Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT01156 , Muscarinic acetylcholine receptor M4
Gene Name CHRM4
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P08173
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT01156
 
Compound ID Compound Name Compound Formula
CP0440162
CHEMBL4583597
   Show/Hide
C24H30N4O2
 1
1
EC50 = 3 nM
   TI
   LI
   LO
   TS
CP0371787
5-(4-Hexyloxy-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2,3,6-tetrahydro-pyridine; oxalic acid
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C14H23N3OS
 2
1
EC50 = 6 nM
   TI
   LI
   LO
   TS
2
EC50 = 18 nM
   TI
   LI
   LO
   TS
CP0411100
2-[(1S,5R)-6-(1-phenylimidazol-2-yl)-3-azabicyclo[3.1.0]hexan-3-yl]-6-pyrazin-2-yl-6-azaspiro[3.4]octane
   Show/Hide
C25H28N6
 1
1
EC50 = 7 nM
   TI
   LI
   LO
   TS
CP0037621
(oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyrrolidin-2-one
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C12H18N2O
 2
1
EC50 = 9 nM
   TI
   LI
   LO
   TS
2
EC50 = 14 nM
   TI
   LI
   LO
   TS
CP0473747
ethyl 2-[4-(3-methoxypyridin-2-yl)piperidin-1-yl]-6-azaspiro[3.4]octane-6-carboxylate
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C21H31N3O3
 1
1
EC50 = 9 nM
   TI
   LI
   LO
   TS
CP0484340
US10030012, Example 38
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C20H31N3O3
 1
1
EC50 = 11 nM
   TI
   LI
   LO
   TS
CP0484339
4-[4-(3-methoxypyridin-2-yl)piperidin-1-yl]-1-pyrazin-2-ylazepane
   Show/Hide
C21H29N5O
 2
1
EC50 = 16 nM
   TI
   LI
   LO
   TS
2
EC50 = 25 nM
   TI
   LI
   LO
   TS
CP0473746
3-[4-[4-(3-methoxypyridin-2-yl)piperidin-1-yl]azepan-1-yl]-1,2,5-thiadiazole
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C19H27N5OS
 1
1
EC50 = 20 nM
   TI
   LI
   LO
   TS
CP0416211
ethyl 4-[[4-(3-methoxypyridin-2-yl)piperidin-1-yl]methyl]piperidine-1-carboxylate
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C20H31N3O3
 1
1
EC50 = 23 nM
   TI
   LI
   LO
   TS
CP0000324
2-acetoxyethyl(trimethyl)ammonium;bromide
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C7H16NO2+
 2
1
EC50 = 43 nM
   TI
   LI
   LO
   TS
2
EC50 = 57 nM
   TI
   LI
   LO
   TS
CP0560056
2-[4-(3-methoxypyridin-2-yl)piperidin-1-yl]-6-pyrazin-2-yl-6-azaspiro[3.4]octane
   Show/Hide
C22H29N5O
 1
1
EC50 = 228 nM
   TI
   LI
   LO
   TS
CP0416210
2-[4-[[4-(3-methoxypyridin-2-yl)piperidin-1-yl]methyl]piperidin-1-yl]pyrazine
   Show/Hide
C21H29N5O
 1
1
EC50 = 296 nM
   TI
   LI
   LO
   TS
CP0484211
3-[4-[4-(3-methoxypyridin-2-yl)piperidin-1-yl]azepan-1-yl]-4-methyl-1,2,5-thiadiazole
   Show/Hide
C20H29N5OS
 1
1
EC50 = 470 nM
   TI
   LI
   LO
   TS
CP0416209
5-[4-[4-(3-methoxypyridin-2-yl)piperidin-1-yl]azepan-1-yl]-1,2,4-thiadiazole
   Show/Hide
C19H27N5OS
 1
1
EC50 = 1100 nM
   TI
   LI
   LO
   TS
CP0440161
3-methoxy-4-[4-[4-(3-methoxypyridin-2-yl)piperidin-1-yl]azepan-1-yl]-1,2,5-thiadiazole
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C20H29N5O2S
 1
1
EC50 = 2510 nM
   TI
   LI
   LO
   TS
CP0478886
4-[4-(3-methoxypyridin-2-yl)piperidin-1-yl]-1-(3-methylpyrazin-2-yl)azepane
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C22H31N5O
 2
1
EC50 = 3410 nM
   TI
   LI
   LO
   TS
2
EC50 = 3550 nM
   TI
   LI
   LO
   TS
CP0484350
4-[4-(3-methoxypyridin-2-yl)piperidin-1-yl]-1-(6-methylpyrazin-2-yl)azepane
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C22H31N5O
 2
1
EC50 = 9830 nM
   TI
   LI
   LO
   TS
2
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0426531
2-[4-[4-(3-methoxypyridin-2-yl)piperidin-1-yl]azepan-1-yl]-4-methyl-1,3-thiazole
   Show/Hide
C21H30N4OS
 2
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
2
EC50 > 2740 nM
   TI
   LI
   LO
   TS
CP0473744
4-[4-(3-methoxypyridin-2-yl)piperidin-1-yl]-1-pyridin-4-ylazepane
   Show/Hide
C22H30N4O
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0473745
4-[4-(3-methoxypyridin-2-yl)piperidin-1-yl]-1-pyrimidin-2-ylazepane
   Show/Hide
C21H29N5O
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0484351
4-[4-(3-methoxypyridin-2-yl)piperidin-1-yl]-1-pyrimidin-5-ylazepane
   Show/Hide
C21H29N5O
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0487591
4-[4-(3-methoxypyridin-2-yl)piperidin-1-yl]-1-pyridin-3-ylazepane
   Show/Hide
C22H30N4O
 1
1
EC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0533561
4-[4-(3-methoxypyridin-2-yl)piperidin-1-yl]-1-pyridin-2-ylazepane
   Show/Hide
C22H30N4O
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0534439
4-[4-(3-methoxypyridin-2-yl)piperidin-1-yl]-1-pyridazin-3-ylazepane
   Show/Hide
C21H29N5O
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0543876
2-[4-[4-(3-methoxypyridin-2-yl)piperidin-1-yl]azepan-1-yl]-1,3,4-thiadiazole
   Show/Hide
C19H27N5OS
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0560053
2-[4-[4-(3-methoxypyridin-2-yl)piperidin-1-yl]azepan-1-yl]-1,3-thiazole
   Show/Hide
C20H28N4OS
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0569587
N-ethyl-4-[4-(3-methoxypyridin-2-yl)piperidin-1-yl]azepane-1-sulfonamide
   Show/Hide
C19H32N4O3S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0533560
4-[4-(3-methoxypyridin-2-yl)piperidin-1-yl]-1-(5-methylpyrazin-2-yl)azepane
   Show/Hide
C22H31N5O
 1
1
EC50 > 4160 nM
   TI
   LI
   LO
   TS
CP0484348
N-ethyl-4-[4-(3-methoxypyridin-2-yl)piperidin-1-yl]azepane-1-carboxamide
   Show/Hide
C20H32N4O2
 1
1
EC50 > 5990 nM
   TI
   LI
   LO
   TS
CP0416208
1-[4-[4-(3-methoxypyridin-2-yl)piperidin-1-yl]azepan-1-yl]butan-1-one
   Show/Hide
C21H33N3O2
 1
1
EC50 > 8880 nM
   TI
   LI
   LO
   TS
CP0578043
propan-2-yl 4-[4-(3-methoxypyridin-2-yl)piperidin-1-yl]azepane-1-carboxylate
   Show/Hide
C21H33N3O3
 1
1
EC50 > 9250 nM
   TI
   LI
   LO
   TS
CP0484349
2-methylpropyl 4-[4-(3-methoxypyridin-2-yl)piperidin-1-yl]azepane-1-carboxylate
   Show/Hide
C22H35N3O3
 1
1
EC50 > 9930 nM
   TI
   LI
   LO
   TS
CP0416405
4-[2-[(1E,3E,5E)-5-[1-[6-[[3,5-bis[2-[3-[1-[4-[1-[2-oxo-2-(6-oxo-5H-benzo[b][1,4]benzodiazepin-11-yl)ethyl]piperidin-4-yl]butyl]imidazol-4-yl]propanoylamino]ethylcarbamoyl]phenyl]methylamino]-6-oxohexyl]-3,3-dimethyl-5-sulfoindol-2-ylidene]penta-1,3-dienyl]-3,3-dimethylindol-1-ium-1-yl]butane-1-sulfonate;2,2,2-trifluoroacetic acid
   Show/Hide
C114H132F9N17O21S2
 1
1
IC50 = 37.15 nM
   TI
   LI
   LO
   TS
CP0390406
4-[(2Z)-2-[(2E,4E)-5-[3,3-dimethyl-1-[6-oxo-6-[2-[4-[4-[1-[2-oxo-2-(6-oxo-5H-benzo[b][1,4]benzodiazepin-11-yl)ethyl]piperidin-4-yl]butyl]piperazin-1-yl]ethylamino]hexyl]indol-1-ium-2-yl]penta-2,4-dienylidene]-3,3-dimethylindol-1-yl]butane-1-sulfonate;2,2,2-trifluoroacetic acid
   Show/Hide
C71H87F9N8O12S
 1
1
IC50 = 91.2 nM
   TI
   LI
   LO
   TS
CP0390408
4-[2-[(1E,3E,5E)-5-[3,3-dimethyl-1-[6-oxo-6-[2-[4-[4-[1-[2-oxo-2-(6-oxo-5H-benzo[b][1,4]benzodiazepin-11-yl)ethyl]piperidin-4-yl]butyl]piperazin-1-yl]ethylamino]hexyl]-5-sulfoindol-2-ylidene]penta-1,3-dienyl]-3,3-dimethylindol-1-ium-1-yl]butane-1-sulfonate;2,2,2-trifluoroacetic acid
   Show/Hide
C69H86F6N8O13S2
 1
1
IC50 = 102.33 nM
   TI
   LI
   LO
   TS
CP0396867
4-[2-[(1E,3E,5E)-5-[3,3-dimethyl-1-[6-oxo-6-[2-[3-[1-[4-[1-[2-oxo-2-(6-oxo-5H-benzo[b][1,4]benzodiazepin-11-yl)ethyl]piperidin-4-yl]butyl]imidazol-4-yl]propanoylamino]ethylamino]hexyl]-5-sulfoindol-2-ylidene]penta-1,3-dienyl]-3,3-dimethylindol-1-ium-1-yl]butane-1-sulfonate;2,2,2-trifluoroacetic acid
   Show/Hide
C69H84F3N9O12S2
 1
1
IC50 = 138.04 nM
   TI
   LI
   LO
   TS