Brief Information of the Compound and Protein
Compound Name
 Compound Info 
N-[3-[[4-[5-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazol-4-yl]pyridin-2-yl]amino]-4-methoxyphenyl]prop-2-enamide
    Show/Hide
 PubChem ID
CID: 134959408
Canonical SMILES
COc1ccc(NC(=O)C=C)cc1Nc1cc(ccn1)-c1[nH]c(SC)nc1-c1ccc(F)cc1
    Show/Hide
Compound Formula C25H22FN5O2S
Compound Structure
Protein Name
 Protein Info 
Epidermal growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase EGFR family
Uniprot ID
P00533
Gene Name
EGFR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 330 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  3
1
IC50 = 0.26 nM
   TI
   LI
   LO
   TS
2
IC50 = 6.5 nM
   TI
   LI
   LO
   TS
3
IC50 = 130 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 <= 0.5 nM
2 IC50 < 1 nM
3 IC50 = 90 nM