Brief Information of the Cell Line and Protein
Cell Line ID: CL000004 , SH-SY5Y
Synonyms
SH-Sy5y
SHSY5Y
SHSY-5Y
SK-SH-SY5Y
SY5Y
SH-SY5Y Parental
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0019
Protein ID: PT01019 , 5-hydroxytryptamine receptor 2B
Gene Name HTR2B
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P41595
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000004  Protein ID: PT01019
 
Compound ID Compound Name Compound Formula
CP0497804
4-methyl-1-spiro[cyclopentane-3,9'-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene]-1-ylpiperidine-4-carboxylic acid
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C26H31NO2
 1
1
Ki = 3.162 nM
   TI
   LI
   LO
   TS
CP0493859
3-methyl-1-[(3S)-spiro[cyclopentane-3,9'-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene]-1-yl]pyrrolidine-3-carboxylic acid
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C25H29NO2
 1
1
Ki = 10 nM
   TI
   LI
   LO
   TS
CP0374587
3-[4-(1,2-dimethyl-10H-imidazo[1,2-b][2]benzazepin-4-yl)piperazin-1-yl]-2,2-dimethylpropanoic acid
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C23H30N4O2
 1
1
Ki = 15.85 nM
   TI
   LI
   LO
   TS
CP0472908
(3S)-N,N-dimethylspiro[cyclopentane-3,9'-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene]-1-amine
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C21H25N
 1
1
Ki = 15.85 nM
   TI
   LI
   LO
   TS
CP0374588
3-[4-(1-chloro-10H-imidazo[1,2-b][2]benzazepin-4-yl)piperazin-1-yl]-2,2-dimethylpropanoic acid
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C21H25ClN4O2
 1
1
Ki = 25.12 nM
   TI
   LI
   LO
   TS
CP0040455
(Z)-2-butenedioate;10-(1-methyl-4-piperidinylidene)-5H-benzo[1,2]cyclohepta[3,4-b]thiophen-4-one
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C19H19NOS
 1
1
Ki = 31.62 nM
   TI
   LI
   LO
   TS
CP0497806
2-(1-spiro[cyclopentane-3,9'-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene]-1-ylazetidin-3-yl)acetic acid
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C24H27NO2
 1
1
Ki = 39.81 nM
   TI
   LI
   LO
   TS
CP0477585
2,2-dimethyl-3-[4-(2-methyl-10H-imidazo[1,2-b][2]benzazepin-4-yl)piperazin-1-yl]propanoic acid
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C22H28N4O2
 1
1
Ki = 63.1 nM
   TI
   LI
   LO
   TS
CP0279245
1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dibenzo[a,d]-cyclohepten]-3-yl)-3-azetidinecarboxylic Acid
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C23H25NO2
 1
1
Ki = 79.43 nM
   TI
   LI
   LO
   TS
CP0402437
3-[4-(2-chloro-10H-imidazo[1,2-b][2]benzazepin-4-yl)piperazin-1-yl]-2,2-dimethylpropanoic acid
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C21H25ClN4O2
 1
1
Ki = 100 nM
   TI
   LI
   LO
   TS
CP0497802
1-[(3S)-spiro[cyclopentane-3,9'-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene]-1-yl]pyrrolidine-3-carboxylic acid
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C24H27NO2
 1
1
Ki = 100 nM
   TI
   LI
   LO
   TS
CP0477603
3-[4-(1-methoxy-10H-imidazo[1,2-b][2]benzazepin-4-yl)piperazin-1-yl]-2,2-dimethylpropanoic acid
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C22H28N4O3
 1
1
Ki = 158.49 nM
   TI
   LI
   LO
   TS
CP0340560
(-)-1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dibenzo-[a,d]cyclohepten]-3-yl)-4-piperidinecarboxylic Acid
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C25H29NO2
 1
1
Ki = 158.49 nM
   TI
   LI
   LO
   TS
CP0379543
4-hydroxy-1-spiro[cyclopentane-3,9'-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene]-1-ylpiperidine-4-carboxylic acid
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C25H29NO3
 1
1
Ki = 251.19 nM
   TI
   LI
   LO
   TS
CP0523799
2-(1-spiro[cyclopentane-3,9'-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene]-1-ylazetidin-3-ylidene)acetic acid
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C24H25NO2
 1
1
Ki = 251.19 nM
   TI
   LI
   LO
   TS
CP0374581
4-piperazin-1-yl-10H-imidazo[1,2-b][2]benzazepine
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C16H18N4
 1
1
Ki = 316.23 nM
   TI
   LI
   LO
   TS
CP0374589
3-[4-(2-fluoro-10H-imidazo[1,2-b][2]benzazepin-4-yl)piperazin-1-yl]-2,2-dimethylpropanoic acid
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C21H25FN4O2
 1
1
Ki = 316.23 nM
   TI
   LI
   LO
   TS
CP0342216
3-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dibenzo[a,d]-cyclohepten]-3-yl)-3-azabicyclo[3.1.0]hexane-1-carboxylic Acid
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C25H27NO2
 1
1
Ki = 398.11 nM
   TI
   LI
   LO
   TS
CP0487906
3-[4-(10H-imidazo[1,2-b][2]benzazepin-4-yl)-2,6-dimethylpiperazin-1-yl]propanoic acid
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C21H26N4O2
 1
1
Ki = 630.96 nM
   TI
   LI
   LO
   TS
CP0335817
1-(11'H-Spiro[cyclopentane-1,10'-dibenzo[b,f]oxepin]-3-yl)-3-azetidinecarboxylic Acid
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C22H23NO3
 1
1
Ki = 794.33 nM
   TI
   LI
   LO
   TS
CP0379547
2-[1-[(3S)-spiro[cyclopentane-3,9'-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene]-1-yl]pyrrolidin-3-yl]acetic acid
   Show/Hide
C25H29NO2
 1
1
Ki = 1000 nM
   TI
   LI
   LO
   TS
CP0524075
2-(1-spiro[cyclopentane-3,9'-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene]-1-ylpiperidin-4-yl)acetic acid
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C26H31NO2
 1
1
Ki = 1000 nM
   TI
   LI
   LO
   TS
CP0075436
(2,3-Dimethoxy-phenyl)-{1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-methanol
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C22H28FNO3
 1
1
Ki = 1258.93 nM
   TI
   LI
   LO
   TS
CP0475730
(3R)-1-[(3S)-spiro[cyclopentane-3,9'-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene]-1-yl]piperidine-3-carboxylic acid
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C25H29NO2
 1
1
Ki = 1258.93 nM
   TI
   LI
   LO
   TS
CP0497808
methyl 1-[(3S)-spiro[cyclopentane-3,9'-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene]-1-yl]-3,6-dihydro-2H-pyridine-5-carboxylate
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C26H29NO2
 1
1
Ki = 1258.93 nM
   TI
   LI
   LO
   TS
CP0505536
4-[(3S)-spiro[cyclopentane-3,9'-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene]-1-yl]piperazine-2-carboxylic acid
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C24H28N2O2
 1
1
Ki = 1258.93 nM
   TI
   LI
   LO
   TS
CP0470855
3-[4-(10H-imidazo[1,2-b][2]benzazepin-4-yl)piperazin-1-yl]-2,2-dimethylpropanoic acid
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C21H26N4O2
 1
1
Ki = 1584.89 nM
   TI
   LI
   LO
   TS
CP0493852
1-spiro[6H-benzo[b][1]benzoxepine-5,3'-cyclopentane]-1'-ylpiperidine-4-carboxylic acid
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C24H27NO3
 1
1
Ki = 1584.89 nM
   TI
   LI
   LO
   TS
CP0374582
3-[4-(10H-imidazo[1,2-b][2]benzazepin-4-yl)piperazin-1-yl]propanoic acid
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C19H22N4O2
 1
1
Ki > 794.33 nM
   TI
   LI
   LO
   TS
CP0374584
2-[[4-(10H-imidazo[1,2-b][2]benzazepin-4-yl)piperazin-1-yl]methyl]prop-2-enoic acid
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C20H22N4O2
 1
1
Ki > 794.33 nM
   TI
   LI
   LO
   TS
CP0374585
3-[4-(10H-imidazo[1,2-b][2]benzazepin-4-yl)piperazin-1-yl]cyclobutane-1-carboxylic acid
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C21H24N4O2
 1
1
Ki > 794.33 nM
   TI
   LI
   LO
   TS
CP0374583
3-[4-(10H-imidazo[1,2-b][2]benzazepin-4-yl)-1,4-diazepan-1-yl]-2,2-dimethylpropanoic acid
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C22H28N4O2
 1
1
Ki > 1995.26 nM
   TI
   LI
   LO
   TS
CP0279246
3-[[(3R)-spiro[cyclopentane-3,9'-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene]-1-yl]amino]propanoic acid
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C22H25NO2
 1
1
Ki > 1995.26 nM
   TI
   LI
   LO
   TS
CP0279247
3-[[(3S)-spiro[cyclopentane-3,9'-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene]-1-yl]amino]propanoic acid
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C22H25NO2
 1
1
Ki > 1995.26 nM
   TI
   LI
   LO
   TS
CP0351011
1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dibenzo[a,d]-cyclohepten]-3-yl)-1,2,5,6-tetrahydro-3-pyridinecarboxylic Acid
   Show/Hide
C25H27NO2
 1
1
Ki > 1995.26 nM
   TI
   LI
   LO
   TS
CP0379554
3-fluoro-1-[(3S)-spiro[cyclopentane-3,9'-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene]-1-yl]piperidine-3-carboxylic acid
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C25H28FNO2
 1
1
Ki > 1995.26 nM
   TI
   LI
   LO
   TS
CP0379562
1-[(3R)-spiro[cyclopentane-3,9'-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene]-1-yl]-3,6-dihydro-2H-pyridine-5-carboxylic acid
   Show/Hide
C25H27NO2
 1
1
Ki > 1995.26 nM
   TI
   LI
   LO
   TS
CP0406094
1-(3-chloro-5-oxospiro[benzo[b][1]benzoxepine-6,3'-cyclopentane]-1'-yl)piperidine-4-carboxylic acid
   Show/Hide
C24H24ClNO4
 1
1
Ki > 1995.26 nM
   TI
   LI
   LO
   TS
CP0406107
1-spiro[6H-benzo[b][1]benzoxepine-5,3'-cyclopentane]-1'-yl-3,6-dihydro-2H-pyridine-5-carboxylic acid
   Show/Hide
C24H25NO3
 1
1
Ki > 1995.26 nM
   TI
   LI
   LO
   TS
CP0454555
4-fluoro-1-spiro[6H-benzo[b][1]benzoxepine-5,3'-cyclopentane]-1'-ylpiperidine-4-carboxylic acid
   Show/Hide
C24H26FNO3
 1
1
Ki > 1995.26 nM
   TI
   LI
   LO
   TS
CP0472909
1-(3-fluoro-5-oxospiro[benzo[b][1]benzothiepine-6,3'-cyclopentane]-1'-yl)piperidine-4-carboxylic acid
   Show/Hide
C24H24FNO3S
 1
1
Ki > 1995.26 nM
   TI
   LI
   LO
   TS
CP0493850
1-spiro[cyclopentane-3,9'-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene]-1-yl-3,6-dihydro-2H-pyridine-4-carboxylic acid
   Show/Hide
C25H27NO2
 1
1
Ki > 1995.26 nM
   TI
   LI
   LO
   TS
CP0493851
1-(6'-fluorospiro[cyclopentane-3,10'-tricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,11,13-hexaene]-1-yl)-3,6-dihydro-2H-pyridine-5-carboxylic acid
   Show/Hide
C25H26FNO2
 1
1
Ki > 1995.26 nM
   TI
   LI
   LO
   TS
CP0493856
1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dibenzo[a,d]-cyclohepten]-3-yl)-4-fluoro-4-piperidinecarboxylic Acid
   Show/Hide
C25H28FNO2
 1
1
Ki > 1995.26 nM
   TI
   LI
   LO
   TS
CP0497801
(3R)-1-(3-chloro-5-oxospiro[benzo[b][1]benzoxepine-6,3'-cyclopentane]-1'-yl)piperidine-3-carboxylic acid
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C24H24ClNO4
 1
1
Ki > 1995.26 nM
   TI
   LI
   LO
   TS
CP0497803
4-[(3S)-spiro[cyclopentane-3,9'-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene]-1-yl]morpholine-2-carboxylic acid
   Show/Hide
C24H27NO3
 1
1
Ki > 1995.26 nM
   TI
   LI
   LO
   TS
CP0505534
1-spiro[6H-benzo[b][1]benzoxepine-5,3'-cyclopentane]-1'-yl-3,6-dihydro-2H-pyridine-4-carboxylic acid
   Show/Hide
C24H25NO3
 1
1
Ki > 1995.26 nM
   TI
   LI
   LO
   TS
CP0505545
(3R)-1-spiro[6H-benzo[b][1]benzoxepine-5,3'-cyclopentane]-1'-ylpiperidine-3-carboxylic acid
   Show/Hide
C24H27NO3
 1
1
Ki > 1995.26 nM
   TI
   LI
   LO
   TS
CP0511822
(1S,5R)-3-spiro[cyclopentane-3,9'-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene]-1-yl-3-azabicyclo[3.1.0]hexane-6-carboxylic acid
   Show/Hide
C25H27NO2
 1
1
Ki > 1995.26 nM
   TI
   LI
   LO
   TS