Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT00853 , Renin
Gene Name REN
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID P00797
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT00853
 
Compound ID Compound Name Compound Formula
CP0579965
US10155731, Example 270
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C22H32N6O4
 1
1
IC50 = 0.4 nM
   TI
   LI
   LO
   TS
CP0580055
methyl N-[3-[3-[(1R)-1-[cyclopropyl-[(2R)-morpholine-2-carbonyl]amino]ethyl]pyrrolo[2,3-b]pyridin-1-yl]propyl]carbamate
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C22H31N5O4
 1
1
IC50 = 0.4 nM
   TI
   LI
   LO
   TS
CP0570268
methyl N-[3-[3-[[cyclopropyl-[(2R)-morpholine-2-carbonyl]amino]methyl]-6-methylpyrrolo[2,3-b]pyridin-1-yl]propyl]carbamate
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C22H31N5O4
 1
1
IC50 = 0.8 nM
   TI
   LI
   LO
   TS
CP0579590
methyl N-[3-[3-[[cyclopropyl-[(2R)-morpholine-2-carbonyl]amino]methyl]indol-1-yl]propyl]carbamate
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C22H30N4O4
 1
1
IC50 = 0.9 nM
   TI
   LI
   LO
   TS
CP0571665
methyl N-[3-[7-[(1R)-1-[cyclopropyl-[(2R)-morpholine-2-carbonyl]amino]ethyl]pyrrolo[2,3-b]pyrazin-5-yl]propyl]carbamate
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C21H30N6O4
 1
1
IC50 = 1.7 nM
   TI
   LI
   LO
   TS
CP0576867
methyl N-[3-[3-[[cyclopropyl-[(2R)-morpholine-2-carbonyl]amino]methyl]pyrrolo[2,3-b]pyridin-1-yl]propyl]carbamate
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C21H29N5O4
 1
1
IC50 = 3.1 nM
   TI
   LI
   LO
   TS
CP0580056
US10155731, Example 268
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C21H30N6O4
 1
1
IC50 = 3.6 nM
   TI
   LI
   LO
   TS
CP0577007
US10155731, Example 271
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C22H32N6O4
 1
1
IC50 = 3.7 nM
   TI
   LI
   LO
   TS
CP0577006
methyl N-[3-[3-[[cyclopropyl-[(2R)-morpholine-2-carbonyl]amino]methyl]-4-methylpyrrolo[2,3-b]pyridin-1-yl]propyl]carbamate
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C22H31N5O4
 1
1
IC50 = 7.8 nM
   TI
   LI
   LO
   TS
CP0569514
US8975252, 39
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C21H29N3O3
 1
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
CP0570269
methyl N-[3-[3-[(1S)-1-[cyclopropyl-[(2R)-morpholine-2-carbonyl]amino]ethyl]pyrrolo[2,3-b]pyridin-1-yl]propyl]carbamate
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C22H31N5O4
 1
1
IC50 = 84 nM
   TI
   LI
   LO
   TS
CP0578794
(2R)-N-cyclopropyl-N-[[1-(3-methoxypropyl)pyrrolo[2,3-b]pyridin-3-yl]methyl]morpholine-2-carboxamide
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C20H28N4O3
 1
1
IC50 = 159 nM
   TI
   LI
   LO
   TS
CP0569913
(2R)-N-cyclopropyl-N-[[1-(3-methoxypropyl)pyrrolo[3,2-b]pyridin-3-yl]methyl]morpholine-2-carboxamide
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C20H28N4O3
 1
1
IC50 = 453 nM
   TI
   LI
   LO
   TS
CP0576866
(2R)-N-cyclopropyl-N-[[1-(3-methoxypropyl)indazol-3-yl]methyl]morpholine-2-carboxamide
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C20H28N4O3
 1
1
IC50 = 1076 nM
   TI
   LI
   LO
   TS
CP0570267
(2R)-N-cyclopropyl-N-[[1-(3-methoxypropyl)pyrrolo[2,3-c]pyridin-3-yl]methyl]morpholine-2-carboxamide
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C20H28N4O3
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0578289
(2R)-N-cyclopropyl-N-[[1-(3-methoxypropyl)pyrrolo[3,2-c]pyridin-3-yl]methyl]morpholine-2-carboxamide
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C20H28N4O3
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS