Brief Information of the Compound and Protein
Compound Name
9-[(3R,4R)-4-fluoro-1-methylpyrrolidin-3-yl]-7-methyl-2-[(7-methylquinolin-6-yl)amino]purin-8-one
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PubChem ID
CID: 168275101
Canonical SMILES
CN1C[C@@H](F)[C@@H](C1)n1c2nc(Nc3cc4cccnc4cc3C)ncc2n(C)c1=O
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Compound Formula C21H22FN7O
Compound Structure
Protein Name
DNA-dependent protein kinase catalytic subunit
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
Atypical protein kinase group
>
Atypical protein kinase PIKK family
Uniprot ID
P78527
Gene Name
PRKDC
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000068 A-549 Homo sapiens (Human)  1
1
IC50 = 128 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.64 nM