Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT01479 , 3',5'-cyclic-AMP phosphodiesterase 4A
 Protein Info 
Gene Name PDE4A
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID P27815
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006
 Cell Line Info 
 Protein ID: PT01479
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0500068
 Compound Info 
2-[(2-fluorophenyl)methoxy]-9,10-dimethoxy-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one
   Show/Hide
C21H19FN2O4
  1
1
IC50 = 372 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0573421
 Compound Info 
2-(benzylamino)-9,10-dimethoxy-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one
   Show/Hide
C21H21N3O3
  1
1
IC50 = 553 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0535032
 Compound Info 
9,10-dimethoxy-2-(2-pyridin-2-yloxyethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one
   Show/Hide
C21H21N3O5
  1
1
IC50 = 586 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0486535
 Compound Info 
2-[(3-fluoropyridin-2-yl)methoxy]-9,10-dimethoxy-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one
   Show/Hide
C20H18FN3O4
  1
1
IC50 = 1088 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0532953
 Compound Info 
9,10-dimethoxy-2-(2-phenoxyethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one
   Show/Hide
C22H22N2O5
  1
1
IC50 = 2115 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0512709
 Compound Info 
9,10-dimethoxy-2-(oxolan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one
   Show/Hide
C19H22N2O5
  1
1
IC50 = 2165 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0486534
 Compound Info 
2-[(2-fluorophenyl)methoxy]-9-methoxy-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one
   Show/Hide
C20H17FN2O3
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0511849
 Compound Info 
2-[(2-fluorophenyl)methoxy]-10-methoxy-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one
   Show/Hide
C20H17FN2O3
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0539843
 Compound Info 
2-[(3-fluoropyridin-2-yl)methoxy]-9-methoxy-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one
   Show/Hide
C19H16FN3O3
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0552896
 Compound Info 
2-[(2-fluorophenyl)methoxy]-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one
   Show/Hide
C19H15FN2O2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0486533
 Compound Info 
9-methoxy-2-(2-phenoxyethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one
   Show/Hide
C21H20N2O4
  1
1
IC50 > 10 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS