Brief Information of the Compound and Protein
Compound Name
 Compound Info 
5-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1-yl}-benzofuran-2-carboxylic acid amide
    Show/Hide
 PubChem ID
CID: 6918314
SID: 14930538
Canonical SMILES
NC(=O)c1cc2cc(ccc2o1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
    Show/Hide
Compound Formula C26H27N5O2
Compound Structure
Protein Name
 Protein Info 
5-hydroxytryptamine receptor 1A
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Serotonin receptor
Uniprot ID
P08908
Gene Name
HTR1A
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
Ki = 9.7 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  4
1
EC50 = 0.12 nM
   TI
   LI
   LO
   TS
2
EC50 = 0.79 nM
   TI
   LI
   LO
   TS
3
Ki = 0.2 nM
   TI
   LI
   LO
   TS
4
Ki = 28 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.11 nM
2 Ki = 0.3 nM