 nM
   TI
   LI
   LO
   TS
CP0373373
3-(4-(2-Chloroacetyl)piperazin-1-yl)-5,7-dihydroxy-4-methyl-2H-chromen-2-one
   Show/Hide
C16H17ClN2O5
 1
1
IC50 = 8580 nM
   TI
   LI
   LO
   TS
CP0442870
1-(4-(4-(2,4-dichlorobenzyloxy)pyrimidin-2-yl)piperazin-1-yl)-2-(1-methyl-1H-imidazol-4-yl)ethanone
   Show/Hide
C21H22Cl2N6O2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0456935
1-(4-(4-(2,4-dichlorobenzyloxy)pyrimidin-2-yl)piperazin-1-yl)-2-(pyridin-3-yl)ethanone
   Show/Hide
C22H21Cl2N5O2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0464679
(4-(4-(2,4-dichlorobenzylamino)pyrimidin-2-yl)piperazin-1-yl)(piperidin-4-yl)methanone
   Show/Hide
C21H26Cl2N6O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0464680
N-[3-[[4-[(2,4-dichlorophenyl)methoxy]pyrimidin-2-yl]amino]propyl]-1-methylpiperidine-3-carboxamide
   Show/Hide
C21H27Cl2N5O2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0492075
(4-(4-(2,4-dichlorobenzyloxy)pyrimidin-2-yl)piperazin-1-yl)(pyridin-3-yl)methanone
   Show/Hide
C21H19Cl2N5O2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0516019
N-[2-[[4-[(2,4-dichlorophenyl)methoxy]pyrimidin-2-yl]amino]ethyl]-1-methylpiperidine-3-carboxamide
   Show/Hide
C20H25Cl2N5O2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0525177
(4-(4-(2,4-dichlorobenzylamino)pyrimidin-2-yl)piperazin-1-yl)(azetidin-3-yl)methanone
   Show/Hide
C19H22Cl2N6O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0423568
3-(4-(2-Ethylbutyl)piperazin-1-yl)-5,7-dihydroxy-4-methyl-2H-chromen-2-one
   Show/Hide
C20H28N2O4
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0510486
5,7-Dihydroxy-3-(4-(2-methoxyphenyl)piperazin-1-yl)-4-methyl-2H-chromen-2-one
   Show/Hide
C21H22N2O5
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0510485
5,7-Dihydroxy-4-methyl-3-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)-2H-chromen-2-one
   Show/Hide
C21H19F3N2O4
 1
1
IC50 = 15100 nM
   TI
   LI
   LO
   TS
CP0510488
3-(4-(2,3-Dimethylphenyl)piperazin-1-yl)-5,7-dihydroxy-4-methyl-2H-chromen-2-one
   Show/Hide
C22H24N2O4
 1
1
IC50 = 31300 nM
   TI
   LI
   LO
   TS
CP0430738
3-(4-(4-Fluorophenyl)piperazin-1-yl)-5,7-dihydroxy-4-methyl-2H-chromen-2-one
   Show/Hide
C20H19FN2O4
 1
1
IC50 = 58500 nM
   TI
   LI
   LO
   TS